Effects of adenotonsillectomy in children with sickle cell disease. Van Geyzel L., Singh B., Inusa B., Akthar M., Bossley C., Kozlowska W., Rees D., Chakravorty S., Ruiz G., Hore I., & Gupta A. 2016.
Effects of adenotonsillectomy in children with sickle cell disease [link]Paper  abstract   bibtex   
Introduction: Children with Sickle cell disease (SCD) have a higher prevalence of Obstructive sleep apnea (OSA) and OSA has been identified as an important comorbidity in children with SCD. There evidence linking nocturnal desaturations with an increased rate of both vaso-occlusive episodes (VOE) and acute chest syndrome (ACS). Methods: In our centre, all children and adolescents with SCD and OSA are evaluated for adenotonsillar hypertrophy, as adenotonsillectomy may be curative in some. Retrospective review of children with SCD who underwent adenotonsillectomyfor OSA between 2004 to 2015. Sleep study data and admission rates due to VOE & ACS were compared, before & after adenotonsillectomy. Results: 37 children with SCD underwent adenotonsillectomy during this time frame. 22 children (13 male) with a median age of 7 years (range 3-12 years) had sleep study before and after adenotonsillectomy. Discussion: Children with SCD and OSA, who had adenotonsillectomy, appeared to have a significant increase in overnight nadir oxygen saturations, as well as a reduction in the overnight ODI; but no change in the rates of severe ACS or VOE. Further testing by a randomised controlled trial or prospective longitudinal study is needed.
@misc{van_geyzel_l._effects_2016,
	title = {Effects of adenotonsillectomy in children with sickle cell disease},
	url = {http://erj.ersjournals.com/content/48/suppl_60/PA4353},
	abstract = {Introduction: Children with Sickle cell disease (SCD) have a higher prevalence of Obstructive sleep apnea (OSA) and OSA has been identified as an important comorbidity in children with SCD. There evidence linking nocturnal desaturations with an increased rate of both vaso-occlusive episodes (VOE) and acute chest syndrome (ACS). Methods: In our centre, all children and adolescents with SCD and OSA are evaluated for adenotonsillar hypertrophy, as adenotonsillectomy may be curative in some. Retrospective review of children with SCD who underwent adenotonsillectomyfor OSA between 2004 to 2015. Sleep study data and admission rates due to VOE \& ACS were compared, before \& after adenotonsillectomy. Results: 37 children with SCD underwent adenotonsillectomy during this time frame. 22 children (13 male) with a median age of 7 years (range 3-12 years) had sleep study before and after adenotonsillectomy. Discussion: Children with SCD and OSA, who had adenotonsillectomy, appeared to have a significant increase in overnight nadir oxygen saturations, as well as a reduction in the overnight ODI; but no change in the rates of severe ACS or VOE. Further testing by a randomised controlled trial or prospective longitudinal study is needed.},
	urldate = {0048-01-02},
	journal = {European Respiratory Journal},
	author = {{Van Geyzel L.} and {Singh B.} and {Inusa B.} and {Akthar M.} and {Bossley C.} and {Kozlowska W.} and {Rees D.} and {Chakravorty S.} and {Ruiz G.} and {Hore I.} and {Gupta A.}},
	year = {2016},
	keywords = {*adenotonsillectomy, *sickle cell anemia, Child, acute chest syndrome, adenotonsillar hypertrophy, adolescent, apnea monitoring, clinical article, controlled clinical trial, controlled study, female, human, longitudinal study, male, oxygen saturation, randomized controlled trial, retrospective study, sleep disordered breathing}
}

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