Neurophysiological correlates of dissociative symptoms. van der Kruijs, S. J., Bodde, N. M., Carrette, E., Lazeron, R. H., Vonck, K. E., Boon, P. A., Langereis, G. R., Cluitmans, P. J., Feijs, L. M., Hofman, P. A., Backes, W. H., Jansen, J. F., & Aldenkamp, A. P. J Neurol Neurosurg Psychiatry, 85(2):174-9, 2014. van der Kruijs, Sylvie J M Bodde, Nynke M G Carrette, Evelien Lazeron, Richard H C Vonck, Kristl E J Boon, Paul A J M Langereis, Geert R Cluitmans, Pierre J M Feijs, Loe M G Hofman, Paul A M Backes, Walter H Jansen, Jacobus F A Aldenkamp, A P eng Review England 2012/11/24 06:00 J Neurol Neurosurg Psychiatry. 2014 Feb;85(2):174-9. doi: 10.1136/jnnp-2012-302905. Epub 2012 Nov 22.
Paper doi abstract bibtex OBJECTIVE: Dissociation is a mental process with psychological and somatoform manifestations, which is closely related to hypnotic suggestibility and essentially shows the ability to obtain distance from reality. An increased tendency to dissociate is a frequently reported characteristic of patients with functional neurological symptoms and syndromes (FNSS), which account for a substantial part of all neurological admissions. This review aims to investigate what heart rate variability (HRV), EEG and neuroimaging data (MRI) reveal about the nature of dissociation and related conditions. METHODS: Studies reporting HRV, EEG and neuroimaging data related to hypnosis, dissociation and FNSS were identified by searching the electronic databases Pubmed and ScienceDirect. RESULTS: The majority of the identified studies concerned the physiological characteristics of hypnosis; relatively few investigations on dissociation related FNSS were identified. General findings were increased parasympathetic functioning during hypnosis (as measured by HRV), and lower HRV in patients with FNSS. The large variety of EEG and functional MRI investigations with diverse results challenges definite conclusions, but evidence suggests that subcortical as well as (pre)frontal regions serve emotion regulation in dissociative conditions. Functional connectivity analyses suggest the presence of altered brain networks in patients with FNSS, in which limbic areas have an increased influence on motor preparatory regions. CONCLUSIONS: HRV, EEG and (functional) MRI are sensitive methods to detect physiological changes related to dissociation and dissociative disorders such as FNSS, and can possibly provide more information about their aetiology. The use of such measures could eventually provide biomarkers for earlier identification of patients at risk and appropriate treatment of dissociative conditions.
@article{RN171,
author = {van der Kruijs, S. J. and Bodde, N. M. and Carrette, E. and Lazeron, R. H. and Vonck, K. E. and Boon, P. A. and Langereis, G. R. and Cluitmans, P. J. and Feijs, L. M. and Hofman, P. A. and Backes, W. H. and Jansen, J. F. and Aldenkamp, A. P.},
title = {Neurophysiological correlates of dissociative symptoms},
journal = {J Neurol Neurosurg Psychiatry},
volume = {85},
number = {2},
pages = {174-9},
note = {van der Kruijs, Sylvie J M
Bodde, Nynke M G
Carrette, Evelien
Lazeron, Richard H C
Vonck, Kristl E J
Boon, Paul A J M
Langereis, Geert R
Cluitmans, Pierre J M
Feijs, Loe M G
Hofman, Paul A M
Backes, Walter H
Jansen, Jacobus F A
Aldenkamp, A P
eng
Review
England
2012/11/24 06:00
J Neurol Neurosurg Psychiatry. 2014 Feb;85(2):174-9. doi: 10.1136/jnnp-2012-302905. Epub 2012 Nov 22.},
abstract = {OBJECTIVE: Dissociation is a mental process with psychological and somatoform manifestations, which is closely related to hypnotic suggestibility and essentially shows the ability to obtain distance from reality. An increased tendency to dissociate is a frequently reported characteristic of patients with functional neurological symptoms and syndromes (FNSS), which account for a substantial part of all neurological admissions. This review aims to investigate what heart rate variability (HRV), EEG and neuroimaging data (MRI) reveal about the nature of dissociation and related conditions. METHODS: Studies reporting HRV, EEG and neuroimaging data related to hypnosis, dissociation and FNSS were identified by searching the electronic databases Pubmed and ScienceDirect. RESULTS: The majority of the identified studies concerned the physiological characteristics of hypnosis; relatively few investigations on dissociation related FNSS were identified. General findings were increased parasympathetic functioning during hypnosis (as measured by HRV), and lower HRV in patients with FNSS. The large variety of EEG and functional MRI investigations with diverse results challenges definite conclusions, but evidence suggests that subcortical as well as (pre)frontal regions serve emotion regulation in dissociative conditions. Functional connectivity analyses suggest the presence of altered brain networks in patients with FNSS, in which limbic areas have an increased influence on motor preparatory regions. CONCLUSIONS: HRV, EEG and (functional) MRI are sensitive methods to detect physiological changes related to dissociation and dissociative disorders such as FNSS, and can possibly provide more information about their aetiology. The use of such measures could eventually provide biomarkers for earlier identification of patients at risk and appropriate treatment of dissociative conditions.},
keywords = {Brain/physiology/*physiopathology
Brain Waves/*physiology
Dissociative Disorders/complications/*physiopathology
*Functional Neuroimaging
Heart Rate/*physiology
Humans
Hypnosis
Nervous System Diseases/complications/*physiopathology/psychology
Eeg
Functional Imaging
Neurophysiology
Somatisation Disorder},
ISSN = {1468-330X (Electronic)
0022-3050 (Linking)},
DOI = {10.1136/jnnp-2012-302905},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23175855
https://jnnp.bmj.com/content/85/2/174.long},
year = {2014},
type = {Journal Article}
}
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General findings were increased parasympathetic functioning during hypnosis (as measured by HRV), and lower HRV in patients with FNSS. The large variety of EEG and functional MRI investigations with diverse results challenges definite conclusions, but evidence suggests that subcortical as well as (pre)frontal regions serve emotion regulation in dissociative conditions. Functional connectivity analyses suggest the presence of altered brain networks in patients with FNSS, in which limbic areas have an increased influence on motor preparatory regions. CONCLUSIONS: HRV, EEG and (functional) MRI are sensitive methods to detect physiological changes related to dissociation and dissociative disorders such as FNSS, and can possibly provide more information about their aetiology. 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The large variety of EEG and functional MRI investigations with diverse results challenges definite conclusions, but evidence suggests that subcortical as well as (pre)frontal regions serve emotion regulation in dissociative conditions. Functional connectivity analyses suggest the presence of altered brain networks in patients with FNSS, in which limbic areas have an increased influence on motor preparatory regions. CONCLUSIONS: HRV, EEG and (functional) MRI are sensitive methods to detect physiological changes related to dissociation and dissociative disorders such as FNSS, and can possibly provide more information about their aetiology. 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