Spatiotemporal Intracellular Nitric Oxide Signaling Captured using Internalized, Near Infrared Fluorescent Carbon Nanotube Nanosensors. Ulissi, Z. W., Sen, F., Gong, X., Sen, S., Iverson, N., Boghossian, A. A., Godoy, L., Wogan, G., Mukhopadhyay, D., & Strano, M. S. Nano Letters, 14:4887-4894, 2014.
Spatiotemporal Intracellular Nitric Oxide Signaling Captured using Internalized, Near Infrared Fluorescent Carbon Nanotube Nanosensors [link]Paper  doi  abstract   bibtex   1 download  
Fluorescent nanosensor probes have suffered from limited molecular recognition and a dearth of strategies for spatial-temporal operation in cell culture. In this work, we spatially imaged the dynamics of nitric oxide (NO) signaling, important in numerous pathologies and physiological functions, using intracellular near-infrared fluorescent single-walled carbon nanotubes. The observed spatial-temporal NO signaling gradients clarify and refine the existing paradigm of NO signaling based on averaged local concentrations. This work enables the study of transient intracellular phenomena associated with signaling and therapeutics.
@Article{bib:jsk,
  Title                    = {Spatiotemporal Intracellular Nitric Oxide Signaling Captured using Internalized, Near Infrared Fluorescent Carbon Nanotube Nanosensors},
  Author                   = {Ulissi, Zachary W. and Sen, Fatih and Gong, Xun and Sen, Selda and Iverson, Nicole and Boghossian, Ardemis A. and Godoy, Luiz and Wogan, Gerald and Mukhopadhyay, D. and Strano, Michael S.},
  Journal                  = {Nano Letters},
  Year                     = {2014},
  Pages                    = {4887-4894},
  Volume                   = {14},

  Abstract                 = {Fluorescent nanosensor probes have suffered from limited molecular recognition and a dearth of strategies for spatial-temporal operation in cell culture. In this work, we spatially imaged the dynamics of nitric oxide (NO) signaling, important in numerous pathologies and physiological functions, using intracellular near-infrared fluorescent single-walled carbon nanotubes. The observed spatial-temporal NO signaling gradients clarify and refine the existing paradigm of NO signaling based on averaged local concentrations. This work enables the study of transient intracellular phenomena associated with signaling and therapeutics.},
  Doi                      = {10.1021/nl502338y},
  Owner                    = {zulissi},
  Timestamp                = {2014.07.12},
  Url                      = {http://pubs.acs.org/doi/abs/10.1021/nl502338y}
}

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