The influenza A virus NS genome segment displays lineage-specific patterns in predicted RNA secondary structure. Vasin, A., Petrova, A., Egorov, V., Plotnikova, M., Klotchenko, S., Karpenko, M., & Kiselev, O. BMC Research Notes, BioMed Central Ltd., 2016. cited By 6![The influenza A virus NS genome segment displays lineage-specific patterns in predicted RNA secondary structure [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background: Influenza A virus (IAV) is a segmented negative-sense RNA virus that causes seasonal epidemics and periodic pandemics in humans. Two regions (nucleotide positions 82-148 and 497-564) in the positive-sense RNA of the NS segment fold into a multi-branch loop or hairpin structures. Results: We studied 25,384 NS segment positive-sense RNA unique sequences of human and non-human IAVs in order to predict secondary RNA structures of the 82-148 and 497-564 regions using RNAfold software, and determined their host- and lineage-specific distributions. Hairpins prevailed in avian and avian-origin human IAVs, including H1N1pdm1918 and H5N1. In human and swine IAV hairpins distribution varied between evolutionary lineages. Conclusions: These results suggest a possible functional role for these RNA secondary structures and the need for experimental evaluation of these structures in the influenza life cycle. © 2016 The Author(s).
@ARTICLE{Vasin2016,
author={Vasin, A.V. and Petrova, A.V. and Egorov, V.V. and Plotnikova, M.A. and Klotchenko, S.A. and Karpenko, M.N. and Kiselev, O.I.},
title={The influenza A virus NS genome segment displays lineage-specific patterns in predicted RNA secondary structure},
journal={BMC Research Notes},
year={2016},
volume={9},
number={1},
doi={10.1186/s13104-016-2083-6},
art_number={279},
note={cited By 6},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84974721006&doi=10.1186%2fs13104-016-2083-6&partnerID=40&md5=f1376d24d3b93b6d9f0ce60f93d9ce9a},
affiliation={Research Institute of Influenza, St-Petersburg, 197376, Russian Federation; Peter the Great St-Petersburg Polytechnic University, St-Petersburg, 195251, Russian Federation},
abstract={Background: Influenza A virus (IAV) is a segmented negative-sense RNA virus that causes seasonal epidemics and periodic pandemics in humans. Two regions (nucleotide positions 82-148 and 497-564) in the positive-sense RNA of the NS segment fold into a multi-branch loop or hairpin structures. Results: We studied 25,384 NS segment positive-sense RNA unique sequences of human and non-human IAVs in order to predict secondary RNA structures of the 82-148 and 497-564 regions using RNAfold software, and determined their host- and lineage-specific distributions. Hairpins prevailed in avian and avian-origin human IAVs, including H1N1pdm1918 and H5N1. In human and swine IAV hairpins distribution varied between evolutionary lineages. Conclusions: These results suggest a possible functional role for these RNA secondary structures and the need for experimental evaluation of these structures in the influenza life cycle. © 2016 The Author(s).},
author_keywords={Evolution; Influenza A virus; NS gene; Pathogenicity; RNA hairpin; RNA secondary structure},
correspondence_address1={Vasin, A.V.; Research Institute of InfluenzaRussian Federation; email: vasin@influenza.spb.ru},
publisher={BioMed Central Ltd.},
issn={17560500},
pubmed_id={27206548},
language={English},
abbrev_source_title={BMC Res. Notes},
document_type={Article},
source={Scopus},
}
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