URB-754: A new class of designer drug and 12 synthetic cannabinoids detected in illegal products. Uchiyama, N., Kawamura, M., Kikura-Hanajiri, R., & Goda, Y. Forensic Science International, 227(1):21--32, April, 2013.
URB-754: A new class of designer drug and 12 synthetic cannabinoids detected in illegal products [link]Paper  doi  abstract   bibtex   
URB-754 (6-methyl-2-[(4-methylphenyl)amino]-1-benzoxazin-4-one) was identified as a new type of designer drug in illegal products. Though many of the synthetic cannabinoids detected in illegal products are known to have affinities for cannabinoid CB1/CB2 receptors, URB-754 was reported to inhibit an endocannabinoid deactivating enzyme. Furthermore, an unknown compound (N,5-dimethyl-N-(1-oxo-1-(p-tolyl)butan-2-yl)-2-(N′-(p-tolyl)ureido)benzamide), which is deduced to be the product of a reaction between URB-754 and a cathinone derivative 4-methylbuphedrone (4-Me-MABP), was identified along with URB-754 and 4-Me-MABP in the same product. It is of interest that the product of a reaction between two different types of designer drugs, namely, a cannabinoid-related designer drug and a cathinone-type designer drug, was found in one illegal product. In addition, 12 cannabimimetic compounds, 5-fluoropentyl-3-pyridinoylindole, JWH-307, JWH-030, UR-144, 5FUR-144 (synonym: XLR11), (4-methylnaphtyl)-JWH-022 [synonym: N-(5-fluoropentyl)-JWH-122], AM-2232, (4-methylnaphtyl)-AM-2201 (MAM-2201), N-(4-pentenyl)-JWH-122, JWH-213, (4-ethylnaphtyl)-AM-2201 (EAM-2201) and AB-001, were also detected herein as newly distributed designer drugs in Japan. Furthermore, a tryptamine derivative, 4-hydroxy-diethyltryptamine (4-OH-DET), was detected together with a synthetic cannabinoid, APINACA, in the same product.
@article{ uchiyama_urb-754:_2013,
  title = {{URB}-754: {A} new class of designer drug and 12 synthetic cannabinoids detected in illegal products},
  volume = {227},
  issn = {0379-0738},
  shorttitle = {{URB}-754},
  url = {http://www.fsijournal.org/article/S0379-0738(12)00434-3/abstract},
  doi = {10.1016/j.forsciint.2012.08.047},
  abstract = {URB-754 (6-methyl-2-[(4-methylphenyl)amino]-1-benzoxazin-4-one) was identified as a new type of designer drug in illegal products. Though many of the synthetic cannabinoids detected in illegal products are known to have affinities for cannabinoid CB1/CB2 receptors, URB-754 was reported to inhibit an endocannabinoid deactivating enzyme. Furthermore, an unknown compound (N,5-dimethyl-N-(1-oxo-1-(p-tolyl)butan-2-yl)-2-(N′-(p-tolyl)ureido)benzamide), which is deduced to be the product of a reaction between URB-754 and a cathinone derivative 4-methylbuphedrone (4-Me-MABP), was identified along with URB-754 and 4-Me-MABP in the same product. It is of interest that the product of a reaction between two different types of designer drugs, namely, a cannabinoid-related designer drug and a cathinone-type designer drug, was found in one illegal product. In addition, 12 cannabimimetic compounds, 5-fluoropentyl-3-pyridinoylindole, JWH-307, JWH-030, UR-144, 5FUR-144 (synonym: XLR11), (4-methylnaphtyl)-JWH-022 [synonym: N-(5-fluoropentyl)-JWH-122], AM-2232, (4-methylnaphtyl)-AM-2201 (MAM-2201), N-(4-pentenyl)-JWH-122, JWH-213, (4-ethylnaphtyl)-AM-2201 (EAM-2201) and AB-001, were also detected herein as newly distributed designer drugs in Japan. Furthermore, a tryptamine derivative, 4-hydroxy-diethyltryptamine (4-OH-DET), was detected together with a synthetic cannabinoid, APINACA, in the same product.},
  number = {1},
  urldate = {2013-04-07TZ},
  journal = {Forensic Science International},
  author = {Uchiyama, Nahoko and Kawamura, Maiko and Kikura-Hanajiri, Ruri and Goda, Yukihiro},
  month = {April},
  year = {2013},
  keywords = {(4-Ethylnaphtyl)-AM-2201 (EAM-2201), (N,5-dimethyl-N-(1-oxo-1-(p-tolyl) butan-2-yl)-2-(N′-(p-tolyl)ureido)benzamide), 4-Methylbuphedrone, 5-Fluoropentyl-3-pyridinoylindole, Synthetic cannabinoids, URB-754},
  pages = {21--32}
}

Downloads: 0