Reduced amplification efficiency of the RNA-dependent-RNA-polymerase (RdRp) target enables tracking of the Delta SARS-CoV-2 variant using routine diagnostic tests. Valley-Omar, Z., Marais, G., Iranzadeh, A., Naidoo, M., Korsman, S., Maponga, T., Hussey, H., Davies, M., Boulle, A., Doolabh, D., Laubscher, M., Deetlefs, J., Maritz, J., Scott, L., Msomi, N., Tegally, H., de Oliveira, T., Bhiman, J., Williamson, C., Preiser, W., Hardie, D., & Hsiao, N. medRxiv, Cold Spring Harbor Laboratory Press, oct, 2021. ![Reduced amplification efficiency of the RNA-dependent-RNA-polymerase (RdRp) target enables tracking of the Delta SARS-CoV-2 variant using routine diagnostic tests [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Routine SARS-CoV-2 surveillance in the Western Cape region of South Africa (January-August 2021) found a reduced PCR amplification efficiency of the RdRp gene target of the Seegene, Allplex 2019-nCoV diagnostic assay when detecting the Delta variant. We propose that this can be used as a surrogate for variant detection.
@article{Valley-Omar2021,
abstract = {Routine SARS-CoV-2 surveillance in the Western Cape region of South Africa (January-August 2021) found a reduced PCR amplification efficiency of the RdRp gene target of the Seegene, Allplex 2019-nCoV diagnostic assay when detecting the Delta variant. We propose that this can be used as a surrogate for variant detection.},
author = {Valley-Omar, Ziyaad and Marais, Gert and Iranzadeh, Arash and Naidoo, Michelle and Korsman, Stephen and Maponga, Tongai and Hussey, Hannah and Davies, Mary-Ann and Boulle, Andrew and Doolabh, Deelan and Laubscher, Mariska and Deetlefs, JD and Maritz, Jean and Scott, Lesley and Msomi, Nokukhanya and Tegally, Houriiyah and de Oliveira, Tulio and Bhiman, Jinal and Williamson, Carolyn and Preiser, Wolfgang and Hardie, Diana and Hsiao, Nei-yuan},
doi = {10.1101/2021.10.01.21264408},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Valley-Omar et al. - 2021 - Reduced amplification efficiency of the RNA-dependent-RNA-polymerase (RdRp) target enables tracking of the D.pdf:pdf},
journal = {medRxiv},
keywords = {OA,fund{\_}ack,original},
mendeley-tags = {OA,fund{\_}ack,original},
month = {oct},
pages = {2021.10.01.21264408},
publisher = {Cold Spring Harbor Laboratory Press},
title = {{Reduced amplification efficiency of the RNA-dependent-RNA-polymerase (RdRp) target enables tracking of the Delta SARS-CoV-2 variant using routine diagnostic tests}},
url = {https://www.medrxiv.org/content/10.1101/2021.10.01.21264408v1 https://www.medrxiv.org/content/10.1101/2021.10.01.21264408v1.abstract},
year = {2021}
}
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