@article{RN336,
   author = {van der Heide, F. C. T. and Steens, I. L. M. and Limmen, B. and Mokhtar, S. and van Boxtel, M. P. J. and Schram, M. T. and Kohler, S. and Kroon, A. A. and van der Kallen, C. J. H. and Dagnelie, P. C. and van Dongen, Mcjm and Eussen, Sjpm and Berendschot, Ttjm and Webers, C. A. B. and van Greevenbroek, M. M. J. and Koster, A. and van Sloten, T. T. and Jansen, J. F. A. and Backes, W. H. and Stehouwer, C. D. A.},
   title = {Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure-The Maastricht Study},
   journal = {Alzheimers Dement},
   note = {van der Heide, Frank C T
Steens, Indra L M
Limmen, Betsie
Mokhtar, Sara
van Boxtel, Martin P J
Schram, Miranda T
Kohler, Sebastian
Kroon, Abraham A
van der Kallen, Carla J H
Dagnelie, Pieter C
van Dongen, Martien C J M
Eussen, Simone J P M
Berendschot, Tos T J M
Webers, Carroll A B
van Greevenbroek, Marleen M J
Koster, Annemarie
van Sloten, Thomas T
Jansen, Jacobus F A
Backes, Walter H
Stehouwer, Coen D A
eng
31O.041/OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs/
Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC, Maastricht, the Netherlands), CARIM School for Cardiovascular Diseases (Maastricht, the Netherlands), CAPHRI School for Public Health and Primary Care (Maastricht, the Netherlands), NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands), Perimed (Jarfalla, Sweden), and by unrestricted grants from Janssen-Cilag B.V. (Tilburg, the Netherlands), Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands), and Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands)/
916.19.074/VENI research/
2018T025/Netherlands Organization for Scientific Research and the Netherlands Organization for Health Research and Development, and a Dutch Heart Foundation research/
2021.81.004/Diabetes Fonds Fellowship/
Alzheimers Dement. 2023 Aug 23. doi: 10.1002/alz.13442.},
   abstract = {INTRODUCTION: The retina may provide non-invasive, scalable biomarkers for monitoring cerebral neurodegeneration. METHODS: We used cross-sectional data from The Maastricht study (n = 3436; mean age 59.3 years; 48% men; and 21% with type 2 diabetes [the latter oversampled by design]). We evaluated associations of retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thicknesses with cognitive performance and magnetic resonance imaging indices (global grey and white matter volume, hippocampal volume, whole brain node degree, global efficiency, clustering coefficient, and local efficiency). RESULTS: After adjustment, lower thicknesses of most inner retinal layers were significantly associated with worse cognitive performance, lower grey and white matter volume, lower hippocampal volume, and worse brain white matter network structure assessed from lower whole brain node degree, lower global efficiency, higher clustering coefficient, and higher local efficiency. DISCUSSION: The retina may provide biomarkers that are informative of cerebral neurodegenerative changes in the pathobiology of dementia.},
   keywords = {brain structural connectivity
brain volume
clustering coefficient
cognitive function
cognitive performance
global efficiency
graph theory
grey matter
local efficiency
magnetic resonance imaging (MRI)
optical coherence tomography (OCT)
retinal imaging
retinal neurodegeneration
white matter
whole brain node degree},
   ISSN = {1552-5279 (Electronic)
1552-5260 (Linking)},
   DOI = {10.1002/alz.13442},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/37611119},
   year = {2023},
   type = {Journal Article}
}

{"_id":"FJpD7mv9DJCjRhgXK","bibbaseid":"vanderheide-steens-limmen-mokhtar-vanboxtel-schram-kohler-kroon-etal-thinnerinnerretinallayersareassociatedwithlowercognitiveperformancelowerbrainvolumeandalteredwhitematternetworkstructurethemaastrichtstudy-2023","author_short":["van der Heide, F. C. T.","Steens, I. L. M.","Limmen, B.","Mokhtar, S.","van Boxtel, M. P. J.","Schram, M. T.","Kohler, S.","Kroon, A. A.","van der Kallen, C. J. H.","Dagnelie, P. C.","van Dongen, M.","Eussen, S.","Berendschot, T.","Webers, C. A. B.","van Greevenbroek, M. M. J.","Koster, A.","van Sloten, T. T.","Jansen, J. F. A.","Backes, W. H.","Stehouwer, C. D. A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van","der"],"lastnames":["Heide"],"firstnames":["F.","C.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Steens"],"firstnames":["I.","L.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Limmen"],"firstnames":["B."],"suffixes":[]},{"propositions":[],"lastnames":["Mokhtar"],"firstnames":["S."],"suffixes":[]},{"propositions":["van"],"lastnames":["Boxtel"],"firstnames":["M.","P.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Schram"],"firstnames":["M.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Kohler"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Kroon"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Kallen"],"firstnames":["C.","J.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Dagnelie"],"firstnames":["P.","C."],"suffixes":[]},{"propositions":["van"],"lastnames":["Dongen"],"firstnames":["Mcjm"],"suffixes":[]},{"propositions":[],"lastnames":["Eussen"],"firstnames":["Sjpm"],"suffixes":[]},{"propositions":[],"lastnames":["Berendschot"],"firstnames":["Ttjm"],"suffixes":[]},{"propositions":[],"lastnames":["Webers"],"firstnames":["C.","A.","B."],"suffixes":[]},{"propositions":["van"],"lastnames":["Greevenbroek"],"firstnames":["M.","M.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Koster"],"firstnames":["A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Sloten"],"firstnames":["T.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Stehouwer"],"firstnames":["C.","D.","A."],"suffixes":[]}],"title":"Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure-The Maastricht Study","journal":"Alzheimers Dement","note":"van der Heide, Frank C T Steens, Indra L M Limmen, Betsie Mokhtar, Sara van Boxtel, Martin P J Schram, Miranda T Kohler, Sebastian Kroon, Abraham A van der Kallen, Carla J H Dagnelie, Pieter C van Dongen, Martien C J M Eussen, Simone J P M Berendschot, Tos T J M Webers, Carroll A B van Greevenbroek, Marleen M J Koster, Annemarie van Sloten, Thomas T Jansen, Jacobus F A Backes, Walter H Stehouwer, Coen D A eng 31O.041/OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs/ Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC, Maastricht, the Netherlands), CARIM School for Cardiovascular Diseases (Maastricht, the Netherlands), CAPHRI School for Public Health and Primary Care (Maastricht, the Netherlands), NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands), Perimed (Jarfalla, Sweden), and by unrestricted grants from Janssen-Cilag B.V. (Tilburg, the Netherlands), Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands), and Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands)/ 916.19.074/VENI research/ 2018T025/Netherlands Organization for Scientific Research and the Netherlands Organization for Health Research and Development, and a Dutch Heart Foundation research/ 2021.81.004/Diabetes Fonds Fellowship/ Alzheimers Dement. 2023 Aug 23. doi: 10.1002/alz.13442.","abstract":"INTRODUCTION: The retina may provide non-invasive, scalable biomarkers for monitoring cerebral neurodegeneration. METHODS: We used cross-sectional data from The Maastricht study (n = 3436; mean age 59.3 years; 48% men; and 21% with type 2 diabetes [the latter oversampled by design]). We evaluated associations of retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thicknesses with cognitive performance and magnetic resonance imaging indices (global grey and white matter volume, hippocampal volume, whole brain node degree, global efficiency, clustering coefficient, and local efficiency). RESULTS: After adjustment, lower thicknesses of most inner retinal layers were significantly associated with worse cognitive performance, lower grey and white matter volume, lower hippocampal volume, and worse brain white matter network structure assessed from lower whole brain node degree, lower global efficiency, higher clustering coefficient, and higher local efficiency. DISCUSSION: The retina may provide biomarkers that are informative of cerebral neurodegenerative changes in the pathobiology of dementia.","keywords":"brain structural connectivity brain volume clustering coefficient cognitive function cognitive performance global efficiency graph theory grey matter local efficiency magnetic resonance imaging (MRI) optical coherence tomography (OCT) retinal imaging retinal neurodegeneration white matter whole brain node degree","issn":"1552-5279 (Electronic) 1552-5260 (Linking)","doi":"10.1002/alz.13442","url":"https://www.ncbi.nlm.nih.gov/pubmed/37611119","year":"2023","bibtex":"@article{RN336,\n author = {van der Heide, F. C. T. and Steens, I. L. M. and Limmen, B. and Mokhtar, S. and van Boxtel, M. P. J. and Schram, M. T. and Kohler, S. and Kroon, A. A. and van der Kallen, C. J. H. and Dagnelie, P. C. and van Dongen, Mcjm and Eussen, Sjpm and Berendschot, Ttjm and Webers, C. A. B. and van Greevenbroek, M. M. J. and Koster, A. and van Sloten, T. T. and Jansen, J. F. A. and Backes, W. H. and Stehouwer, C. D. A.},\n title = {Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure-The Maastricht Study},\n journal = {Alzheimers Dement},\n note = {van der Heide, Frank C T\nSteens, Indra L M\nLimmen, Betsie\nMokhtar, Sara\nvan Boxtel, Martin P J\nSchram, Miranda T\nKohler, Sebastian\nKroon, Abraham A\nvan der Kallen, Carla J H\nDagnelie, Pieter C\nvan Dongen, Martien C J M\nEussen, Simone J P M\nBerendschot, Tos T J M\nWebers, Carroll A B\nvan Greevenbroek, Marleen M J\nKoster, Annemarie\nvan Sloten, Thomas T\nJansen, Jacobus F A\nBackes, Walter H\nStehouwer, Coen D A\neng\n31O.041/OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs/\nStichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC, Maastricht, the Netherlands), CARIM School for Cardiovascular Diseases (Maastricht, the Netherlands), CAPHRI School for Public Health and Primary Care (Maastricht, the Netherlands), NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands), Perimed (Jarfalla, Sweden), and by unrestricted grants from Janssen-Cilag B.V. (Tilburg, the Netherlands), Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands), and Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands)/\n916.19.074/VENI research/\n2018T025/Netherlands Organization for Scientific Research and the Netherlands Organization for Health Research and Development, and a Dutch Heart Foundation research/\n2021.81.004/Diabetes Fonds Fellowship/\nAlzheimers Dement. 2023 Aug 23. doi: 10.1002/alz.13442.},\n abstract = {INTRODUCTION: The retina may provide non-invasive, scalable biomarkers for monitoring cerebral neurodegeneration. METHODS: We used cross-sectional data from The Maastricht study (n = 3436; mean age 59.3 years; 48% men; and 21% with type 2 diabetes [the latter oversampled by design]). We evaluated associations of retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thicknesses with cognitive performance and magnetic resonance imaging indices (global grey and white matter volume, hippocampal volume, whole brain node degree, global efficiency, clustering coefficient, and local efficiency). RESULTS: After adjustment, lower thicknesses of most inner retinal layers were significantly associated with worse cognitive performance, lower grey and white matter volume, lower hippocampal volume, and worse brain white matter network structure assessed from lower whole brain node degree, lower global efficiency, higher clustering coefficient, and higher local efficiency. DISCUSSION: The retina may provide biomarkers that are informative of cerebral neurodegenerative changes in the pathobiology of dementia.},\n keywords = {brain structural connectivity\nbrain volume\nclustering coefficient\ncognitive function\ncognitive performance\nglobal efficiency\ngraph theory\ngrey matter\nlocal efficiency\nmagnetic resonance imaging (MRI)\noptical coherence tomography (OCT)\nretinal imaging\nretinal neurodegeneration\nwhite matter\nwhole brain node degree},\n ISSN = {1552-5279 (Electronic)\n1552-5260 (Linking)},\n DOI = {10.1002/alz.13442},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/37611119},\n year = {2023},\n type = {Journal Article}\n}\n\n","author_short":["van der Heide, F. C. T.","Steens, I. L. M.","Limmen, B.","Mokhtar, S.","van Boxtel, M. P. J.","Schram, M. T.","Kohler, S.","Kroon, A. A.","van der Kallen, C. J. H.","Dagnelie, P. C.","van Dongen, M.","Eussen, S.","Berendschot, T.","Webers, C. A. B.","van Greevenbroek, M. M. 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