@article{RN339,
   author = {van Kruining, D. and Losen, M. and Crivelli, S. M. and de Jong, J. J. A. and Jansen, J. F. A. and Backes, W. H. and Monereo-Sanchez, J. and van Boxtel, M. P. J. and Kohler, S. and Linden, D. E. J. and Schram, M. T. and Mielke, M. M. and Martinez-Martinez, P.},
   title = {Plasma ceramides relate to mild cognitive impairment in middle-aged men: The Maastricht Study},
   journal = {Alzheimers Dement (Amst)},
   volume = {15},
   number = {3},
   pages = {e12459},
   note = {van Kruining, Daan
Losen, Mario
Crivelli, Simone M
de Jong, Joost J A
Jansen, Jacobus F A
Backes, Walter H
Monereo-Sanchez, Jennifer
van Boxtel, Martin P J
Kohler, Sebastian
Linden, David E J
Schram, Miranda T
Mielke, Michelle M
Martinez-Martinez, Pilar
eng
Alzheimers Dement (Amst). 2023 Sep 5;15(3):e12459. doi: 10.1002/dad2.12459. eCollection 2023 Jul-Sep.},
   abstract = {INTRODUCTION: There is an urgent need for biomarkers identifying individuals at risk of early-stage cognitive impairment. Using cross-sectional data from The Maastricht Study, this study included 197 individuals with mild cognitive impairment (MCI) and 200 cognitively unimpaired individuals aged 40 to 75, matched by age, sex, and educational level. METHODS: We assessed the association of plasma sphingolipid and ceramide transfer protein (CERT) levels with MCI and adjusted for potentially confounding risk factors. Furthermore, the relationship of plasma sphingolipids and CERTs with magnetic resonance imaging brain volumes was assessed and age- and sex-stratified analyses were performed. RESULTS: Associations of plasma ceramide species C18:0 and C24:1 and combined plasma ceramide chain lengths (ceramide risk score) with MCI were moderated by sex, but not by age, and higher levels were associated with MCI in men. No associations were found among women. In addition, higher levels of ceramide C20:0, C22:0, and C24:1, but not the ceramide risk score, were associated with larger volume of the hippocampus after controlling for covariates, independent of MCI. Although higher plasma ceramide C18:0 was related to higher plasma CERT levels, no association of CERT levels was found with MCI or brain volumes. DISCUSSION: Our results warrant further analysis of plasma ceramides as potential markers for MCI in middle-aged men. In contrast to previous studies, no associations of plasma sphingolipids with MCI or brain volumes were found in women, independent of age. These results highlight the importance of accounting for sex- and age-related factors when examining sphingolipid and CERT metabolism related to cognitive function.},
   keywords = {Alzheimer's disease
biomarkers
ceramide
ceramide risk score
ceramide transfer protein
magnetic resonance imaging
mild cognitive impairment
plasma sphingolipids
sex differences
disclose. Author disclosures are available in the supporting information.},
   ISSN = {2352-8729 (Print)
2352-8729 (Linking)},
   DOI = {10.1002/dad2.12459},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/37675435},
   year = {2023},
   type = {Journal Article}
}

{"_id":"4sxkSE2Fu38AaPKdT","bibbaseid":"vankruining-losen-crivelli-dejong-jansen-backes-monereosanchez-vanboxtel-etal-plasmaceramidesrelatetomildcognitiveimpairmentinmiddleagedmenthemaastrichtstudy-2023","author_short":["van Kruining, D.","Losen, M.","Crivelli, S. M.","de Jong, J. J. A.","Jansen, J. F. A.","Backes, W. H.","Monereo-Sanchez, J.","van Boxtel, M. P. J.","Kohler, S.","Linden, D. E. J.","Schram, M. T.","Mielke, M. M.","Martinez-Martinez, P."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van"],"lastnames":["Kruining"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Losen"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Crivelli"],"firstnames":["S.","M."],"suffixes":[]},{"propositions":["de"],"lastnames":["Jong"],"firstnames":["J.","J.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Monereo-Sanchez"],"firstnames":["J."],"suffixes":[]},{"propositions":["van"],"lastnames":["Boxtel"],"firstnames":["M.","P.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Kohler"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Linden"],"firstnames":["D.","E.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Schram"],"firstnames":["M.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Mielke"],"firstnames":["M.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Martinez-Martinez"],"firstnames":["P."],"suffixes":[]}],"title":"Plasma ceramides relate to mild cognitive impairment in middle-aged men: The Maastricht Study","journal":"Alzheimers Dement (Amst)","volume":"15","number":"3","pages":"e12459","note":"van Kruining, Daan Losen, Mario Crivelli, Simone M de Jong, Joost J A Jansen, Jacobus F A Backes, Walter H Monereo-Sanchez, Jennifer van Boxtel, Martin P J Kohler, Sebastian Linden, David E J Schram, Miranda T Mielke, Michelle M Martinez-Martinez, Pilar eng Alzheimers Dement (Amst). 2023 Sep 5;15(3):e12459. doi: 10.1002/dad2.12459. eCollection 2023 Jul-Sep.","abstract":"INTRODUCTION: There is an urgent need for biomarkers identifying individuals at risk of early-stage cognitive impairment. Using cross-sectional data from The Maastricht Study, this study included 197 individuals with mild cognitive impairment (MCI) and 200 cognitively unimpaired individuals aged 40 to 75, matched by age, sex, and educational level. METHODS: We assessed the association of plasma sphingolipid and ceramide transfer protein (CERT) levels with MCI and adjusted for potentially confounding risk factors. Furthermore, the relationship of plasma sphingolipids and CERTs with magnetic resonance imaging brain volumes was assessed and age- and sex-stratified analyses were performed. RESULTS: Associations of plasma ceramide species C18:0 and C24:1 and combined plasma ceramide chain lengths (ceramide risk score) with MCI were moderated by sex, but not by age, and higher levels were associated with MCI in men. No associations were found among women. In addition, higher levels of ceramide C20:0, C22:0, and C24:1, but not the ceramide risk score, were associated with larger volume of the hippocampus after controlling for covariates, independent of MCI. Although higher plasma ceramide C18:0 was related to higher plasma CERT levels, no association of CERT levels was found with MCI or brain volumes. DISCUSSION: Our results warrant further analysis of plasma ceramides as potential markers for MCI in middle-aged men. In contrast to previous studies, no associations of plasma sphingolipids with MCI or brain volumes were found in women, independent of age. These results highlight the importance of accounting for sex- and age-related factors when examining sphingolipid and CERT metabolism related to cognitive function.","keywords":"Alzheimer's disease biomarkers ceramide ceramide risk score ceramide transfer protein magnetic resonance imaging mild cognitive impairment plasma sphingolipids sex differences disclose. Author disclosures are available in the supporting information.","issn":"2352-8729 (Print) 2352-8729 (Linking)","doi":"10.1002/dad2.12459","url":"https://www.ncbi.nlm.nih.gov/pubmed/37675435","year":"2023","bibtex":"@article{RN339,\n author = {van Kruining, D. and Losen, M. and Crivelli, S. M. and de Jong, J. J. A. and Jansen, J. F. A. and Backes, W. H. and Monereo-Sanchez, J. and van Boxtel, M. P. J. and Kohler, S. and Linden, D. E. J. and Schram, M. T. and Mielke, M. M. and Martinez-Martinez, P.},\n title = {Plasma ceramides relate to mild cognitive impairment in middle-aged men: The Maastricht Study},\n journal = {Alzheimers Dement (Amst)},\n volume = {15},\n number = {3},\n pages = {e12459},\n note = {van Kruining, Daan\nLosen, Mario\nCrivelli, Simone M\nde Jong, Joost J A\nJansen, Jacobus F A\nBackes, Walter H\nMonereo-Sanchez, Jennifer\nvan Boxtel, Martin P J\nKohler, Sebastian\nLinden, David E J\nSchram, Miranda T\nMielke, Michelle M\nMartinez-Martinez, Pilar\neng\nAlzheimers Dement (Amst). 2023 Sep 5;15(3):e12459. doi: 10.1002/dad2.12459. eCollection 2023 Jul-Sep.},\n abstract = {INTRODUCTION: There is an urgent need for biomarkers identifying individuals at risk of early-stage cognitive impairment. Using cross-sectional data from The Maastricht Study, this study included 197 individuals with mild cognitive impairment (MCI) and 200 cognitively unimpaired individuals aged 40 to 75, matched by age, sex, and educational level. METHODS: We assessed the association of plasma sphingolipid and ceramide transfer protein (CERT) levels with MCI and adjusted for potentially confounding risk factors. Furthermore, the relationship of plasma sphingolipids and CERTs with magnetic resonance imaging brain volumes was assessed and age- and sex-stratified analyses were performed. RESULTS: Associations of plasma ceramide species C18:0 and C24:1 and combined plasma ceramide chain lengths (ceramide risk score) with MCI were moderated by sex, but not by age, and higher levels were associated with MCI in men. No associations were found among women. In addition, higher levels of ceramide C20:0, C22:0, and C24:1, but not the ceramide risk score, were associated with larger volume of the hippocampus after controlling for covariates, independent of MCI. Although higher plasma ceramide C18:0 was related to higher plasma CERT levels, no association of CERT levels was found with MCI or brain volumes. DISCUSSION: Our results warrant further analysis of plasma ceramides as potential markers for MCI in middle-aged men. In contrast to previous studies, no associations of plasma sphingolipids with MCI or brain volumes were found in women, independent of age. These results highlight the importance of accounting for sex- and age-related factors when examining sphingolipid and CERT metabolism related to cognitive function.},\n keywords = {Alzheimer's disease\nbiomarkers\nceramide\nceramide risk score\nceramide transfer protein\nmagnetic resonance imaging\nmild cognitive impairment\nplasma sphingolipids\nsex differences\ndisclose. Author disclosures are available in the supporting information.},\n ISSN = {2352-8729 (Print)\n2352-8729 (Linking)},\n DOI = {10.1002/dad2.12459},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/37675435},\n year = {2023},\n type = {Journal Article}\n}\n\n","author_short":["van Kruining, D.","Losen, M.","Crivelli, S. M.","de Jong, J. J. A.","Jansen, J. F. 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Author disclosures are available in the supporting information."],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","dataSources":["TCkfRWJAZvbLAZi29"],"keywords":["alzheimer's disease biomarkers ceramide ceramide risk score ceramide transfer protein magnetic resonance imaging mild cognitive impairment plasma sphingolipids sex differences disclose. author disclosures are available in the supporting information."],"search_terms":["plasma","ceramides","relate","mild","cognitive","impairment","middle","aged","men","maastricht","study","van kruining","losen","crivelli","de jong","jansen","backes","monereo-sanchez","van boxtel","kohler","linden","schram","mielke","martinez-martinez"],"title":"Plasma ceramides relate to mild cognitive impairment in middle-aged men: The Maastricht Study","year":2023}