@article{RN306,
   author = {van Dinther, M. and Voorter, P. H. M. and Schram, M. T. and Berendschot, Ttjm and Houben, Ajhm and Webers, C. A. B. and van Oostenbrugge, R. J. and Backes, W. H. and Staals, J. and Jansen, J. F. A.},
   title = {Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI},
   journal = {J Neurol Sci},
   volume = {440},
   pages = {120359},
   note = {van Dinther, Maud
Voorter, Paulien H M
Schram, Miranda T
Berendschot, Tos T J M
Houben, Alfons J H M
Webers, Carroll A B
van Oostenbrugge, Robert J
Backes, Walter H
Staals, Julie
Jansen, Jacobus F A
eng
Netherlands
J Neurol Sci. 2022 Jul 28;440:120359. doi: 10.1016/j.jns.2022.120359.},
   abstract = {BACKGROUND AND AIMS: The easily accessible retinal vessels provide a unique opportunity to study a proxy for cerebral small vessels. Associations between retinal vessel diameters and macrostructural brain white matter changes have already been demonstrated. Alterations in microvascular function, likely precede these structural abnormalities. We examined whether retinal microvascular function is related to cerebral microvascular properties, assessed by the intravoxel incoherent motion (IVIM) effect in brain MRI. METHODS: Seventy participants (age 60 +/- 8 years, 41% women) from the population-based Maastricht Study underwent brain IVIM diffusion imaging (3 Tesla) to determine the microvascular measures f (perfusion volume fraction) and D* (pseudo-diffusion of circulating blood). The retinal arteriolar and venular dilation response to flicker light stimulation were measured by a dynamic vessel analyzer. Linear regression analysis was used to investigate associations between retinal vasoreactivity and IVIM measures in white matter hyperintensities (WMH), normal-appearing white matter (NAWM) and cortical gray matter (CGM). RESULTS: More retinal arteriolar dilation was significantly associated with stronger pseudo-diffusion (D*) in the NAWM and CGM (beta 0.280 [95% CI 0.084-0.475], and beta 0.310 [95% CI 0.091-0.528], respectively), but not with the cerebral blood volume fraction (f). No associations were observed between retinal venular dilation response and cerebrovascular IVIM measures. CONCLUSIONS: Variations in retinal arteriolar microvascular function and microcirculatory properties in the brain are linked. The retina could serve as a proxy for early detection of brain microvascular dysfunction.},
   keywords = {Cerebral small vessels
Dynamic vessel analyzer
Intravoxel incoherent motion
Magnetic resonance imaging
Retinal vessels
Small vessel disease},
   ISSN = {1878-5883 (Electronic)
0022-510X (Linking)},
   DOI = {10.1016/j.jns.2022.120359},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/35917773},
   year = {2022},
   type = {Journal Article}
}

{"_id":"oM2Dn4easRGC92tid","bibbaseid":"vandinther-voorter-schram-berendschot-houben-webers-vanoostenbrugge-backes-etal-retinalmicrovascularfunctionisassociatedwiththecerebralmicrocirculationasdeterminedbyintravoxelincoherentmotionmri-2022","author_short":["van Dinther, M.","Voorter, P. H. M.","Schram, M. T.","Berendschot, T.","Houben, A.","Webers, C. A. B.","van Oostenbrugge, R. J.","Backes, W. H.","Staals, J.","Jansen, J. F. A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van"],"lastnames":["Dinther"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Voorter"],"firstnames":["P.","H.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Schram"],"firstnames":["M.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Berendschot"],"firstnames":["Ttjm"],"suffixes":[]},{"propositions":[],"lastnames":["Houben"],"firstnames":["Ajhm"],"suffixes":[]},{"propositions":[],"lastnames":["Webers"],"firstnames":["C.","A.","B."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Staals"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]}],"title":"Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI","journal":"J Neurol Sci","volume":"440","pages":"120359","note":"van Dinther, Maud Voorter, Paulien H M Schram, Miranda T Berendschot, Tos T J M Houben, Alfons J H M Webers, Carroll A B van Oostenbrugge, Robert J Backes, Walter H Staals, Julie Jansen, Jacobus F A eng Netherlands J Neurol Sci. 2022 Jul 28;440:120359. doi: 10.1016/j.jns.2022.120359.","abstract":"BACKGROUND AND AIMS: The easily accessible retinal vessels provide a unique opportunity to study a proxy for cerebral small vessels. Associations between retinal vessel diameters and macrostructural brain white matter changes have already been demonstrated. Alterations in microvascular function, likely precede these structural abnormalities. We examined whether retinal microvascular function is related to cerebral microvascular properties, assessed by the intravoxel incoherent motion (IVIM) effect in brain MRI. METHODS: Seventy participants (age 60 +/- 8 years, 41% women) from the population-based Maastricht Study underwent brain IVIM diffusion imaging (3 Tesla) to determine the microvascular measures f (perfusion volume fraction) and D* (pseudo-diffusion of circulating blood). The retinal arteriolar and venular dilation response to flicker light stimulation were measured by a dynamic vessel analyzer. Linear regression analysis was used to investigate associations between retinal vasoreactivity and IVIM measures in white matter hyperintensities (WMH), normal-appearing white matter (NAWM) and cortical gray matter (CGM). RESULTS: More retinal arteriolar dilation was significantly associated with stronger pseudo-diffusion (D*) in the NAWM and CGM (beta 0.280 [95% CI 0.084-0.475], and beta 0.310 [95% CI 0.091-0.528], respectively), but not with the cerebral blood volume fraction (f). No associations were observed between retinal venular dilation response and cerebrovascular IVIM measures. CONCLUSIONS: Variations in retinal arteriolar microvascular function and microcirculatory properties in the brain are linked. The retina could serve as a proxy for early detection of brain microvascular dysfunction.","keywords":"Cerebral small vessels Dynamic vessel analyzer Intravoxel incoherent motion Magnetic resonance imaging Retinal vessels Small vessel disease","issn":"1878-5883 (Electronic) 0022-510X (Linking)","doi":"10.1016/j.jns.2022.120359","url":"https://www.ncbi.nlm.nih.gov/pubmed/35917773","year":"2022","bibtex":"@article{RN306,\n author = {van Dinther, M. and Voorter, P. H. M. and Schram, M. T. and Berendschot, Ttjm and Houben, Ajhm and Webers, C. A. B. and van Oostenbrugge, R. J. and Backes, W. H. and Staals, J. and Jansen, J. F. A.},\n title = {Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI},\n journal = {J Neurol Sci},\n volume = {440},\n pages = {120359},\n note = {van Dinther, Maud\nVoorter, Paulien H M\nSchram, Miranda T\nBerendschot, Tos T J M\nHouben, Alfons J H M\nWebers, Carroll A B\nvan Oostenbrugge, Robert J\nBackes, Walter H\nStaals, Julie\nJansen, Jacobus F A\neng\nNetherlands\nJ Neurol Sci. 2022 Jul 28;440:120359. doi: 10.1016/j.jns.2022.120359.},\n abstract = {BACKGROUND AND AIMS: The easily accessible retinal vessels provide a unique opportunity to study a proxy for cerebral small vessels. Associations between retinal vessel diameters and macrostructural brain white matter changes have already been demonstrated. Alterations in microvascular function, likely precede these structural abnormalities. We examined whether retinal microvascular function is related to cerebral microvascular properties, assessed by the intravoxel incoherent motion (IVIM) effect in brain MRI. METHODS: Seventy participants (age 60 +/- 8 years, 41% women) from the population-based Maastricht Study underwent brain IVIM diffusion imaging (3 Tesla) to determine the microvascular measures f (perfusion volume fraction) and D* (pseudo-diffusion of circulating blood). The retinal arteriolar and venular dilation response to flicker light stimulation were measured by a dynamic vessel analyzer. Linear regression analysis was used to investigate associations between retinal vasoreactivity and IVIM measures in white matter hyperintensities (WMH), normal-appearing white matter (NAWM) and cortical gray matter (CGM). RESULTS: More retinal arteriolar dilation was significantly associated with stronger pseudo-diffusion (D*) in the NAWM and CGM (beta 0.280 [95% CI 0.084-0.475], and beta 0.310 [95% CI 0.091-0.528], respectively), but not with the cerebral blood volume fraction (f). No associations were observed between retinal venular dilation response and cerebrovascular IVIM measures. CONCLUSIONS: Variations in retinal arteriolar microvascular function and microcirculatory properties in the brain are linked. The retina could serve as a proxy for early detection of brain microvascular dysfunction.},\n keywords = {Cerebral small vessels\nDynamic vessel analyzer\nIntravoxel incoherent motion\nMagnetic resonance imaging\nRetinal vessels\nSmall vessel disease},\n ISSN = {1878-5883 (Electronic)\n0022-510X (Linking)},\n DOI = {10.1016/j.jns.2022.120359},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/35917773},\n year = {2022},\n type = {Journal Article}\n}\n\n","author_short":["van Dinther, M.","Voorter, P. H. M.","Schram, M. T.","Berendschot, T.","Houben, A.","Webers, C. A. B.","van Oostenbrugge, R. J.","Backes, W. H.","Staals, J.","Jansen, J. F. A."],"key":"RN306","id":"RN306","bibbaseid":"vandinther-voorter-schram-berendschot-houben-webers-vanoostenbrugge-backes-etal-retinalmicrovascularfunctionisassociatedwiththecerebralmicrocirculationasdeterminedbyintravoxelincoherentmotionmri-2022","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/35917773"},"keyword":["Cerebral small vessels Dynamic vessel analyzer Intravoxel incoherent motion Magnetic resonance imaging Retinal vessels Small vessel disease"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","dataSources":["TCkfRWJAZvbLAZi29"],"keywords":["cerebral small vessels dynamic vessel analyzer intravoxel incoherent motion magnetic resonance imaging retinal vessels small vessel disease"],"search_terms":["retinal","microvascular","function","associated","cerebral","microcirculation","determined","intravoxel","incoherent","motion","mri","van dinther","voorter","schram","berendschot","houben","webers","van oostenbrugge","backes","staals","jansen"],"title":"Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI","year":2022}