@article{RN217,
   author = {Veugen, M. G. J. and Henry, R. M. A. and Brunner-La Rocca, H. P. and Dagnelie, P. C. and Schram, M. T. and van Agtmaal, M. J. M. and van der Kallen, C. J. H. and Sep, S. J. S. and van Boxtel, M. P. J. and Bekers, O. and Meex, S. J. R. and Jansen, J. F. A. and Kroon, A. A. and Stehouwer, C. D. A.},
   title = {Cross-Sectional Associations Between Cardiac Biomarkers, Cognitive Performance, and Structural Brain Changes Are Modified by Age},
   journal = {Arterioscler Thromb Vasc Biol},
   volume = {38},
   number = {8},
   pages = {1948-1958},
   note = {Veugen, Marja G J
Henry, Ronald M A
Brunner-La Rocca, Hans-Peter
Dagnelie, Pieter C
Schram, Miranda T
van Agtmaal, Marnix J M
van der Kallen, Carla J H
Sep, Simone J S
van Boxtel, Martin P J
Bekers, Otto
Meex, Steven J R
Jansen, Jacobus F A
Kroon, Abraham A
Stehouwer, Coen D A
eng
Observational Study
Research Support, Non-U.S. Gov't
2018/06/30 06:00
Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1948-1958. doi: 10.1161/ATVBAHA.118.311082.},
   abstract = {Objective- NT-proBNP (N-terminal pro-B-type natriuretic peptide) and cardiac troponin T (cTNT) are associated with cognitive performance. Whether this extends to individuals <60 years of age is unclear. We investigated whether age modified the associations between NT-proBNP and cTNT and cognitive performance and structural brain changes. Approach and Results- In 3011 individuals (60+/-8 years; 49% women), NT-proBNP and cTNT, memory, information processing speed and executive functioning, grey matter (GM) and white matter, and white matter hyperintensity (WMH) volumes were determined. We used regression, adjusted for educational level, cardiovascular factors, and lifestyle factors, to test whether cross-sectional associations between biomarkers and cognitive performance and structural brain changes were modified by age (<60 versus >/=60 years). >/=60 years, higher NT-proBNP was associated with lower memory (beta [SD] per 10-fold higher level [95% confidence interval (CI)], -0.11 [-0.22 to -0.00]), information processing speed (-0.12 [95% CI, -0.21 to -0.03]), executive functioning (-0.12 [95% CI, -0.22 to -0.03]), and smaller GM (beta [mL] per 10-fold higher level, -6.89 [95% CI, -11.58 to -2.20]). Additionally, higher cTNT was associated with lower memory (-0.33 [95% CI, -0.53 to -0.12]) and information processing speed (-0.17 [95% CI, -0.3 to -0.01]); with smaller GM (-16.07 [95% CI, -24.90 to -7.24]) and greater WMH (10(beta) WMH per 10-fold higher level, 0.31 [95% CI, 0.10-0.52]). <60 years, NT-proBNP and cTNT were not associated with cognitive performance ( Pinteraction, <0.10). In contrast, higher NT-proBNP was associated with smaller GM (-7.43 [95% CI, -11.70 to -3.16]) and greater WMH (0.13 [95% CI, 0.01-0.25]; Pinteraction,>0.10). Higher cTNT was associated with greater WMH (0.18 [95% CI, -0.01 to 0.37]; Pinteraction,>0.10) but not with GM (0.07 [95% CI, -6.87 to 7.02]; Pinteraction, <0.10). Conclusions- Biomarkers of cardiac injury are continuously associated with structural brain changes in both older and younger individuals but with poorer cognitive performance only in older individuals. These findings stress the continuous nature of the heart-brain axis in the development of cognitive impairment.},
   keywords = {Age Factors
Aged
*Aging/blood/pathology/psychology
Biomarkers/blood
*Cognition
Cognition Disorders/diagnosis/physiopathology/*psychology
Cognitive Aging
Cross-Sectional Studies
Executive Function
Female
Gray Matter/diagnostic imaging/*pathology/physiopathology
Health Status
Heart Diseases/*blood/diagnosis/physiopathology
Humans
Magnetic Resonance Imaging
Male
Memory
Mental Health
Middle Aged
Natriuretic Peptide, Brain/*blood
Neuropsychological Tests
Peptide Fragments/*blood
Prospective Studies
Risk Factors
Troponin T/*blood
White Matter/diagnostic imaging/*pathology/physiopathology
*brain
*humans
*natriuretic peptide, brain
*troponin T
*white matter},
   ISSN = {1524-4636 (Electronic)
1079-5642 (Linking)},
   DOI = {10.1161/ATVBAHA.118.311082},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/29954754},
   year = {2018},
   type = {Journal Article}
}

{"_id":"EMnTSjqexu2jNDZW4","bibbaseid":"veugen-henry-brunnerlarocca-dagnelie-schram-vanagtmaal-vanderkallen-sep-etal-crosssectionalassociationsbetweencardiacbiomarkerscognitiveperformanceandstructuralbrainchangesaremodifiedbyage-2018","downloads":0,"creationDate":"2019-02-05T09:46:38.906Z","title":"Cross-Sectional Associations Between Cardiac Biomarkers, Cognitive Performance, and Structural Brain Changes Are Modified by Age","author_short":["Veugen, M. G. J.","Henry, R. M. A.","Brunner-La Rocca, H. P.","Dagnelie, P. C.","Schram, M. T.","van Agtmaal, M. J. M.","van der Kallen, C. J. H.","Sep, S. J. S.","van Boxtel, M. P. J.","Bekers, O.","Meex, S. J. R.","Jansen, J. F. A.","Kroon, A. A.","Stehouwer, C. D. A."],"year":2018,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Veugen"],"firstnames":["M.","G.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Henry"],"firstnames":["R.","M.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Brunner-La","Rocca"],"firstnames":["H.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Dagnelie"],"firstnames":["P.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Schram"],"firstnames":["M.","T."],"suffixes":[]},{"propositions":["van"],"lastnames":["Agtmaal"],"firstnames":["M.","J.","M."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Kallen"],"firstnames":["C.","J.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Sep"],"firstnames":["S.","J.","S."],"suffixes":[]},{"propositions":["van"],"lastnames":["Boxtel"],"firstnames":["M.","P.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Bekers"],"firstnames":["O."],"suffixes":[]},{"propositions":[],"lastnames":["Meex"],"firstnames":["S.","J.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Kroon"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Stehouwer"],"firstnames":["C.","D.","A."],"suffixes":[]}],"title":"Cross-Sectional Associations Between Cardiac Biomarkers, Cognitive Performance, and Structural Brain Changes Are Modified by Age","journal":"Arterioscler Thromb Vasc Biol","volume":"38","number":"8","pages":"1948-1958","note":"Veugen, Marja G J Henry, Ronald M A Brunner-La Rocca, Hans-Peter Dagnelie, Pieter C Schram, Miranda T van Agtmaal, Marnix J M van der Kallen, Carla J H Sep, Simone J S van Boxtel, Martin P J Bekers, Otto Meex, Steven J R Jansen, Jacobus F A Kroon, Abraham A Stehouwer, Coen D A eng Observational Study Research Support, Non-U.S. Gov't 2018/06/30 06:00 Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1948-1958. doi: 10.1161/ATVBAHA.118.311082.","abstract":"Objective- NT-proBNP (N-terminal pro-B-type natriuretic peptide) and cardiac troponin T (cTNT) are associated with cognitive performance. Whether this extends to individuals <60 years of age is unclear. We investigated whether age modified the associations between NT-proBNP and cTNT and cognitive performance and structural brain changes. Approach and Results- In 3011 individuals (60+/-8 years; 49% women), NT-proBNP and cTNT, memory, information processing speed and executive functioning, grey matter (GM) and white matter, and white matter hyperintensity (WMH) volumes were determined. We used regression, adjusted for educational level, cardiovascular factors, and lifestyle factors, to test whether cross-sectional associations between biomarkers and cognitive performance and structural brain changes were modified by age (<60 versus >/=60 years). >/=60 years, higher NT-proBNP was associated with lower memory (beta [SD] per 10-fold higher level [95% confidence interval (CI)], -0.11 [-0.22 to -0.00]), information processing speed (-0.12 [95% CI, -0.21 to -0.03]), executive functioning (-0.12 [95% CI, -0.22 to -0.03]), and smaller GM (beta [mL] per 10-fold higher level, -6.89 [95% CI, -11.58 to -2.20]). Additionally, higher cTNT was associated with lower memory (-0.33 [95% CI, -0.53 to -0.12]) and information processing speed (-0.17 [95% CI, -0.3 to -0.01]); with smaller GM (-16.07 [95% CI, -24.90 to -7.24]) and greater WMH (10(beta) WMH per 10-fold higher level, 0.31 [95% CI, 0.10-0.52]). <60 years, NT-proBNP and cTNT were not associated with cognitive performance ( Pinteraction, <0.10). In contrast, higher NT-proBNP was associated with smaller GM (-7.43 [95% CI, -11.70 to -3.16]) and greater WMH (0.13 [95% CI, 0.01-0.25]; Pinteraction,>0.10). Higher cTNT was associated with greater WMH (0.18 [95% CI, -0.01 to 0.37]; Pinteraction,>0.10) but not with GM (0.07 [95% CI, -6.87 to 7.02]; Pinteraction, <0.10). Conclusions- Biomarkers of cardiac injury are continuously associated with structural brain changes in both older and younger individuals but with poorer cognitive performance only in older individuals. These findings stress the continuous nature of the heart-brain axis in the development of cognitive impairment.","keywords":"Age Factors Aged *Aging/blood/pathology/psychology Biomarkers/blood *Cognition Cognition Disorders/diagnosis/physiopathology/*psychology Cognitive Aging Cross-Sectional Studies Executive Function Female Gray Matter/diagnostic imaging/*pathology/physiopathology Health Status Heart Diseases/*blood/diagnosis/physiopathology Humans Magnetic Resonance Imaging Male Memory Mental Health Middle Aged Natriuretic Peptide, Brain/*blood Neuropsychological Tests Peptide Fragments/*blood Prospective Studies Risk Factors Troponin T/*blood White Matter/diagnostic imaging/*pathology/physiopathology *brain *humans *natriuretic peptide, brain *troponin T *white matter","issn":"1524-4636 (Electronic) 1079-5642 (Linking)","doi":"10.1161/ATVBAHA.118.311082","url":"http://www.ncbi.nlm.nih.gov/pubmed/29954754","year":"2018","bibtex":"@article{RN217,\n author = {Veugen, M. G. J. and Henry, R. M. A. and Brunner-La Rocca, H. P. and Dagnelie, P. C. and Schram, M. T. and van Agtmaal, M. J. M. and van der Kallen, C. J. H. and Sep, S. J. S. and van Boxtel, M. P. J. and Bekers, O. and Meex, S. J. R. and Jansen, J. F. A. and Kroon, A. A. and Stehouwer, C. D. A.},\n title = {Cross-Sectional Associations Between Cardiac Biomarkers, Cognitive Performance, and Structural Brain Changes Are Modified by Age},\n journal = {Arterioscler Thromb Vasc Biol},\n volume = {38},\n number = {8},\n pages = {1948-1958},\n note = {Veugen, Marja G J\nHenry, Ronald M A\nBrunner-La Rocca, Hans-Peter\nDagnelie, Pieter C\nSchram, Miranda T\nvan Agtmaal, Marnix J M\nvan der Kallen, Carla J H\nSep, Simone J S\nvan Boxtel, Martin P J\nBekers, Otto\nMeex, Steven J R\nJansen, Jacobus F A\nKroon, Abraham A\nStehouwer, Coen D A\neng\nObservational Study\nResearch Support, Non-U.S. Gov't\n2018/06/30 06:00\nArterioscler Thromb Vasc Biol. 2018 Aug;38(8):1948-1958. doi: 10.1161/ATVBAHA.118.311082.},\n abstract = {Objective- NT-proBNP (N-terminal pro-B-type natriuretic peptide) and cardiac troponin T (cTNT) are associated with cognitive performance. Whether this extends to individuals <60 years of age is unclear. We investigated whether age modified the associations between NT-proBNP and cTNT and cognitive performance and structural brain changes. Approach and Results- In 3011 individuals (60+/-8 years; 49% women), NT-proBNP and cTNT, memory, information processing speed and executive functioning, grey matter (GM) and white matter, and white matter hyperintensity (WMH) volumes were determined. We used regression, adjusted for educational level, cardiovascular factors, and lifestyle factors, to test whether cross-sectional associations between biomarkers and cognitive performance and structural brain changes were modified by age (<60 versus >/=60 years). >/=60 years, higher NT-proBNP was associated with lower memory (beta [SD] per 10-fold higher level [95% confidence interval (CI)], -0.11 [-0.22 to -0.00]), information processing speed (-0.12 [95% CI, -0.21 to -0.03]), executive functioning (-0.12 [95% CI, -0.22 to -0.03]), and smaller GM (beta [mL] per 10-fold higher level, -6.89 [95% CI, -11.58 to -2.20]). Additionally, higher cTNT was associated with lower memory (-0.33 [95% CI, -0.53 to -0.12]) and information processing speed (-0.17 [95% CI, -0.3 to -0.01]); with smaller GM (-16.07 [95% CI, -24.90 to -7.24]) and greater WMH (10(beta) WMH per 10-fold higher level, 0.31 [95% CI, 0.10-0.52]). <60 years, NT-proBNP and cTNT were not associated with cognitive performance ( Pinteraction, <0.10). In contrast, higher NT-proBNP was associated with smaller GM (-7.43 [95% CI, -11.70 to -3.16]) and greater WMH (0.13 [95% CI, 0.01-0.25]; Pinteraction,>0.10). Higher cTNT was associated with greater WMH (0.18 [95% CI, -0.01 to 0.37]; Pinteraction,>0.10) but not with GM (0.07 [95% CI, -6.87 to 7.02]; Pinteraction, <0.10). Conclusions- Biomarkers of cardiac injury are continuously associated with structural brain changes in both older and younger individuals but with poorer cognitive performance only in older individuals. These findings stress the continuous nature of the heart-brain axis in the development of cognitive impairment.},\n keywords = {Age Factors\nAged\n*Aging/blood/pathology/psychology\nBiomarkers/blood\n*Cognition\nCognition Disorders/diagnosis/physiopathology/*psychology\nCognitive Aging\nCross-Sectional Studies\nExecutive Function\nFemale\nGray Matter/diagnostic imaging/*pathology/physiopathology\nHealth Status\nHeart Diseases/*blood/diagnosis/physiopathology\nHumans\nMagnetic Resonance Imaging\nMale\nMemory\nMental Health\nMiddle Aged\nNatriuretic Peptide, Brain/*blood\nNeuropsychological Tests\nPeptide Fragments/*blood\nProspective Studies\nRisk Factors\nTroponin T/*blood\nWhite Matter/diagnostic imaging/*pathology/physiopathology\n*brain\n*humans\n*natriuretic peptide, brain\n*troponin T\n*white matter},\n ISSN = {1524-4636 (Electronic)\n1079-5642 (Linking)},\n DOI = {10.1161/ATVBAHA.118.311082},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/29954754},\n year = {2018},\n type = {Journal Article}\n}\n\n","author_short":["Veugen, M. G. J.","Henry, R. M. A.","Brunner-La Rocca, H. P.","Dagnelie, P. C.","Schram, M. T.","van Agtmaal, M. J. M.","van der Kallen, C. J. H.","Sep, S. J. S.","van Boxtel, M. P. J.","Bekers, O.","Meex, S. J. R.","Jansen, J. F. A.","Kroon, A. A.","Stehouwer, C. D. 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