Exercise differentially regulates synaptic proteins associated to the function of BDNF. Vaynman, S. S, Ying, Z., Yin, D., & Gomez-Pinilla, F. Brain research, 1070(1):124–30, January, 2006. ![Exercise differentially regulates synaptic proteins associated to the function of BDNF. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex We explored the capacity of exercise to impact select events comprising synaptic transmission under the direction of brain-derived neurotrophic factor (BDNF), which may be central to the events by which exercise potentiates synaptic function. We used a specific immunoadhesin chimera (TrkB-IgG) that mimics the BDNF receptor, TrkB, to selectively block BDNF in the hippocampus during 3 days of voluntary wheel running. We measured resultant synapsin I, synaptophysin, and syntaxin levels involved in vesicular pool formation, endocytosis, and exocytosis, respectively. Synapsin I is involved in vesicle pool formation and neurotransmitter release, synaptophysin, in the biogenesis of synaptic vesicles and budding, and syntaxin, in vesicle docking and fusion. Exercise preferentially increased synapsin I and synaptophysin levels, without affecting syntaxin. There was a positive correlation between synapsin I and synaptophysin in exercising rats and synapsin I with the amount of exercise. Blocking BDNF abrogated the exercise-induced increases in synapsin I and synatophysin, revealing that exercise regulates select properties of synaptic transmission under the direction of BDNF.
@article{vaynman_exercise_2006,
title = {Exercise differentially regulates synaptic proteins associated to the function of {BDNF}.},
volume = {1070},
issn = {0006-8993},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16413508},
abstract = {We explored the capacity of exercise to impact select events comprising synaptic transmission under the direction of brain-derived neurotrophic factor (BDNF), which may be central to the events by which exercise potentiates synaptic function. We used a specific immunoadhesin chimera (TrkB-IgG) that mimics the BDNF receptor, TrkB, to selectively block BDNF in the hippocampus during 3 days of voluntary wheel running. We measured resultant synapsin I, synaptophysin, and syntaxin levels involved in vesicular pool formation, endocytosis, and exocytosis, respectively. Synapsin I is involved in vesicle pool formation and neurotransmitter release, synaptophysin, in the biogenesis of synaptic vesicles and budding, and syntaxin, in vesicle docking and fusion. Exercise preferentially increased synapsin I and synaptophysin levels, without affecting syntaxin. There was a positive correlation between synapsin I and synaptophysin in exercising rats and synapsin I with the amount of exercise. Blocking BDNF abrogated the exercise-induced increases in synapsin I and synatophysin, revealing that exercise regulates select properties of synaptic transmission under the direction of BDNF.},
number = {1},
urldate = {2014-02-03},
journal = {Brain research},
author = {Vaynman, Shoshanna S and Ying, Zhe and Yin, Dali and Gomez-Pinilla, Fernando},
month = jan,
year = {2006},
pmid = {16413508},
keywords = {Animals, Brain-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor: antagonists \& i, Brain-Derived Neurotrophic Factor: physiology, Hippocampus, Hippocampus: metabolism, Immunoglobulin G, Immunoglobulin G: genetics, Male, Motor Activity, Motor Activity: physiology, Nerve Tissue Proteins, Nerve Tissue Proteins: metabolism, Rats, Receptor, Recombinant Fusion Proteins, Recombinant Fusion Proteins: pharmacology, Sprague-Dawley, Synapses, Synapses: metabolism, Synapsins, Synapsins: metabolism, Synaptic Transmission, Synaptic Transmission: physiology, Synaptic Vesicles, Synaptic Vesicles: metabolism, Synaptophysin, Synaptophysin: metabolism, trkB, trkB: genetics},
pages = {124--30},
}
Downloads: 0
{"_id":"5FRXz2p5Lc78bssi7","bibbaseid":"vaynman-ying-yin-gomezpinilla-exercisedifferentiallyregulatessynapticproteinsassociatedtothefunctionofbdnf-2006","author_short":["Vaynman, S. S","Ying, Z.","Yin, D.","Gomez-Pinilla, F."],"bibdata":{"bibtype":"article","type":"article","title":"Exercise differentially regulates synaptic proteins associated to the function of BDNF.","volume":"1070","issn":"0006-8993","url":"http://www.ncbi.nlm.nih.gov/pubmed/16413508","abstract":"We explored the capacity of exercise to impact select events comprising synaptic transmission under the direction of brain-derived neurotrophic factor (BDNF), which may be central to the events by which exercise potentiates synaptic function. We used a specific immunoadhesin chimera (TrkB-IgG) that mimics the BDNF receptor, TrkB, to selectively block BDNF in the hippocampus during 3 days of voluntary wheel running. We measured resultant synapsin I, synaptophysin, and syntaxin levels involved in vesicular pool formation, endocytosis, and exocytosis, respectively. Synapsin I is involved in vesicle pool formation and neurotransmitter release, synaptophysin, in the biogenesis of synaptic vesicles and budding, and syntaxin, in vesicle docking and fusion. Exercise preferentially increased synapsin I and synaptophysin levels, without affecting syntaxin. There was a positive correlation between synapsin I and synaptophysin in exercising rats and synapsin I with the amount of exercise. Blocking BDNF abrogated the exercise-induced increases in synapsin I and synatophysin, revealing that exercise regulates select properties of synaptic transmission under the direction of BDNF.","number":"1","urldate":"2014-02-03","journal":"Brain research","author":[{"propositions":[],"lastnames":["Vaynman"],"firstnames":["Shoshanna","S"],"suffixes":[]},{"propositions":[],"lastnames":["Ying"],"firstnames":["Zhe"],"suffixes":[]},{"propositions":[],"lastnames":["Yin"],"firstnames":["Dali"],"suffixes":[]},{"propositions":[],"lastnames":["Gomez-Pinilla"],"firstnames":["Fernando"],"suffixes":[]}],"month":"January","year":"2006","pmid":"16413508","keywords":"Animals, Brain-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor: antagonists & i, Brain-Derived Neurotrophic Factor: physiology, Hippocampus, Hippocampus: metabolism, Immunoglobulin G, Immunoglobulin G: genetics, Male, Motor Activity, Motor Activity: physiology, Nerve Tissue Proteins, Nerve Tissue Proteins: metabolism, Rats, Receptor, Recombinant Fusion Proteins, Recombinant Fusion Proteins: pharmacology, Sprague-Dawley, Synapses, Synapses: metabolism, Synapsins, Synapsins: metabolism, Synaptic Transmission, Synaptic Transmission: physiology, Synaptic Vesicles, Synaptic Vesicles: metabolism, Synaptophysin, Synaptophysin: metabolism, trkB, trkB: genetics","pages":"124–30","bibtex":"@article{vaynman_exercise_2006,\n\ttitle = {Exercise differentially regulates synaptic proteins associated to the function of {BDNF}.},\n\tvolume = {1070},\n\tissn = {0006-8993},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/16413508},\n\tabstract = {We explored the capacity of exercise to impact select events comprising synaptic transmission under the direction of brain-derived neurotrophic factor (BDNF), which may be central to the events by which exercise potentiates synaptic function. We used a specific immunoadhesin chimera (TrkB-IgG) that mimics the BDNF receptor, TrkB, to selectively block BDNF in the hippocampus during 3 days of voluntary wheel running. We measured resultant synapsin I, synaptophysin, and syntaxin levels involved in vesicular pool formation, endocytosis, and exocytosis, respectively. Synapsin I is involved in vesicle pool formation and neurotransmitter release, synaptophysin, in the biogenesis of synaptic vesicles and budding, and syntaxin, in vesicle docking and fusion. Exercise preferentially increased synapsin I and synaptophysin levels, without affecting syntaxin. There was a positive correlation between synapsin I and synaptophysin in exercising rats and synapsin I with the amount of exercise. Blocking BDNF abrogated the exercise-induced increases in synapsin I and synatophysin, revealing that exercise regulates select properties of synaptic transmission under the direction of BDNF.},\n\tnumber = {1},\n\turldate = {2014-02-03},\n\tjournal = {Brain research},\n\tauthor = {Vaynman, Shoshanna S and Ying, Zhe and Yin, Dali and Gomez-Pinilla, Fernando},\n\tmonth = jan,\n\tyear = {2006},\n\tpmid = {16413508},\n\tkeywords = {Animals, Brain-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor: antagonists \\& i, Brain-Derived Neurotrophic Factor: physiology, Hippocampus, Hippocampus: metabolism, Immunoglobulin G, Immunoglobulin G: genetics, Male, Motor Activity, Motor Activity: physiology, Nerve Tissue Proteins, Nerve Tissue Proteins: metabolism, Rats, Receptor, Recombinant Fusion Proteins, Recombinant Fusion Proteins: pharmacology, Sprague-Dawley, Synapses, Synapses: metabolism, Synapsins, Synapsins: metabolism, Synaptic Transmission, Synaptic Transmission: physiology, Synaptic Vesicles, Synaptic Vesicles: metabolism, Synaptophysin, Synaptophysin: metabolism, trkB, trkB: genetics},\n\tpages = {124--30},\n}\n\n","author_short":["Vaynman, S. S","Ying, Z.","Yin, D.","Gomez-Pinilla, F."],"key":"vaynman_exercise_2006","id":"vaynman_exercise_2006","bibbaseid":"vaynman-ying-yin-gomezpinilla-exercisedifferentiallyregulatessynapticproteinsassociatedtothefunctionofbdnf-2006","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/16413508"},"keyword":["Animals","Brain-Derived Neurotrophic Factor","Brain-Derived Neurotrophic Factor: antagonists & i","Brain-Derived Neurotrophic Factor: physiology","Hippocampus","Hippocampus: metabolism","Immunoglobulin G","Immunoglobulin G: genetics","Male","Motor Activity","Motor Activity: physiology","Nerve Tissue Proteins","Nerve Tissue Proteins: metabolism","Rats","Receptor","Recombinant Fusion Proteins","Recombinant Fusion Proteins: pharmacology","Sprague-Dawley","Synapses","Synapses: metabolism","Synapsins","Synapsins: metabolism","Synaptic Transmission","Synaptic Transmission: physiology","Synaptic Vesicles","Synaptic Vesicles: metabolism","Synaptophysin","Synaptophysin: metabolism","trkB","trkB: genetics"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/asrommel","dataSources":["J8fbWsdsy3xAaB3pX"],"keywords":["animals","brain-derived neurotrophic factor","brain-derived neurotrophic factor: antagonists & i","brain-derived neurotrophic factor: physiology","hippocampus","hippocampus: metabolism","immunoglobulin g","immunoglobulin g: genetics","male","motor activity","motor activity: physiology","nerve tissue proteins","nerve tissue proteins: metabolism","rats","receptor","recombinant fusion proteins","recombinant fusion proteins: pharmacology","sprague-dawley","synapses","synapses: metabolism","synapsins","synapsins: metabolism","synaptic transmission","synaptic transmission: physiology","synaptic vesicles","synaptic vesicles: metabolism","synaptophysin","synaptophysin: metabolism","trkb","trkb: genetics"],"search_terms":["exercise","differentially","regulates","synaptic","proteins","associated","function","bdnf","vaynman","ying","yin","gomez-pinilla"],"title":"Exercise differentially regulates synaptic proteins associated to the function of BDNF.","year":2006}