A high-resolution enhancer atlas of the developing telencephalon. Visel, A., Taher, L., Girgis, H., May, D., Golonzhka, O., Hoch, R. V, McKinsey, G. L, Pattabiraman, K., Silberberg, S. N, Blow, M. J, Hansen, D. V, Nord, A. S, Akiyama, J. A, Holt, A., Hosseini, R., Phouanenavong, S., Plajzer-Frick, I., Shoukry, M., Afzal, V., Kaplan, T., Kriegstein, A. R, Rubin, E. M, Ovcharenko, I., Pennacchio, L. A, & Rubenstein, J. L R Cell, 152(4):895–908, January, 2013. abstract bibtex The mammalian telencephalon plays critical roles in cognition, motor function, and emotion. Though many of the genes required for its development have been identified, the distant-acting regulatory sequences orchestrating their in vivo expression are mostly unknown. Here, we describe a digital atlas of in vivo enhancers active in subregions of the developing telencephalon. We identified more than 4,600 candidate embryonic forebrain enhancers and studied the in vivo activity of 329 of these sequences in transgenic mouse embryos. We generated serial sets of histological brain sections for 145 reproducible forebrain enhancers, resulting in a publicly accessible web-based data collection comprising more than 32,000 sections. We also used epigenomic analysis of human and mouse cortex tissue to directly compare the genome-wide enhancer architecture in these species. These data provide a primary resource for investigating gene regulatory mechanisms of telencephalon development and enable studies of the role of distant-acting enhancers in neurodevelopmental disorders.
@ARTICLE{Visel2013-hi,
title = "A high-resolution enhancer atlas of the developing telencephalon",
author = "Visel, Axel and Taher, Leila and Girgis, Hani and May, Dalit and
Golonzhka, Olga and Hoch, Renee V and McKinsey, Gabriel L and
Pattabiraman, Kartik and Silberberg, Shanni N and Blow, Matthew J
and Hansen, David V and Nord, Alex S and Akiyama, Jennifer A and
Holt, Amy and Hosseini, Roya and Phouanenavong, Sengthavy and
Plajzer-Frick, Ingrid and Shoukry, Malak and Afzal, Veena and
Kaplan, Tommy and Kriegstein, Arnold R and Rubin, Edward M and
Ovcharenko, Ivan and Pennacchio, Len A and Rubenstein, John L R",
abstract = "The mammalian telencephalon plays critical roles in cognition,
motor function, and emotion. Though many of the genes required
for its development have been identified, the distant-acting
regulatory sequences orchestrating their in vivo expression are
mostly unknown. Here, we describe a digital atlas of in vivo
enhancers active in subregions of the developing telencephalon.
We identified more than 4,600 candidate embryonic forebrain
enhancers and studied the in vivo activity of 329 of these
sequences in transgenic mouse embryos. We generated serial sets
of histological brain sections for 145 reproducible forebrain
enhancers, resulting in a publicly accessible web-based data
collection comprising more than 32,000 sections. We also used
epigenomic analysis of human and mouse cortex tissue to directly
compare the genome-wide enhancer architecture in these species.
These data provide a primary resource for investigating gene
regulatory mechanisms of telencephalon development and enable
studies of the role of distant-acting enhancers in
neurodevelopmental disorders.",
journal = "Cell",
volume = 152,
number = 4,
pages = "895--908",
month = jan,
year = 2013,
language = "en"
}
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L R"],"bibdata":{"bibtype":"article","type":"article","title":"A high-resolution enhancer atlas of the developing telencephalon","author":[{"propositions":[],"lastnames":["Visel"],"firstnames":["Axel"],"suffixes":[]},{"propositions":[],"lastnames":["Taher"],"firstnames":["Leila"],"suffixes":[]},{"propositions":[],"lastnames":["Girgis"],"firstnames":["Hani"],"suffixes":[]},{"propositions":[],"lastnames":["May"],"firstnames":["Dalit"],"suffixes":[]},{"propositions":[],"lastnames":["Golonzhka"],"firstnames":["Olga"],"suffixes":[]},{"propositions":[],"lastnames":["Hoch"],"firstnames":["Renee","V"],"suffixes":[]},{"propositions":[],"lastnames":["McKinsey"],"firstnames":["Gabriel","L"],"suffixes":[]},{"propositions":[],"lastnames":["Pattabiraman"],"firstnames":["Kartik"],"suffixes":[]},{"propositions":[],"lastnames":["Silberberg"],"firstnames":["Shanni","N"],"suffixes":[]},{"propositions":[],"lastnames":["Blow"],"firstnames":["Matthew","J"],"suffixes":[]},{"propositions":[],"lastnames":["Hansen"],"firstnames":["David","V"],"suffixes":[]},{"propositions":[],"lastnames":["Nord"],"firstnames":["Alex","S"],"suffixes":[]},{"propositions":[],"lastnames":["Akiyama"],"firstnames":["Jennifer","A"],"suffixes":[]},{"propositions":[],"lastnames":["Holt"],"firstnames":["Amy"],"suffixes":[]},{"propositions":[],"lastnames":["Hosseini"],"firstnames":["Roya"],"suffixes":[]},{"propositions":[],"lastnames":["Phouanenavong"],"firstnames":["Sengthavy"],"suffixes":[]},{"propositions":[],"lastnames":["Plajzer-Frick"],"firstnames":["Ingrid"],"suffixes":[]},{"propositions":[],"lastnames":["Shoukry"],"firstnames":["Malak"],"suffixes":[]},{"propositions":[],"lastnames":["Afzal"],"firstnames":["Veena"],"suffixes":[]},{"propositions":[],"lastnames":["Kaplan"],"firstnames":["Tommy"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]},{"propositions":[],"lastnames":["Rubin"],"firstnames":["Edward","M"],"suffixes":[]},{"propositions":[],"lastnames":["Ovcharenko"],"firstnames":["Ivan"],"suffixes":[]},{"propositions":[],"lastnames":["Pennacchio"],"firstnames":["Len","A"],"suffixes":[]},{"propositions":[],"lastnames":["Rubenstein"],"firstnames":["John","L","R"],"suffixes":[]}],"abstract":"The mammalian telencephalon plays critical roles in cognition, motor function, and emotion. Though many of the genes required for its development have been identified, the distant-acting regulatory sequences orchestrating their in vivo expression are mostly unknown. Here, we describe a digital atlas of in vivo enhancers active in subregions of the developing telencephalon. We identified more than 4,600 candidate embryonic forebrain enhancers and studied the in vivo activity of 329 of these sequences in transgenic mouse embryos. We generated serial sets of histological brain sections for 145 reproducible forebrain enhancers, resulting in a publicly accessible web-based data collection comprising more than 32,000 sections. We also used epigenomic analysis of human and mouse cortex tissue to directly compare the genome-wide enhancer architecture in these species. These data provide a primary resource for investigating gene regulatory mechanisms of telencephalon development and enable studies of the role of distant-acting enhancers in neurodevelopmental disorders.","journal":"Cell","volume":"152","number":"4","pages":"895–908","month":"January","year":"2013","language":"en","bibtex":"@ARTICLE{Visel2013-hi,\n title = \"A high-resolution enhancer atlas of the developing telencephalon\",\n author = \"Visel, Axel and Taher, Leila and Girgis, Hani and May, Dalit and\n Golonzhka, Olga and Hoch, Renee V and McKinsey, Gabriel L and\n Pattabiraman, Kartik and Silberberg, Shanni N and Blow, Matthew J\n and Hansen, David V and Nord, Alex S and Akiyama, Jennifer A and\n Holt, Amy and Hosseini, Roya and Phouanenavong, Sengthavy and\n Plajzer-Frick, Ingrid and Shoukry, Malak and Afzal, Veena and\n Kaplan, Tommy and Kriegstein, Arnold R and Rubin, Edward M and\n Ovcharenko, Ivan and Pennacchio, Len A and Rubenstein, John L R\",\n abstract = \"The mammalian telencephalon plays critical roles in cognition,\n motor function, and emotion. Though many of the genes required\n for its development have been identified, the distant-acting\n regulatory sequences orchestrating their in vivo expression are\n mostly unknown. Here, we describe a digital atlas of in vivo\n enhancers active in subregions of the developing telencephalon.\n We identified more than 4,600 candidate embryonic forebrain\n enhancers and studied the in vivo activity of 329 of these\n sequences in transgenic mouse embryos. We generated serial sets\n of histological brain sections for 145 reproducible forebrain\n enhancers, resulting in a publicly accessible web-based data\n collection comprising more than 32,000 sections. We also used\n epigenomic analysis of human and mouse cortex tissue to directly\n compare the genome-wide enhancer architecture in these species.\n These data provide a primary resource for investigating gene\n regulatory mechanisms of telencephalon development and enable\n studies of the role of distant-acting enhancers in\n neurodevelopmental disorders.\",\n journal = \"Cell\",\n volume = 152,\n number = 4,\n pages = \"895--908\",\n month = jan,\n year = 2013,\n language = \"en\"\n}\n\n","author_short":["Visel, A.","Taher, L.","Girgis, H.","May, D.","Golonzhka, O.","Hoch, R. V","McKinsey, G. L","Pattabiraman, K.","Silberberg, S. N","Blow, M. J","Hansen, D. V","Nord, A. S","Akiyama, J. A","Holt, A.","Hosseini, R.","Phouanenavong, S.","Plajzer-Frick, I.","Shoukry, M.","Afzal, V.","Kaplan, T.","Kriegstein, A. R","Rubin, E. M","Ovcharenko, I.","Pennacchio, L. A","Rubenstein, J. 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