Blood-brain barrier impairment in dementia: current and future in vivo assessments. van de Haar, H. J., Burgmans, S., Hofman, P. A., Verhey, F. R., Jansen, J. F., & Backes, W. H. Neurosci Biobehav Rev, 49:71-81, 2015. van de Haar, Harm J Burgmans, Saartje Hofman, Paul A M Verhey, Frans R J Jansen, Jacobus F A Backes, Walter H eng Review 2014/12/20 06:00 Neurosci Biobehav Rev. 2015 Feb;49:71-81. doi: 10.1016/j.neubiorev.2014.11.022. Epub 2014 Dec 15.![Blood-brain barrier impairment in dementia: current and future in vivo assessments [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Increasing evidence indicates that blood-brain barrier (BBB) impairment may play a role in the pathophysiology of cognitive decline and dementia. In vivo imaging studies are needed to quantify and localize the BBB defects during life, contemplating the circulatory properties. We reviewed the literature for imaging studies investigating BBB impairment in patients suffering from dementia. After selection, 11 imaging studies were included, of which 6 used contrast-enhanced magnetic resonance imaging (MRI), 2 used contrast-enhanced computed tomography (CT), and 3 positron emission tomography (PET). Primarily the MRI studies hint at a subtle increasing permeability of the BBB, particularly in patients already exhibiting cerebrovascular pathology. More elaborate studies are required to provide convincing evidence on BBB impairment in patients with various stages of dementia with and without obvious cerebrovascular pathology. In the future, dynamic contrast enhanced MRI techniques and transport specific imaging using PET may further detail the research on the molecular nature of BBB defects.
@article{RN176,
author = {van de Haar, H. J. and Burgmans, S. and Hofman, P. A. and Verhey, F. R. and Jansen, J. F. and Backes, W. H.},
title = {Blood-brain barrier impairment in dementia: current and future in vivo assessments},
journal = {Neurosci Biobehav Rev},
volume = {49},
pages = {71-81},
note = {van de Haar, Harm J
Burgmans, Saartje
Hofman, Paul A M
Verhey, Frans R J
Jansen, Jacobus F A
Backes, Walter H
eng
Review
2014/12/20 06:00
Neurosci Biobehav Rev. 2015 Feb;49:71-81. doi: 10.1016/j.neubiorev.2014.11.022. Epub 2014 Dec 15.},
abstract = {Increasing evidence indicates that blood-brain barrier (BBB) impairment may play a role in the pathophysiology of cognitive decline and dementia. In vivo imaging studies are needed to quantify and localize the BBB defects during life, contemplating the circulatory properties. We reviewed the literature for imaging studies investigating BBB impairment in patients suffering from dementia. After selection, 11 imaging studies were included, of which 6 used contrast-enhanced magnetic resonance imaging (MRI), 2 used contrast-enhanced computed tomography (CT), and 3 positron emission tomography (PET). Primarily the MRI studies hint at a subtle increasing permeability of the BBB, particularly in patients already exhibiting cerebrovascular pathology. More elaborate studies are required to provide convincing evidence on BBB impairment in patients with various stages of dementia with and without obvious cerebrovascular pathology. In the future, dynamic contrast enhanced MRI techniques and transport specific imaging using PET may further detail the research on the molecular nature of BBB defects.},
keywords = {Animals
Blood-Brain Barrier/*pathology/*physiopathology
Dementia/*pathology/*physiopathology
Humans
Alzheimer's disease
Blood-brain barrier
Ct
Contrast-enhanced
Dce-mri
Dementia
Pet
Vascular dementia},
ISSN = {1873-7528 (Electronic)
0149-7634 (Linking)},
DOI = {10.1016/j.neubiorev.2014.11.022},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25524876
https://www.sciencedirect.com/science/article/abs/pii/S0149763414003479?via%3Dihub},
year = {2015},
type = {Journal Article}
}
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