Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?. Vermeulen, S. J T, Chen, T R, Speleman, F., Nollet, F H, Roy, F M V., & Mareel, M M Cancer genetics and cytogenetics, 107(1):76--9, November, 1998. Paper abstract bibtex Four human colon cancer cell lines, HCT-8, HRT-18, DLD-1, and HCT-15, with an epithelioid morphotype reproducibly formed alpha-catenin-deficient round cells. Using DNA fingerprinting, we found that these four cell lines have an identical genetic background. Our finding strongly suggests a genetic background for the reproducible loss of alpha-catenin and the ensuing acquisition of invasiveness in all four cell lines.
@article{ Vermeulen1998,
author = {Stefan J T Vermeulen and T R Chen and Frank Speleman and F H Nollet and F M Van Roy and M M Mareel},
title = {Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?},
journal = {Cancer genetics and cytogenetics},
abstract = {Four human colon cancer cell lines, HCT-8, HRT-18, DLD-1, and HCT-15, with an epithelioid morphotype reproducibly formed alpha-catenin-deficient round cells. Using DNA fingerprinting, we found that these four cell lines have an identical genetic background. Our finding strongly suggests a genetic background for the reproducible loss of alpha-catenin and the ensuing acquisition of invasiveness in all four cell lines.},
issn = {0165-4608},
month = {November},
pages = {76--9},
volume = {107},
number = {1},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9809040} ,
year = {1998}
}
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