On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review. van der Knaap, N., Aries, M. J. H., van der Horst, I. C. C., & Jansen, J. F. A. Neuroimage Clin, 42:103589, 2024. van der Knaap, Noa Aries, Marcel J H van der Horst, Iwan C C Jansen, Jacobus F A eng Review Netherlands 2024/03/11 Neuroimage Clin. 2024 Mar 6;42:103589. doi: 10.1016/j.nicl.2024.103589.
On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review [link]Paper  doi  abstract   bibtex   
Many Coronavirus Disease 2019 (COVID-19) patients are suffering from long-term neuropsychological sequelae. These patients may benefit from a better understanding of the underlying neuropathophysiological mechanisms and identification of potential biomarkers and treatment targets. Structural clinical neuroimaging techniques have limited ability to visualize subtle cerebral abnormalities and to investigate brain function. This scoping review assesses the merits and potential of advanced neuroimaging techniques in COVID-19 using literature including advanced neuroimaging or postmortem analyses in adult COVID-19 patients published from the start of the pandemic until December 2023. Findings were summarized according to distinct categories of reported cerebral abnormalities revealed by different imaging techniques. Although no unified COVID-19-specific pattern could be subtracted, a broad range of cerebral abnormalities were revealed by advanced neuroimaging (likely attributable to hypoxic, vascular, and inflammatory pathology), even in absence of structural clinical imaging findings. These abnormalities are validated by postmortem examinations. This scoping review emphasizes the added value of advanced neuroimaging compared to structural clinical imaging and highlights implications for brain functioning and long-term consequences in COVID-19.
@article{RN354,
   author = {van der Knaap, N. and Aries, M. J. H. and van der Horst, I. C. C. and Jansen, J. F. A.},
   title = {On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review},
   journal = {Neuroimage Clin},
   volume = {42},
   pages = {103589},
   note = {van der Knaap, Noa
Aries, Marcel J H
van der Horst, Iwan C C
Jansen, Jacobus F A
eng
Review
Netherlands
2024/03/11
Neuroimage Clin. 2024 Mar 6;42:103589. doi: 10.1016/j.nicl.2024.103589.},
   abstract = {Many Coronavirus Disease 2019 (COVID-19) patients are suffering from long-term neuropsychological sequelae. These patients may benefit from a better understanding of the underlying neuropathophysiological mechanisms and identification of potential biomarkers and treatment targets. Structural clinical neuroimaging techniques have limited ability to visualize subtle cerebral abnormalities and to investigate brain function. This scoping review assesses the merits and potential of advanced neuroimaging techniques in COVID-19 using literature including advanced neuroimaging or postmortem analyses in adult COVID-19 patients published from the start of the pandemic until December 2023. Findings were summarized according to distinct categories of reported cerebral abnormalities revealed by different imaging techniques. Although no unified COVID-19-specific pattern could be subtracted, a broad range of cerebral abnormalities were revealed by advanced neuroimaging (likely attributable to hypoxic, vascular, and inflammatory pathology), even in absence of structural clinical imaging findings. These abnormalities are validated by postmortem examinations. This scoping review emphasizes the added value of advanced neuroimaging compared to structural clinical imaging and highlights implications for brain functioning and long-term consequences in COVID-19.},
   keywords = {Advanced neuroimaging
Covid-19
Magnetic resonance imaging
Positron emission tomography
long-COVID},
   ISSN = {2213-1582 (Electronic)
2213-1582 (Linking)},
   DOI = {10.1016/j.nicl.2024.103589},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/38461701},
   year = {2024},
   type = {Journal Article}
}

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