@ARTICLE{Vasllev201611,
author={Vasllev, A.G. and Trashkov, A.P. and Verlov, N.A. and Kovalenko, A.L. and Petrov, A.Yu. and Valeev, V.V.},
title={Assessment of specific pharmacologic activity of unifusol on endothelium dysfunction model induced by n-nitro-l-arginine methyl ether},
journal={Eksperimental'naya i Klinicheskaya Farmakologiya},
year={2016},
volume={79},
number={11},
pages={11-14},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014867578&partnerID=40&md5=18fb70c18a00b0d7533945e24d527a58},
affiliation={M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, ul. Maurice Thorez44, St. Petersburg, 194223, Russian Federation; Institute of Toxicology, Federal Medico-Biological Agency, ul. Bekhtereva 1, St. Petersburg, 192019, Russian Federation},
abstract={Specific pharmacologic activity of sodium-L-arginine succinate (unifusol) was studied on endothelium dysfunction model (EDM) in rats. EDM was induced by daily administration of N-nitro-L-arginine methyl ether (L-NAME). The effectiveness of experimental therapy with unifusol was assessed by changes in the arterial pressure level, duration of endothelium-dependent and -independent vasodilation, and the blood concentration of endothelial dysfunction markers including VEGF, NO, endothelin-1 and the number of desquamated endotheliocytes. Administration of unifusol favors correction of blood vessel endothelium state as manifested by normalization of its functional activity and reduction of the apoptosis of endotheliocytes. In addition, the obtained results unambiguously confirm considerable vasodilating and antihypertensive effects of unifusol.},
author_keywords={Arterial hypertension;  Endothelial dysfunction;  Rats;  Sodium-L-arginine succinate;  Unifusol;  Vasodilation},
publisher={Izdatel'stvo Meditsina},
issn={08692092},
pubmed_id={29791109},
language={Russian},
abbrev_source_title={Eksp. Klinicheskaya Farmakol.},
document_type={Article},
source={Scopus},
}

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