@article{RN188,
   author = {van de Haar, H. J. and Jansen, J. F. A. and van Osch, M. J. P. and van Buchem, M. A. and Muller, M. and Wong, S. M. and Hofman, P. A. M. and Burgmans, S. and Verhey, F. R. J. and Backes, W. H.},
   title = {Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging},
   journal = {Neurobiol Aging},
   volume = {45},
   pages = {190-196},
   note = {van de Haar, Harm J
Jansen, Jacobus F A
van Osch, Matthias J P
van Buchem, Mark A
Muller, Majon
Wong, Sau May
Hofman, Paul A M
Burgmans, Saartje
Verhey, Frans R J
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2016/07/28 06:00
Neurobiol Aging. 2016 Sep;45:190-196. doi: 10.1016/j.neurobiolaging.2016.06.006. Epub 2016 Jun 17.},
   abstract = {The neurovascular unit, which protects neuronal cells and supplies them with essential molecules, plays an important role in the pathophysiology of Alzheimer's Disease (AD). The aim of this study was to noninvasively investigate 2 linked functional elements of the neurovascular unit, blood-brain barrier (BBB) permeability and cerebral blood flow (CBF), in patients with early AD and healthy controls. Therefore, both dynamic contrast-enhanced magnetic resonance imaging and arterial spin labeling magnetic resonance imaging were applied to measure BBB permeability and CBF, respectively. The patients with early AD showed significantly lower CBF and local blood volume in the gray matter, compared with controls. In the patients, we also found that a reduction in CBF is correlated with an increase in leakage rate. This finding supports the hypothesis that neurovascular damage, and in particular impairment of the neurovascular unit constitutes the pathophysiological link between CBF reduction and BBB impairment in AD.},
   keywords = {Aged
Aged, 80 and over
Alzheimer Disease/*diagnostic imaging/*etiology/pathology
Blood-Brain Barrier/diagnostic imaging/pathology/physiopathology
Cerebrovascular Circulation/physiology
Female
Gray Matter/blood supply/diagnostic imaging
Humans
Magnetic Resonance Imaging/*methods
Male
Microvessels/diagnostic imaging/pathology/physiopathology
*Alzheimer's disease
*Blood-brain barrier
*Cerebral hemodynamics
*Dementia
*Magnetic resonance imaging},
   ISSN = {1558-1497 (Electronic)
0197-4580 (Linking)},
   DOI = {10.1016/j.neurobiolaging.2016.06.006},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27459939
https://www.sciencedirect.com/science/article/abs/pii/S0197458016301063?via%3Dihub},
   year = {2016},
   type = {Journal Article}
}

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H."],"year":2016,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van","de"],"lastnames":["Haar"],"firstnames":["H.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Osch"],"firstnames":["M.","J.","P."],"suffixes":[]},{"propositions":["van"],"lastnames":["Buchem"],"firstnames":["M.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Muller"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Wong"],"firstnames":["S.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Burgmans"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Verhey"],"firstnames":["F.","R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging","journal":"Neurobiol Aging","volume":"45","pages":"190-196","note":"van de Haar, Harm J Jansen, Jacobus F A van Osch, Matthias J P van Buchem, Mark A Muller, Majon Wong, Sau May Hofman, Paul A M Burgmans, Saartje Verhey, Frans R J Backes, Walter H eng Research Support, Non-U.S. Gov't 2016/07/28 06:00 Neurobiol Aging. 2016 Sep;45:190-196. doi: 10.1016/j.neurobiolaging.2016.06.006. Epub 2016 Jun 17.","abstract":"The neurovascular unit, which protects neuronal cells and supplies them with essential molecules, plays an important role in the pathophysiology of Alzheimer's Disease (AD). The aim of this study was to noninvasively investigate 2 linked functional elements of the neurovascular unit, blood-brain barrier (BBB) permeability and cerebral blood flow (CBF), in patients with early AD and healthy controls. Therefore, both dynamic contrast-enhanced magnetic resonance imaging and arterial spin labeling magnetic resonance imaging were applied to measure BBB permeability and CBF, respectively. The patients with early AD showed significantly lower CBF and local blood volume in the gray matter, compared with controls. In the patients, we also found that a reduction in CBF is correlated with an increase in leakage rate. This finding supports the hypothesis that neurovascular damage, and in particular impairment of the neurovascular unit constitutes the pathophysiological link between CBF reduction and BBB impairment in AD.","keywords":"Aged Aged, 80 and over Alzheimer Disease/*diagnostic imaging/*etiology/pathology Blood-Brain Barrier/diagnostic imaging/pathology/physiopathology Cerebrovascular Circulation/physiology Female Gray Matter/blood supply/diagnostic imaging Humans Magnetic Resonance Imaging/*methods Male Microvessels/diagnostic imaging/pathology/physiopathology *Alzheimer's disease *Blood-brain barrier *Cerebral hemodynamics *Dementia *Magnetic resonance imaging","issn":"1558-1497 (Electronic) 0197-4580 (Linking)","doi":"10.1016/j.neurobiolaging.2016.06.006","url":"http://www.ncbi.nlm.nih.gov/pubmed/27459939 https://www.sciencedirect.com/science/article/abs/pii/S0197458016301063?via%3Dihub","year":"2016","bibtex":"@article{RN188,\n author = {van de Haar, H. J. and Jansen, J. F. A. and van Osch, M. J. P. and van Buchem, M. A. and Muller, M. and Wong, S. M. and Hofman, P. A. M. and Burgmans, S. and Verhey, F. R. J. and Backes, W. H.},\n title = {Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging},\n journal = {Neurobiol Aging},\n volume = {45},\n pages = {190-196},\n note = {van de Haar, Harm J\nJansen, Jacobus F A\nvan Osch, Matthias J P\nvan Buchem, Mark A\nMuller, Majon\nWong, Sau May\nHofman, Paul A M\nBurgmans, Saartje\nVerhey, Frans R J\nBackes, Walter H\neng\nResearch Support, Non-U.S. Gov't\n2016/07/28 06:00\nNeurobiol Aging. 2016 Sep;45:190-196. doi: 10.1016/j.neurobiolaging.2016.06.006. Epub 2016 Jun 17.},\n abstract = {The neurovascular unit, which protects neuronal cells and supplies them with essential molecules, plays an important role in the pathophysiology of Alzheimer's Disease (AD). The aim of this study was to noninvasively investigate 2 linked functional elements of the neurovascular unit, blood-brain barrier (BBB) permeability and cerebral blood flow (CBF), in patients with early AD and healthy controls. Therefore, both dynamic contrast-enhanced magnetic resonance imaging and arterial spin labeling magnetic resonance imaging were applied to measure BBB permeability and CBF, respectively. The patients with early AD showed significantly lower CBF and local blood volume in the gray matter, compared with controls. In the patients, we also found that a reduction in CBF is correlated with an increase in leakage rate. This finding supports the hypothesis that neurovascular damage, and in particular impairment of the neurovascular unit constitutes the pathophysiological link between CBF reduction and BBB impairment in AD.},\n keywords = {Aged\nAged, 80 and over\nAlzheimer Disease/*diagnostic imaging/*etiology/pathology\nBlood-Brain Barrier/diagnostic imaging/pathology/physiopathology\nCerebrovascular Circulation/physiology\nFemale\nGray Matter/blood supply/diagnostic imaging\nHumans\nMagnetic Resonance Imaging/*methods\nMale\nMicrovessels/diagnostic imaging/pathology/physiopathology\n*Alzheimer's disease\n*Blood-brain barrier\n*Cerebral hemodynamics\n*Dementia\n*Magnetic resonance imaging},\n ISSN = {1558-1497 (Electronic)\n0197-4580 (Linking)},\n DOI = {10.1016/j.neurobiolaging.2016.06.006},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/27459939\nhttps://www.sciencedirect.com/science/article/abs/pii/S0197458016301063?via%3Dihub},\n year = {2016},\n type = {Journal Article}\n}\n\n","author_short":["van de Haar, H. 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