@article{RN324,
   author = {van der Heide, F. C. T. and Eussen, Sjpm and Houben, Ajhm and Henry, R. M. A. and Kroon, A. A. and van der Kallen, C. J. H. and Dagnelie, P. C. and van Dongen, Mcjm and Berendschot, Ttjm and Schouten, Jsag and Webers, C. A. B. and van Greevenbroek, M. M. J. and Wesselius, A. and Schalkwijk, C. G. and Koster, A. and Jansen, J. F. A. and Backes, W. H. and Beulens, J. W. J. and Stehouwer, C. D. A.},
   title = {Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study},
   journal = {Cardiovasc Diabetol},
   volume = {22},
   number = {1},
   pages = {67},
   note = {van der Heide, Frank C T
Eussen, Simone J P M
Houben, Alfons J H M
Henry, Ronald M A
Kroon, Abraham A
van der Kallen, Carla J H
Dagnelie, Pieter C
van Dongen, Martien C J M
Berendschot, Tos T J M
Schouten, Jan S A G
Webers, Carroll A B
van Greevenbroek, Marleen M J
Wesselius, Anke
Schalkwijk, Casper G
Koster, Annemarie
Jansen, Jacobus F A
Backes, Walter H
Beulens, Joline W J
Stehouwer, Coen D A
eng
England
Cardiovasc Diabetol. 2023 Mar 24;22(1):67. doi: 10.1186/s12933-023-01783-x.},
   abstract = {BACKGROUND: Microvascular dysfunction (MVD) is an important contributor to major clinical disease such as stroke, dementia, depression, retinopathy, and chronic kidney disease. Alcohol consumption may be a determinant of MVD. OBJECTIVE: Main objectives were (1) to study whether alcohol consumption was associated with MVD as assessed in the brain, retina, skin, kidney and in the blood; and (2) to investigate whether associations differed by history of cardiovascular disease or sex. DESIGN: We used cross-sectional data from The Maastricht Study (N = 3,120 participants, 50.9% men, mean age 60 years, and 27.5% with type 2 diabetes [the latter oversampled by design]). We used regression analyses to study the association between total alcohol (per unit and in the categories, i.e. none, light, moderate, high) and MVD, where all measures of MVD were combined into a total MVD composite score (expressed in SD). We adjusted all associations for potential confounders; and tested for interaction by sex, and history of cardiovascular disease. Additionally we tested for interaction with glucose metabolism status. RESULTS: The association between total alcohol consumption and MVD was non-linear, i.e. J-shaped. Moderate versus light total alcohol consumption was significantly associated with less MVD, after full adjustment (beta [95% confidence interval], -0.10 [-0.19; -0.01]). The shape of the curve differed with sex (P(interaction) = 0.03), history of cardiovascular disease (P(interaction) < 0.001), and glucose metabolism status (P(interaction) = 0.02). CONCLUSIONS: The present cross-sectional, population-based study found evidence that alcohol consumption may have an effect on MVD. Hence, although increasing alcohol consumption cannot be recommended as a policy, this study suggests that prevention of MVD may be possible through dietary interventions.},
   keywords = {Male
Humans
Middle Aged
Female
*Cardiovascular Diseases/diagnosis/epidemiology/complications
*Diabetes Mellitus, Type 2
Cross-Sectional Studies
Alcohol Drinking/adverse effects/epidemiology
Glucose
Albuminuria
Alcohol
Beer
Cardiovascular risk factor
Cerebral small vessel disease
Dyslipidemia
Endothelial cell dysfunction
Ethanol
Flicker light-induced increase in retinal microvascular diameter
Heat-induced skin hyperemia
History of cardiovascular disease
Hypertension
Microvascular dysfunction
Microvasculature
Plasma biomarkers
Retinal microvascular diameters
Smoking
Spirits
Type 2 diabetes
Wine},
   ISSN = {1475-2840 (Electronic)
1475-2840 (Linking)},
   DOI = {10.1186/s12933-023-01783-x},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/36964536},
   year = {2023},
   type = {Journal Article}
}

{"_id":"Tf68pm7XDBwM48Kuh","bibbaseid":"vanderheide-eussen-houben-henry-kroon-vanderkallen-dagnelie-vandongen-etal-alcoholconsumptionandmicrovasculardysfunctionajshapedassociationthemaastrichtstudy-2023","author_short":["van der Heide, F. C. T.","Eussen, S.","Houben, A.","Henry, R. M. A.","Kroon, A. A.","van der Kallen, C. J. H.","Dagnelie, P. C.","van Dongen, M.","Berendschot, T.","Schouten, J.","Webers, C. A. B.","van Greevenbroek, M. M. J.","Wesselius, A.","Schalkwijk, C. G.","Koster, A.","Jansen, J. F. A.","Backes, W. H.","Beulens, J. W. J.","Stehouwer, C. D. A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van","der"],"lastnames":["Heide"],"firstnames":["F.","C.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Eussen"],"firstnames":["Sjpm"],"suffixes":[]},{"propositions":[],"lastnames":["Houben"],"firstnames":["Ajhm"],"suffixes":[]},{"propositions":[],"lastnames":["Henry"],"firstnames":["R.","M.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Kroon"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Kallen"],"firstnames":["C.","J.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Dagnelie"],"firstnames":["P.","C."],"suffixes":[]},{"propositions":["van"],"lastnames":["Dongen"],"firstnames":["Mcjm"],"suffixes":[]},{"propositions":[],"lastnames":["Berendschot"],"firstnames":["Ttjm"],"suffixes":[]},{"propositions":[],"lastnames":["Schouten"],"firstnames":["Jsag"],"suffixes":[]},{"propositions":[],"lastnames":["Webers"],"firstnames":["C.","A.","B."],"suffixes":[]},{"propositions":["van"],"lastnames":["Greevenbroek"],"firstnames":["M.","M.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Wesselius"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Schalkwijk"],"firstnames":["C.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Koster"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Beulens"],"firstnames":["J.","W.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Stehouwer"],"firstnames":["C.","D.","A."],"suffixes":[]}],"title":"Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study","journal":"Cardiovasc Diabetol","volume":"22","number":"1","pages":"67","note":"van der Heide, Frank C T Eussen, Simone J P M Houben, Alfons J H M Henry, Ronald M A Kroon, Abraham A van der Kallen, Carla J H Dagnelie, Pieter C van Dongen, Martien C J M Berendschot, Tos T J M Schouten, Jan S A G Webers, Carroll A B van Greevenbroek, Marleen M J Wesselius, Anke Schalkwijk, Casper G Koster, Annemarie Jansen, Jacobus F A Backes, Walter H Beulens, Joline W J Stehouwer, Coen D A eng England Cardiovasc Diabetol. 2023 Mar 24;22(1):67. doi: 10.1186/s12933-023-01783-x.","abstract":"BACKGROUND: Microvascular dysfunction (MVD) is an important contributor to major clinical disease such as stroke, dementia, depression, retinopathy, and chronic kidney disease. Alcohol consumption may be a determinant of MVD. OBJECTIVE: Main objectives were (1) to study whether alcohol consumption was associated with MVD as assessed in the brain, retina, skin, kidney and in the blood; and (2) to investigate whether associations differed by history of cardiovascular disease or sex. DESIGN: We used cross-sectional data from The Maastricht Study (N = 3,120 participants, 50.9% men, mean age 60 years, and 27.5% with type 2 diabetes [the latter oversampled by design]). We used regression analyses to study the association between total alcohol (per unit and in the categories, i.e. none, light, moderate, high) and MVD, where all measures of MVD were combined into a total MVD composite score (expressed in SD). We adjusted all associations for potential confounders; and tested for interaction by sex, and history of cardiovascular disease. Additionally we tested for interaction with glucose metabolism status. RESULTS: The association between total alcohol consumption and MVD was non-linear, i.e. J-shaped. Moderate versus light total alcohol consumption was significantly associated with less MVD, after full adjustment (beta [95% confidence interval], -0.10 [-0.19; -0.01]). The shape of the curve differed with sex (P(interaction) = 0.03), history of cardiovascular disease (P(interaction) < 0.001), and glucose metabolism status (P(interaction) = 0.02). CONCLUSIONS: The present cross-sectional, population-based study found evidence that alcohol consumption may have an effect on MVD. Hence, although increasing alcohol consumption cannot be recommended as a policy, this study suggests that prevention of MVD may be possible through dietary interventions.","keywords":"Male Humans Middle Aged Female *Cardiovascular Diseases/diagnosis/epidemiology/complications *Diabetes Mellitus, Type 2 Cross-Sectional Studies Alcohol Drinking/adverse effects/epidemiology Glucose Albuminuria Alcohol Beer Cardiovascular risk factor Cerebral small vessel disease Dyslipidemia Endothelial cell dysfunction Ethanol Flicker light-induced increase in retinal microvascular diameter Heat-induced skin hyperemia History of cardiovascular disease Hypertension Microvascular dysfunction Microvasculature Plasma biomarkers Retinal microvascular diameters Smoking Spirits Type 2 diabetes Wine","issn":"1475-2840 (Electronic) 1475-2840 (Linking)","doi":"10.1186/s12933-023-01783-x","url":"https://www.ncbi.nlm.nih.gov/pubmed/36964536","year":"2023","bibtex":"@article{RN324,\n author = {van der Heide, F. C. T. and Eussen, Sjpm and Houben, Ajhm and Henry, R. M. A. and Kroon, A. A. and van der Kallen, C. J. H. and Dagnelie, P. C. and van Dongen, Mcjm and Berendschot, Ttjm and Schouten, Jsag and Webers, C. A. B. and van Greevenbroek, M. M. J. and Wesselius, A. and Schalkwijk, C. G. and Koster, A. and Jansen, J. F. A. and Backes, W. H. and Beulens, J. W. J. and Stehouwer, C. D. A.},\n title = {Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study},\n journal = {Cardiovasc Diabetol},\n volume = {22},\n number = {1},\n pages = {67},\n note = {van der Heide, Frank C T\nEussen, Simone J P M\nHouben, Alfons J H M\nHenry, Ronald M A\nKroon, Abraham A\nvan der Kallen, Carla J H\nDagnelie, Pieter C\nvan Dongen, Martien C J M\nBerendschot, Tos T J M\nSchouten, Jan S A G\nWebers, Carroll A B\nvan Greevenbroek, Marleen M J\nWesselius, Anke\nSchalkwijk, Casper G\nKoster, Annemarie\nJansen, Jacobus F A\nBackes, Walter H\nBeulens, Joline W J\nStehouwer, Coen D A\neng\nEngland\nCardiovasc Diabetol. 2023 Mar 24;22(1):67. doi: 10.1186/s12933-023-01783-x.},\n abstract = {BACKGROUND: Microvascular dysfunction (MVD) is an important contributor to major clinical disease such as stroke, dementia, depression, retinopathy, and chronic kidney disease. Alcohol consumption may be a determinant of MVD. OBJECTIVE: Main objectives were (1) to study whether alcohol consumption was associated with MVD as assessed in the brain, retina, skin, kidney and in the blood; and (2) to investigate whether associations differed by history of cardiovascular disease or sex. DESIGN: We used cross-sectional data from The Maastricht Study (N = 3,120 participants, 50.9% men, mean age 60 years, and 27.5% with type 2 diabetes [the latter oversampled by design]). We used regression analyses to study the association between total alcohol (per unit and in the categories, i.e. none, light, moderate, high) and MVD, where all measures of MVD were combined into a total MVD composite score (expressed in SD). We adjusted all associations for potential confounders; and tested for interaction by sex, and history of cardiovascular disease. Additionally we tested for interaction with glucose metabolism status. RESULTS: The association between total alcohol consumption and MVD was non-linear, i.e. J-shaped. Moderate versus light total alcohol consumption was significantly associated with less MVD, after full adjustment (beta [95% confidence interval], -0.10 [-0.19; -0.01]). The shape of the curve differed with sex (P(interaction) = 0.03), history of cardiovascular disease (P(interaction) < 0.001), and glucose metabolism status (P(interaction) = 0.02). CONCLUSIONS: The present cross-sectional, population-based study found evidence that alcohol consumption may have an effect on MVD. Hence, although increasing alcohol consumption cannot be recommended as a policy, this study suggests that prevention of MVD may be possible through dietary interventions.},\n keywords = {Male\nHumans\nMiddle Aged\nFemale\n*Cardiovascular Diseases/diagnosis/epidemiology/complications\n*Diabetes Mellitus, Type 2\nCross-Sectional Studies\nAlcohol Drinking/adverse effects/epidemiology\nGlucose\nAlbuminuria\nAlcohol\nBeer\nCardiovascular risk factor\nCerebral small vessel disease\nDyslipidemia\nEndothelial cell dysfunction\nEthanol\nFlicker light-induced increase in retinal microvascular diameter\nHeat-induced skin hyperemia\nHistory of cardiovascular disease\nHypertension\nMicrovascular dysfunction\nMicrovasculature\nPlasma biomarkers\nRetinal microvascular diameters\nSmoking\nSpirits\nType 2 diabetes\nWine},\n ISSN = {1475-2840 (Electronic)\n1475-2840 (Linking)},\n DOI = {10.1186/s12933-023-01783-x},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/36964536},\n year = {2023},\n type = {Journal Article}\n}\n\n","author_short":["van der Heide, F. C. T.","Eussen, S.","Houben, A.","Henry, R. M. A.","Kroon, A. A.","van der Kallen, C. J. H.","Dagnelie, P. C.","van Dongen, M.","Berendschot, T.","Schouten, J.","Webers, C. A. B.","van Greevenbroek, M. M. J.","Wesselius, A.","Schalkwijk, C. G.","Koster, A.","Jansen, J. F. A.","Backes, W. H.","Beulens, J. W. J.","Stehouwer, C. D. A."],"key":"RN324","id":"RN324","bibbaseid":"vanderheide-eussen-houben-henry-kroon-vanderkallen-dagnelie-vandongen-etal-alcoholconsumptionandmicrovasculardysfunctionajshapedassociationthemaastrichtstudy-2023","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/36964536"},"keyword":["Male Humans Middle Aged Female *Cardiovascular Diseases/diagnosis/epidemiology/complications *Diabetes Mellitus","Type 2 Cross-Sectional Studies Alcohol Drinking/adverse effects/epidemiology Glucose Albuminuria Alcohol Beer Cardiovascular risk factor Cerebral small vessel disease Dyslipidemia Endothelial cell dysfunction Ethanol Flicker light-induced increase in retinal microvascular diameter Heat-induced skin hyperemia History of cardiovascular disease Hypertension Microvascular dysfunction Microvasculature Plasma biomarkers Retinal microvascular diameters Smoking Spirits Type 2 diabetes Wine"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","dataSources":["TCkfRWJAZvbLAZi29"],"keywords":["male humans middle aged female *cardiovascular diseases/diagnosis/epidemiology/complications *diabetes mellitus","type 2 cross-sectional studies alcohol drinking/adverse effects/epidemiology glucose albuminuria alcohol beer cardiovascular risk factor cerebral small vessel disease dyslipidemia endothelial cell dysfunction ethanol flicker light-induced increase in retinal microvascular diameter heat-induced skin hyperemia history of cardiovascular disease hypertension microvascular dysfunction microvasculature plasma biomarkers retinal microvascular diameters smoking spirits type 2 diabetes wine"],"search_terms":["alcohol","consumption","microvascular","dysfunction","shaped","association","maastricht","study","van der heide","eussen","houben","henry","kroon","van der kallen","dagnelie","van dongen","berendschot","schouten","webers","van greevenbroek","wesselius","schalkwijk","koster","jansen","backes","beulens","stehouwer"],"title":"Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study","year":2023}