TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis: Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and Baló's Concentric Sclerosis. Völk, S., Unterrainer, M., Albert, N. L., Havla, J., Gerdes, L. A., Schumacher, M., Brendel, M., Kaiser, L., Adorjan, K., Rupprecht, R., Bartenstein, P., Kümpfel, T., & Danek, A. Clinical Nuclear Medicine, 45(10):e447–e448, October, 2020. Number: 10doi abstract bibtex PET targeting the translocator protein (TSPO) expression is an interesting approach to detect neuroinflammation, as TSPO is upregulated in activated macrophages and microglia. Considering the variable pathophysiology of multiple sclerosis (MS) variants, we compare TSPO PET using F-GE-180 in 3 different demyelinating diseases of the central nervous system: relapsing-remitting MS, tumefactive MS, and Baló's concentric sclerosis. Visualization of neuroinflammation and its PET patterns in addition to MRI may contribute to accurate distinction and monitoring of central nervous system demyelination.
@article{volk_tspo_2020,
title = {{TSPO} {PET} {With} {18F}-{GE}-180 to {Differentiate} {Variants} of {Multiple} {Sclerosis}: {Relapsing}-{Remitting} {Multiple} {Sclerosis}, {Tumefactive} {Demyelination}, and {Baló}'s {Concentric} {Sclerosis}},
volume = {45},
issn = {1536-0229},
shorttitle = {{TSPO} {PET} {With} {18F}-{GE}-180 to {Differentiate} {Variants} of {Multiple} {Sclerosis}},
doi = {10.1097/RLU.0000000000003220},
abstract = {PET targeting the translocator protein (TSPO) expression is an interesting approach to detect neuroinflammation, as TSPO is upregulated in activated macrophages and microglia. Considering the variable pathophysiology of multiple sclerosis (MS) variants, we compare TSPO PET using F-GE-180 in 3 different demyelinating diseases of the central nervous system: relapsing-remitting MS, tumefactive MS, and Baló's concentric sclerosis. Visualization of neuroinflammation and its PET patterns in addition to MRI may contribute to accurate distinction and monitoring of central nervous system demyelination.},
language = {eng},
number = {10},
journal = {Clinical Nuclear Medicine},
author = {Völk, Stefanie and Unterrainer, Marcus and Albert, Nathalie L. and Havla, Joachim and Gerdes, Lisa Ann and Schumacher, Minh and Brendel, Matthias and Kaiser, Lena and Adorjan, Kristina and Rupprecht, Rainer and Bartenstein, Peter and Kümpfel, Tania and Danek, Adrian},
month = oct,
year = {2020},
pmid = {32796248},
note = {Number: 10},
keywords = {MS, [18F]GE-180},
pages = {e447--e448},
}
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