@article{Ulugut2024,
abstract = {INTRODUCTION: Although frontotemporal dementia (FTD) with right anterior temporal  lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. METHODS: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments. RESULTS: Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations. DISCUSSION: This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients. HIGHLIGHTS: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.},
author = {Ulugut, Hulya and Bertoux, Maxime and Younes, Kyan and Montembeault, Maxime and Fumagalli, Giorgio G and Samanci, Bedia and Ill{\'{a}}n-Gala, Ignacio and Kuchcinski, Gregory and Leroy, Melanie and Thompson, Jennifer C and Kobylecki, Christopher and Santillo, Alexander F and Englund, Elisabet and Wald{\"{o}}, Maria Landqvist and Riedl, Lina and {Van den Stock}, Jan and Vandenbulcke, Mathieu and Vandenberghe, Rik and Laforce, Robert Jr and Ducharme, Simon and Pressman, Peter S and Caramelli, Paulo and de Souza, Leonardo Cruz and Takada, Leonel T and Gurvit, Hakan and Hansson, Oskar and Diehl-Schmid, Janine and Galimberti, Daniela and Pasquier, Florence and Miller, Bruce L and Scheltens, Philip and Ossenkoppele, Rik and van der Flier, Wiesje M and Barkhof, Frederik and Fox, Nick C and Sturm, Virginia E and Miyagawa, Toji and Whitwell, Jennifer L and Boeve, Bradley and Rohrer, Jonathan D and Gorno-Tempini, Maria Luisa and Josephs, Keith A and Snowden, Julie and Warren, Jason D and Rankin, Katherine P and Pijnenburg, Yolande A L},
doi = {10.1002/alz.14076},
institution = {International rtvFTD Working Group},
issn = {1552-5279 (Electronic)},
journal = {Alzheimer's & dementia : the journal of the Alzheimer's Association},
keywords = {Aged,Atrophy,Female,Frontotemporal Dementia,Humans,Male,Middle Aged,Neuropsychological Tests,Retrospective Studies,Temporal Lobe,diagnosis,diagnostic imaging,pathology,statistics & numerical data},
language = {eng},
month = {aug},
number = {8},
pages = {5647--5661},
pmid = {38982845},
title = {{Clinical recognition of frontotemporal dementia with right anterior temporal  predominance: A multicenter retrospective cohort study.}},
volume = {20},
year = {2024}
}

{"_id":"KQQnSCtYMXkrsCTKZ","bibbaseid":"ulugut-bertoux-younes-montembeault-fumagalli-samanci-illngala-kuchcinski-etal-clinicalrecognitionoffrontotemporaldementiawithrightanteriortemporalpredominanceamulticenterretrospectivecohortstudy-2024","author_short":["Ulugut, H.","Bertoux, M.","Younes, K.","Montembeault, M.","Fumagalli, G. G","Samanci, B.","Illán-Gala, I.","Kuchcinski, G.","Leroy, M.","Thompson, J. C","Kobylecki, C.","Santillo, A. F","Englund, E.","Waldö, M. L.","Riedl, L.","Van den Stock, J.","Vandenbulcke, M.","Vandenberghe, R.","Laforce, R. J.","Ducharme, S.","Pressman, P. S","Caramelli, P.","de Souza, L. C.","Takada, L. T","Gurvit, H.","Hansson, O.","Diehl-Schmid, J.","Galimberti, D.","Pasquier, F.","Miller, B. L","Scheltens, P.","Ossenkoppele, R.","van der Flier, W. M","Barkhof, F.","Fox, N. C","Sturm, V. E","Miyagawa, T.","Whitwell, J. L","Boeve, B.","Rohrer, J. D","Gorno-Tempini, M. L.","Josephs, K. A","Snowden, J.","Warren, J. D","Rankin, K. P","Pijnenburg, Y. A L"],"bibdata":{"bibtype":"article","type":"article","abstract":"INTRODUCTION: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. METHODS: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments. RESULTS: Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations. DISCUSSION: This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients. HIGHLIGHTS: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.","author":[{"propositions":[],"lastnames":["Ulugut"],"firstnames":["Hulya"],"suffixes":[]},{"propositions":[],"lastnames":["Bertoux"],"firstnames":["Maxime"],"suffixes":[]},{"propositions":[],"lastnames":["Younes"],"firstnames":["Kyan"],"suffixes":[]},{"propositions":[],"lastnames":["Montembeault"],"firstnames":["Maxime"],"suffixes":[]},{"propositions":[],"lastnames":["Fumagalli"],"firstnames":["Giorgio","G"],"suffixes":[]},{"propositions":[],"lastnames":["Samanci"],"firstnames":["Bedia"],"suffixes":[]},{"propositions":[],"lastnames":["Illán-Gala"],"firstnames":["Ignacio"],"suffixes":[]},{"propositions":[],"lastnames":["Kuchcinski"],"firstnames":["Gregory"],"suffixes":[]},{"propositions":[],"lastnames":["Leroy"],"firstnames":["Melanie"],"suffixes":[]},{"propositions":[],"lastnames":["Thompson"],"firstnames":["Jennifer","C"],"suffixes":[]},{"propositions":[],"lastnames":["Kobylecki"],"firstnames":["Christopher"],"suffixes":[]},{"propositions":[],"lastnames":["Santillo"],"firstnames":["Alexander","F"],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Elisabet"],"suffixes":[]},{"propositions":[],"lastnames":["Waldö"],"firstnames":["Maria","Landqvist"],"suffixes":[]},{"propositions":[],"lastnames":["Riedl"],"firstnames":["Lina"],"suffixes":[]},{"propositions":[],"lastnames":["Van den Stock"],"firstnames":["Jan"],"suffixes":[]},{"propositions":[],"lastnames":["Vandenbulcke"],"firstnames":["Mathieu"],"suffixes":[]},{"propositions":[],"lastnames":["Vandenberghe"],"firstnames":["Rik"],"suffixes":[]},{"propositions":[],"lastnames":["Laforce"],"firstnames":["Robert","Jr"],"suffixes":[]},{"propositions":[],"lastnames":["Ducharme"],"firstnames":["Simon"],"suffixes":[]},{"propositions":[],"lastnames":["Pressman"],"firstnames":["Peter","S"],"suffixes":[]},{"propositions":[],"lastnames":["Caramelli"],"firstnames":["Paulo"],"suffixes":[]},{"propositions":["de"],"lastnames":["Souza"],"firstnames":["Leonardo","Cruz"],"suffixes":[]},{"propositions":[],"lastnames":["Takada"],"firstnames":["Leonel","T"],"suffixes":[]},{"propositions":[],"lastnames":["Gurvit"],"firstnames":["Hakan"],"suffixes":[]},{"propositions":[],"lastnames":["Hansson"],"firstnames":["Oskar"],"suffixes":[]},{"propositions":[],"lastnames":["Diehl-Schmid"],"firstnames":["Janine"],"suffixes":[]},{"propositions":[],"lastnames":["Galimberti"],"firstnames":["Daniela"],"suffixes":[]},{"propositions":[],"lastnames":["Pasquier"],"firstnames":["Florence"],"suffixes":[]},{"propositions":[],"lastnames":["Miller"],"firstnames":["Bruce","L"],"suffixes":[]},{"propositions":[],"lastnames":["Scheltens"],"firstnames":["Philip"],"suffixes":[]},{"propositions":[],"lastnames":["Ossenkoppele"],"firstnames":["Rik"],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Flier"],"firstnames":["Wiesje","M"],"suffixes":[]},{"propositions":[],"lastnames":["Barkhof"],"firstnames":["Frederik"],"suffixes":[]},{"propositions":[],"lastnames":["Fox"],"firstnames":["Nick","C"],"suffixes":[]},{"propositions":[],"lastnames":["Sturm"],"firstnames":["Virginia","E"],"suffixes":[]},{"propositions":[],"lastnames":["Miyagawa"],"firstnames":["Toji"],"suffixes":[]},{"propositions":[],"lastnames":["Whitwell"],"firstnames":["Jennifer","L"],"suffixes":[]},{"propositions":[],"lastnames":["Boeve"],"firstnames":["Bradley"],"suffixes":[]},{"propositions":[],"lastnames":["Rohrer"],"firstnames":["Jonathan","D"],"suffixes":[]},{"propositions":[],"lastnames":["Gorno-Tempini"],"firstnames":["Maria","Luisa"],"suffixes":[]},{"propositions":[],"lastnames":["Josephs"],"firstnames":["Keith","A"],"suffixes":[]},{"propositions":[],"lastnames":["Snowden"],"firstnames":["Julie"],"suffixes":[]},{"propositions":[],"lastnames":["Warren"],"firstnames":["Jason","D"],"suffixes":[]},{"propositions":[],"lastnames":["Rankin"],"firstnames":["Katherine","P"],"suffixes":[]},{"propositions":[],"lastnames":["Pijnenburg"],"firstnames":["Yolande","A","L"],"suffixes":[]}],"doi":"10.1002/alz.14076","institution":"International rtvFTD Working Group","issn":"1552-5279 (Electronic)","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","keywords":"Aged,Atrophy,Female,Frontotemporal Dementia,Humans,Male,Middle Aged,Neuropsychological Tests,Retrospective Studies,Temporal Lobe,diagnosis,diagnostic imaging,pathology,statistics & numerical data","language":"eng","month":"aug","number":"8","pages":"5647–5661","pmid":"38982845","title":"Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study.","volume":"20","year":"2024","bibtex":"@article{Ulugut2024,\nabstract = {INTRODUCTION: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. METHODS: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments. RESULTS: Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations. DISCUSSION: This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients. HIGHLIGHTS: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. 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