@article{vasanthakrishnan_wolbachia_2016,
	title = {Wolbachia confers sex-specific resistance and tolerance to enteric but not systemic bacterial infection in {Drosophila}},
	copyright = {© 2016, Published by Cold Spring Harbor Laboratory Press. The copyright holder for this pre-print is the author. All rights reserved. The material may not be redistributed, re-used or adapted without the author's permission.},
	url = {http://biorxiv.org/content/biorxiv/early/2016/04/02/045757.full.pdf},
	doi = {10.1101/045757},
	abstract = {Wolbachia-mediated protection against viral infection has been extensively demonstrated in Drosophila and in mosquitoes that are artificially inoculated with D. melanogaster Wolbachia (wMel), but to date no evidence for Wolbachia-mediated antibacterial protection has been demonstrated in Drosophila. Here we show that D. melanogaster carrying wMel shows reduced mortality during enteric - but not systemic - infection with the opportunist pathogen Pseudomonas aeruginosa, and that protection is more pronounced in male flies. Wolbachia-mediated protection is associated with increased early expression of the antimicrobial peptide attacinA, followed by increased expression of a ROS detoxification gene (gstD8), and other tissue damage repair genes which together contribute to greater host resistance and disease tolerance. These results highlight that the route of infection is important for symbiont-mediated protection from infection, that Wolbachia can protect hosts by eliciting a combination of resistance and disease tolerance mechanisms, and that these effects are sexually dimorphic.},
	language = {en},
	urldate = {2016-04-03TZ},
	journal = {bioRxiv},
	author = {Vasanthakrishnan, Radhakrishnan B. and Vanika, Gupta and Siva-Jothy, Jonathon A. and Monteith, Katy M. and Brown, Sam P. and Vale, Pedro F.},
	month = apr,
	year = {2016},
	keywords = {Drosophila, Infection tolerance, Wolbachia},
	pages = {045757}
}

{"_id":"XsHCkGxctaYtepZkj","bibbaseid":"vasanthakrishnan-vanika-sivajothy-monteith-brown-vale-wolbachiaconferssexspecificresistanceandtolerancetoentericbutnotsystemicbacterialinfectionindrosophila-2016","downloads":0,"creationDate":"2016-11-08T18:20:46.408Z","title":"Wolbachia confers sex-specific resistance and tolerance to enteric but not systemic bacterial infection in Drosophila","author_short":["Vasanthakrishnan, R. B.","Vanika, G.","Siva-Jothy, J. A.","Monteith, K. M.","Brown, S. P.","Vale, P. F."],"year":2016,"bibtype":"article","biburl":"http://bibbase.org/show?bib=https%3A%2F%2Fapi.zotero.org%2Fusers%2F837863%2Fcollections%2FM9VMJBQG%2Fitems%3Fkey%3DqMJ1H7Kt0tQc6yugAT9ntJVv%26format%3Dbibtex%26limit%3D100","bibdata":{"bibtype":"article","type":"article","title":"Wolbachia confers sex-specific resistance and tolerance to enteric but not systemic bacterial infection in Drosophila","copyright":"© 2016, Published by Cold Spring Harbor Laboratory Press. The copyright holder for this pre-print is the author. All rights reserved. The material may not be redistributed, re-used or adapted without the author's permission.","url":"http://biorxiv.org/content/biorxiv/early/2016/04/02/045757.full.pdf","doi":"10.1101/045757","abstract":"Wolbachia-mediated protection against viral infection has been extensively demonstrated in Drosophila and in mosquitoes that are artificially inoculated with D. melanogaster Wolbachia (wMel), but to date no evidence for Wolbachia-mediated antibacterial protection has been demonstrated in Drosophila. Here we show that D. melanogaster carrying wMel shows reduced mortality during enteric - but not systemic - infection with the opportunist pathogen Pseudomonas aeruginosa, and that protection is more pronounced in male flies. Wolbachia-mediated protection is associated with increased early expression of the antimicrobial peptide attacinA, followed by increased expression of a ROS detoxification gene (gstD8), and other tissue damage repair genes which together contribute to greater host resistance and disease tolerance. These results highlight that the route of infection is important for symbiont-mediated protection from infection, that Wolbachia can protect hosts by eliciting a combination of resistance and disease tolerance mechanisms, and that these effects are sexually dimorphic.","language":"en","urldate":"2016-04-03TZ","journal":"bioRxiv","author":[{"propositions":[],"lastnames":["Vasanthakrishnan"],"firstnames":["Radhakrishnan","B."],"suffixes":[]},{"propositions":[],"lastnames":["Vanika"],"firstnames":["Gupta"],"suffixes":[]},{"propositions":[],"lastnames":["Siva-Jothy"],"firstnames":["Jonathon","A."],"suffixes":[]},{"propositions":[],"lastnames":["Monteith"],"firstnames":["Katy","M."],"suffixes":[]},{"propositions":[],"lastnames":["Brown"],"firstnames":["Sam","P."],"suffixes":[]},{"propositions":[],"lastnames":["Vale"],"firstnames":["Pedro","F."],"suffixes":[]}],"month":"April","year":"2016","keywords":"Drosophila, Infection tolerance, Wolbachia","pages":"045757","bibtex":"@article{vasanthakrishnan_wolbachia_2016,\n\ttitle = {Wolbachia confers sex-specific resistance and tolerance to enteric but not systemic bacterial infection in {Drosophila}},\n\tcopyright = {© 2016, Published by Cold Spring Harbor Laboratory Press. The copyright holder for this pre-print is the author. All rights reserved. The material may not be redistributed, re-used or adapted without the author's permission.},\n\turl = {http://biorxiv.org/content/biorxiv/early/2016/04/02/045757.full.pdf},\n\tdoi = {10.1101/045757},\n\tabstract = {Wolbachia-mediated protection against viral infection has been extensively demonstrated in Drosophila and in mosquitoes that are artificially inoculated with D. melanogaster Wolbachia (wMel), but to date no evidence for Wolbachia-mediated antibacterial protection has been demonstrated in Drosophila. Here we show that D. melanogaster carrying wMel shows reduced mortality during enteric - but not systemic - infection with the opportunist pathogen Pseudomonas aeruginosa, and that protection is more pronounced in male flies. Wolbachia-mediated protection is associated with increased early expression of the antimicrobial peptide attacinA, followed by increased expression of a ROS detoxification gene (gstD8), and other tissue damage repair genes which together contribute to greater host resistance and disease tolerance. These results highlight that the route of infection is important for symbiont-mediated protection from infection, that Wolbachia can protect hosts by eliciting a combination of resistance and disease tolerance mechanisms, and that these effects are sexually dimorphic.},\n\tlanguage = {en},\n\turldate = {2016-04-03TZ},\n\tjournal = {bioRxiv},\n\tauthor = {Vasanthakrishnan, Radhakrishnan B. and Vanika, Gupta and Siva-Jothy, Jonathon A. and Monteith, Katy M. and Brown, Sam P. and Vale, Pedro F.},\n\tmonth = apr,\n\tyear = {2016},\n\tkeywords = {Drosophila, Infection tolerance, Wolbachia},\n\tpages = {045757}\n}\n\n","author_short":["Vasanthakrishnan, R. B.","Vanika, G.","Siva-Jothy, J. A.","Monteith, K. M.","Brown, S. P.","Vale, P. F."],"key":"vasanthakrishnan_wolbachia_2016","id":"vasanthakrishnan_wolbachia_2016","bibbaseid":"vasanthakrishnan-vanika-sivajothy-monteith-brown-vale-wolbachiaconferssexspecificresistanceandtolerancetoentericbutnotsystemicbacterialinfectionindrosophila-2016","role":"author","urls":{"Paper":"http://biorxiv.org/content/biorxiv/early/2016/04/02/045757.full.pdf"},"keyword":["Drosophila","Infection tolerance","Wolbachia"],"downloads":0},"search_terms":["wolbachia","confers","sex","specific","resistance","tolerance","enteric","systemic","bacterial","infection","drosophila","vasanthakrishnan","vanika","siva-jothy","monteith","brown","vale"],"keywords":["drosophila melanogaster","infection tolerance","pseudomonas aeruginosa","sexual dimorphism","wolbachia","drosophila"],"authorIDs":["5822177e232e4b486700002e"],"dataSources":["LQYspbZfHGMWnKPFH"]}