@article{RN445,
   author = {van den Driest, J. J. and Schiphof, D. and de Wilde, M. and Bindels, P. J. E. and van der Lei, J. and Bierma-Zeinstra, S. M. A.},
   title = {Opioid prescriptions in patients with osteoarthritis: a population-based cohort study},
   journal = {Rheumatology (Oxford)},
   volume = {59},
   number = {9},
   pages = {2462-2470},
   note = {1462-0332 van den Driest, Jacoline J Schiphof, Dieuwke de Wilde, Marcel Bindels, Patrick J E van der Lei, Johan Bierma-Zeinstra, Sita M A Evaluation Study Journal Article England 2020/01/22 Rheumatology (Oxford). 2020 Sep 1;59(9):2462-2470. doi: 10.1093/rheumatology/kez646.},
   abstract = {OBJECTIVES: To examine the incidence, prevalence and trends for opioid prescriptions in patients with OA. Furthermore, types of opioids prescribed and long-term prescription rates were examined. Finally, the patient characteristics associated with the prescription of opioids were assessed. METHODS: A population-based cohort study was conducted using the Integrated Primary Care Information database. Incidence and prevalence of opioid prescriptions were calculated for the period 2008-2017. Logistic regression was used to assess which patient characteristics were associated with opioid prescriptions. RESULTS: In total, 157 904 OA patients were included. The overall prescription rate remained fairly stable, at around 100 incident and 170 prevalent prescriptions per 1000 person years. However, the incident prescription rate for oxycodone increased from 7.1 to 40.7 per 1000 person years and for fentanyl from 4.2 to 7.4 per 1000 person years. The incident prescription rate for paracetamol/codeine decreased from 63.0 to 13.3 per 1000 person years. Per follow-up year, long-term use was found in 3% of the patients with incident OA. Finally, factors associated with more prescriptions were increasing age, OA in ≥2 joint groups [odds ratio (OR) 1.56; 95% CI: 1.51, 1.65] and the presence of other musculoskeletal disorders (OR 4.91; 95% CI: 4.76, 5.05). Men were less likely to be prescribed opioids (OR 0.78; 95% CI: 0.76, 0.80). CONCLUSION: Prescription rates for opioids remained stable, but types of opioids prescribed changed. Oxycodone and fentanyl were increasingly prescribed, while prescriptions of paracetamol/codeine decreased. Since the benefit of opioids for OA pain is questionable and side effects are common, opioids should be prescribed with caution.},
   keywords = {Adult
Aged
Aged, 80 and over
Analgesics, Opioid/*therapeutic use
Databases, Factual
Drug Prescriptions/*statistics & numerical data
Female
Humans
Logistic Models
Male
Middle Aged
Netherlands
Osteoarthritis/*drug therapy
Practice Patterns, Physicians'/*statistics & numerical data
Primary Health Care/*statistics & numerical data
analgesics
opioids
osteoarthritis
pain ,
ISSN = 1462-0324 (Print) 1462-0324 ,
DOI = 10.1093/rheumatology/kez646},
   year = {2020},
   type = {Journal Article}
}

{"_id":"yC7gZ8kMkhTtx6whb","bibbaseid":"vandendriest-schiphof-dewilde-bindels-vanderlei-biermazeinstra-opioidprescriptionsinpatientswithosteoarthritisapopulationbasedcohortstudy-2020","author_short":["van den Driest, J. J.","Schiphof, D.","de Wilde, M.","Bindels, P. J. E.","van der Lei, J.","Bierma-Zeinstra, S. M. A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van","den"],"lastnames":["Driest"],"firstnames":["J.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Schiphof"],"firstnames":["D."],"suffixes":[]},{"propositions":["de"],"lastnames":["Wilde"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Bindels"],"firstnames":["P.","J.","E."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Lei"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Bierma-Zeinstra"],"firstnames":["S.","M.","A."],"suffixes":[]}],"title":"Opioid prescriptions in patients with osteoarthritis: a population-based cohort study","journal":"Rheumatology (Oxford)","volume":"59","number":"9","pages":"2462-2470","note":"1462-0332 van den Driest, Jacoline J Schiphof, Dieuwke de Wilde, Marcel Bindels, Patrick J E van der Lei, Johan Bierma-Zeinstra, Sita M A Evaluation Study Journal Article England 2020/01/22 Rheumatology (Oxford). 2020 Sep 1;59(9):2462-2470. doi: 10.1093/rheumatology/kez646.","abstract":"OBJECTIVES: To examine the incidence, prevalence and trends for opioid prescriptions in patients with OA. Furthermore, types of opioids prescribed and long-term prescription rates were examined. Finally, the patient characteristics associated with the prescription of opioids were assessed. METHODS: A population-based cohort study was conducted using the Integrated Primary Care Information database. Incidence and prevalence of opioid prescriptions were calculated for the period 2008-2017. Logistic regression was used to assess which patient characteristics were associated with opioid prescriptions. RESULTS: In total, 157 904 OA patients were included. The overall prescription rate remained fairly stable, at around 100 incident and 170 prevalent prescriptions per 1000 person years. However, the incident prescription rate for oxycodone increased from 7.1 to 40.7 per 1000 person years and for fentanyl from 4.2 to 7.4 per 1000 person years. The incident prescription rate for paracetamol/codeine decreased from 63.0 to 13.3 per 1000 person years. Per follow-up year, long-term use was found in 3% of the patients with incident OA. Finally, factors associated with more prescriptions were increasing age, OA in ≥2 joint groups [odds ratio (OR) 1.56; 95% CI: 1.51, 1.65] and the presence of other musculoskeletal disorders (OR 4.91; 95% CI: 4.76, 5.05). Men were less likely to be prescribed opioids (OR 0.78; 95% CI: 0.76, 0.80). CONCLUSION: Prescription rates for opioids remained stable, but types of opioids prescribed changed. Oxycodone and fentanyl were increasingly prescribed, while prescriptions of paracetamol/codeine decreased. Since the benefit of opioids for OA pain is questionable and side effects are common, opioids should be prescribed with caution.","keywords":"Adult Aged Aged, 80 and over Analgesics, Opioid/*therapeutic use Databases, Factual Drug Prescriptions/*statistics & numerical data Female Humans Logistic Models Male Middle Aged Netherlands Osteoarthritis/*drug therapy Practice Patterns, Physicians'/*statistics & numerical data Primary Health Care/*statistics & numerical data analgesics opioids osteoarthritis pain , ISSN = 1462-0324 (Print) 1462-0324 , DOI = 10.1093/rheumatology/kez646","year":"2020","bibtex":"@article{RN445,\r\n author = {van den Driest, J. J. and Schiphof, D. and de Wilde, M. and Bindels, P. J. E. and van der Lei, J. and Bierma-Zeinstra, S. M. A.},\r\n title = {Opioid prescriptions in patients with osteoarthritis: a population-based cohort study},\r\n journal = {Rheumatology (Oxford)},\r\n volume = {59},\r\n number = {9},\r\n pages = {2462-2470},\r\n note = {1462-0332 van den Driest, Jacoline J Schiphof, Dieuwke de Wilde, Marcel Bindels, Patrick J E van der Lei, Johan Bierma-Zeinstra, Sita M A Evaluation Study Journal Article England 2020/01/22 Rheumatology (Oxford). 2020 Sep 1;59(9):2462-2470. doi: 10.1093/rheumatology/kez646.},\r\n abstract = {OBJECTIVES: To examine the incidence, prevalence and trends for opioid prescriptions in patients with OA. Furthermore, types of opioids prescribed and long-term prescription rates were examined. Finally, the patient characteristics associated with the prescription of opioids were assessed. METHODS: A population-based cohort study was conducted using the Integrated Primary Care Information database. Incidence and prevalence of opioid prescriptions were calculated for the period 2008-2017. Logistic regression was used to assess which patient characteristics were associated with opioid prescriptions. RESULTS: In total, 157 904 OA patients were included. The overall prescription rate remained fairly stable, at around 100 incident and 170 prevalent prescriptions per 1000 person years. However, the incident prescription rate for oxycodone increased from 7.1 to 40.7 per 1000 person years and for fentanyl from 4.2 to 7.4 per 1000 person years. The incident prescription rate for paracetamol/codeine decreased from 63.0 to 13.3 per 1000 person years. Per follow-up year, long-term use was found in 3% of the patients with incident OA. Finally, factors associated with more prescriptions were increasing age, OA in ≥2 joint groups [odds ratio (OR) 1.56; 95% CI: 1.51, 1.65] and the presence of other musculoskeletal disorders (OR 4.91; 95% CI: 4.76, 5.05). Men were less likely to be prescribed opioids (OR 0.78; 95% CI: 0.76, 0.80). CONCLUSION: Prescription rates for opioids remained stable, but types of opioids prescribed changed. Oxycodone and fentanyl were increasingly prescribed, while prescriptions of paracetamol/codeine decreased. Since the benefit of opioids for OA pain is questionable and side effects are common, opioids should be prescribed with caution.},\r\n keywords = {Adult\r\nAged\r\nAged, 80 and over\r\nAnalgesics, Opioid/*therapeutic use\r\nDatabases, Factual\r\nDrug Prescriptions/*statistics & numerical data\r\nFemale\r\nHumans\r\nLogistic Models\r\nMale\r\nMiddle Aged\r\nNetherlands\r\nOsteoarthritis/*drug therapy\r\nPractice Patterns, Physicians'/*statistics & numerical data\r\nPrimary Health Care/*statistics & numerical data\r\nanalgesics\r\nopioids\r\nosteoarthritis\r\npain ,\r\nISSN = 1462-0324 (Print) 1462-0324 ,\r\nDOI = 10.1093/rheumatology/kez646},\r\n year = {2020},\r\n type = {Journal Article}\r\n}\r\n\r\n","author_short":["van den Driest, J. J.","Schiphof, D.","de Wilde, M.","Bindels, P. J. E.","van der Lei, J.","Bierma-Zeinstra, S. M. A."],"key":"RN445","id":"RN445","bibbaseid":"vandendriest-schiphof-dewilde-bindels-vanderlei-biermazeinstra-opioidprescriptionsinpatientswithosteoarthritisapopulationbasedcohortstudy-2020","role":"author","urls":{},"keyword":["Adult Aged Aged","80 and over Analgesics","Opioid/*therapeutic use Databases","Factual Drug Prescriptions/*statistics & numerical data Female Humans Logistic Models Male Middle Aged Netherlands Osteoarthritis/*drug therapy Practice Patterns","Physicians'/*statistics & numerical data Primary Health Care/*statistics & numerical data analgesics opioids osteoarthritis pain","ISSN = 1462-0324 (Print) 1462-0324","DOI = 10.1093/rheumatology/kez646"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/network/files/qwipow2DJsAxqNp83","dataSources":["PJSqX8FMpCPRdw3CQ","qLDnCcKM9omXNrRY8","TB9sD3avjy7bNxfgS","vDmJPYmHEKAT3tMNL","PcZMFHooKwpboi2he","jZMXEeHTfokmisJDv"],"keywords":["adult aged aged","80 and over analgesics","opioid/*therapeutic use databases","factual drug prescriptions/*statistics & numerical data female humans logistic models male middle aged netherlands osteoarthritis/*drug therapy practice patterns","physicians'/*statistics & numerical data primary health care/*statistics & numerical data analgesics opioids osteoarthritis pain","issn = 1462-0324 (print) 1462-0324","doi = 10.1093/rheumatology/kez646"],"search_terms":["opioid","prescriptions","patients","osteoarthritis","population","based","cohort","study","van den driest","schiphof","de wilde","bindels","van der lei","bierma-zeinstra"],"title":"Opioid prescriptions in patients with osteoarthritis: a population-based cohort study","year":2020}