@article{RN236,
   author = {van der Kruijs, S. J. and Vonck, K. E. and Feijs, L. M. and Bodde, N. M. and Lazeron, R. H. and Carrette, E. and Boon, P. A. and Backes, W. H. and Jansen, J. F. and Aldenkamp, A. P. and Cluitmans, P. J.},
   title = {Autonomic nervous system functioning associated with epileptic seizures: Analysis of heart rate variability},
   journal = {J Neurol Neurophysiol},
   volume = {5},
   number = {4},
   pages = {1000215},
   abstract = {Objective: Little is known about the (peri-) ictal changes in autonomic nervous system activity of epileptic
seizures. Such information may be useful for seizure prediction paradigms and differential diagnosis between
epilepsy and psychogenic non-epileptic seizures (PNES). The current study investigated the peri-ictal time course of
heart rate variability (HRV) measures, which reflect autonomic nervous system functioning.
Methods: HRV measures were extracted from electrocardiography data collected during 1-7 days of videoelectroencephalography
monitoring of 17 patients with epilepsy and 20 patients with PNES. Heart rate (HR) and
HRV measures (standard deviation of average beat-to-beat intervals (SDANN), root mean square of successive
differences (RMSSD), high frequency (HF) power, low frequency (LF) power and very low frequency (VLF) power)
were averaged over consecutive five-minute intervals. Quantitative analyses of Poincaré plot parameters (SD1, SD2
and SD1/SD2 ratio) were also performed. In addition, differences with HRV parameters of patients with PNES were
explored.
Results: In epilepsy, no significant pre-ictal changes in HR and HRV parameters were observed. During
seizures, HR, SDANN, SD1 and SD1/SD2 ratio significantly increased while VLF power significantly decreased. In
the five-minute interval immediately following seizures, HR, SDANN and SD1 were back to pre-seizure levels, while
VLF power remained significantly decreased and SD1/SD2 ratio remained significantly increased. Significant
between-group differences were identified for several pre-ictal and ictal HRV parameters, but not for post-ictal
measurements.
Conclusion: The ictal HR and HRV changes reflect increased sympathetic system activation during epileptic
seizures. The HRV parameters of patients with epilepsy differed significantly from the peri-ictal HRV pattern of
patients with PNES, which suggested increased sympathetic system activation and decreased vagal tone shortly
before PNES and return to normal levels shortly after the episode. Implications for differential diagnosis and
treatment are discussed.},
   keywords = {Epilepsy
Psychogenic
Non-epileptic seizures
Heart rate variability
Vagal tone
Autonomic nervous system},
   ISSN = {2155-9562},
   DOI = {10.4172/2155-9562-5-1000215},
   url = {https://www.omicsonline.org/open-access/autonomic-nervous-system-functioning-associated-with-epileptic-seizures-analysis-of-heart-rate-variability-2155-9562-5-1000215.php?aid=30282},
   year = {2014},
   type = {Journal Article}
}

{"_id":"RDTeBi3YWb2LNHKHX","bibbaseid":"vanderkruijs-vonck-feijs-bodde-lazeron-carrette-boon-backes-etal-autonomicnervoussystemfunctioningassociatedwithepilepticseizuresanalysisofheartratevariability-2014","downloads":0,"creationDate":"2018-08-03T14:29:50.294Z","title":"Autonomic nervous system functioning associated with epileptic seizures: Analysis of heart rate variability","author_short":["van der Kruijs, S. J.","Vonck, K. E.","Feijs, L. M.","Bodde, N. M.","Lazeron, R. H.","Carrette, E.","Boon, P. A.","Backes, W. H.","Jansen, J. F.","Aldenkamp, A. P.","Cluitmans, P. J."],"year":2014,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van","der"],"lastnames":["Kruijs"],"firstnames":["S.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Vonck"],"firstnames":["K.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Feijs"],"firstnames":["L.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Bodde"],"firstnames":["N.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Lazeron"],"firstnames":["R.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Carrette"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Boon"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Cluitmans"],"firstnames":["P.","J."],"suffixes":[]}],"title":"Autonomic nervous system functioning associated with epileptic seizures: Analysis of heart rate variability","journal":"J Neurol Neurophysiol","volume":"5","number":"4","pages":"1000215","abstract":"Objective: Little is known about the (peri-) ictal changes in autonomic nervous system activity of epileptic seizures. Such information may be useful for seizure prediction paradigms and differential diagnosis between epilepsy and psychogenic non-epileptic seizures (PNES). The current study investigated the peri-ictal time course of heart rate variability (HRV) measures, which reflect autonomic nervous system functioning. Methods: HRV measures were extracted from electrocardiography data collected during 1-7 days of videoelectroencephalography monitoring of 17 patients with epilepsy and 20 patients with PNES. Heart rate (HR) and HRV measures (standard deviation of average beat-to-beat intervals (SDANN), root mean square of successive differences (RMSSD), high frequency (HF) power, low frequency (LF) power and very low frequency (VLF) power) were averaged over consecutive five-minute intervals. Quantitative analyses of Poincaré plot parameters (SD1, SD2 and SD1/SD2 ratio) were also performed. In addition, differences with HRV parameters of patients with PNES were explored. Results: In epilepsy, no significant pre-ictal changes in HR and HRV parameters were observed. During seizures, HR, SDANN, SD1 and SD1/SD2 ratio significantly increased while VLF power significantly decreased. In the five-minute interval immediately following seizures, HR, SDANN and SD1 were back to pre-seizure levels, while VLF power remained significantly decreased and SD1/SD2 ratio remained significantly increased. Significant between-group differences were identified for several pre-ictal and ictal HRV parameters, but not for post-ictal measurements. Conclusion: The ictal HR and HRV changes reflect increased sympathetic system activation during epileptic seizures. The HRV parameters of patients with epilepsy differed significantly from the peri-ictal HRV pattern of patients with PNES, which suggested increased sympathetic system activation and decreased vagal tone shortly before PNES and return to normal levels shortly after the episode. Implications for differential diagnosis and treatment are discussed.","keywords":"Epilepsy Psychogenic Non-epileptic seizures Heart rate variability Vagal tone Autonomic nervous system","issn":"2155-9562","doi":"10.4172/2155-9562-5-1000215","url":"https://www.omicsonline.org/open-access/autonomic-nervous-system-functioning-associated-with-epileptic-seizures-analysis-of-heart-rate-variability-2155-9562-5-1000215.php?aid=30282","year":"2014","bibtex":"@article{RN236,\n author = {van der Kruijs, S. J. and Vonck, K. E. and Feijs, L. M. and Bodde, N. M. and Lazeron, R. H. and Carrette, E. and Boon, P. A. and Backes, W. H. and Jansen, J. F. and Aldenkamp, A. P. and Cluitmans, P. J.},\n title = {Autonomic nervous system functioning associated with epileptic seizures: Analysis of heart rate variability},\n journal = {J Neurol Neurophysiol},\n volume = {5},\n number = {4},\n pages = {1000215},\n abstract = {Objective: Little is known about the (peri-) ictal changes in autonomic nervous system activity of epileptic\nseizures. Such information may be useful for seizure prediction paradigms and differential diagnosis between\nepilepsy and psychogenic non-epileptic seizures (PNES). The current study investigated the peri-ictal time course of\nheart rate variability (HRV) measures, which reflect autonomic nervous system functioning.\nMethods: HRV measures were extracted from electrocardiography data collected during 1-7 days of videoelectroencephalography\nmonitoring of 17 patients with epilepsy and 20 patients with PNES. Heart rate (HR) and\nHRV measures (standard deviation of average beat-to-beat intervals (SDANN), root mean square of successive\ndifferences (RMSSD), high frequency (HF) power, low frequency (LF) power and very low frequency (VLF) power)\nwere averaged over consecutive five-minute intervals. Quantitative analyses of Poincaré plot parameters (SD1, SD2\nand SD1/SD2 ratio) were also performed. In addition, differences with HRV parameters of patients with PNES were\nexplored.\nResults: In epilepsy, no significant pre-ictal changes in HR and HRV parameters were observed. During\nseizures, HR, SDANN, SD1 and SD1/SD2 ratio significantly increased while VLF power significantly decreased. In\nthe five-minute interval immediately following seizures, HR, SDANN and SD1 were back to pre-seizure levels, while\nVLF power remained significantly decreased and SD1/SD2 ratio remained significantly increased. Significant\nbetween-group differences were identified for several pre-ictal and ictal HRV parameters, but not for post-ictal\nmeasurements.\nConclusion: The ictal HR and HRV changes reflect increased sympathetic system activation during epileptic\nseizures. The HRV parameters of patients with epilepsy differed significantly from the peri-ictal HRV pattern of\npatients with PNES, which suggested increased sympathetic system activation and decreased vagal tone shortly\nbefore PNES and return to normal levels shortly after the episode. Implications for differential diagnosis and\ntreatment are discussed.},\n keywords = {Epilepsy\nPsychogenic\nNon-epileptic seizures\nHeart rate variability\nVagal tone\nAutonomic nervous system},\n ISSN = {2155-9562},\n DOI = {10.4172/2155-9562-5-1000215},\n url = {https://www.omicsonline.org/open-access/autonomic-nervous-system-functioning-associated-with-epileptic-seizures-analysis-of-heart-rate-variability-2155-9562-5-1000215.php?aid=30282},\n year = {2014},\n type = {Journal Article}\n}\n\n","author_short":["van der Kruijs, S. J.","Vonck, K. E.","Feijs, L. M.","Bodde, N. M.","Lazeron, R. H.","Carrette, E.","Boon, P. A.","Backes, W. H.","Jansen, J. F.","Aldenkamp, A. P.","Cluitmans, P. J."],"key":"RN236","id":"RN236","bibbaseid":"vanderkruijs-vonck-feijs-bodde-lazeron-carrette-boon-backes-etal-autonomicnervoussystemfunctioningassociatedwithepilepticseizuresanalysisofheartratevariability-2014","role":"author","urls":{"Paper":"https://www.omicsonline.org/open-access/autonomic-nervous-system-functioning-associated-with-epileptic-seizures-analysis-of-heart-rate-variability-2155-9562-5-1000215.php?aid=30282"},"keyword":["Epilepsy Psychogenic Non-epileptic seizures Heart rate variability Vagal tone Autonomic nervous system"],"metadata":{"authorlinks":{"jansen, j":"https://www.jansenjfa.com/publications/"}},"downloads":0,"html":""},"search_terms":["autonomic","nervous","system","functioning","associated","epileptic","seizures","analysis","heart","rate","variability","van der kruijs","vonck","feijs","bodde","lazeron","carrette","boon","backes","jansen","aldenkamp","cluitmans"],"keywords":["epilepsy psychogenic non-epileptic seizures heart rate variability vagal tone autonomic nervous system"],"authorIDs":["TEAWLnKpXtQE8hs6C"],"dataSources":["TCkfRWJAZvbLAZi29"]}