@article{RN316,
   author = {van den Kerkhof, M. and van der Thiel, M. M. and van Oostenbrugge, R. J. and Postma, A. A. and Kroon, A. A. and Backes, W. H. and Jansen, J. F.},
   title = {Impaired damping of cerebral blood flow velocity pulsatility is associated with the number of perivascular spaces as measured with 7T MRI},
   journal = {J Cereb Blood Flow Metab},
   pages = {271678X231153374},
   note = {van den Kerkhof, Marieke
van der Thiel, Merel M
van Oostenbrugge, Robert J
Postma, Alida A
Kroon, Abraham A
Backes, Walter H
Jansen, Jacobus Fa
eng
J Cereb Blood Flow Metab. 2023 Jan 26:271678X231153374. doi: 10.1177/0271678X231153374.},
   abstract = {Arterial walls stiffen with age, cardiovascular risk factors, and various vascular diseases, which may lead to less damping of the arterial blood flow pulse, subsequent microvascular damage, and enlarged perivascular spaces (PVS). However, the exact interplay between these processes is unclear. This study aimed to investigate the relation between blood flow velocity pulsatility in the small lenticulostriate arteries and their supplying middle cerebral artery and the respective damping factor (DF), with the number of MRI-visible PVS in elderly subjects. Blood flow velocity waveforms were obtained in 45 subjects (median age [range]: 64 [48-81] years, 47% male) using 7T MRI. PVS were scored in the basal ganglia (BG) and centrum semiovale (CSO). Spearman correlation analyses were used to determine associations of the blood flow pulsatility and the DF, with PVS score, adjusted for age and sex. We found a significant association between a lower DF and a higher number of PVS in the BG (r(s) = -0.352, P = 0.021), but not in the CSO. This finding supports the supposed pathophysiological mechanism in which excessive kinetic energy deposition leads to damage of small perforating arteries and contributes to the enlargement of PVS at the level of the BG, but possible other pathways might also be of influence.},
   keywords = {7t mri
blood flow velocity pulsatility
damping factor
lenticulostriate arteries
perivascular spaces},
   ISSN = {1559-7016 (Electronic)
0271-678X (Linking)},
   DOI = {10.1177/0271678X231153374},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/36704826},
   year = {2023},
   type = {Journal Article}
}

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F."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van","den"],"lastnames":["Kerkhof"],"firstnames":["M."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Thiel"],"firstnames":["M.","M."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Postma"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Kroon"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]}],"title":"Impaired damping of cerebral blood flow velocity pulsatility is associated with the number of perivascular spaces as measured with 7T MRI","journal":"J Cereb Blood Flow Metab","pages":"271678X231153374","note":"van den Kerkhof, Marieke van der Thiel, Merel M van Oostenbrugge, Robert J Postma, Alida A Kroon, Abraham A Backes, Walter H Jansen, Jacobus Fa eng J Cereb Blood Flow Metab. 2023 Jan 26:271678X231153374. doi: 10.1177/0271678X231153374.","abstract":"Arterial walls stiffen with age, cardiovascular risk factors, and various vascular diseases, which may lead to less damping of the arterial blood flow pulse, subsequent microvascular damage, and enlarged perivascular spaces (PVS). However, the exact interplay between these processes is unclear. This study aimed to investigate the relation between blood flow velocity pulsatility in the small lenticulostriate arteries and their supplying middle cerebral artery and the respective damping factor (DF), with the number of MRI-visible PVS in elderly subjects. Blood flow velocity waveforms were obtained in 45 subjects (median age [range]: 64 [48-81] years, 47% male) using 7T MRI. PVS were scored in the basal ganglia (BG) and centrum semiovale (CSO). Spearman correlation analyses were used to determine associations of the blood flow pulsatility and the DF, with PVS score, adjusted for age and sex. We found a significant association between a lower DF and a higher number of PVS in the BG (r(s) = -0.352, P = 0.021), but not in the CSO. This finding supports the supposed pathophysiological mechanism in which excessive kinetic energy deposition leads to damage of small perforating arteries and contributes to the enlargement of PVS at the level of the BG, but possible other pathways might also be of influence.","keywords":"7t mri blood flow velocity pulsatility damping factor lenticulostriate arteries perivascular spaces","issn":"1559-7016 (Electronic) 0271-678X (Linking)","doi":"10.1177/0271678X231153374","url":"https://www.ncbi.nlm.nih.gov/pubmed/36704826","year":"2023","bibtex":"@article{RN316,\n author = {van den Kerkhof, M. and van der Thiel, M. M. and van Oostenbrugge, R. J. and Postma, A. A. and Kroon, A. A. and Backes, W. H. and Jansen, J. F.},\n title = {Impaired damping of cerebral blood flow velocity pulsatility is associated with the number of perivascular spaces as measured with 7T MRI},\n journal = {J Cereb Blood Flow Metab},\n pages = {271678X231153374},\n note = {van den Kerkhof, Marieke\nvan der Thiel, Merel M\nvan Oostenbrugge, Robert J\nPostma, Alida A\nKroon, Abraham A\nBackes, Walter H\nJansen, Jacobus Fa\neng\nJ Cereb Blood Flow Metab. 2023 Jan 26:271678X231153374. doi: 10.1177/0271678X231153374.},\n abstract = {Arterial walls stiffen with age, cardiovascular risk factors, and various vascular diseases, which may lead to less damping of the arterial blood flow pulse, subsequent microvascular damage, and enlarged perivascular spaces (PVS). However, the exact interplay between these processes is unclear. This study aimed to investigate the relation between blood flow velocity pulsatility in the small lenticulostriate arteries and their supplying middle cerebral artery and the respective damping factor (DF), with the number of MRI-visible PVS in elderly subjects. Blood flow velocity waveforms were obtained in 45 subjects (median age [range]: 64 [48-81] years, 47% male) using 7T MRI. PVS were scored in the basal ganglia (BG) and centrum semiovale (CSO). Spearman correlation analyses were used to determine associations of the blood flow pulsatility and the DF, with PVS score, adjusted for age and sex. We found a significant association between a lower DF and a higher number of PVS in the BG (r(s) = -0.352, P = 0.021), but not in the CSO. This finding supports the supposed pathophysiological mechanism in which excessive kinetic energy deposition leads to damage of small perforating arteries and contributes to the enlargement of PVS at the level of the BG, but possible other pathways might also be of influence.},\n keywords = {7t mri\nblood flow velocity pulsatility\ndamping factor\nlenticulostriate arteries\nperivascular spaces},\n ISSN = {1559-7016 (Electronic)\n0271-678X (Linking)},\n DOI = {10.1177/0271678X231153374},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/36704826},\n year = {2023},\n type = {Journal Article}\n}\n\n","author_short":["van den Kerkhof, M.","van der Thiel, M. M.","van Oostenbrugge, R. J.","Postma, A. A.","Kroon, A. A.","Backes, W. H.","Jansen, J. 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