@article{van_weehaeghe_moving_2020,
	title = {Moving towards multicenter therapeutic trials in {ALS}: feasibility of data pooling using different {TSPO} positron emission tomography ({PET}) radioligands},
	issn = {1535-5667},
	shorttitle = {Moving towards multicenter therapeutic trials in {ALS}},
	doi = {10.2967/jnumed.119.241059},
	abstract = {RATIONALE: Neuroinflammation has been implicated in Amyotrophic Lateral Sclerosis (ALS) and can be visualized using translocator protein (TSPO) radioligands. To become a reliable pharmacodynamic biomarker for ALS multicenter trials, some challenges have to be overcome. We aimed to investigate whether multicenter data pooling of different TSPO tracers (11C-PBR28 and 18F-DPA714) is feasible, after validation of an established 11C-PBR28 PET pseudoreference analysis technique for 18F-DPA714. Methods: 7 ALS-Belgium (58.9±6.7 years,5M) and 8 HV-Belgium (52.1±15.2 years,3M); and 7 ALS-US (53.4±9.8 years,5M) and 7 HV-US (54.6±9.6 years,4M) from a previously published study (1) underwent dynamic 18F-DPA714 (Leuven, Belgium) or 11C-PBR28 (Boston, US) PET-MR scans. For 18F-DPA714, volume of distribution (VT) maps were compared to standardized uptake value ratios (SUVR)40-60 calculated using the pseudoreference regions (1)cerebellum, (2)occipital cortex, and (3)whole brain without ventricles (WB-ventricles). Also for 11C-PBR28, SUVR60-90 using WB-ventricles were calculated. Results: In line with previous studies, increased 18F-DPA714 uptake (17.0±5.6\%) in primary motor cortices was observed in ALS, as measured by both VT and SUVR40-60 approaches. Highest sensitivity was found for SUVRWB-ventricles (average cluster 21.6±0.1\%). 18F-DPA714 VT ratio and SUVR40-60 results were highly correlated (r{\textgreater}0.8, p{\textless}0.001). A similar pattern of increased uptake (average cluster 20.5±0.5\%) in primary motor cortices was observed in ALS with 11C-PBR28 using the SUVRWB-ventricles. Analysis of the 18F-DPA714 and 11C-PBR28 data together, resulted in a more extensive pattern of significant increased glial activation in the bilateral primary motor cortices. Conclusion: The same pseudoreference region analysis technique for 11C-PBR28 PET imaging can be extended towards 18F-DPA714 PET. Therefore, in ALS, standardized analysis across these two tracers enables pooling of TSPO PET data across multiple centers and increase power of TSPO as biomarker for future therapeutic trials.},
	language = {eng},
	journal = {Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine},
	author = {Van Weehaeghe, Donatienne and Babu, Suma and De Vocht, Joke and Zurcher, Nicole R. and Chew, Sheena and Tseng, Chieh-En J. and Loggia, Marco L. and Koole, Michel and Rezaei, Ahmadreza and Schramm, Georg and Van Damme, Philip and Hooker, Jacob M. and Van Laere, Koen and Atassi, Nazem},
	month = mar,
	year = {2020},
	pmid = {32169920},
	keywords = {ALS, [11C]PBR28, [18F]DPA-714, multiple tracer},
}

{"_id":"gaQ56DGrdtXwykroN","bibbaseid":"vanweehaeghe-babu-devocht-zurcher-chew-tseng-loggia-koole-etal-movingtowardsmulticentertherapeutictrialsinalsfeasibilityofdatapoolingusingdifferenttspopositronemissiontomographypetradioligands-2020","author_short":["Van Weehaeghe, D.","Babu, S.","De Vocht, J.","Zurcher, N. R.","Chew, S.","Tseng, C. J.","Loggia, M. L.","Koole, M.","Rezaei, A.","Schramm, G.","Van Damme, P.","Hooker, J. M.","Van Laere, K.","Atassi, N."],"bibdata":{"bibtype":"article","type":"article","title":"Moving towards multicenter therapeutic trials in ALS: feasibility of data pooling using different TSPO positron emission tomography (PET) radioligands","issn":"1535-5667","shorttitle":"Moving towards multicenter therapeutic trials in ALS","doi":"10.2967/jnumed.119.241059","abstract":"RATIONALE: Neuroinflammation has been implicated in Amyotrophic Lateral Sclerosis (ALS) and can be visualized using translocator protein (TSPO) radioligands. To become a reliable pharmacodynamic biomarker for ALS multicenter trials, some challenges have to be overcome. We aimed to investigate whether multicenter data pooling of different TSPO tracers (11C-PBR28 and 18F-DPA714) is feasible, after validation of an established 11C-PBR28 PET pseudoreference analysis technique for 18F-DPA714. Methods: 7 ALS-Belgium (58.9±6.7 years,5M) and 8 HV-Belgium (52.1±15.2 years,3M); and 7 ALS-US (53.4±9.8 years,5M) and 7 HV-US (54.6±9.6 years,4M) from a previously published study (1) underwent dynamic 18F-DPA714 (Leuven, Belgium) or 11C-PBR28 (Boston, US) PET-MR scans. For 18F-DPA714, volume of distribution (VT) maps were compared to standardized uptake value ratios (SUVR)40-60 calculated using the pseudoreference regions (1)cerebellum, (2)occipital cortex, and (3)whole brain without ventricles (WB-ventricles). Also for 11C-PBR28, SUVR60-90 using WB-ventricles were calculated. Results: In line with previous studies, increased 18F-DPA714 uptake (17.0±5.6%) in primary motor cortices was observed in ALS, as measured by both VT and SUVR40-60 approaches. Highest sensitivity was found for SUVRWB-ventricles (average cluster 21.6±0.1%). 18F-DPA714 VT ratio and SUVR40-60 results were highly correlated (r\\textgreater0.8, p\\textless0.001). A similar pattern of increased uptake (average cluster 20.5±0.5%) in primary motor cortices was observed in ALS with 11C-PBR28 using the SUVRWB-ventricles. Analysis of the 18F-DPA714 and 11C-PBR28 data together, resulted in a more extensive pattern of significant increased glial activation in the bilateral primary motor cortices. Conclusion: The same pseudoreference region analysis technique for 11C-PBR28 PET imaging can be extended towards 18F-DPA714 PET. Therefore, in ALS, standardized analysis across these two tracers enables pooling of TSPO PET data across multiple centers and increase power of TSPO as biomarker for future therapeutic trials.","language":"eng","journal":"Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine","author":[{"propositions":[],"lastnames":["Van","Weehaeghe"],"firstnames":["Donatienne"],"suffixes":[]},{"propositions":[],"lastnames":["Babu"],"firstnames":["Suma"],"suffixes":[]},{"propositions":[],"lastnames":["De","Vocht"],"firstnames":["Joke"],"suffixes":[]},{"propositions":[],"lastnames":["Zurcher"],"firstnames":["Nicole","R."],"suffixes":[]},{"propositions":[],"lastnames":["Chew"],"firstnames":["Sheena"],"suffixes":[]},{"propositions":[],"lastnames":["Tseng"],"firstnames":["Chieh-En","J."],"suffixes":[]},{"propositions":[],"lastnames":["Loggia"],"firstnames":["Marco","L."],"suffixes":[]},{"propositions":[],"lastnames":["Koole"],"firstnames":["Michel"],"suffixes":[]},{"propositions":[],"lastnames":["Rezaei"],"firstnames":["Ahmadreza"],"suffixes":[]},{"propositions":[],"lastnames":["Schramm"],"firstnames":["Georg"],"suffixes":[]},{"propositions":[],"lastnames":["Van","Damme"],"firstnames":["Philip"],"suffixes":[]},{"propositions":[],"lastnames":["Hooker"],"firstnames":["Jacob","M."],"suffixes":[]},{"propositions":[],"lastnames":["Van","Laere"],"firstnames":["Koen"],"suffixes":[]},{"propositions":[],"lastnames":["Atassi"],"firstnames":["Nazem"],"suffixes":[]}],"month":"March","year":"2020","pmid":"32169920","keywords":"ALS, [11C]PBR28, [18F]DPA-714, multiple tracer","bibtex":"@article{van_weehaeghe_moving_2020,\n\ttitle = {Moving towards multicenter therapeutic trials in {ALS}: feasibility of data pooling using different {TSPO} positron emission tomography ({PET}) radioligands},\n\tissn = {1535-5667},\n\tshorttitle = {Moving towards multicenter therapeutic trials in {ALS}},\n\tdoi = {10.2967/jnumed.119.241059},\n\tabstract = {RATIONALE: Neuroinflammation has been implicated in Amyotrophic Lateral Sclerosis (ALS) and can be visualized using translocator protein (TSPO) radioligands. To become a reliable pharmacodynamic biomarker for ALS multicenter trials, some challenges have to be overcome. We aimed to investigate whether multicenter data pooling of different TSPO tracers (11C-PBR28 and 18F-DPA714) is feasible, after validation of an established 11C-PBR28 PET pseudoreference analysis technique for 18F-DPA714. Methods: 7 ALS-Belgium (58.9±6.7 years,5M) and 8 HV-Belgium (52.1±15.2 years,3M); and 7 ALS-US (53.4±9.8 years,5M) and 7 HV-US (54.6±9.6 years,4M) from a previously published study (1) underwent dynamic 18F-DPA714 (Leuven, Belgium) or 11C-PBR28 (Boston, US) PET-MR scans. For 18F-DPA714, volume of distribution (VT) maps were compared to standardized uptake value ratios (SUVR)40-60 calculated using the pseudoreference regions (1)cerebellum, (2)occipital cortex, and (3)whole brain without ventricles (WB-ventricles). Also for 11C-PBR28, SUVR60-90 using WB-ventricles were calculated. Results: In line with previous studies, increased 18F-DPA714 uptake (17.0±5.6\\%) in primary motor cortices was observed in ALS, as measured by both VT and SUVR40-60 approaches. Highest sensitivity was found for SUVRWB-ventricles (average cluster 21.6±0.1\\%). 18F-DPA714 VT ratio and SUVR40-60 results were highly correlated (r{\\textgreater}0.8, p{\\textless}0.001). A similar pattern of increased uptake (average cluster 20.5±0.5\\%) in primary motor cortices was observed in ALS with 11C-PBR28 using the SUVRWB-ventricles. Analysis of the 18F-DPA714 and 11C-PBR28 data together, resulted in a more extensive pattern of significant increased glial activation in the bilateral primary motor cortices. Conclusion: The same pseudoreference region analysis technique for 11C-PBR28 PET imaging can be extended towards 18F-DPA714 PET. Therefore, in ALS, standardized analysis across these two tracers enables pooling of TSPO PET data across multiple centers and increase power of TSPO as biomarker for future therapeutic trials.},\n\tlanguage = {eng},\n\tjournal = {Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine},\n\tauthor = {Van Weehaeghe, Donatienne and Babu, Suma and De Vocht, Joke and Zurcher, Nicole R. and Chew, Sheena and Tseng, Chieh-En J. and Loggia, Marco L. and Koole, Michel and Rezaei, Ahmadreza and Schramm, Georg and Van Damme, Philip and Hooker, Jacob M. and Van Laere, Koen and Atassi, Nazem},\n\tmonth = mar,\n\tyear = {2020},\n\tpmid = {32169920},\n\tkeywords = {ALS, [11C]PBR28, [18F]DPA-714, multiple tracer},\n}\n\n","author_short":["Van Weehaeghe, D.","Babu, S.","De Vocht, J.","Zurcher, N. R.","Chew, S.","Tseng, C. J.","Loggia, M. L.","Koole, M.","Rezaei, A.","Schramm, G.","Van Damme, P.","Hooker, J. M.","Van Laere, K.","Atassi, N."],"key":"van_weehaeghe_moving_2020","id":"van_weehaeghe_moving_2020","bibbaseid":"vanweehaeghe-babu-devocht-zurcher-chew-tseng-loggia-koole-etal-movingtowardsmulticentertherapeutictrialsinalsfeasibilityofdatapoolingusingdifferenttspopositronemissiontomographypetradioligands-2020","role":"author","urls":{},"keyword":["ALS","[11C]PBR28","[18F]DPA-714","multiple tracer"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/2578974/items?key=shyTUsV2MHKoKxRm0WpYkzGf&format=bibtex&limit=100","dataSources":["bPgHzsPz2cnBX3hPQ"],"keywords":["als","[11c]pbr28","[18f]dpa-714","multiple tracer"],"search_terms":["moving","towards","multicenter","therapeutic","trials","als","feasibility","data","pooling","using","different","tspo","positron","emission","tomography","pet","radioligands","van weehaeghe","babu","de vocht","zurcher","chew","tseng","loggia","koole","rezaei","schramm","van damme","hooker","van laere","atassi"],"title":"Moving towards multicenter therapeutic trials in ALS: feasibility of data pooling using different TSPO positron emission tomography (PET) radioligands","year":2020}