@article{RN175,
   author = {van Bussel, F. C. and Backes, W. H. and Hofman, P. A. and van Oostenbrugge, R. J. and Kessels, A. G. and van Boxtel, M. P. and Schram, M. T. and Stehouwer, C. D. and Wildberger, J. E. and Jansen, J. F.},
   title = {On the interplay of microvasculature, parenchyma, and memory in type 2 diabetes},
   journal = {Diabetes Care},
   volume = {38},
   number = {5},
   pages = {876-82},
   note = {van Bussel, Frank C
Backes, Walter H
Hofman, Paul A
van Oostenbrugge, Robert J
Kessels, Alfons G
van Boxtel, Martin P
Schram, Miranda T
Stehouwer, Coen D
Wildberger, Joachim E
Jansen, Jacobus F
eng
Observational Study
Research Support, Non-U.S. Gov't
2015/02/19 06:00
Diabetes Care. 2015 May;38(5):876-82. doi: 10.2337/dc14-2043. Epub 2015 Feb 17.},
   abstract = {OBJECTIVE: Type 2 diabetes is associated with accelerated cognitive decline, especially regarding memory for which the hippocampus plays an essential role. The pathophysiological mechanisms still remain to be elucidated. The purpose of this study is to examine whether hippocampal microvascular and microstructural changes are related to type 2 diabetes (based on status or based on fasting blood glucose [FBG] levels) and verbal memory performance. RESEARCH DESIGN AND METHODS: Thirty-nine participants with type 2 diabetes (64.5 +/- 6.1 years old) and 34 participants without type 2 diabetes (58.3 +/- 9.2 years old) underwent detailed cognitive assessments and 3-Tesla MRI using intravoxel incoherent motion (IVIM) MRI. Multivariate regression analyses controlling for age, sex, education level, BMI, systolic blood pressure, hematocrit level, and relative hippocampal volume were performed to examine associations between hippocampal IVIM measures, type 2 diabetes (status and FBG), and memory performance. RESULTS: For the microvasculature, blood perfusion volume (f) was larger in participants with type 2 diabetes, f and blood flow (fD*) increased with higher FBG levels, and microvascular pseudodiffusion (D*) and fD*, which are indicative of altered microvasculature, were higher in participants with both relatively high FBG levels and low memory performance. In addition, fD* increased with lower memory performance. For the parenchymal microstructure, the diffusion (D), indicative of injured microstructure, was higher with reduced memory performance. CONCLUSIONS: In addition to the parenchymal microstructure, especially the microvascular properties of the hippocampus are altered in participants with both type 2 diabetes and memory problems and possibly hint at an underlying vascular mechanism.},
   keywords = {Adult
Aged
Case-Control Studies
Cognition Disorders/physiopathology/psychology
Diabetes Mellitus, Type 2/*physiopathology/psychology
Female
Hippocampus/*blood supply
Humans
Magnetic Resonance Angiography/methods
Male
Memory/physiology
Memory Disorders/*physiopathology/psychology
Microvessels/physiology
Middle Aged
Prospective Studies},
   ISSN = {1935-5548 (Electronic)
0149-5992 (Linking)},
   DOI = {10.2337/dc14-2043},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25690006
https://care.diabetesjournals.org/content/diacare/38/5/876.full.pdf},
   year = {2015},
   type = {Journal Article}
}

{"_id":"o2YcusXLvpkQXpwZL","bibbaseid":"vanbussel-backes-hofman-vanoostenbrugge-kessels-vanboxtel-schram-stehouwer-etal-ontheinterplayofmicrovasculatureparenchymaandmemoryintype2diabetes-2015","downloads":0,"creationDate":"2017-09-02T18:10:13.473Z","title":"On the interplay of microvasculature, parenchyma, and memory in type 2 diabetes","author_short":["van Bussel, F. C.","Backes, W. H.","Hofman, P. A.","van Oostenbrugge, R. J.","Kessels, A. G.","van Boxtel, M. P.","Schram, M. T.","Stehouwer, C. D.","Wildberger, J. E.","Jansen, J. F."],"year":2015,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van"],"lastnames":["Bussel"],"firstnames":["F.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Kessels"],"firstnames":["A.","G."],"suffixes":[]},{"propositions":["van"],"lastnames":["Boxtel"],"firstnames":["M.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Schram"],"firstnames":["M.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Stehouwer"],"firstnames":["C.","D."],"suffixes":[]},{"propositions":[],"lastnames":["Wildberger"],"firstnames":["J.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]}],"title":"On the interplay of microvasculature, parenchyma, and memory in type 2 diabetes","journal":"Diabetes Care","volume":"38","number":"5","pages":"876-82","note":"van Bussel, Frank C Backes, Walter H Hofman, Paul A van Oostenbrugge, Robert J Kessels, Alfons G van Boxtel, Martin P Schram, Miranda T Stehouwer, Coen D Wildberger, Joachim E Jansen, Jacobus F eng Observational Study Research Support, Non-U.S. Gov't 2015/02/19 06:00 Diabetes Care. 2015 May;38(5):876-82. doi: 10.2337/dc14-2043. Epub 2015 Feb 17.","abstract":"OBJECTIVE: Type 2 diabetes is associated with accelerated cognitive decline, especially regarding memory for which the hippocampus plays an essential role. The pathophysiological mechanisms still remain to be elucidated. The purpose of this study is to examine whether hippocampal microvascular and microstructural changes are related to type 2 diabetes (based on status or based on fasting blood glucose [FBG] levels) and verbal memory performance. RESEARCH DESIGN AND METHODS: Thirty-nine participants with type 2 diabetes (64.5 +/- 6.1 years old) and 34 participants without type 2 diabetes (58.3 +/- 9.2 years old) underwent detailed cognitive assessments and 3-Tesla MRI using intravoxel incoherent motion (IVIM) MRI. Multivariate regression analyses controlling for age, sex, education level, BMI, systolic blood pressure, hematocrit level, and relative hippocampal volume were performed to examine associations between hippocampal IVIM measures, type 2 diabetes (status and FBG), and memory performance. RESULTS: For the microvasculature, blood perfusion volume (f) was larger in participants with type 2 diabetes, f and blood flow (fD*) increased with higher FBG levels, and microvascular pseudodiffusion (D*) and fD*, which are indicative of altered microvasculature, were higher in participants with both relatively high FBG levels and low memory performance. In addition, fD* increased with lower memory performance. For the parenchymal microstructure, the diffusion (D), indicative of injured microstructure, was higher with reduced memory performance. CONCLUSIONS: In addition to the parenchymal microstructure, especially the microvascular properties of the hippocampus are altered in participants with both type 2 diabetes and memory problems and possibly hint at an underlying vascular mechanism.","keywords":"Adult Aged Case-Control Studies Cognition Disorders/physiopathology/psychology Diabetes Mellitus, Type 2/*physiopathology/psychology Female Hippocampus/*blood supply Humans Magnetic Resonance Angiography/methods Male Memory/physiology Memory Disorders/*physiopathology/psychology Microvessels/physiology Middle Aged Prospective Studies","issn":"1935-5548 (Electronic) 0149-5992 (Linking)","doi":"10.2337/dc14-2043","url":"http://www.ncbi.nlm.nih.gov/pubmed/25690006 https://care.diabetesjournals.org/content/diacare/38/5/876.full.pdf","year":"2015","bibtex":"@article{RN175,\n author = {van Bussel, F. C. and Backes, W. H. and Hofman, P. A. and van Oostenbrugge, R. J. and Kessels, A. G. and van Boxtel, M. P. and Schram, M. T. and Stehouwer, C. D. and Wildberger, J. E. and Jansen, J. F.},\n title = {On the interplay of microvasculature, parenchyma, and memory in type 2 diabetes},\n journal = {Diabetes Care},\n volume = {38},\n number = {5},\n pages = {876-82},\n note = {van Bussel, Frank C\nBackes, Walter H\nHofman, Paul A\nvan Oostenbrugge, Robert J\nKessels, Alfons G\nvan Boxtel, Martin P\nSchram, Miranda T\nStehouwer, Coen D\nWildberger, Joachim E\nJansen, Jacobus F\neng\nObservational Study\nResearch Support, Non-U.S. Gov't\n2015/02/19 06:00\nDiabetes Care. 2015 May;38(5):876-82. doi: 10.2337/dc14-2043. Epub 2015 Feb 17.},\n abstract = {OBJECTIVE: Type 2 diabetes is associated with accelerated cognitive decline, especially regarding memory for which the hippocampus plays an essential role. The pathophysiological mechanisms still remain to be elucidated. The purpose of this study is to examine whether hippocampal microvascular and microstructural changes are related to type 2 diabetes (based on status or based on fasting blood glucose [FBG] levels) and verbal memory performance. RESEARCH DESIGN AND METHODS: Thirty-nine participants with type 2 diabetes (64.5 +/- 6.1 years old) and 34 participants without type 2 diabetes (58.3 +/- 9.2 years old) underwent detailed cognitive assessments and 3-Tesla MRI using intravoxel incoherent motion (IVIM) MRI. Multivariate regression analyses controlling for age, sex, education level, BMI, systolic blood pressure, hematocrit level, and relative hippocampal volume were performed to examine associations between hippocampal IVIM measures, type 2 diabetes (status and FBG), and memory performance. RESULTS: For the microvasculature, blood perfusion volume (f) was larger in participants with type 2 diabetes, f and blood flow (fD*) increased with higher FBG levels, and microvascular pseudodiffusion (D*) and fD*, which are indicative of altered microvasculature, were higher in participants with both relatively high FBG levels and low memory performance. In addition, fD* increased with lower memory performance. For the parenchymal microstructure, the diffusion (D), indicative of injured microstructure, was higher with reduced memory performance. CONCLUSIONS: In addition to the parenchymal microstructure, especially the microvascular properties of the hippocampus are altered in participants with both type 2 diabetes and memory problems and possibly hint at an underlying vascular mechanism.},\n keywords = {Adult\nAged\nCase-Control Studies\nCognition Disorders/physiopathology/psychology\nDiabetes Mellitus, Type 2/*physiopathology/psychology\nFemale\nHippocampus/*blood supply\nHumans\nMagnetic Resonance Angiography/methods\nMale\nMemory/physiology\nMemory Disorders/*physiopathology/psychology\nMicrovessels/physiology\nMiddle Aged\nProspective Studies},\n ISSN = {1935-5548 (Electronic)\n0149-5992 (Linking)},\n DOI = {10.2337/dc14-2043},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/25690006\nhttps://care.diabetesjournals.org/content/diacare/38/5/876.full.pdf},\n year = {2015},\n type = {Journal Article}\n}\n\n","author_short":["van Bussel, F. C.","Backes, W. H.","Hofman, P. A.","van Oostenbrugge, R. J.","Kessels, A. G.","van Boxtel, M. P.","Schram, M. T.","Stehouwer, C. D.","Wildberger, J. E.","Jansen, J. F."],"key":"RN175","id":"RN175","bibbaseid":"vanbussel-backes-hofman-vanoostenbrugge-kessels-vanboxtel-schram-stehouwer-etal-ontheinterplayofmicrovasculatureparenchymaandmemoryintype2diabetes-2015","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/25690006 https://care.diabetesjournals.org/content/diacare/38/5/876.full.pdf"},"keyword":["Adult Aged Case-Control Studies Cognition Disorders/physiopathology/psychology Diabetes Mellitus","Type 2/*physiopathology/psychology Female Hippocampus/*blood supply Humans Magnetic Resonance Angiography/methods Male Memory/physiology Memory Disorders/*physiopathology/psychology Microvessels/physiology Middle Aged Prospective Studies"],"metadata":{"authorlinks":{"jansen, j":"https://www.jansenjfa.com/publications/"}},"downloads":0,"html":""},"search_terms":["interplay","microvasculature","parenchyma","memory","type","diabetes","van bussel","backes","hofman","van oostenbrugge","kessels","van boxtel","schram","stehouwer","wildberger","jansen"],"keywords":["adult aged case-control studies cognition disorders/physiopathology/psychology diabetes mellitus","type 2/*physiopathology/psychology female hippocampus/*blood supply humans magnetic resonance angiography/methods male memory/physiology memory disorders/*physiopathology/psychology microvessels/physiology middle aged prospective studies"],"authorIDs":["23uhM8poXdb926vJG","3Yjj5LyuY4rysZgP4","4Tm3oPxNFFsEkR6pe","59aae01e5ead235c6f00001d","5df0d93396fa76de0100014e","5df1707557cfb4de0100001d","5dfb0b68a8dc13ee01000092","5e024e386ffa15df0100007a","5e384203ca2b4bde010001ff","5e414cd6b7d170df01000174","5e47cbe8af70c7de0100001a","5e4d7a0d08a8e5de0100019e","5e4ea88f64b624de01000110","5e63862c0ddad9de010000b9","5e685fc7149172de01000144","7YnznfJEbNoLRQfCK","9N7zP6DW8bwFjrrji","9uYiZAT4SGYEdwuhG","C8PsDKLjSCW5NR3p7","CHX5tw5dNmS7tFMt9","DB2BA5PJJ7o8mgnGD","DoNKbgB55xkR6SehT","FEbMpouv9cRyJBZv3","GtL5d4iFpEuoJacN7","H6wbK4u5jYRFL8LDs","HLzbcixmNhduwmTFt","Jeci2sNzJiMSDeJvc","NAFTFJTb9GJgC2h6i","QqoDaykDZWJd9YuAu","RLbGKAvkbQAw2q2pz","SEoD5FrxRgf2DKcTT","TCejZCDssndxpTcJg","TEAWLnKpXtQE8hs6C","dGQk363jLcfCvKxGW","dR2ye6bifAsonnNMz","eJ9fizm2KNxBgiNfF","ejNE5EpaKtPzpHp79","gxe8DkJ5qKbznZgZq","hGdeHv63Gb3m6CybW","hShritfXo7Lzr2RkJ","jDvmx9aE5aohaf7P7","rQrciQZhPyL9ovwM8","ryLRyF5HAWnpncbbr","sFGhcvCCManvCwLHz","txfqjmhcnxmvnAv2m","zTR82AHQxLXLWt4wi"],"dataSources":["NcYBKGxxHQiyceke2","TCkfRWJAZvbLAZi29"]}