Three-year changes of cortical 18F-FDG in amnestic vs. non-amnestic sporadic early-onset Alzheimer's disease. Vanhoutte, M., Semah, F., Leclerc, X., Sillaire, A. R., Jaillard, A., Kuchcinski, G., Delbeuck, X., Fahmi, R., Pasquier, F., & Lopes, R. European Journal of Nuclear Medicine and Molecular Imaging, 47(2):304–318, February, 2020. doi abstract bibtex PURPOSE: To examine and compare longitudinal changes of cortical glucose metabolism in amnestic and non-amnestic sporadic forms of early-onset Alzheimer's disease and assess potential associations with neuropsychological performance over a 3-year period time. METHODS: Eighty-two participants meeting criteria for early-onset (\textless 65 years) sporadic form of probable Alzheimer's disease and presenting with a variety of clinical phenotypes (47 amnestic and 35 non-amnestic forms) were included at baseline and followed up for 1.44 ± 1.23 years. All of the participants underwent a work-up at baseline and every year during the follow-up period, which includes clinical examination, neuropsychological testing, genotyping, cerebrospinal fluid biomarker assays, and structural MRI and 18F-FDG PET. Vertex-wise partial volume-corrected glucose metabolic maps across the entire cortical surface were generated and longitudinally assessed together with the neuropsychological scores using linear mixed-effects modeling as a function of amnestic and non-amnestic sporadic forms of early-onset Alzheimer's disease. RESULTS: Similar evolution patterns of glucose metabolic decline between amnestic and non-amnestic forms were observed in widespread neocortical cortices. However, only non-amnestic forms appeared to have a greater reduction of glucose metabolism in lateral orbitofrontal and bilateral medial temporal cortices associated with more severe declines of neuropsychological performance compared with amnestic forms. Furthermore, results suggest that glucose metabolic decline in amnestic forms would progress along an anterior-to-posterior axis, whereas glucose metabolic decline in non-amnestic forms would progress along a posterior-to-anterior axis. CONCLUSIONS: We found differences in spatial distribution and temporal trajectory of glucose metabolic decline between amnestic and non-amnestic early-onset Alzheimer's disease groups, suggesting that one might want to consider treating the two forms of the disease as two separate entities.
@article{vanhoutte_three-year_2020,
title = {Three-year changes of cortical {18F}-{FDG} in amnestic vs. non-amnestic sporadic early-onset {Alzheimer}'s disease},
volume = {47},
issn = {1619-7089},
doi = {10.1007/s00259-019-04519-w},
abstract = {PURPOSE: To examine and compare longitudinal changes of cortical glucose metabolism in amnestic and non-amnestic sporadic forms of early-onset Alzheimer's disease and assess potential associations with neuropsychological performance over a 3-year period time.
METHODS: Eighty-two participants meeting criteria for early-onset ({\textless} 65 years) sporadic form of probable Alzheimer's disease and presenting with a variety of clinical phenotypes (47 amnestic and 35 non-amnestic forms) were included at baseline and followed up for 1.44 ± 1.23 years. All of the participants underwent a work-up at baseline and every year during the follow-up period, which includes clinical examination, neuropsychological testing, genotyping, cerebrospinal fluid biomarker assays, and structural MRI and 18F-FDG PET. Vertex-wise partial volume-corrected glucose metabolic maps across the entire cortical surface were generated and longitudinally assessed together with the neuropsychological scores using linear mixed-effects modeling as a function of amnestic and non-amnestic sporadic forms of early-onset Alzheimer's disease.
RESULTS: Similar evolution patterns of glucose metabolic decline between amnestic and non-amnestic forms were observed in widespread neocortical cortices. However, only non-amnestic forms appeared to have a greater reduction of glucose metabolism in lateral orbitofrontal and bilateral medial temporal cortices associated with more severe declines of neuropsychological performance compared with amnestic forms. Furthermore, results suggest that glucose metabolic decline in amnestic forms would progress along an anterior-to-posterior axis, whereas glucose metabolic decline in non-amnestic forms would progress along a posterior-to-anterior axis.
CONCLUSIONS: We found differences in spatial distribution and temporal trajectory of glucose metabolic decline between amnestic and non-amnestic early-onset Alzheimer's disease groups, suggesting that one might want to consider treating the two forms of the disease as two separate entities.},
language = {eng},
number = {2},
journal = {European Journal of Nuclear Medicine and Molecular Imaging},
author = {Vanhoutte, Matthieu and Semah, Franck and Leclerc, Xavier and Sillaire, Adeline Rollin and Jaillard, Alice and Kuchcinski, Grégory and Delbeuck, Xavier and Fahmi, Rachid and Pasquier, Florence and Lopes, Renaud},
month = feb,
year = {2020},
pmid = {31606833},
keywords = {Cognition, Linear mixed-effects modeling, Longitudinal glucose metabolism, Positron emission tomography, Sporadic early-onset Alzheimer’s disease},
pages = {304--318}
}
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METHODS: Eighty-two participants meeting criteria for early-onset (\\textless 65 years) sporadic form of probable Alzheimer's disease and presenting with a variety of clinical phenotypes (47 amnestic and 35 non-amnestic forms) were included at baseline and followed up for 1.44 ± 1.23 years. All of the participants underwent a work-up at baseline and every year during the follow-up period, which includes clinical examination, neuropsychological testing, genotyping, cerebrospinal fluid biomarker assays, and structural MRI and 18F-FDG PET. Vertex-wise partial volume-corrected glucose metabolic maps across the entire cortical surface were generated and longitudinally assessed together with the neuropsychological scores using linear mixed-effects modeling as a function of amnestic and non-amnestic sporadic forms of early-onset Alzheimer's disease. RESULTS: Similar evolution patterns of glucose metabolic decline between amnestic and non-amnestic forms were observed in widespread neocortical cortices. However, only non-amnestic forms appeared to have a greater reduction of glucose metabolism in lateral orbitofrontal and bilateral medial temporal cortices associated with more severe declines of neuropsychological performance compared with amnestic forms. Furthermore, results suggest that glucose metabolic decline in amnestic forms would progress along an anterior-to-posterior axis, whereas glucose metabolic decline in non-amnestic forms would progress along a posterior-to-anterior axis. CONCLUSIONS: We found differences in spatial distribution and temporal trajectory of glucose metabolic decline between amnestic and non-amnestic early-onset Alzheimer's disease groups, suggesting that one might want to consider treating the two forms of the disease as two separate entities.","language":"eng","number":"2","journal":"European Journal of Nuclear Medicine and Molecular Imaging","author":[{"propositions":[],"lastnames":["Vanhoutte"],"firstnames":["Matthieu"],"suffixes":[]},{"propositions":[],"lastnames":["Semah"],"firstnames":["Franck"],"suffixes":[]},{"propositions":[],"lastnames":["Leclerc"],"firstnames":["Xavier"],"suffixes":[]},{"propositions":[],"lastnames":["Sillaire"],"firstnames":["Adeline","Rollin"],"suffixes":[]},{"propositions":[],"lastnames":["Jaillard"],"firstnames":["Alice"],"suffixes":[]},{"propositions":[],"lastnames":["Kuchcinski"],"firstnames":["Grégory"],"suffixes":[]},{"propositions":[],"lastnames":["Delbeuck"],"firstnames":["Xavier"],"suffixes":[]},{"propositions":[],"lastnames":["Fahmi"],"firstnames":["Rachid"],"suffixes":[]},{"propositions":[],"lastnames":["Pasquier"],"firstnames":["Florence"],"suffixes":[]},{"propositions":[],"lastnames":["Lopes"],"firstnames":["Renaud"],"suffixes":[]}],"month":"February","year":"2020","pmid":"31606833","keywords":"Cognition, Linear mixed-effects modeling, Longitudinal glucose metabolism, Positron emission tomography, Sporadic early-onset Alzheimer’s disease","pages":"304–318","bibtex":"@article{vanhoutte_three-year_2020,\n\ttitle = {Three-year changes of cortical {18F}-{FDG} in amnestic vs. non-amnestic sporadic early-onset {Alzheimer}'s disease},\n\tvolume = {47},\n\tissn = {1619-7089},\n\tdoi = {10.1007/s00259-019-04519-w},\n\tabstract = {PURPOSE: To examine and compare longitudinal changes of cortical glucose metabolism in amnestic and non-amnestic sporadic forms of early-onset Alzheimer's disease and assess potential associations with neuropsychological performance over a 3-year period time.\nMETHODS: Eighty-two participants meeting criteria for early-onset ({\\textless} 65 years) sporadic form of probable Alzheimer's disease and presenting with a variety of clinical phenotypes (47 amnestic and 35 non-amnestic forms) were included at baseline and followed up for 1.44 ± 1.23 years. All of the participants underwent a work-up at baseline and every year during the follow-up period, which includes clinical examination, neuropsychological testing, genotyping, cerebrospinal fluid biomarker assays, and structural MRI and 18F-FDG PET. Vertex-wise partial volume-corrected glucose metabolic maps across the entire cortical surface were generated and longitudinally assessed together with the neuropsychological scores using linear mixed-effects modeling as a function of amnestic and non-amnestic sporadic forms of early-onset Alzheimer's disease.\nRESULTS: Similar evolution patterns of glucose metabolic decline between amnestic and non-amnestic forms were observed in widespread neocortical cortices. However, only non-amnestic forms appeared to have a greater reduction of glucose metabolism in lateral orbitofrontal and bilateral medial temporal cortices associated with more severe declines of neuropsychological performance compared with amnestic forms. Furthermore, results suggest that glucose metabolic decline in amnestic forms would progress along an anterior-to-posterior axis, whereas glucose metabolic decline in non-amnestic forms would progress along a posterior-to-anterior axis.\nCONCLUSIONS: We found differences in spatial distribution and temporal trajectory of glucose metabolic decline between amnestic and non-amnestic early-onset Alzheimer's disease groups, suggesting that one might want to consider treating the two forms of the disease as two separate entities.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {European Journal of Nuclear Medicine and Molecular Imaging},\n\tauthor = {Vanhoutte, Matthieu and Semah, Franck and Leclerc, Xavier and Sillaire, Adeline Rollin and Jaillard, Alice and Kuchcinski, Grégory and Delbeuck, Xavier and Fahmi, Rachid and Pasquier, Florence and Lopes, Renaud},\n\tmonth = feb,\n\tyear = {2020},\n\tpmid = {31606833},\n\tkeywords = {Cognition, Linear mixed-effects modeling, Longitudinal glucose metabolism, Positron emission tomography, Sporadic early-onset Alzheimer’s disease},\n\tpages = {304--318}\n}\n\n","author_short":["Vanhoutte, M.","Semah, F.","Leclerc, X.","Sillaire, A. 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