@article{van_der_linden_increased_2003,
	title = {Increased risk of achilles tendon rupture with quinolone antibacterial use, especially in elderly patients taking oral corticosteroids},
	volume = {163},
	issn = {0003-9926},
	doi = {10.1001/archinte.163.15.1801},
	abstract = {BACKGROUND: In several case reports, the occurrence of Achilles tendon rupture has been attributed to the use of quinolones, but the epidemiologic evidence for this association is scanty.
METHODS: We conducted a population-based case-control study in the General Practice Research Database in the United Kingdom during the period 1988 through 1998. Cases were defined as all persons who had a first-time recording of an Achilles tendon rupture, and who had at least 18 months of valid history before the index date. As a control group, we randomly sampled 50 000 patients with at least 18 months of valid history who were assigned a random date as index date.
RESULTS: We identified 1367 cases that met the inclusion criteria. The adjusted odds ratio (OR) for Achilles tendon rupture was 4.3 (95\% confidence interval [CI], 2.4-7.8) for current exposure to quinolones, 2.4 (95\% CI, 1.5-3.7) for recent exposure, and 1.4 (95\% CI, 0.9-2.1) for past exposure. The OR of Achilles tendon rupture was 6.4 (95\% CI, 3.0-13.7) in patients aged 60 to 79 years and 20.4 (95\% CI, 4.6-90.1) in patients aged 80 years or older. In persons aged 60 years and older, the OR was 28.4 (95\% CI, 7.0-115.3) for current exposure to ofloxacin, while the ORs were 3.6 (95\% CI, 1.4-9.1) and 14.2 (95\% CI, 1.6-128.6) for ciprofloxacin and norfloxacin, respectively. Approximately 2\% to 6\% of all Achilles tendon ruptures in people older than 60 years can be attributed to quinolones.
CONCLUSIONS: Current exposure to quinolones increased the risk of Achilles tendon rupture. The risk is highest among elderly patients who were concomitantly treated with corticosteroids.},
	language = {eng},
	number = {15},
	journal = {Archives of Internal Medicine},
	author = {van der Linden, Paul D. and Sturkenboom, Miriam C. J. M. and Herings, Ron M. C. and Leufkens, Hubert M. G. and Rowlands, Sam and Stricker, Bruno H. Ch},
	month = aug,
	year = {2003},
	pmid = {12912715},
	keywords = {4-Quinolones, Achilles Tendon, Administration, Oral, Adrenal Cortex Hormones, Adult, Aged, Aged, 80 and over, Anti-Infective Agents, Anti-Inflammatory Agents, Case-Control Studies, Drug Therapy, Combination, Family Practice, Female, Great Britain, Humans, Male, Middle Aged, Odds Ratio, Risk Assessment, Risk Factors, Rupture, Spontaneous, Steroids},
	pages = {1801--1807}
}

{"_id":"pyKda7XBD3uF7nB69","bibbaseid":"vanderlinden-sturkenboom-herings-leufkens-rowlands-stricker-increasedriskofachillestendonrupturewithquinoloneantibacterialuseespeciallyinelderlypatientstakingoralcorticosteroids-2003","downloads":0,"creationDate":"2017-08-15T09:38:10.804Z","title":"Increased risk of achilles tendon rupture with quinolone antibacterial use, especially in elderly patients taking oral corticosteroids","author_short":["van der Linden, P. D.","Sturkenboom, M. C. J. M.","Herings, R. M. C.","Leufkens, H. M. G.","Rowlands, S.","Stricker, B. H. C."],"year":2003,"bibtype":"article","biburl":"http://bibbase.org/zotero/veegee78","bibdata":{"bibtype":"article","type":"article","title":"Increased risk of achilles tendon rupture with quinolone antibacterial use, especially in elderly patients taking oral corticosteroids","volume":"163","issn":"0003-9926","doi":"10.1001/archinte.163.15.1801","abstract":"BACKGROUND: In several case reports, the occurrence of Achilles tendon rupture has been attributed to the use of quinolones, but the epidemiologic evidence for this association is scanty. METHODS: We conducted a population-based case-control study in the General Practice Research Database in the United Kingdom during the period 1988 through 1998. Cases were defined as all persons who had a first-time recording of an Achilles tendon rupture, and who had at least 18 months of valid history before the index date. As a control group, we randomly sampled 50 000 patients with at least 18 months of valid history who were assigned a random date as index date. RESULTS: We identified 1367 cases that met the inclusion criteria. The adjusted odds ratio (OR) for Achilles tendon rupture was 4.3 (95% confidence interval [CI], 2.4-7.8) for current exposure to quinolones, 2.4 (95% CI, 1.5-3.7) for recent exposure, and 1.4 (95% CI, 0.9-2.1) for past exposure. The OR of Achilles tendon rupture was 6.4 (95% CI, 3.0-13.7) in patients aged 60 to 79 years and 20.4 (95% CI, 4.6-90.1) in patients aged 80 years or older. In persons aged 60 years and older, the OR was 28.4 (95% CI, 7.0-115.3) for current exposure to ofloxacin, while the ORs were 3.6 (95% CI, 1.4-9.1) and 14.2 (95% CI, 1.6-128.6) for ciprofloxacin and norfloxacin, respectively. Approximately 2% to 6% of all Achilles tendon ruptures in people older than 60 years can be attributed to quinolones. CONCLUSIONS: Current exposure to quinolones increased the risk of Achilles tendon rupture. The risk is highest among elderly patients who were concomitantly treated with corticosteroids.","language":"eng","number":"15","journal":"Archives of Internal Medicine","author":[{"propositions":["van","der"],"lastnames":["Linden"],"firstnames":["Paul","D."],"suffixes":[]},{"propositions":[],"lastnames":["Sturkenboom"],"firstnames":["Miriam","C.","J.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Herings"],"firstnames":["Ron","M.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Leufkens"],"firstnames":["Hubert","M.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Rowlands"],"firstnames":["Sam"],"suffixes":[]},{"propositions":[],"lastnames":["Stricker"],"firstnames":["Bruno","H.","Ch"],"suffixes":[]}],"month":"August","year":"2003","pmid":"12912715","keywords":"4-Quinolones, Achilles Tendon, Administration, Oral, Adrenal Cortex Hormones, Adult, Aged, Aged, 80 and over, Anti-Infective Agents, Anti-Inflammatory Agents, Case-Control Studies, Drug Therapy, Combination, Family Practice, Female, Great Britain, Humans, Male, Middle Aged, Odds Ratio, Risk Assessment, Risk Factors, Rupture, Spontaneous, Steroids","pages":"1801--1807","bibtex":"@article{van_der_linden_increased_2003,\n\ttitle = {Increased risk of achilles tendon rupture with quinolone antibacterial use, especially in elderly patients taking oral corticosteroids},\n\tvolume = {163},\n\tissn = {0003-9926},\n\tdoi = {10.1001/archinte.163.15.1801},\n\tabstract = {BACKGROUND: In several case reports, the occurrence of Achilles tendon rupture has been attributed to the use of quinolones, but the epidemiologic evidence for this association is scanty.\nMETHODS: We conducted a population-based case-control study in the General Practice Research Database in the United Kingdom during the period 1988 through 1998. Cases were defined as all persons who had a first-time recording of an Achilles tendon rupture, and who had at least 18 months of valid history before the index date. As a control group, we randomly sampled 50 000 patients with at least 18 months of valid history who were assigned a random date as index date.\nRESULTS: We identified 1367 cases that met the inclusion criteria. The adjusted odds ratio (OR) for Achilles tendon rupture was 4.3 (95\\% confidence interval [CI], 2.4-7.8) for current exposure to quinolones, 2.4 (95\\% CI, 1.5-3.7) for recent exposure, and 1.4 (95\\% CI, 0.9-2.1) for past exposure. The OR of Achilles tendon rupture was 6.4 (95\\% CI, 3.0-13.7) in patients aged 60 to 79 years and 20.4 (95\\% CI, 4.6-90.1) in patients aged 80 years or older. In persons aged 60 years and older, the OR was 28.4 (95\\% CI, 7.0-115.3) for current exposure to ofloxacin, while the ORs were 3.6 (95\\% CI, 1.4-9.1) and 14.2 (95\\% CI, 1.6-128.6) for ciprofloxacin and norfloxacin, respectively. Approximately 2\\% to 6\\% of all Achilles tendon ruptures in people older than 60 years can be attributed to quinolones.\nCONCLUSIONS: Current exposure to quinolones increased the risk of Achilles tendon rupture. The risk is highest among elderly patients who were concomitantly treated with corticosteroids.},\n\tlanguage = {eng},\n\tnumber = {15},\n\tjournal = {Archives of Internal Medicine},\n\tauthor = {van der Linden, Paul D. and Sturkenboom, Miriam C. J. M. and Herings, Ron M. C. and Leufkens, Hubert M. G. and Rowlands, Sam and Stricker, Bruno H. Ch},\n\tmonth = aug,\n\tyear = {2003},\n\tpmid = {12912715},\n\tkeywords = {4-Quinolones, Achilles Tendon, Administration, Oral, Adrenal Cortex Hormones, Adult, Aged, Aged, 80 and over, Anti-Infective Agents, Anti-Inflammatory Agents, Case-Control Studies, Drug Therapy, Combination, Family Practice, Female, Great Britain, Humans, Male, Middle Aged, Odds Ratio, Risk Assessment, Risk Factors, Rupture, Spontaneous, Steroids},\n\tpages = {1801--1807}\n}\n\n","author_short":["van der Linden, P. D.","Sturkenboom, M. C. J. M.","Herings, R. M. C.","Leufkens, H. M. G.","Rowlands, S.","Stricker, B. H. 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