Tunable and precise miniature lithium heater for point-of-care applications. Udugama, B., Kadhiresan, P., & Chan, W. C. W. PNAS, 117(9):4632–4641, March, 2020. Publisher: National Academy of Sciences Section: Biological SciencesPaper Paper doi abstract bibtex Point-of-care diagnostic assays often involve multistep reactions, requiring a wide range of precise temperatures. Although precise heating is critical to performing these assays, it is challenging to provide it in an electricity-free format away from established infrastructure. Chemical heaters are electricity-free and use exothermic reactions. However, they are unsuitable for point-of-care multistep reactions because they sacrifice portability, have a narrow range of achievable temperatures, and long ramp-up times. Here we developed a miniature heater by modulating the lithium–water reaction kinetics using bubbles in a channel. Our heaters are up to 8,000 times smaller than current devices and can provide precise (within 5 °C) and tunable heating from 37 °C to 65 °C (∆TRT = 12 °C to 40 °C) with ramp-up times of a minute. We demonstrate field portablity and stability and show their use in an electricity-free multistep workflow that needs a range of temperatures. Ultimately, we envision providing better access to cutting edge biochemical techniques, including diagnostics, by making portable and electricity-free heating available at any location.
@article{udugama_tunable_2020,
title = {Tunable and precise miniature lithium heater for point-of-care applications},
volume = {117},
copyright = {© 2020 . https://www.pnas.org/site/aboutpnas/licenses.xhtmlPublished under the PNAS license.},
issn = {0027-8424, 1091-6490},
url = {https://www.pnas.org/content/117/9/4632},
doi = {10.1073/pnas.1916562117},
abstract = {Point-of-care diagnostic assays often involve multistep reactions, requiring a wide range of precise temperatures. Although precise heating is critical to performing these assays, it is challenging to provide it in an electricity-free format away from established infrastructure. Chemical heaters are electricity-free and use exothermic reactions. However, they are unsuitable for point-of-care multistep reactions because they sacrifice portability, have a narrow range of achievable temperatures, and long ramp-up times. Here we developed a miniature heater by modulating the lithium–water reaction kinetics using bubbles in a channel. Our heaters are up to 8,000 times smaller than current devices and can provide precise (within 5 °C) and tunable heating from 37 °C to 65 °C (∆TRT = 12 °C to 40 °C) with ramp-up times of a minute. We demonstrate field portablity and stability and show their use in an electricity-free multistep workflow that needs a range of temperatures. Ultimately, we envision providing better access to cutting edge biochemical techniques, including diagnostics, by making portable and electricity-free heating available at any location.},
language = {en},
number = {9},
urldate = {2021-11-06},
journal = {PNAS},
author = {Udugama, Buddhisha and Kadhiresan, Pranav and Chan, Warren C. W.},
month = mar,
year = {2020},
pmid = {32071225},
note = {Publisher: National Academy of Sciences
Section: Biological Sciences},
keywords = {chemical heater, diagnostics, point of care},
pages = {4632--4641},
file = {Full Text PDF:files/1820/Udugama et al. - 2020 - Tunable and precise miniature lithium heater for p.pdf:application/pdf;Snapshot:files/1821/4632.html:text/html},
url_Paper = {https://inbs.med.utoronto.ca/wp-content/uploads/2020/08/4632.full_.pdf}
}
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However, they are unsuitable for point-of-care multistep reactions because they sacrifice portability, have a narrow range of achievable temperatures, and long ramp-up times. Here we developed a miniature heater by modulating the lithium–water reaction kinetics using bubbles in a channel. Our heaters are up to 8,000 times smaller than current devices and can provide precise (within 5 °C) and tunable heating from 37 °C to 65 °C (∆TRT = 12 °C to 40 °C) with ramp-up times of a minute. We demonstrate field portablity and stability and show their use in an electricity-free multistep workflow that needs a range of temperatures. 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