Effects of BDE-85 on the oxidative status and nerve conduction in rodents. Vagula, M. C, Kubeldis, N., & Nelatury, C. F International journal of toxicology, 30(4):428–34, August, 2011. Paper doi abstract bibtex BDE-85 is a congener of a class of flame-retardant compounds called polybrominated diphenyl ethers (PBDEs). Although there are some studies on other congeners of PBDEs, there are none on the toxicity potential of this penta-BDE member. This study, therefore, reports the oxidative status and sciatic nerve conduction properties following BDE-85 treatment in rodents. The oxidative stress markers, lipid hydroperoxides, and the activities of antioxidant enzymes, namely superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and catalase, in the exposed mice liver and brain tissues showed tissue-specific alterations following intraperitoneal injection of 0.25 mg/kg body weight of BDE-85 for 4 days. The results indicate a significant disruption in the oxidant/antioxidant equilibrium and setting in of oxidative stress. Isolated sciatic nerves of rats exposed to 5 µg/mL or 20 µg/mL of BDE-85 showed a significant reduction in nerve conduction velocity and compound action potential amplitudes, indicating physiological damage to the sciatic nerves.
@article{vagula_effects_2011,
title = {Effects of {BDE}-85 on the oxidative status and nerve conduction in rodents.},
volume = {30},
issn = {1092-874X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21772022},
doi = {10.1177/1091581811411109},
abstract = {BDE-85 is a congener of a class of flame-retardant compounds called polybrominated diphenyl ethers (PBDEs). Although there are some studies on other congeners of PBDEs, there are none on the toxicity potential of this penta-BDE member. This study, therefore, reports the oxidative status and sciatic nerve conduction properties following BDE-85 treatment in rodents. The oxidative stress markers, lipid hydroperoxides, and the activities of antioxidant enzymes, namely superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and catalase, in the exposed mice liver and brain tissues showed tissue-specific alterations following intraperitoneal injection of 0.25 mg/kg body weight of BDE-85 for 4 days. The results indicate a significant disruption in the oxidant/antioxidant equilibrium and setting in of oxidative stress. Isolated sciatic nerves of rats exposed to 5 µg/mL or 20 µg/mL of BDE-85 showed a significant reduction in nerve conduction velocity and compound action potential amplitudes, indicating physiological damage to the sciatic nerves.},
number = {4},
journal = {International journal of toxicology},
author = {Vagula, Mary C and Kubeldis, Nathan and Nelatury, Charles F},
month = aug,
year = {2011},
pmid = {21772022},
keywords = {Animals, Antioxidants, Antioxidants: metabolism, Biological Markers, Brain, Brain: drug effects, Catalase, Catalase: metabolism, Flame Retardants: toxicity, Flame retardants, Glutathione Peroxidase, Glutathione Peroxidase: metabolism, Glutathione Transferase, Glutathione Transferase: metabolism, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: toxicity, Lipid Peroxides, Lipid Peroxides: metabolism, Liver, Liver: drug effects, Male, Mice, Neural Conduction, Neural Conduction: drug effects, Oxidative Stress, Oxidative Stress: drug effects, Rats, Reactive Oxygen Species, Reactive Oxygen Species: metabolism, Sprague-Dawley, Superoxide Dismutase, Superoxide Dismutase: metabolism},
pages = {428--34},
}
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The oxidative stress markers, lipid hydroperoxides, and the activities of antioxidant enzymes, namely superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and catalase, in the exposed mice liver and brain tissues showed tissue-specific alterations following intraperitoneal injection of 0.25 mg/kg body weight of BDE-85 for 4 days. The results indicate a significant disruption in the oxidant/antioxidant equilibrium and setting in of oxidative stress. Isolated sciatic nerves of rats exposed to 5 µg/mL or 20 µg/mL of BDE-85 showed a significant reduction in nerve conduction velocity and compound action potential amplitudes, indicating physiological damage to the sciatic nerves.","number":"4","journal":"International journal of toxicology","author":[{"propositions":[],"lastnames":["Vagula"],"firstnames":["Mary","C"],"suffixes":[]},{"propositions":[],"lastnames":["Kubeldis"],"firstnames":["Nathan"],"suffixes":[]},{"propositions":[],"lastnames":["Nelatury"],"firstnames":["Charles","F"],"suffixes":[]}],"month":"August","year":"2011","pmid":"21772022","keywords":"Animals, Antioxidants, Antioxidants: metabolism, Biological Markers, Brain, Brain: drug effects, Catalase, Catalase: metabolism, Flame Retardants: toxicity, Flame retardants, Glutathione Peroxidase, Glutathione Peroxidase: metabolism, Glutathione Transferase, Glutathione Transferase: metabolism, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: toxicity, Lipid Peroxides, Lipid Peroxides: metabolism, Liver, Liver: drug effects, Male, Mice, Neural Conduction, Neural Conduction: drug effects, Oxidative Stress, Oxidative Stress: drug effects, Rats, Reactive Oxygen Species, Reactive Oxygen Species: metabolism, Sprague-Dawley, Superoxide Dismutase, Superoxide Dismutase: metabolism","pages":"428–34","bibtex":"@article{vagula_effects_2011,\n\ttitle = {Effects of {BDE}-85 on the oxidative status and nerve conduction in rodents.},\n\tvolume = {30},\n\tissn = {1092-874X},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/21772022},\n\tdoi = {10.1177/1091581811411109},\n\tabstract = {BDE-85 is a congener of a class of flame-retardant compounds called polybrominated diphenyl ethers (PBDEs). 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