@article{RN265,
   author = {Verheggen, I. C. M. and de Jong, J. J. A. and van Boxtel, M. P. J. and Postma, A. A. and Jansen, J. F. A. and Verhey, F. R. J. and Backes, W. H.},
   title = {Imaging the role of blood-brain barrier disruption in normal cognitive ageing},
   journal = {Geroscience},
   note = {Verheggen, Inge C M
de Jong, Joost J A
van Boxtel, Martin P J
Postma, Alida A
Jansen, Jacobus F A
Verhey, Frans R J
Backes, Walter H
eng
406-15-031/Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Switzerland
Geroscience. 2020 Oct 6. pii: 10.1007/s11357-020-00282-1. doi: 10.1007/s11357-020-00282-1.},
   abstract = {To investigate whether blood-brain barrier (BBB) disruption is a potential mechanism of usual age-related cognitive decline, we conducted dynamic contrast-enhanced (DCE) MRI to measure BBB leakage in a healthy sample, and investigated the association with longitudinal cognitive decline. In a sample of neurologically and cognitively healthy, older individuals, BBB leakage rate in the white and grey matter and hippocampus was measured using DCE MRI with pharmacokinetic modelling. Regression analysis was performed to investigate whether the leakage rate was associated with decline in cognitive performance (memory encoding, memory retrieval, executive functioning and processing speed) over 12 years. White and grey matter BBB leakages were significantly associated with decline in memory retrieval. No significant relations were found between hippocampal BBB leakage and cognitive performance. BBB disruption already being associated with usual cognitive ageing, supports that this neurovascular alteration is a possible explanation for the cognitive decline inherent to the ageing process. More insight into BBB leakage during the normal ageing process could improve estimation and interpretation of leakage rate in pathological conditions. The current results might also stimulate the search for strategies to maintain BBB integrity and help increase the proportion people experiencing successful ageing. Netherlands Trial Register number: NL6358, date of registration: 2017-03-24.},
   keywords = {Blood-brain barrier
Cerebrovascular dysfunction
Cognitive ageing
Dynamic contrast-enhanced MRI
Successful ageing},
   ISSN = {2509-2723 (Electronic)
2509-2723 (Linking)},
   DOI = {10.1007/s11357-020-00282-1},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/33025410},
   year = {2020},
   type = {Journal Article}
}

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H."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Verheggen"],"firstnames":["I.","C.","M."],"suffixes":[]},{"propositions":["de"],"lastnames":["Jong"],"firstnames":["J.","J.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Boxtel"],"firstnames":["M.","P.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Postma"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Verhey"],"firstnames":["F.","R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Imaging the role of blood-brain barrier disruption in normal cognitive ageing","journal":"Geroscience","note":"Verheggen, Inge C M de Jong, Joost J A van Boxtel, Martin P J Postma, Alida A Jansen, Jacobus F A Verhey, Frans R J Backes, Walter H eng 406-15-031/Nederlandse Organisatie voor Wetenschappelijk Onderzoek Switzerland Geroscience. 2020 Oct 6. pii: 10.1007/s11357-020-00282-1. doi: 10.1007/s11357-020-00282-1.","abstract":"To investigate whether blood-brain barrier (BBB) disruption is a potential mechanism of usual age-related cognitive decline, we conducted dynamic contrast-enhanced (DCE) MRI to measure BBB leakage in a healthy sample, and investigated the association with longitudinal cognitive decline. In a sample of neurologically and cognitively healthy, older individuals, BBB leakage rate in the white and grey matter and hippocampus was measured using DCE MRI with pharmacokinetic modelling. Regression analysis was performed to investigate whether the leakage rate was associated with decline in cognitive performance (memory encoding, memory retrieval, executive functioning and processing speed) over 12 years. White and grey matter BBB leakages were significantly associated with decline in memory retrieval. No significant relations were found between hippocampal BBB leakage and cognitive performance. BBB disruption already being associated with usual cognitive ageing, supports that this neurovascular alteration is a possible explanation for the cognitive decline inherent to the ageing process. More insight into BBB leakage during the normal ageing process could improve estimation and interpretation of leakage rate in pathological conditions. The current results might also stimulate the search for strategies to maintain BBB integrity and help increase the proportion people experiencing successful ageing. Netherlands Trial Register number: NL6358, date of registration: 2017-03-24.","keywords":"Blood-brain barrier Cerebrovascular dysfunction Cognitive ageing Dynamic contrast-enhanced MRI Successful ageing","issn":"2509-2723 (Electronic) 2509-2723 (Linking)","doi":"10.1007/s11357-020-00282-1","url":"https://www.ncbi.nlm.nih.gov/pubmed/33025410","year":"2020","bibtex":"@article{RN265,\n author = {Verheggen, I. C. M. and de Jong, J. J. A. and van Boxtel, M. P. J. and Postma, A. A. and Jansen, J. F. A. and Verhey, F. R. J. and Backes, W. H.},\n title = {Imaging the role of blood-brain barrier disruption in normal cognitive ageing},\n journal = {Geroscience},\n note = {Verheggen, Inge C M\nde Jong, Joost J A\nvan Boxtel, Martin P J\nPostma, Alida A\nJansen, Jacobus F A\nVerhey, Frans R J\nBackes, Walter H\neng\n406-15-031/Nederlandse Organisatie voor Wetenschappelijk Onderzoek\nSwitzerland\nGeroscience. 2020 Oct 6. pii: 10.1007/s11357-020-00282-1. doi: 10.1007/s11357-020-00282-1.},\n abstract = {To investigate whether blood-brain barrier (BBB) disruption is a potential mechanism of usual age-related cognitive decline, we conducted dynamic contrast-enhanced (DCE) MRI to measure BBB leakage in a healthy sample, and investigated the association with longitudinal cognitive decline. In a sample of neurologically and cognitively healthy, older individuals, BBB leakage rate in the white and grey matter and hippocampus was measured using DCE MRI with pharmacokinetic modelling. Regression analysis was performed to investigate whether the leakage rate was associated with decline in cognitive performance (memory encoding, memory retrieval, executive functioning and processing speed) over 12 years. White and grey matter BBB leakages were significantly associated with decline in memory retrieval. No significant relations were found between hippocampal BBB leakage and cognitive performance. BBB disruption already being associated with usual cognitive ageing, supports that this neurovascular alteration is a possible explanation for the cognitive decline inherent to the ageing process. More insight into BBB leakage during the normal ageing process could improve estimation and interpretation of leakage rate in pathological conditions. The current results might also stimulate the search for strategies to maintain BBB integrity and help increase the proportion people experiencing successful ageing. 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