@article{RN318,
   author = {van den Kerkhof, M. and van der Thiel, M. M. and Postma, A. A. and van Oostenbrugge, R. J. and Kroon, A. A. and Jansen, J. F. A. and Backes, W. H.},
   title = {Hypertension Correlates With Stronger Blood Flow Pulsatility in Small Perforating Cerebral Arteries Assessed With 7 Tesla Magnetic Resonance Imaging},
   journal = {Hypertension},
   note = {van den Kerkhof, Marieke
van der Thiel, Merel M
Postma, Alida A
van Oostenbrugge, Robert J
Kroon, Abraham A
Jansen, Jacobus F A
Backes, Walter H
eng
Hypertension. 2023 Feb 1. doi: 10.1161/HYPERTENSIONAHA.122.19866.},
   abstract = {BACKGROUND: Hypertension alters the structure and function of cerebral blood vessels, and is an important risk factor for stroke and cerebral small vessel disease. However, the pathophysiological process is not yet well understood. This study aimed to investigate the relationship between the pulsatility measures in small perforating arteries and hypertension, since hypertension-induced arterial stiffening may lead to a higher blood flow pulsatility and lower damping. METHODS: We examined 28 patients with essential hypertension and 25 age- and sex-matched healthy controls (mean age: 63.4, range: 43-81 years, 26 males). Blood flow velocity waveforms were acquired in the lenticulostriate arteries (LSAs) and the middle cerebral artery using phase-contrast MRI at 7 Tesla. Several cerebral small vessel disease markers were scored. The velocity and pulsatility measures were compared between the hypertensives and controls. RESULTS: A higher pulsatility index in the LSAs and a lower damping factor was found in the hypertensive compared to the normotensive group (P=0.015, P=0.015, respectively), but no association was found for the pulsatility index in the middle cerebral artery. Higher systolic and mean arterial pressures were associated with higher pulsatility index in the lenticulostriate artery and damping factor. For diastolic blood pressure, only an association with a lower damping factor was found. Adjusting for cerebral small vessel disease score did not alter these relationships. CONCLUSIONS: This study shows a higher pulsatility index in the LSAs and a lower damping factor in subjects with hypertension, independent of cerebral small vessel disease presence. This supports the hypothesis that hypertension-induced arterial remodeling may alter the intracerebral blood flow velocity profiles, which could eventually contribute to cerebral tissue damage. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NL7537 and NL8798.},
   keywords = {damping
hypertension
lenticulostriate arteries
neurovascular
pulsatility},
   ISSN = {1524-4563 (Electronic)
0194-911X (Linking)},
   DOI = {10.1161/HYPERTENSIONAHA.122.19866},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/36722349},
   year = {2023},
   type = {Journal Article}
}

{"_id":"y4GdmKTnrgFWN6DBZ","bibbaseid":"vandenkerkhof-vanderthiel-postma-vanoostenbrugge-kroon-jansen-backes-hypertensioncorrelateswithstrongerbloodflowpulsatilityinsmallperforatingcerebralarteriesassessedwith7teslamagneticresonanceimaging-2023","author_short":["van den Kerkhof, M.","van der Thiel, M. M.","Postma, A. A.","van Oostenbrugge, R. J.","Kroon, A. A.","Jansen, J. F. A.","Backes, W. H."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van","den"],"lastnames":["Kerkhof"],"firstnames":["M."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Thiel"],"firstnames":["M.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Postma"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Kroon"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Hypertension Correlates With Stronger Blood Flow Pulsatility in Small Perforating Cerebral Arteries Assessed With 7 Tesla Magnetic Resonance Imaging","journal":"Hypertension","note":"van den Kerkhof, Marieke van der Thiel, Merel M Postma, Alida A van Oostenbrugge, Robert J Kroon, Abraham A Jansen, Jacobus F A Backes, Walter H eng Hypertension. 2023 Feb 1. doi: 10.1161/HYPERTENSIONAHA.122.19866.","abstract":"BACKGROUND: Hypertension alters the structure and function of cerebral blood vessels, and is an important risk factor for stroke and cerebral small vessel disease. However, the pathophysiological process is not yet well understood. This study aimed to investigate the relationship between the pulsatility measures in small perforating arteries and hypertension, since hypertension-induced arterial stiffening may lead to a higher blood flow pulsatility and lower damping. METHODS: We examined 28 patients with essential hypertension and 25 age- and sex-matched healthy controls (mean age: 63.4, range: 43-81 years, 26 males). Blood flow velocity waveforms were acquired in the lenticulostriate arteries (LSAs) and the middle cerebral artery using phase-contrast MRI at 7 Tesla. Several cerebral small vessel disease markers were scored. The velocity and pulsatility measures were compared between the hypertensives and controls. RESULTS: A higher pulsatility index in the LSAs and a lower damping factor was found in the hypertensive compared to the normotensive group (P=0.015, P=0.015, respectively), but no association was found for the pulsatility index in the middle cerebral artery. Higher systolic and mean arterial pressures were associated with higher pulsatility index in the lenticulostriate artery and damping factor. For diastolic blood pressure, only an association with a lower damping factor was found. Adjusting for cerebral small vessel disease score did not alter these relationships. CONCLUSIONS: This study shows a higher pulsatility index in the LSAs and a lower damping factor in subjects with hypertension, independent of cerebral small vessel disease presence. This supports the hypothesis that hypertension-induced arterial remodeling may alter the intracerebral blood flow velocity profiles, which could eventually contribute to cerebral tissue damage. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NL7537 and NL8798.","keywords":"damping hypertension lenticulostriate arteries neurovascular pulsatility","issn":"1524-4563 (Electronic) 0194-911X (Linking)","doi":"10.1161/HYPERTENSIONAHA.122.19866","url":"https://www.ncbi.nlm.nih.gov/pubmed/36722349","year":"2023","bibtex":"@article{RN318,\n author = {van den Kerkhof, M. and van der Thiel, M. M. and Postma, A. A. and van Oostenbrugge, R. J. and Kroon, A. A. and Jansen, J. F. A. and Backes, W. H.},\n title = {Hypertension Correlates With Stronger Blood Flow Pulsatility in Small Perforating Cerebral Arteries Assessed With 7 Tesla Magnetic Resonance Imaging},\n journal = {Hypertension},\n note = {van den Kerkhof, Marieke\nvan der Thiel, Merel M\nPostma, Alida A\nvan Oostenbrugge, Robert J\nKroon, Abraham A\nJansen, Jacobus F A\nBackes, Walter H\neng\nHypertension. 2023 Feb 1. doi: 10.1161/HYPERTENSIONAHA.122.19866.},\n abstract = {BACKGROUND: Hypertension alters the structure and function of cerebral blood vessels, and is an important risk factor for stroke and cerebral small vessel disease. However, the pathophysiological process is not yet well understood. This study aimed to investigate the relationship between the pulsatility measures in small perforating arteries and hypertension, since hypertension-induced arterial stiffening may lead to a higher blood flow pulsatility and lower damping. METHODS: We examined 28 patients with essential hypertension and 25 age- and sex-matched healthy controls (mean age: 63.4, range: 43-81 years, 26 males). Blood flow velocity waveforms were acquired in the lenticulostriate arteries (LSAs) and the middle cerebral artery using phase-contrast MRI at 7 Tesla. Several cerebral small vessel disease markers were scored. The velocity and pulsatility measures were compared between the hypertensives and controls. RESULTS: A higher pulsatility index in the LSAs and a lower damping factor was found in the hypertensive compared to the normotensive group (P=0.015, P=0.015, respectively), but no association was found for the pulsatility index in the middle cerebral artery. Higher systolic and mean arterial pressures were associated with higher pulsatility index in the lenticulostriate artery and damping factor. For diastolic blood pressure, only an association with a lower damping factor was found. Adjusting for cerebral small vessel disease score did not alter these relationships. CONCLUSIONS: This study shows a higher pulsatility index in the LSAs and a lower damping factor in subjects with hypertension, independent of cerebral small vessel disease presence. This supports the hypothesis that hypertension-induced arterial remodeling may alter the intracerebral blood flow velocity profiles, which could eventually contribute to cerebral tissue damage. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NL7537 and NL8798.},\n keywords = {damping\nhypertension\nlenticulostriate arteries\nneurovascular\npulsatility},\n ISSN = {1524-4563 (Electronic)\n0194-911X (Linking)},\n DOI = {10.1161/HYPERTENSIONAHA.122.19866},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/36722349},\n year = {2023},\n type = {Journal Article}\n}\n\n","author_short":["van den Kerkhof, M.","van der Thiel, M. M.","Postma, A. A.","van Oostenbrugge, R. J.","Kroon, A. A.","Jansen, J. F. A.","Backes, W. H."],"key":"RN318","id":"RN318","bibbaseid":"vandenkerkhof-vanderthiel-postma-vanoostenbrugge-kroon-jansen-backes-hypertensioncorrelateswithstrongerbloodflowpulsatilityinsmallperforatingcerebralarteriesassessedwith7teslamagneticresonanceimaging-2023","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/36722349"},"keyword":["damping hypertension lenticulostriate arteries neurovascular pulsatility"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","dataSources":["TCkfRWJAZvbLAZi29"],"keywords":["damping hypertension lenticulostriate arteries neurovascular pulsatility"],"search_terms":["hypertension","correlates","stronger","blood","flow","pulsatility","small","perforating","cerebral","arteries","assessed","tesla","magnetic","resonance","imaging","van den kerkhof","van der thiel","postma","van oostenbrugge","kroon","jansen","backes"],"title":"Hypertension Correlates With Stronger Blood Flow Pulsatility in Small Perforating Cerebral Arteries Assessed With 7 Tesla Magnetic Resonance Imaging","year":2023}