@article{RN215,
   author = {van Veenendaal, T. M. and Backes, W. H. and van Bussel, F. C. G. and Edden, R. A. E. and Puts, N. A. J. and Aldenkamp, A. P. and Jansen, J. F. A.},
   title = {Glutamate quantification by PRESS or MEGA-PRESS: Validation, repeatability, and concordance},
   journal = {Magn Reson Imaging},
   volume = {48},
   pages = {107-114},
   note = {van Veenendaal, Tamar M
Backes, Walter H
van Bussel, Frank C G
Edden, Richard A E
Puts, Nicolaas A J
Aldenkamp, Albert P
Jansen, Jacobus F A
eng
Research Support, Non-U.S. Gov't
Validation Study
Netherlands
2018/01/07 06:00
Magn Reson Imaging. 2018 May;48:107-114. doi: 10.1016/j.mri.2017.12.029. Epub 2018 Jan 3.},
   abstract = {PURPOSE: While PRESS is often employed to measure glutamate concentrations, MEGA-PRESS enables simultaneous Glx (glutamate and glutamine) and GABA measurements. This study aimed to compare validation, repeatability, and concordance of different approaches for glutamate quantification at 3T to aid future studies in their selection of the appropriate sequence and quantification method. MATERIALS AND METHODS: Nine phantoms with different glutamate and glutamine concentrations and five healthy participants were scanned twice to assess respectively the validation and repeatability of measurements with PRESS and MEGA-PRESS. To assess concordance between the different methods, results from 95 human participants were compared. PRESS, MEGA-PRESS (i.e. difference), and the MEGA-PRESS OFF spectra were analyzed with both LCModel and Gannet. RESULTS: In vitro, excellent agreement was shown between actual and measured glutamate concentrations for all measurements (r>0.98). In vivo CVs were better for PRESS (2.9%) than MEGA-PRESS (4.9%) and MEGA-PRESS OFF (4.2%). However, the concordance between the sequences was low (PRESS and MEGA-PRESS OFF, r=0.3) to modest (MEGA-PRESS versus MEGA-PRESS OFF, r=0.8). CONCLUSION: Both PRESS and MEGA-PRESS can be employed to measure in vivo glutamate concentrations, although PRESS shows a better repeatability. Comparisons between in vivo glutamate measures of different sequences however need to be interpreted cautiously.},
   keywords = {Adult
Brain/diagnostic imaging/*metabolism
Brain Mapping/*methods
Female
Glutamic Acid/analysis/*metabolism
Humans
Magnetic Resonance Spectroscopy/*methods
Male
*Phantoms, Imaging
Reference Values
Reproducibility of Results
*Glutamate
*Glx
*In vitro
*In vivo
*MR spectroscopy},
   ISSN = {1873-5894 (Electronic)
0730-725X (Linking)},
   DOI = {10.1016/j.mri.2017.12.029},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/29306050
https://www.sciencedirect.com/science/article/abs/pii/S0730725X1730303X?via%3Dihub},
   year = {2018},
   type = {Journal Article}
}

{"_id":"6oNqpCQJQv7Fhk6iJ","bibbaseid":"vanveenendaal-backes-vanbussel-edden-puts-aldenkamp-jansen-glutamatequantificationbypressormegapressvalidationrepeatabilityandconcordance-2018","downloads":0,"creationDate":"2018-08-03T14:29:50.302Z","title":"Glutamate quantification by PRESS or MEGA-PRESS: Validation, repeatability, and concordance","author_short":["van Veenendaal, T. M.","Backes, W. H.","van Bussel, F. C. G.","Edden, R. A. E.","Puts, N. A. J.","Aldenkamp, A. P.","Jansen, J. F. A."],"year":2018,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":["van"],"lastnames":["Veenendaal"],"firstnames":["T.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":["van"],"lastnames":["Bussel"],"firstnames":["F.","C.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Edden"],"firstnames":["R.","A.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Puts"],"firstnames":["N.","A.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]}],"title":"Glutamate quantification by PRESS or MEGA-PRESS: Validation, repeatability, and concordance","journal":"Magn Reson Imaging","volume":"48","pages":"107-114","note":"van Veenendaal, Tamar M Backes, Walter H van Bussel, Frank C G Edden, Richard A E Puts, Nicolaas A J Aldenkamp, Albert P Jansen, Jacobus F A eng Research Support, Non-U.S. Gov't Validation Study Netherlands 2018/01/07 06:00 Magn Reson Imaging. 2018 May;48:107-114. doi: 10.1016/j.mri.2017.12.029. Epub 2018 Jan 3.","abstract":"PURPOSE: While PRESS is often employed to measure glutamate concentrations, MEGA-PRESS enables simultaneous Glx (glutamate and glutamine) and GABA measurements. This study aimed to compare validation, repeatability, and concordance of different approaches for glutamate quantification at 3T to aid future studies in their selection of the appropriate sequence and quantification method. MATERIALS AND METHODS: Nine phantoms with different glutamate and glutamine concentrations and five healthy participants were scanned twice to assess respectively the validation and repeatability of measurements with PRESS and MEGA-PRESS. To assess concordance between the different methods, results from 95 human participants were compared. PRESS, MEGA-PRESS (i.e. difference), and the MEGA-PRESS OFF spectra were analyzed with both LCModel and Gannet. RESULTS: In vitro, excellent agreement was shown between actual and measured glutamate concentrations for all measurements (r>0.98). In vivo CVs were better for PRESS (2.9%) than MEGA-PRESS (4.9%) and MEGA-PRESS OFF (4.2%). However, the concordance between the sequences was low (PRESS and MEGA-PRESS OFF, r=0.3) to modest (MEGA-PRESS versus MEGA-PRESS OFF, r=0.8). CONCLUSION: Both PRESS and MEGA-PRESS can be employed to measure in vivo glutamate concentrations, although PRESS shows a better repeatability. Comparisons between in vivo glutamate measures of different sequences however need to be interpreted cautiously.","keywords":"Adult Brain/diagnostic imaging/*metabolism Brain Mapping/*methods Female Glutamic Acid/analysis/*metabolism Humans Magnetic Resonance Spectroscopy/*methods Male *Phantoms, Imaging Reference Values Reproducibility of Results *Glutamate *Glx *In vitro *In vivo *MR spectroscopy","issn":"1873-5894 (Electronic) 0730-725X (Linking)","doi":"10.1016/j.mri.2017.12.029","url":"http://www.ncbi.nlm.nih.gov/pubmed/29306050 https://www.sciencedirect.com/science/article/abs/pii/S0730725X1730303X?via%3Dihub","year":"2018","bibtex":"@article{RN215,\n author = {van Veenendaal, T. M. and Backes, W. H. and van Bussel, F. C. G. and Edden, R. A. E. and Puts, N. A. J. and Aldenkamp, A. P. and Jansen, J. F. A.},\n title = {Glutamate quantification by PRESS or MEGA-PRESS: Validation, repeatability, and concordance},\n journal = {Magn Reson Imaging},\n volume = {48},\n pages = {107-114},\n note = {van Veenendaal, Tamar M\nBackes, Walter H\nvan Bussel, Frank C G\nEdden, Richard A E\nPuts, Nicolaas A J\nAldenkamp, Albert P\nJansen, Jacobus F A\neng\nResearch Support, Non-U.S. Gov't\nValidation Study\nNetherlands\n2018/01/07 06:00\nMagn Reson Imaging. 2018 May;48:107-114. doi: 10.1016/j.mri.2017.12.029. Epub 2018 Jan 3.},\n abstract = {PURPOSE: While PRESS is often employed to measure glutamate concentrations, MEGA-PRESS enables simultaneous Glx (glutamate and glutamine) and GABA measurements. This study aimed to compare validation, repeatability, and concordance of different approaches for glutamate quantification at 3T to aid future studies in their selection of the appropriate sequence and quantification method. MATERIALS AND METHODS: Nine phantoms with different glutamate and glutamine concentrations and five healthy participants were scanned twice to assess respectively the validation and repeatability of measurements with PRESS and MEGA-PRESS. To assess concordance between the different methods, results from 95 human participants were compared. PRESS, MEGA-PRESS (i.e. difference), and the MEGA-PRESS OFF spectra were analyzed with both LCModel and Gannet. RESULTS: In vitro, excellent agreement was shown between actual and measured glutamate concentrations for all measurements (r>0.98). In vivo CVs were better for PRESS (2.9%) than MEGA-PRESS (4.9%) and MEGA-PRESS OFF (4.2%). However, the concordance between the sequences was low (PRESS and MEGA-PRESS OFF, r=0.3) to modest (MEGA-PRESS versus MEGA-PRESS OFF, r=0.8). CONCLUSION: Both PRESS and MEGA-PRESS can be employed to measure in vivo glutamate concentrations, although PRESS shows a better repeatability. Comparisons between in vivo glutamate measures of different sequences however need to be interpreted cautiously.},\n keywords = {Adult\nBrain/diagnostic imaging/*metabolism\nBrain Mapping/*methods\nFemale\nGlutamic Acid/analysis/*metabolism\nHumans\nMagnetic Resonance Spectroscopy/*methods\nMale\n*Phantoms, Imaging\nReference Values\nReproducibility of Results\n*Glutamate\n*Glx\n*In vitro\n*In vivo\n*MR spectroscopy},\n ISSN = {1873-5894 (Electronic)\n0730-725X (Linking)},\n DOI = {10.1016/j.mri.2017.12.029},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/29306050\nhttps://www.sciencedirect.com/science/article/abs/pii/S0730725X1730303X?via%3Dihub},\n year = {2018},\n type = {Journal Article}\n}\n\n","author_short":["van Veenendaal, T. M.","Backes, W. H.","van Bussel, F. C. G.","Edden, R. A. E.","Puts, N. A. J.","Aldenkamp, A. P.","Jansen, J. F. A."],"key":"RN215","id":"RN215","bibbaseid":"vanveenendaal-backes-vanbussel-edden-puts-aldenkamp-jansen-glutamatequantificationbypressormegapressvalidationrepeatabilityandconcordance-2018","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/29306050 https://www.sciencedirect.com/science/article/abs/pii/S0730725X1730303X?via%3Dihub"},"keyword":["Adult Brain/diagnostic imaging/*metabolism Brain Mapping/*methods Female Glutamic Acid/analysis/*metabolism Humans Magnetic Resonance Spectroscopy/*methods Male *Phantoms","Imaging Reference Values Reproducibility of Results *Glutamate *Glx *In vitro *In vivo *MR spectroscopy"],"metadata":{"authorlinks":{"jansen, j":"https://www.jansenjfa.com/publications/"}},"downloads":0,"html":""},"search_terms":["glutamate","quantification","press","mega","press","validation","repeatability","concordance","van veenendaal","backes","van bussel","edden","puts","aldenkamp","jansen"],"keywords":["adult brain/diagnostic imaging/*metabolism brain mapping/*methods female glutamic acid/analysis/*metabolism humans magnetic resonance spectroscopy/*methods male *phantoms","imaging reference values reproducibility of results *glutamate *glx *in vitro *in vivo *mr spectroscopy"],"authorIDs":["TEAWLnKpXtQE8hs6C"],"dataSources":["NcYBKGxxHQiyceke2","TCkfRWJAZvbLAZi29"]}