Moderate static magnetic field (6 mT)-induced lipid rafts rearrangement increases silver NPS uptake in human lymphocytes. Vergallo, C., Panzarini, E., Tenuzzo, B., Mariano, S., Tata, A., & Dini, L. Molecules, MDPI AG, 2020. cited By 0![Moderate static magnetic field (6 mT)-induced lipid rafts rearrangement increases silver NPS uptake in human lymphocytes [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex One of the most relevant drawbacks in medicine is the ability of drugs and/or imaging agents to reach cells. Nanotechnology opened new horizons in drug delivery, and silver nanoparticles (AgNPs) represent a promising delivery vehicle for their adjustable size and shape, high-density surface ligand attachment, etc. AgNPs cellular uptake involves different endocytosis mechanisms, including lipid raft-mediated endocytosis. Since static magnetic fields (SMFs) exposure induces plasma membrane perturbation, including the rearrangement of lipid rafts, we investigated whether SMF could increase the amount of AgNPs able to pass the peripheral blood lymphocytes (PBLs) plasma membrane. To this purpose, the effect of 6-mT SMF exposure on the redistribution of two main lipid raft components (i.e., disialoganglioside GD3, cholesterol) and on AgNPs uptake efficiency was investigated. Results showed that 6 mT SMF: (i) induces a time-dependent GD3 and cholesterol redistribution in plasma membrane lipid rafts and modulates gene expression of ATP-binding cassette transporter A1 (ABCA1), (ii) increases reactive oxygen species (ROS) production and lipid peroxidation, (iii) does not induce cell death and (iv) induces lipid rafts rearrangement, that, in turn, favors the uptake of AgNPs. Thus, it derives that SMF exposure could be exploited to enhance the internalization of NPs-loaded therapeutic or diagnostic molecules. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
@ARTICLE{Vergallo2020,
author={Vergallo, C. and Panzarini, E. and Tenuzzo, B.A. and Mariano, S. and Tata, A.M. and Dini, L.},
title={Moderate static magnetic field (6 mT)-induced lipid rafts rearrangement increases silver NPS uptake in human lymphocytes},
journal={Molecules},
year={2020},
volume={25},
number={6},
doi={10.3390/molecules25061398},
art_number={1398},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082084417&doi=10.3390%2fmolecules25061398&partnerID=40&md5=a31df3c069ee1ca6b93ddb12be22599e},
abstract={One of the most relevant drawbacks in medicine is the ability of drugs and/or imaging agents to reach cells. Nanotechnology opened new horizons in drug delivery, and silver nanoparticles (AgNPs) represent a promising delivery vehicle for their adjustable size and shape, high-density surface ligand attachment, etc. AgNPs cellular uptake involves different endocytosis mechanisms, including lipid raft-mediated endocytosis. Since static magnetic fields (SMFs) exposure induces plasma membrane perturbation, including the rearrangement of lipid rafts, we investigated whether SMF could increase the amount of AgNPs able to pass the peripheral blood lymphocytes (PBLs) plasma membrane. To this purpose, the effect of 6-mT SMF exposure on the redistribution of two main lipid raft components (i.e., disialoganglioside GD3, cholesterol) and on AgNPs uptake efficiency was investigated. Results showed that 6 mT SMF: (i) induces a time-dependent GD3 and cholesterol redistribution in plasma membrane lipid rafts and modulates gene expression of ATP-binding cassette transporter A1 (ABCA1), (ii) increases reactive oxygen species (ROS) production and lipid peroxidation, (iii) does not induce cell death and (iv) induces lipid rafts rearrangement, that, in turn, favors the uptake of AgNPs. Thus, it derives that SMF exposure could be exploited to enhance the internalization of NPs-loaded therapeutic or diagnostic molecules. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).},
publisher={MDPI AG},
issn={14203049},
coden={MOLEF},
pubmed_id={32204392},
document_type={Article},
source={Scopus},
}
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