@article{RN214,
   author = {van Veenendaal, T. M. and Backes, W. H. and Tse, D. H. Y. and Scheenen, T. W. J. and Klomp, D. W. and Hofman, P. A. M. and Rouhl, R. P. W. and Vlooswijk, M. C. G. and Aldenkamp, A. P. and Jansen, J. F. A.},
   title = {High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy},
   journal = {Neuroimage Clin},
   volume = {19},
   pages = {47-55},
   note = {van Veenendaal, Tamar M
Backes, Walter H
Tse, Desmond H Y
Scheenen, Tom W J
Klomp, Dennis W
Hofman, Paul A M
Rouhl, Rob P W
Vlooswijk, Marielle C G
Aldenkamp, Albert P
Jansen, Jacobus F A
eng
Research Support, Non-U.S. Gov't
Netherlands
2018/07/24 06:00
Neuroimage Clin. 2018 Apr 4;19:47-55. doi: 10.1016/j.nicl.2018.04.006. eCollection 2018.},
   abstract = {The brain can be considered a network, existing of multiple interconnected areas with various functions. MRI provides opportunities to map the large-scale network organization of the brain. We tap into the neurobiochemical dimension of these networks, as neuronal functioning and signal trafficking across distributed brain regions relies on the release and presence of neurotransmitters. Using high-field MR spectroscopic imaging at 7.0T, we obtained a non-invasive snapshot of the spatial distribution of the neurotransmitters GABA and glutamate, and investigated interregional associations of these neurotransmitters. We demonstrate that interregional correlations of glutamate and GABA concentrations can be conceptualized as networks. Furthermore, patients with epilepsy display an increased number of glutamate and GABA connections and increased average strength of the GABA network. The increased glutamate and GABA connectivity in epilepsy might indicate a disrupted neurotransmitter balance. In addition to epilepsy, the 'neurotransmitter networks' concept might also provide new insights for other neurological diseases.},
   keywords = {Adult
Aged
Brain/*pathology/physiopathology
*Brain Mapping
Epilepsy/*pathology/physiopathology
Female
Glutamic Acid/metabolism
Humans
Magnetic Resonance Imaging/methods
Male
Middle Aged
Nerve Net/diagnostic imaging/physiology
Neural Pathways/physiology
Neurons/metabolism
Neurotransmitter Agents/*metabolism
Young Adult
gamma-Aminobutyric Acid/metabolism
*7t
*Gaba
*Glutamate
*MR spectroscopic imaging
*Networks},
   ISSN = {2213-1582 (Electronic)
2213-1582 (Linking)},
   DOI = {10.1016/j.nicl.2018.04.006},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/30035001
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051471/pdf/main.pdf},
   year = {2018},
   type = {Journal Article}
}

{"_id":"ByHshAhJ5KcKL7gzA","bibbaseid":"vanveenendaal-backes-tse-scheenen-klomp-hofman-rouhl-vlooswijk-etal-highfieldimagingoflargescaleneurotransmitternetworksproofofconceptandinitialapplicationtoepilepsy-2018","downloads":1,"creationDate":"2018-08-03T14:29:50.300Z","title":"High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy","author_short":["van Veenendaal, T. M.","Backes, W. H.","Tse, D. H. Y.","Scheenen, T. W. J.","Klomp, D. W.","Hofman, P. A. M.","Rouhl, R. P. W.","Vlooswijk, M. C. G.","Aldenkamp, A. P.","Jansen, J. F. A."],"year":2018,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van"],"lastnames":["Veenendaal"],"firstnames":["T.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Tse"],"firstnames":["D.","H.","Y."],"suffixes":[]},{"propositions":[],"lastnames":["Scheenen"],"firstnames":["T.","W.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Klomp"],"firstnames":["D.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Rouhl"],"firstnames":["R.","P.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Vlooswijk"],"firstnames":["M.","C.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]}],"title":"High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy","journal":"Neuroimage Clin","volume":"19","pages":"47-55","note":"van Veenendaal, Tamar M Backes, Walter H Tse, Desmond H Y Scheenen, Tom W J Klomp, Dennis W Hofman, Paul A M Rouhl, Rob P W Vlooswijk, Marielle C G Aldenkamp, Albert P Jansen, Jacobus F A eng Research Support, Non-U.S. Gov't Netherlands 2018/07/24 06:00 Neuroimage Clin. 2018 Apr 4;19:47-55. doi: 10.1016/j.nicl.2018.04.006. eCollection 2018.","abstract":"The brain can be considered a network, existing of multiple interconnected areas with various functions. MRI provides opportunities to map the large-scale network organization of the brain. We tap into the neurobiochemical dimension of these networks, as neuronal functioning and signal trafficking across distributed brain regions relies on the release and presence of neurotransmitters. Using high-field MR spectroscopic imaging at 7.0T, we obtained a non-invasive snapshot of the spatial distribution of the neurotransmitters GABA and glutamate, and investigated interregional associations of these neurotransmitters. We demonstrate that interregional correlations of glutamate and GABA concentrations can be conceptualized as networks. Furthermore, patients with epilepsy display an increased number of glutamate and GABA connections and increased average strength of the GABA network. The increased glutamate and GABA connectivity in epilepsy might indicate a disrupted neurotransmitter balance. In addition to epilepsy, the 'neurotransmitter networks' concept might also provide new insights for other neurological diseases.","keywords":"Adult Aged Brain/*pathology/physiopathology *Brain Mapping Epilepsy/*pathology/physiopathology Female Glutamic Acid/metabolism Humans Magnetic Resonance Imaging/methods Male Middle Aged Nerve Net/diagnostic imaging/physiology Neural Pathways/physiology Neurons/metabolism Neurotransmitter Agents/*metabolism Young Adult gamma-Aminobutyric Acid/metabolism *7t *Gaba *Glutamate *MR spectroscopic imaging *Networks","issn":"2213-1582 (Electronic) 2213-1582 (Linking)","doi":"10.1016/j.nicl.2018.04.006","url":"http://www.ncbi.nlm.nih.gov/pubmed/30035001 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051471/pdf/main.pdf","year":"2018","bibtex":"@article{RN214,\n author = {van Veenendaal, T. M. and Backes, W. H. and Tse, D. H. Y. and Scheenen, T. W. J. and Klomp, D. W. and Hofman, P. A. M. and Rouhl, R. P. W. and Vlooswijk, M. C. G. and Aldenkamp, A. P. and Jansen, J. F. A.},\n title = {High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy},\n journal = {Neuroimage Clin},\n volume = {19},\n pages = {47-55},\n note = {van Veenendaal, Tamar M\nBackes, Walter H\nTse, Desmond H Y\nScheenen, Tom W J\nKlomp, Dennis W\nHofman, Paul A M\nRouhl, Rob P W\nVlooswijk, Marielle C G\nAldenkamp, Albert P\nJansen, Jacobus F A\neng\nResearch Support, Non-U.S. Gov't\nNetherlands\n2018/07/24 06:00\nNeuroimage Clin. 2018 Apr 4;19:47-55. doi: 10.1016/j.nicl.2018.04.006. eCollection 2018.},\n abstract = {The brain can be considered a network, existing of multiple interconnected areas with various functions. MRI provides opportunities to map the large-scale network organization of the brain. We tap into the neurobiochemical dimension of these networks, as neuronal functioning and signal trafficking across distributed brain regions relies on the release and presence of neurotransmitters. Using high-field MR spectroscopic imaging at 7.0T, we obtained a non-invasive snapshot of the spatial distribution of the neurotransmitters GABA and glutamate, and investigated interregional associations of these neurotransmitters. We demonstrate that interregional correlations of glutamate and GABA concentrations can be conceptualized as networks. Furthermore, patients with epilepsy display an increased number of glutamate and GABA connections and increased average strength of the GABA network. The increased glutamate and GABA connectivity in epilepsy might indicate a disrupted neurotransmitter balance. In addition to epilepsy, the 'neurotransmitter networks' concept might also provide new insights for other neurological diseases.},\n keywords = {Adult\nAged\nBrain/*pathology/physiopathology\n*Brain Mapping\nEpilepsy/*pathology/physiopathology\nFemale\nGlutamic Acid/metabolism\nHumans\nMagnetic Resonance Imaging/methods\nMale\nMiddle Aged\nNerve Net/diagnostic imaging/physiology\nNeural Pathways/physiology\nNeurons/metabolism\nNeurotransmitter Agents/*metabolism\nYoung Adult\ngamma-Aminobutyric Acid/metabolism\n*7t\n*Gaba\n*Glutamate\n*MR spectroscopic imaging\n*Networks},\n ISSN = {2213-1582 (Electronic)\n2213-1582 (Linking)},\n DOI = {10.1016/j.nicl.2018.04.006},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/30035001\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051471/pdf/main.pdf},\n year = {2018},\n type = {Journal Article}\n}\n\n","author_short":["van Veenendaal, T. M.","Backes, W. H.","Tse, D. H. Y.","Scheenen, T. W. J.","Klomp, D. W.","Hofman, P. A. M.","Rouhl, R. P. 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