@article{RN361,
   author = {van Dinther, M. and Voorter, P. H. M. and Zhang, E. and van Kuijk, S. M. J. and Jansen, J. F. A. and van Oostenbrugge, R. J. and Backes, W. H. and Staals, J.},
   title = {The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach},
   journal = {Geroscience},
   note = {van Dinther, Maud
Voorter, Paulien H M
Zhang, Eleana
van Kuijk, Sander M J
Jansen, Jacobus F A
van Oostenbrugge, Robert J
Backes, Walter H
Staals, Julie
eng
848109/HORIZON EUROPE Health/
017.009.048/Nederlandse Organisatie voor Wetenschappelijk Onderzoek/
Switzerland
2024/06/18
Geroscience. 2024 Jun 18. doi: 10.1007/s11357-024-01235-8.},
   abstract = {Growing evidence indicates an important role of neurovascular unit (NVU) dysfunction in the pathophysiology of cerebral small vessel disease (cSVD). Individually measurable functions of the NVU have been correlated with cognitive function, but a combined analysis is lacking. We aimed to perform a unified analysis of NVU function and its relation with cognitive performance. The relationship between NVU function in the white matter and cognitive performance (both latent variables composed of multiple measurable variables) was investigated in 73 patients with cSVD (mean age 70 +/- 10 years, 41% women) using canonical correlation analysis. MRI-based NVU function measures included (1) the intravoxel incoherent motion derived perfusion volume fraction (f) and microvascular diffusivity (D*), reflecting cerebral microvascular flow; (2) the IVIM derived intermediate volume fraction (f(int)), indicative of the perivascular clearance system; and (3) the dynamic contrast-enhanced MRI derived blood-brain barrier (BBB) leakage rate (K(i)) and leakage volume fraction (V(L)), reflecting BBB integrity. Cognitive performance was composed of 13 cognitive test scores. Canonical correlation analysis revealed a strong correlation between the latent variables NVU function and cognitive performance (r 0.73; p = 0.02). For the NVU, the dominating variables were D*, f(int), and K(i). Cognitive performance was driven by multiple cognitive tests comprising different cognitive domains. The functionality of the NVU is correlated with cognitive performance in cSVD. Instead of focusing on individual pathophysiological mechanisms, future studies should target NVU dysfunction as a whole to acquire a coherent understanding of the complex disease mechanisms that occur in the NVU in cSVD.Trial registration: NTR3786 (Dutch Trial Register).},
   keywords = {Cerebral small vessel disease
Cognitive function
Magnetic resonance imaging
Microvascular function
Neurovascular unit},
   ISSN = {2509-2723 (Electronic)
2509-2723 (Linking)},
   DOI = {10.1007/s11357-024-01235-8},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/38888875},
   year = {2024},
   type = {Journal Article}
}

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H.","Staals, J."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van"],"lastnames":["Dinther"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Voorter"],"firstnames":["P.","H.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["E."],"suffixes":[]},{"propositions":["van"],"lastnames":["Kuijk"],"firstnames":["S.","M.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Staals"],"firstnames":["J."],"suffixes":[]}],"title":"The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach","journal":"Geroscience","note":"van Dinther, Maud Voorter, Paulien H M Zhang, Eleana van Kuijk, Sander M J Jansen, Jacobus F A van Oostenbrugge, Robert J Backes, Walter H Staals, Julie eng 848109/HORIZON EUROPE Health/ 017.009.048/Nederlandse Organisatie voor Wetenschappelijk Onderzoek/ Switzerland 2024/06/18 Geroscience. 2024 Jun 18. doi: 10.1007/s11357-024-01235-8.","abstract":"Growing evidence indicates an important role of neurovascular unit (NVU) dysfunction in the pathophysiology of cerebral small vessel disease (cSVD). Individually measurable functions of the NVU have been correlated with cognitive function, but a combined analysis is lacking. We aimed to perform a unified analysis of NVU function and its relation with cognitive performance. The relationship between NVU function in the white matter and cognitive performance (both latent variables composed of multiple measurable variables) was investigated in 73 patients with cSVD (mean age 70 +/- 10 years, 41% women) using canonical correlation analysis. MRI-based NVU function measures included (1) the intravoxel incoherent motion derived perfusion volume fraction (f) and microvascular diffusivity (D*), reflecting cerebral microvascular flow; (2) the IVIM derived intermediate volume fraction (f(int)), indicative of the perivascular clearance system; and (3) the dynamic contrast-enhanced MRI derived blood-brain barrier (BBB) leakage rate (K(i)) and leakage volume fraction (V(L)), reflecting BBB integrity. Cognitive performance was composed of 13 cognitive test scores. Canonical correlation analysis revealed a strong correlation between the latent variables NVU function and cognitive performance (r 0.73; p = 0.02). For the NVU, the dominating variables were D*, f(int), and K(i). Cognitive performance was driven by multiple cognitive tests comprising different cognitive domains. The functionality of the NVU is correlated with cognitive performance in cSVD. Instead of focusing on individual pathophysiological mechanisms, future studies should target NVU dysfunction as a whole to acquire a coherent understanding of the complex disease mechanisms that occur in the NVU in cSVD.Trial registration: NTR3786 (Dutch Trial Register).","keywords":"Cerebral small vessel disease Cognitive function Magnetic resonance imaging Microvascular function Neurovascular unit","issn":"2509-2723 (Electronic) 2509-2723 (Linking)","doi":"10.1007/s11357-024-01235-8","url":"https://www.ncbi.nlm.nih.gov/pubmed/38888875","year":"2024","bibtex":"@article{RN361,\n author = {van Dinther, M. and Voorter, P. H. M. and Zhang, E. and van Kuijk, S. M. J. and Jansen, J. F. A. and van Oostenbrugge, R. J. and Backes, W. H. and Staals, J.},\n title = {The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach},\n journal = {Geroscience},\n note = {van Dinther, Maud\nVoorter, Paulien H M\nZhang, Eleana\nvan Kuijk, Sander M J\nJansen, Jacobus F A\nvan Oostenbrugge, Robert J\nBackes, Walter H\nStaals, Julie\neng\n848109/HORIZON EUROPE Health/\n017.009.048/Nederlandse Organisatie voor Wetenschappelijk Onderzoek/\nSwitzerland\n2024/06/18\nGeroscience. 2024 Jun 18. doi: 10.1007/s11357-024-01235-8.},\n abstract = {Growing evidence indicates an important role of neurovascular unit (NVU) dysfunction in the pathophysiology of cerebral small vessel disease (cSVD). Individually measurable functions of the NVU have been correlated with cognitive function, but a combined analysis is lacking. We aimed to perform a unified analysis of NVU function and its relation with cognitive performance. The relationship between NVU function in the white matter and cognitive performance (both latent variables composed of multiple measurable variables) was investigated in 73 patients with cSVD (mean age 70 +/- 10 years, 41% women) using canonical correlation analysis. MRI-based NVU function measures included (1) the intravoxel incoherent motion derived perfusion volume fraction (f) and microvascular diffusivity (D*), reflecting cerebral microvascular flow; (2) the IVIM derived intermediate volume fraction (f(int)), indicative of the perivascular clearance system; and (3) the dynamic contrast-enhanced MRI derived blood-brain barrier (BBB) leakage rate (K(i)) and leakage volume fraction (V(L)), reflecting BBB integrity. Cognitive performance was composed of 13 cognitive test scores. Canonical correlation analysis revealed a strong correlation between the latent variables NVU function and cognitive performance (r 0.73; p = 0.02). For the NVU, the dominating variables were D*, f(int), and K(i). Cognitive performance was driven by multiple cognitive tests comprising different cognitive domains. The functionality of the NVU is correlated with cognitive performance in cSVD. Instead of focusing on individual pathophysiological mechanisms, future studies should target NVU dysfunction as a whole to acquire a coherent understanding of the complex disease mechanisms that occur in the NVU in cSVD.Trial registration: NTR3786 (Dutch Trial Register).},\n keywords = {Cerebral small vessel disease\nCognitive function\nMagnetic resonance imaging\nMicrovascular function\nNeurovascular unit},\n ISSN = {2509-2723 (Electronic)\n2509-2723 (Linking)},\n DOI = {10.1007/s11357-024-01235-8},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/38888875},\n year = {2024},\n type = {Journal Article}\n}\n\n","author_short":["van Dinther, M.","Voorter, P. H. M.","Zhang, E.","van Kuijk, S. M. J.","Jansen, J. F. A.","van Oostenbrugge, R. 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