Interaction between blood-brain barrier and glymphatic system in solute clearance

Interaction between blood-brain barrier and glymphatic system in solute clearance. Verheggen, I. C. M., Van Boxtel, M. P. J., Verhey, F. R. J., Jansen, J. F. A., & Backes, W. H. Neurosci Biobehav Rev, 90:26-33, 2018. Verheggen, I C M Van Boxtel, M P J Verhey, F R J Jansen, J F A Backes, W H eng Research Support, Non-U.S. Gov't Review 2018/04/03 06:00 Neurosci Biobehav Rev. 2018 Jul;90:26-33. doi: 10.1016/j.neubiorev.2018.03.028. Epub 2018 Mar 30.

Paper doi abstract bibtex

Neurovascular pathology concurs with protein accumulation, as the brain vasculature is important for waste clearance. Interstitial solutes, such as amyloid-beta, were previously thought to be primarily cleared from the brain by blood-brain barrier transport. Recently, the glymphatic system was discovered, in which cerebrospinal fluid is exchanged with interstitial fluid, facilitated by the aquaporin-4 water channels on the astroglial endfeet. Glymphatic flow can clear solutes from the interstitial space. Blood-brain barrier transport and glymphatic clearance likely serve complementary roles with partially overlapping mechanisms providing a well-conditioned neuronal environment. Disruption of these mechanisms can lead to protein accumulation and may initiate neurodegenerative disorders, for instance amyloid-beta accumulation and Alzheimer's disease. Although both mechanisms seem to have a similar purpose, their interaction has not been clearly discussed previously. This review focusses on this interaction in healthy and pathological conditions. Future health initiatives improving waste clearance might delay or even prevent onset of neurodegenerative disorders. Defining glymphatic flow kinetics using imaging may become an alternative way to identify those at risk of Alzheimer's disease.

@article{RN216,
   author = {Verheggen, I. C. M. and Van Boxtel, M. P. J. and Verhey, F. R. J. and Jansen, J. F. A. and Backes, W. H.},
   title = {Interaction between blood-brain barrier and glymphatic system in solute clearance},
   journal = {Neurosci Biobehav Rev},
   volume = {90},
   pages = {26-33},
   note = {Verheggen, I C M
Van Boxtel, M P J
Verhey, F R J
Jansen, J F A
Backes, W H
eng
Research Support, Non-U.S. Gov't
Review
2018/04/03 06:00
Neurosci Biobehav Rev. 2018 Jul;90:26-33. doi: 10.1016/j.neubiorev.2018.03.028. Epub 2018 Mar 30.},
   abstract = {Neurovascular pathology concurs with protein accumulation, as the brain vasculature is important for waste clearance. Interstitial solutes, such as amyloid-beta, were previously thought to be primarily cleared from the brain by blood-brain barrier transport. Recently, the glymphatic system was discovered, in which cerebrospinal fluid is exchanged with interstitial fluid, facilitated by the aquaporin-4 water channels on the astroglial endfeet. Glymphatic flow can clear solutes from the interstitial space. Blood-brain barrier transport and glymphatic clearance likely serve complementary roles with partially overlapping mechanisms providing a well-conditioned neuronal environment. Disruption of these mechanisms can lead to protein accumulation and may initiate neurodegenerative disorders, for instance amyloid-beta accumulation and Alzheimer's disease. Although both mechanisms seem to have a similar purpose, their interaction has not been clearly discussed previously. This review focusses on this interaction in healthy and pathological conditions. Future health initiatives improving waste clearance might delay or even prevent onset of neurodegenerative disorders. Defining glymphatic flow kinetics using imaging may become an alternative way to identify those at risk of Alzheimer's disease.},
   keywords = {Alzheimer Disease/immunology/*metabolism
Aquaporin 4/metabolism
Blood-Brain Barrier/*metabolism
Brain/*metabolism
Glymphatic System/*metabolism
Humans
Kinetics
*Alzheimer's disease
*Amyloid-beta
*Bbb
*Blood-brain barrier
*Clearance
*Glymphatic system
*Imaging},
   ISSN = {1873-7528 (Electronic)
0149-7634 (Linking)},
   DOI = {10.1016/j.neubiorev.2018.03.028},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/29608988
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   year = {2018},
   type = {Journal Article}
}

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C. M. and Van Boxtel, M. P. J. and Verhey, F. R. J. and Jansen, J. F. A. and Backes, W. H.},\n title = {Interaction between blood-brain barrier and glymphatic system in solute clearance},\n journal = {Neurosci Biobehav Rev},\n volume = {90},\n pages = {26-33},\n note = {Verheggen, I C M\nVan Boxtel, M P J\nVerhey, F R J\nJansen, J F A\nBackes, W H\neng\nResearch Support, Non-U.S. Gov't\nReview\n2018/04/03 06:00\nNeurosci Biobehav Rev. 2018 Jul;90:26-33. doi: 10.1016/j.neubiorev.2018.03.028. Epub 2018 Mar 30.},\n abstract = {Neurovascular pathology concurs with protein accumulation, as the brain vasculature is important for waste clearance. Interstitial solutes, such as amyloid-beta, were previously thought to be primarily cleared from the brain by blood-brain barrier transport. Recently, the glymphatic system was discovered, in which cerebrospinal fluid is exchanged with interstitial fluid, facilitated by the aquaporin-4 water channels on the astroglial endfeet. Glymphatic flow can clear solutes from the interstitial space. Blood-brain barrier transport and glymphatic clearance likely serve complementary roles with partially overlapping mechanisms providing a well-conditioned neuronal environment. Disruption of these mechanisms can lead to protein accumulation and may initiate neurodegenerative disorders, for instance amyloid-beta accumulation and Alzheimer's disease. Although both mechanisms seem to have a similar purpose, their interaction has not been clearly discussed previously. This review focusses on this interaction in healthy and pathological conditions. Future health initiatives improving waste clearance might delay or even prevent onset of neurodegenerative disorders. Defining glymphatic flow kinetics using imaging may become an alternative way to identify those at risk of Alzheimer's disease.},\n keywords = {Alzheimer Disease/immunology/*metabolism\nAquaporin 4/metabolism\nBlood-Brain Barrier/*metabolism\nBrain/*metabolism\nGlymphatic System/*metabolism\nHumans\nKinetics\n*Alzheimer's disease\n*Amyloid-beta\n*Bbb\n*Blood-brain barrier\n*Clearance\n*Glymphatic system\n*Imaging},\n ISSN = {1873-7528 (Electronic)\n0149-7634 (Linking)},\n DOI = {10.1016/j.neubiorev.2018.03.028},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/29608988\nhttps://pdf.sciencedirectassets.com/271127/1-s2.0-S0149763418X00050/1-s2.0-S014976341730773X/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEF4aCXVzLWVhc3QtMSJHMEUCIQCQGLYSXBQtb7r4qT6xaeajHMEJn6X2iG8WZ7Vpu8u5MQIgPVGKdIA2FkySMN3tV5iDJKECZpsVyFFnn7STPy7Mk%2FEqtAMIdhADGgwwNTkwMDM1NDY4NjUiDK5vEFyvRtd%2BCavrzSqRA0OF63kv2fsAOKn5lzBazvQ1yL9IkjHlyfXQWjFcvdmRtRiBu4318K2zDokogx4CQbn47M3Gx5tppJhVnhcjAFGxCWXw3PR%2Fw2x2j1VtWVZWPU3fe0lLG7b%2B%2BHGfvaY1L3nAY5mkXF3iNP57UFlAGzhnaj8Nmj2tn5gxzUpRPW2TkNDqI52nJXOh0rP4KwLmtAva2ZfmbO4Z59vpXs%2FB%2FwbfzQaDVQOPcc1OVP29h4PTRKO%2ByHCa9d7W0L0muCaUSkRfN98ZqiYArm6Y605ncr9mDtmDkMlD0TeBMKJ1pg8fIuaApWJCWjwyjO6ZiA3ARle%2BH6EecnASzG1%2FzcedAFwraeiOvkQgcE3thOabOY4DkCa5kijGz31Q%2FW9wSFVZn3IapMwms%2F%2B6124gSXXCtXyNy8SlQrw4B45hM%2BJ88e%2BbepYiuhVc6mwX%2FTNxzqz3A%2Fr01%2Bgn24kL1ou0ee9zRv8xV00ilXIG4vg9%2F9375c%2FT93Bl2VHGftxcddm5zW7MeozVm7o6UDjb3ZS89k%2FMn4QOMKbw1vQFOusB%2FPvv5yV10dZJp4ib90%2BwrNvb6qC3RRTjIYzYDbgqNsem%2BNb3KYh1%2FYp3v8jGG%2BJCmScNCjIyBE2CG%2F2hMNSOxn1OoUlux6ii78X%2BAY7RkHW9mSj1rJnln2oEQkNScHxnNJ%2FNo3ax5qusrILKOw9tHvW9q5ADFKQOUVyoHOUAokB3KVJklHDHlhEFT0PK5Mhxz3Onkx5wpsK%2Fhbg4duEbmCOQN4xvyMGFvkNk9e%2FJuOpG571y6v3An%2FeO1jOyK%2FJXUE6dXWKv1W6P1KqxAAscnr%2Be3EI69v0GtTdE77h57Bs2NPw6z66AX%2FchtQ%3D%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20200414T144330Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTY2Z7GK7HT%2F20200414%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=dfa45cbb3500670ba7455b21ba27f6d478409969359c8f417ce6a56617b3bc5a&hash=dbe077400ff67e5f89443add8d3d1c4b701b1d8fa27cd4b61922729a91c0c082&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S014976341730773X&tid=spdf-dc8e72cd-8fb1-421a-a5d1-6884c0c34e52&sid=011858f4477d9942d7581a16e4804d44a9c6gxrqb&type=client\nhttps://pdf.sciencedirectassets.com/271127/1-s2.0-S0149763418X00050/1-s2.0-S014976341730773X/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEEkaCXVzLWVhc3QtMSJHMEUCIFsxKLCBp8cQcPO6QlXLcytIJMsMsPPdR65rtISCgoT0AiEA9ekDnwKDF1SIna9gmxyGPNilGUNEJzoakvI0jDkOJscqvQMIov%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARADGgwwNTkwMDM1NDY4NjUiDNvP0tGxsH9VeQgQuCqRA2EaG4E7Y1kehsJ1u6F7kIpzy1z1c9M%2B2tiuymbyVBIP7c2VvdPJVRitVUJZYmi8hYRZY7Y6sPHtevCtakr0GbMgNpCySjgESyw4S7ajTEccDbBuo5brGj7%2BGccOSw%2FHPL%2BO5L9jjuQ%2BmIcqgWxuizzvhUWOXVDnBsd1P2qkoDkY2154P21n3bvTjv9iWsgtzYcYxVTCCjNHl1UyH4rZGdMojS7hsyXSv%2Be7uAtLpkjS%2FllVbFUOiCFWZdJMJLS1hByekyYcXT8TCNckp0ufR4iPiFFGZHqllkyyiUrLWaYSMY8BIEfVmmI7GrYHphnSlSV5ftGN%2FUhtgxaE7bmfIrSUroauwhy1DURw2p9zY41p%2Bxp%2F5AdTMFkmGip0lYutFUAedVQJnhDBfMG2fyNH6%2Bp%2FMYNcOTjK7xLryxc5%2FfILcLuGu%2BpBX%2BrsncbkPi29vZkJ5b2c9i%2B8HLsJgUwwzxeqf%2B54jPVUPQPXD0O8Dy5BUg69BuJstJ8qkBWYyS2WJVZYqDBMa3p1qpd2PaiWCnw5MNCls%2FYFOusBlSuN57iKDXxfakcDI0swGY96QEGEnPznQf0vNsmfnYTSCsvEHTwy6QTUvhnwGsrtocZLGYz0EzUyc8NuXlPX5PW6suWR2S3ldOoXehC0zhfAc%2BqaRIyZ9hUk%2B482A%2FqzBjeLYltGqcqGPn1x5O7YVSYauueh2LWO8ix2gF9YO4jW4EpNJZ0C7p20QOUjTMFkATLxRbmwiNjdYVyUcFdFX327187gj8Ul9lNsv38vodLUA7GmS1Xw39skN7VqKVjYQ3Ao010GKSXJQyJptNN1RCb7D78LArUhlBovJCysEU5hWcR5L4RJBT%2FHSg%3D%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20200526T084957Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTY76SQ3WDS%2F20200526%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=3436b47a0344f89fd3ab8f5cc9ee8be30c557ffa805033ed7ad8040c92bb467b&hash=df0d7ae454cf116791c2448224b74a08ef47ba88dacd26006176960b08057e27&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S014976341730773X&tid=spdf-53594a3f-b819-4296-b203-cb73008c61ac&sid=ca5593271e00b340115a01a43f6cad28f5a2gxrqb&type=client},\n year = {2018},\n type = {Journal Article}\n}\n\n","author_short":["Verheggen, I. 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