@article{RN185,
   author = {van Bussel, F. C. and Backes, W. H. and Hofman, P. A. and van Boxtel, M. P. and Schram, M. T. and Stehouwer, C. D. and Wildberger, J. E. and Jansen, J. F.},
   title = {Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements},
   journal = {J Neuroendocrinol},
   volume = {28},
   number = {3},
   pages = {12366},
   note = {van Bussel, F C G
Backes, W H
Hofman, P A M
van Boxtel, M P J
Schram, M T
Stehouwer, C D A
Wildberger, J E
Jansen, J F A
eng
Research Support, Non-U.S. Gov't
2016/01/23 06:00
J Neuroendocrinol. 2016 Mar;28(3):12366. doi: 10.1111/jne.12366.},
   abstract = {Type 2 diabetes mellitus is associated with cognitive decrements. Specifically affected cognitive domains are learning and memory, for which the hippocampus plays an essential role. The pathophysiological mechanism remains to be revealed. The present study examined whether local hippocampal microstructure and white matter connectivity are related to type 2 diabetes and memory performance. Forty participants with type 2 diabetes and 38 participants without type 2 diabetes underwent detailed cognitive assessment and 3-Tesla diffusion magnetic resonance imaging (MRI). Diffusion MRI was performed to assess microstructure (fractional anisotropy and mean diffusivity) and white matter connectivity (tract volume) of the hippocampus, which were compared between participants with and without type 2 diabetes. No differences in hippocampal microstructure were observed. Participants with type 2 diabetes had fewer white matter connections between the hippocampus and frontal lobe (P = 0.017). Participants who scored lower on memory function, regardless of type 2 diabetes, had fewer white matter connections between the hippocampus and temporal lobe (P = 0.017). Taken together, type 2 diabetes and memory decrements appear to be associated with altered hippocampal white matter connectivity.},
   keywords = {Aged
Case-Control Studies
Cognition Disorders/*etiology/pathology
Diabetes Mellitus, Type 2/*complications/*pathology/psychology
Diffusion Tensor Imaging
Female
Hippocampus/*pathology
Humans
Magnetic Resonance Imaging
Male
Memory/physiology
Middle Aged
Nerve Net/*pathology
White Matter/*pathology
cognition
diffusion
hippocampus
memory
white matter connectivity},
   ISSN = {1365-2826 (Electronic)
0953-8194 (Linking)},
   DOI = {10.1111/jne.12366},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/26791354
https://onlinelibrary.wiley.com/doi/abs/10.1111/jne.12366},
   year = {2016},
   type = {Journal Article}
}

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F."],"year":2016,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van"],"lastnames":["Bussel"],"firstnames":["F.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Boxtel"],"firstnames":["M.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Schram"],"firstnames":["M.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Stehouwer"],"firstnames":["C.","D."],"suffixes":[]},{"propositions":[],"lastnames":["Wildberger"],"firstnames":["J.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]}],"title":"Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements","journal":"J Neuroendocrinol","volume":"28","number":"3","pages":"12366","note":"van Bussel, F C G Backes, W H Hofman, P A M van Boxtel, M P J Schram, M T Stehouwer, C D A Wildberger, J E Jansen, J F A eng Research Support, Non-U.S. Gov't 2016/01/23 06:00 J Neuroendocrinol. 2016 Mar;28(3):12366. doi: 10.1111/jne.12366.","abstract":"Type 2 diabetes mellitus is associated with cognitive decrements. Specifically affected cognitive domains are learning and memory, for which the hippocampus plays an essential role. The pathophysiological mechanism remains to be revealed. The present study examined whether local hippocampal microstructure and white matter connectivity are related to type 2 diabetes and memory performance. Forty participants with type 2 diabetes and 38 participants without type 2 diabetes underwent detailed cognitive assessment and 3-Tesla diffusion magnetic resonance imaging (MRI). Diffusion MRI was performed to assess microstructure (fractional anisotropy and mean diffusivity) and white matter connectivity (tract volume) of the hippocampus, which were compared between participants with and without type 2 diabetes. No differences in hippocampal microstructure were observed. Participants with type 2 diabetes had fewer white matter connections between the hippocampus and frontal lobe (P = 0.017). Participants who scored lower on memory function, regardless of type 2 diabetes, had fewer white matter connections between the hippocampus and temporal lobe (P = 0.017). Taken together, type 2 diabetes and memory decrements appear to be associated with altered hippocampal white matter connectivity.","keywords":"Aged Case-Control Studies Cognition Disorders/*etiology/pathology Diabetes Mellitus, Type 2/*complications/*pathology/psychology Diffusion Tensor Imaging Female Hippocampus/*pathology Humans Magnetic Resonance Imaging Male Memory/physiology Middle Aged Nerve Net/*pathology White Matter/*pathology cognition diffusion hippocampus memory white matter connectivity","issn":"1365-2826 (Electronic) 0953-8194 (Linking)","doi":"10.1111/jne.12366","url":"http://www.ncbi.nlm.nih.gov/pubmed/26791354 https://onlinelibrary.wiley.com/doi/abs/10.1111/jne.12366","year":"2016","bibtex":"@article{RN185,\n author = {van Bussel, F. C. and Backes, W. H. and Hofman, P. A. and van Boxtel, M. P. and Schram, M. T. and Stehouwer, C. D. and Wildberger, J. E. and Jansen, J. F.},\n title = {Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements},\n journal = {J Neuroendocrinol},\n volume = {28},\n number = {3},\n pages = {12366},\n note = {van Bussel, F C G\nBackes, W H\nHofman, P A M\nvan Boxtel, M P J\nSchram, M T\nStehouwer, C D A\nWildberger, J E\nJansen, J F A\neng\nResearch Support, Non-U.S. Gov't\n2016/01/23 06:00\nJ Neuroendocrinol. 2016 Mar;28(3):12366. doi: 10.1111/jne.12366.},\n abstract = {Type 2 diabetes mellitus is associated with cognitive decrements. Specifically affected cognitive domains are learning and memory, for which the hippocampus plays an essential role. The pathophysiological mechanism remains to be revealed. The present study examined whether local hippocampal microstructure and white matter connectivity are related to type 2 diabetes and memory performance. Forty participants with type 2 diabetes and 38 participants without type 2 diabetes underwent detailed cognitive assessment and 3-Tesla diffusion magnetic resonance imaging (MRI). Diffusion MRI was performed to assess microstructure (fractional anisotropy and mean diffusivity) and white matter connectivity (tract volume) of the hippocampus, which were compared between participants with and without type 2 diabetes. No differences in hippocampal microstructure were observed. Participants with type 2 diabetes had fewer white matter connections between the hippocampus and frontal lobe (P = 0.017). Participants who scored lower on memory function, regardless of type 2 diabetes, had fewer white matter connections between the hippocampus and temporal lobe (P = 0.017). 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