Alterations in atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation. Verheule, S., Wilson, E., th Everett, T., Shanbhag, S., Golden, C., & Olgin, J. j-C, 107(20):2615–2622, 2003. abstract bibtex BACKGROUND: Clinically, chronic atrial dilatation is associated with an increased incidence of atrial fibrillation (AF), but the underlying mechanism is not clear. We have investigated atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation (MR). METHODS AND RESULTS: Thirteen control and 19 MR dogs (1 month after partial mitral valve avulsion) were studied. Dogs in the MR group were monitored using echocardiography and Holter recording. In open-chest follow-up experiments, electrode arrays were placed on the atria to investigate conduction patterns, effective refractory periods, and inducibility of AF. Alterations in tissue structure and ultrastructure were assessed in atrial tissue samples. At follow-up, left atrial length in MR dogs was 4.09+/-0.45 cm, compared with 3.25+/-0.28 at baseline (P<0.01), corresponding to a volume of 205+/-61% of baseline. At follow-up, no differences in atrial conduction pattern and conduction velocities were noted between control and MR dogs. Effective refractory periods were increased homogeneously throughout the left and right atrium. Sustained AF (>1 hour) was inducible in 10 of 19 MR dogs and none of 13 control dogs (P<0.01). In the dilated MR left atrium, areas of increased interstitial fibrosis and chronic inflammation were accompanied by increased glycogen ultrastructurally. CONCLUSIONS: Chronic atrial dilatation in the absence of overt heart failure leads to an increased vulnerability to AF that is not based on a decrease in wavelength.
@Article{RSM:Ver2003,
author = "S. Verheule and E. Wilson and T. th Everett and S.
Shanbhag and C. Golden and J. Olgin",
title = "Alterations in atrial electrophysiology and tissue
structure in a canine model of chronic atrial
dilatation due to mitral regurgitation",
journal = j-C,
volume = "107",
number = "20",
pages = "2615--2622",
scinote = "1524-4539 (Electronic) Journal Article Research
Support, U.S. Gov't, P.H.S.",
abstract = "BACKGROUND: Clinically, chronic atrial dilatation is
associated with an increased incidence of atrial
fibrillation (AF), but the underlying mechanism is not
clear. We have investigated atrial electrophysiology
and tissue structure in a canine model of chronic
atrial dilatation due to mitral regurgitation (MR).
METHODS AND RESULTS: Thirteen control and 19 MR dogs (1
month after partial mitral valve avulsion) were
studied. Dogs in the MR group were monitored using
echocardiography and Holter recording. In open-chest
follow-up experiments, electrode arrays were placed on
the atria to investigate conduction patterns, effective
refractory periods, and inducibility of AF. Alterations
in tissue structure and ultrastructure were assessed in
atrial tissue samples. At follow-up, left atrial length
in MR dogs was 4.09+/-0.45 cm, compared with
3.25+/-0.28 at baseline (P<0.01), corresponding to a
volume of 205+/-61\% of baseline. At follow-up, no
differences in atrial conduction pattern and conduction
velocities were noted between control and MR dogs.
Effective refractory periods were increased
homogeneously throughout the left and right atrium.
Sustained AF (>1 hour) was inducible in 10 of 19 MR
dogs and none of 13 control dogs (P<0.01). In the
dilated MR left atrium, areas of increased interstitial
fibrosis and chronic inflammation were accompanied by
increased glycogen ultrastructurally. CONCLUSIONS:
Chronic atrial dilatation in the absence of overt heart
failure leads to an increased vulnerability to AF that
is not based on a decrease in wavelength.",
keywords = "Animals Atrial Fibrillation/etiology/physiopathology
Chronic Disease Dilatation,
Pathologic/etiology/pathology/*physiopathology Disease
Models, Animal Disease Susceptibility Dogs
Echocardiography, Transesophageal Electrocardiography,
Ambulatory *Electrophysiologic Techniques, Cardiac
Heart Atria/pathology/*physiopathology/ultrasonography
Heart Conduction System/physiopathology Microscopy,
Electron Mitral Valve
Insufficiency/complications/*physiopathology/ultrasonography
Myocardium/pathology/ultrastructure Ventricular
Function, Left",
year = "2003",
}
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We have investigated atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation (MR). METHODS AND RESULTS: Thirteen control and 19 MR dogs (1 month after partial mitral valve avulsion) were studied. Dogs in the MR group were monitored using echocardiography and Holter recording. In open-chest follow-up experiments, electrode arrays were placed on the atria to investigate conduction patterns, effective refractory periods, and inducibility of AF. Alterations in tissue structure and ultrastructure were assessed in atrial tissue samples. At follow-up, left atrial length in MR dogs was 4.09+/-0.45 cm, compared with 3.25+/-0.28 at baseline (P<0.01), corresponding to a volume of 205+/-61% of baseline. At follow-up, no differences in atrial conduction pattern and conduction velocities were noted between control and MR dogs. Effective refractory periods were increased homogeneously throughout the left and right atrium. Sustained AF (>1 hour) was inducible in 10 of 19 MR dogs and none of 13 control dogs (P<0.01). In the dilated MR left atrium, areas of increased interstitial fibrosis and chronic inflammation were accompanied by increased glycogen ultrastructurally. CONCLUSIONS: Chronic atrial dilatation in the absence of overt heart failure leads to an increased vulnerability to AF that is not based on a decrease in wavelength.","keywords":"Animals Atrial Fibrillation/etiology/physiopathology Chronic Disease Dilatation, Pathologic/etiology/pathology/*physiopathology Disease Models, Animal Disease Susceptibility Dogs Echocardiography, Transesophageal Electrocardiography, Ambulatory *Electrophysiologic Techniques, Cardiac Heart Atria/pathology/*physiopathology/ultrasonography Heart Conduction System/physiopathology Microscopy, Electron Mitral Valve Insufficiency/complications/*physiopathology/ultrasonography Myocardium/pathology/ultrastructure Ventricular Function, Left","year":"2003","bibtex":"@Article{RSM:Ver2003,\n author = \"S. Verheule and E. Wilson and T. th Everett and S.\n Shanbhag and C. Golden and J. Olgin\",\n title = \"Alterations in atrial electrophysiology and tissue\n structure in a canine model of chronic atrial\n dilatation due to mitral regurgitation\",\n journal = j-C,\n volume = \"107\",\n number = \"20\",\n pages = \"2615--2622\",\n scinote = \"1524-4539 (Electronic) Journal Article Research\n Support, U.S. Gov't, P.H.S.\",\n abstract = \"BACKGROUND: Clinically, chronic atrial dilatation is\n associated with an increased incidence of atrial\n fibrillation (AF), but the underlying mechanism is not\n clear. We have investigated atrial electrophysiology\n and tissue structure in a canine model of chronic\n atrial dilatation due to mitral regurgitation (MR).\n METHODS AND RESULTS: Thirteen control and 19 MR dogs (1\n month after partial mitral valve avulsion) were\n studied. Dogs in the MR group were monitored using\n echocardiography and Holter recording. In open-chest\n follow-up experiments, electrode arrays were placed on\n the atria to investigate conduction patterns, effective\n refractory periods, and inducibility of AF. Alterations\n in tissue structure and ultrastructure were assessed in\n atrial tissue samples. At follow-up, left atrial length\n in MR dogs was 4.09+/-0.45 cm, compared with\n 3.25+/-0.28 at baseline (P<0.01), corresponding to a\n volume of 205+/-61\\% of baseline. At follow-up, no\n differences in atrial conduction pattern and conduction\n velocities were noted between control and MR dogs.\n Effective refractory periods were increased\n homogeneously throughout the left and right atrium.\n Sustained AF (>1 hour) was inducible in 10 of 19 MR\n dogs and none of 13 control dogs (P<0.01). In the\n dilated MR left atrium, areas of increased interstitial\n fibrosis and chronic inflammation were accompanied by\n increased glycogen ultrastructurally. CONCLUSIONS:\n Chronic atrial dilatation in the absence of overt heart\n failure leads to an increased vulnerability to AF that\n is not based on a decrease in wavelength.\",\n keywords = \"Animals Atrial Fibrillation/etiology/physiopathology\n Chronic Disease Dilatation,\n Pathologic/etiology/pathology/*physiopathology Disease\n Models, Animal Disease Susceptibility Dogs\n Echocardiography, Transesophageal Electrocardiography,\n Ambulatory *Electrophysiologic Techniques, Cardiac\n Heart Atria/pathology/*physiopathology/ultrasonography\n Heart Conduction System/physiopathology Microscopy,\n Electron Mitral Valve\n Insufficiency/complications/*physiopathology/ultrasonography\n Myocardium/pathology/ultrastructure Ventricular\n Function, Left\",\n year = \"2003\",\n}\n\n","author_short":["Verheule, S.","Wilson, E.","th Everett, T.","Shanbhag, S.","Golden, C.","Olgin, J."],"key":"RSM:Ver2003","id":"RSM:Ver2003","bibbaseid":"verheule-wilson-theverett-shanbhag-golden-olgin-alterationsinatrialelectrophysiologyandtissuestructureinacaninemodelofchronicatrialdilatationduetomitralregurgitation-2003","role":"author","urls":{},"keyword":["Animals Atrial Fibrillation/etiology/physiopathology Chronic Disease Dilatation","Pathologic/etiology/pathology/*physiopathology Disease Models","Animal Disease Susceptibility Dogs Echocardiography","Transesophageal Electrocardiography","Ambulatory *Electrophysiologic Techniques","Cardiac Heart Atria/pathology/*physiopathology/ultrasonography Heart Conduction System/physiopathology Microscopy","Electron Mitral Valve Insufficiency/complications/*physiopathology/ultrasonography Myocardium/pathology/ultrastructure Ventricular Function","Left"],"metadata":{"authorlinks":{}},"downloads":0,"html":""},"search_terms":["alterations","atrial","electrophysiology","tissue","structure","canine","model","chronic","atrial","dilatation","due","mitral","regurgitation","verheule","wilson","th everett","shanbhag","golden","olgin"],"keywords":["animals atrial fibrillation/etiology/physiopathology chronic disease dilatation","pathologic/etiology/pathology/*physiopathology disease models","animal disease susceptibility dogs echocardiography","transesophageal electrocardiography","ambulatory *electrophysiologic techniques","cardiac heart atria/pathology/*physiopathology/ultrasonography heart conduction system/physiopathology microscopy","electron mitral valve insufficiency/complications/*physiopathology/ultrasonography myocardium/pathology/ultrastructure ventricular function","left"],"authorIDs":[],"dataSources":["5HG3Kp8zRwDd7FotB"]}