Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study. Ulugut, H., Bertoux, M., Younes, K., Montembeault, M., Fumagalli, G. G., Samanci, B., Illán-Gala, I., Kuchcinski, G., Leroy, M., Thompson, J. C., Kobylecki, C., Santillo, A. F., Englund, E., Waldö, M. L., Riedl, L., Van den Stock, J., Vandenbulcke, M., Vandenberghe, R., Laforce, R., Ducharme, S., Pressman, P. S., Caramelli, P., de Souza, L. C., Takada, L. T., Gurvit, H., Hansson, O., Diehl-Schmid, J., Galimberti, D., Pasquier, F., Miller, B. L., Scheltens, P., Ossenkoppele, R., van der Flier, W. M., Barkhof, F., Fox, N. C., Sturm, V. E., Miyagawa, T., Whitwell, J. L., Boeve, B., Rohrer, J. D., Gorno-Tempini, M. L., Josephs, K. A., Snowden, J., Warren, J. D., Rankin, K. P., Pijnenburg, Y. A. L., & International rtvFTD Working Group Alzheimer's & Dementia: The Journal of the Alzheimer's Association, July, 2024. doi abstract bibtex INTRODUCTION: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. METHODS: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments. RESULTS: Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations. DISCUSSION: This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients. HIGHLIGHTS: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.
@article{ulugut_clinical_2024,
title = {Clinical recognition of frontotemporal dementia with right anterior temporal predominance: {A} multicenter retrospective cohort study},
copyright = {All rights reserved},
issn = {1552-5279},
shorttitle = {Clinical recognition of frontotemporal dementia with right anterior temporal predominance},
doi = {10.1002/alz.14076},
abstract = {INTRODUCTION: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype.
METHODS: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments.
RESULTS: Common symptoms included mental rigidity/preoccupations (78\%), disinhibition/socially inappropriate behavior (74\%), naming/word-finding difficulties (70\%), memory deficits (67\%), apathy (65\%), loss of empathy (65\%), and face-recognition deficits (60\%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74\%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations.
DISCUSSION: This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients.
HIGHLIGHTS: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.},
language = {eng},
journal = {Alzheimer's \& Dementia: The Journal of the Alzheimer's Association},
author = {Ulugut, Hulya and Bertoux, Maxime and Younes, Kyan and Montembeault, Maxime and Fumagalli, Giorgio G. and Samanci, Bedia and Illán-Gala, Ignacio and Kuchcinski, Gregory and Leroy, Melanie and Thompson, Jennifer C. and Kobylecki, Christopher and Santillo, Alexander F. and Englund, Elisabet and Waldö, Maria Landqvist and Riedl, Lina and Van den Stock, Jan and Vandenbulcke, Mathieu and Vandenberghe, Rik and Laforce, Robert and Ducharme, Simon and Pressman, Peter S. and Caramelli, Paulo and de Souza, Leonardo Cruz and Takada, Leonel T. and Gurvit, Hakan and Hansson, Oskar and Diehl-Schmid, Janine and Galimberti, Daniela and Pasquier, Florence and Miller, Bruce L. and Scheltens, Philip and Ossenkoppele, Rik and van der Flier, Wiesje M. and Barkhof, Frederik and Fox, Nick C. and Sturm, Virginia E. and Miyagawa, Toji and Whitwell, Jennifer L. and Boeve, Bradley and Rohrer, Jonathan D. and Gorno-Tempini, Maria Luisa and Josephs, Keith A. and Snowden, Julie and Warren, Jason D. and Rankin, Katherine P. and Pijnenburg, Yolande A. L. and {International rtvFTD Working Group}},
month = jul,
year = {2024},
pmid = {38982845},
keywords = {Aged, Atrophy, Female, Frontotemporal Dementia, Humans, Male, Middle Aged, Neuropsychological Tests, Retrospective Studies, Temporal Lobe, emotion recognition, frontotemporal dementia, frontotemporal lobar degeneration, right anterior temporal lobe, semantic dementia, social cognition},
}
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{"_id":"KQQnSCtYMXkrsCTKZ","bibbaseid":"ulugut-bertoux-younes-montembeault-fumagalli-samanci-illngala-kuchcinski-etal-clinicalrecognitionoffrontotemporaldementiawithrightanteriortemporalpredominanceamulticenterretrospectivecohortstudy-2024","author_short":["Ulugut, H.","Bertoux, M.","Younes, K.","Montembeault, M.","Fumagalli, G. G.","Samanci, B.","Illán-Gala, I.","Kuchcinski, G.","Leroy, M.","Thompson, J. C.","Kobylecki, C.","Santillo, A. F.","Englund, E.","Waldö, M. L.","Riedl, L.","Van den Stock, J.","Vandenbulcke, M.","Vandenberghe, R.","Laforce, R.","Ducharme, S.","Pressman, P. S.","Caramelli, P.","de Souza, L. C.","Takada, L. T.","Gurvit, H.","Hansson, O.","Diehl-Schmid, J.","Galimberti, D.","Pasquier, F.","Miller, B. L.","Scheltens, P.","Ossenkoppele, R.","van der Flier, W. M.","Barkhof, F.","Fox, N. C.","Sturm, V. E.","Miyagawa, T.","Whitwell, J. L.","Boeve, B.","Rohrer, J. D.","Gorno-Tempini, M. L.","Josephs, K. A.","Snowden, J.","Warren, J. D.","Rankin, K. P.","Pijnenburg, Y. A. L.","International rtvFTD Working Group"],"bibdata":{"bibtype":"article","type":"article","title":"Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study","copyright":"All rights reserved","issn":"1552-5279","shorttitle":"Clinical recognition of frontotemporal dementia with right anterior temporal predominance","doi":"10.1002/alz.14076","abstract":"INTRODUCTION: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. METHODS: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments. RESULTS: Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations. DISCUSSION: This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients. HIGHLIGHTS: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.","language":"eng","journal":"Alzheimer's & Dementia: The Journal of the Alzheimer's Association","author":[{"propositions":[],"lastnames":["Ulugut"],"firstnames":["Hulya"],"suffixes":[]},{"propositions":[],"lastnames":["Bertoux"],"firstnames":["Maxime"],"suffixes":[]},{"propositions":[],"lastnames":["Younes"],"firstnames":["Kyan"],"suffixes":[]},{"propositions":[],"lastnames":["Montembeault"],"firstnames":["Maxime"],"suffixes":[]},{"propositions":[],"lastnames":["Fumagalli"],"firstnames":["Giorgio","G."],"suffixes":[]},{"propositions":[],"lastnames":["Samanci"],"firstnames":["Bedia"],"suffixes":[]},{"propositions":[],"lastnames":["Illán-Gala"],"firstnames":["Ignacio"],"suffixes":[]},{"propositions":[],"lastnames":["Kuchcinski"],"firstnames":["Gregory"],"suffixes":[]},{"propositions":[],"lastnames":["Leroy"],"firstnames":["Melanie"],"suffixes":[]},{"propositions":[],"lastnames":["Thompson"],"firstnames":["Jennifer","C."],"suffixes":[]},{"propositions":[],"lastnames":["Kobylecki"],"firstnames":["Christopher"],"suffixes":[]},{"propositions":[],"lastnames":["Santillo"],"firstnames":["Alexander","F."],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Elisabet"],"suffixes":[]},{"propositions":[],"lastnames":["Waldö"],"firstnames":["Maria","Landqvist"],"suffixes":[]},{"propositions":[],"lastnames":["Riedl"],"firstnames":["Lina"],"suffixes":[]},{"propositions":["Van","den"],"lastnames":["Stock"],"firstnames":["Jan"],"suffixes":[]},{"propositions":[],"lastnames":["Vandenbulcke"],"firstnames":["Mathieu"],"suffixes":[]},{"propositions":[],"lastnames":["Vandenberghe"],"firstnames":["Rik"],"suffixes":[]},{"propositions":[],"lastnames":["Laforce"],"firstnames":["Robert"],"suffixes":[]},{"propositions":[],"lastnames":["Ducharme"],"firstnames":["Simon"],"suffixes":[]},{"propositions":[],"lastnames":["Pressman"],"firstnames":["Peter","S."],"suffixes":[]},{"propositions":[],"lastnames":["Caramelli"],"firstnames":["Paulo"],"suffixes":[]},{"propositions":["de"],"lastnames":["Souza"],"firstnames":["Leonardo","Cruz"],"suffixes":[]},{"propositions":[],"lastnames":["Takada"],"firstnames":["Leonel","T."],"suffixes":[]},{"propositions":[],"lastnames":["Gurvit"],"firstnames":["Hakan"],"suffixes":[]},{"propositions":[],"lastnames":["Hansson"],"firstnames":["Oskar"],"suffixes":[]},{"propositions":[],"lastnames":["Diehl-Schmid"],"firstnames":["Janine"],"suffixes":[]},{"propositions":[],"lastnames":["Galimberti"],"firstnames":["Daniela"],"suffixes":[]},{"propositions":[],"lastnames":["Pasquier"],"firstnames":["Florence"],"suffixes":[]},{"propositions":[],"lastnames":["Miller"],"firstnames":["Bruce","L."],"suffixes":[]},{"propositions":[],"lastnames":["Scheltens"],"firstnames":["Philip"],"suffixes":[]},{"propositions":[],"lastnames":["Ossenkoppele"],"firstnames":["Rik"],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Flier"],"firstnames":["Wiesje","M."],"suffixes":[]},{"propositions":[],"lastnames":["Barkhof"],"firstnames":["Frederik"],"suffixes":[]},{"propositions":[],"lastnames":["Fox"],"firstnames":["Nick","C."],"suffixes":[]},{"propositions":[],"lastnames":["Sturm"],"firstnames":["Virginia","E."],"suffixes":[]},{"propositions":[],"lastnames":["Miyagawa"],"firstnames":["Toji"],"suffixes":[]},{"propositions":[],"lastnames":["Whitwell"],"firstnames":["Jennifer","L."],"suffixes":[]},{"propositions":[],"lastnames":["Boeve"],"firstnames":["Bradley"],"suffixes":[]},{"propositions":[],"lastnames":["Rohrer"],"firstnames":["Jonathan","D."],"suffixes":[]},{"propositions":[],"lastnames":["Gorno-Tempini"],"firstnames":["Maria","Luisa"],"suffixes":[]},{"propositions":[],"lastnames":["Josephs"],"firstnames":["Keith","A."],"suffixes":[]},{"propositions":[],"lastnames":["Snowden"],"firstnames":["Julie"],"suffixes":[]},{"propositions":[],"lastnames":["Warren"],"firstnames":["Jason","D."],"suffixes":[]},{"propositions":[],"lastnames":["Rankin"],"firstnames":["Katherine","P."],"suffixes":[]},{"propositions":[],"lastnames":["Pijnenburg"],"firstnames":["Yolande","A.","L."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["International rtvFTD Working Group"],"suffixes":[]}],"month":"July","year":"2024","pmid":"38982845","keywords":"Aged, Atrophy, Female, Frontotemporal Dementia, Humans, Male, Middle Aged, Neuropsychological Tests, Retrospective Studies, Temporal Lobe, emotion recognition, frontotemporal dementia, frontotemporal lobar degeneration, right anterior temporal lobe, semantic dementia, social cognition","bibtex":"@article{ulugut_clinical_2024,\n\ttitle = {Clinical recognition of frontotemporal dementia with right anterior temporal predominance: {A} multicenter retrospective cohort study},\n\tcopyright = {All rights reserved},\n\tissn = {1552-5279},\n\tshorttitle = {Clinical recognition of frontotemporal dementia with right anterior temporal predominance},\n\tdoi = {10.1002/alz.14076},\n\tabstract = {INTRODUCTION: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype.\nMETHODS: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments.\nRESULTS: Common symptoms included mental rigidity/preoccupations (78\\%), disinhibition/socially inappropriate behavior (74\\%), naming/word-finding difficulties (70\\%), memory deficits (67\\%), apathy (65\\%), loss of empathy (65\\%), and face-recognition deficits (60\\%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74\\%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations.\nDISCUSSION: This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients.\nHIGHLIGHTS: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.},\n\tlanguage = {eng},\n\tjournal = {Alzheimer's \\& Dementia: The Journal of the Alzheimer's Association},\n\tauthor = {Ulugut, Hulya and Bertoux, Maxime and Younes, Kyan and Montembeault, Maxime and Fumagalli, Giorgio G. and Samanci, Bedia and Illán-Gala, Ignacio and Kuchcinski, Gregory and Leroy, Melanie and Thompson, Jennifer C. and Kobylecki, Christopher and Santillo, Alexander F. and Englund, Elisabet and Waldö, Maria Landqvist and Riedl, Lina and Van den Stock, Jan and Vandenbulcke, Mathieu and Vandenberghe, Rik and Laforce, Robert and Ducharme, Simon and Pressman, Peter S. and Caramelli, Paulo and de Souza, Leonardo Cruz and Takada, Leonel T. and Gurvit, Hakan and Hansson, Oskar and Diehl-Schmid, Janine and Galimberti, Daniela and Pasquier, Florence and Miller, Bruce L. and Scheltens, Philip and Ossenkoppele, Rik and van der Flier, Wiesje M. and Barkhof, Frederik and Fox, Nick C. and Sturm, Virginia E. and Miyagawa, Toji and Whitwell, Jennifer L. and Boeve, Bradley and Rohrer, Jonathan D. and Gorno-Tempini, Maria Luisa and Josephs, Keith A. and Snowden, Julie and Warren, Jason D. and Rankin, Katherine P. and Pijnenburg, Yolande A. L. and {International rtvFTD Working Group}},\n\tmonth = jul,\n\tyear = {2024},\n\tpmid = {38982845},\n\tkeywords = {Aged, Atrophy, Female, Frontotemporal Dementia, Humans, Male, Middle Aged, Neuropsychological Tests, Retrospective Studies, Temporal Lobe, emotion recognition, frontotemporal dementia, frontotemporal lobar degeneration, right anterior temporal lobe, semantic dementia, social cognition},\n}\n\n","author_short":["Ulugut, H.","Bertoux, M.","Younes, K.","Montembeault, M.","Fumagalli, G. G.","Samanci, B.","Illán-Gala, I.","Kuchcinski, G.","Leroy, M.","Thompson, J. C.","Kobylecki, C.","Santillo, A. F.","Englund, E.","Waldö, M. L.","Riedl, L.","Van den Stock, J.","Vandenbulcke, M.","Vandenberghe, R.","Laforce, R.","Ducharme, S.","Pressman, P. S.","Caramelli, P.","de Souza, L. C.","Takada, L. T.","Gurvit, H.","Hansson, O.","Diehl-Schmid, J.","Galimberti, D.","Pasquier, F.","Miller, B. L.","Scheltens, P.","Ossenkoppele, R.","van der Flier, W. M.","Barkhof, F.","Fox, N. 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