@article{RN144,
   author = {Vlooswijk, M. C. and Jansen, J. F. and Majoie, H. J. and Hofman, P. A. and de Krom, M. C. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Functional connectivity and language impairment in cryptogenic localization-related epilepsy},
   journal = {Neurology},
   volume = {75},
   number = {5},
   pages = {395-402},
   note = {Vlooswijk, M C G
Jansen, J F A
Majoie, H J M
Hofman, P A M
de Krom, M C T F M
Aldenkamp, A P
Backes, W H
eng
Research Support, Non-U.S. Gov't
2010/08/04 06:00
Neurology. 2010 Aug 3;75(5):395-402. doi: 10.1212/WNL.0b013e3181ebdd3e.},
   abstract = {BACKGROUND: An often underestimated cognitive morbidity in patients with epilepsy is language dysfunction. To investigate the neuronal mechanisms underlying neuropsychological language impairment, activation maps and functional connectivity networks were studied by fMRI of language. METHOD: Fifty-two patients with cryptogenic localization-related epilepsy and 27 healthy controls underwent neuropsychological assessment of IQ, word fluency, and text reading. fMRI was performed with a standard covert word-generation and text-reading paradigm. Functional connectivity analysis comprised cross-correlation of signal time series of the characteristic and most strongly activated regions involved in the language tasks. RESULTS: After careful selection, 34 patients and 20 healthy controls were found eligible for analysis. Patients displayed lower IQ, lower fluency word count, and lower number of words correctly read compared to controls. fMRI activation maps did not differ significantly between patients and controls. For the word-generation paradigm, patients with epilepsy had significantly lower functional connectivity than controls in the prefrontal network. Patients performing worse on the word-fluency test demonstrated a significantly lower mean functional connectivity than controls. Text reading demonstrated lower functional connectivity in patients with epilepsy in the frontotemporal network. Similarly, lower mean functional connectivity was observed in patients with lowest reading performance compared to controls. A relation between reduced functional connectivity and performance on word-fluency and text-reading tests was demonstrated in epilepsy patients. CONCLUSION: Impaired performance on language assessment in epilepsy patients is associated with loss of functional connectivity in the cognitive language networks.},
   keywords = {Adolescent
Adult
Brain/*physiopathology
Brain Mapping
Case-Control Studies
Epilepsies, Partial/*physiopathology
Female
Humans
Intelligence
Intelligence Tests
Language
Language Disorders/*physiopathology
Language Tests
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways/physiopathology
Neuropsychological Tests
Reading
Signal Processing, Computer-Assisted
Young Adult},
   ISSN = {1526-632X (Electronic)
0028-3878 (Linking)},
   DOI = {10.1212/WNL.0b013e3181ebdd3e},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/20679633
https://n.neurology.org/content/75/5/395.long},
   year = {2010},
   type = {Journal Article}
}

{"_id":"eQStJ7BcJj6zwfT4N","bibbaseid":"vlooswijk-jansen-majoie-hofman-dekrom-aldenkamp-backes-functionalconnectivityandlanguageimpairmentincryptogeniclocalizationrelatedepilepsy-2010","downloads":0,"creationDate":"2017-09-02T18:10:13.554Z","title":"Functional connectivity and language impairment in cryptogenic localization-related epilepsy","author_short":["Vlooswijk, M. C.","Jansen, J. F.","Majoie, H. J.","Hofman, P. A.","de Krom, M. C.","Aldenkamp, A. P.","Backes, W. H."],"year":2010,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Vlooswijk"],"firstnames":["M.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Majoie"],"firstnames":["H.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":["de"],"lastnames":["Krom"],"firstnames":["M.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Functional connectivity and language impairment in cryptogenic localization-related epilepsy","journal":"Neurology","volume":"75","number":"5","pages":"395-402","note":"Vlooswijk, M C G Jansen, J F A Majoie, H J M Hofman, P A M de Krom, M C T F M Aldenkamp, A P Backes, W H eng Research Support, Non-U.S. Gov't 2010/08/04 06:00 Neurology. 2010 Aug 3;75(5):395-402. doi: 10.1212/WNL.0b013e3181ebdd3e.","abstract":"BACKGROUND: An often underestimated cognitive morbidity in patients with epilepsy is language dysfunction. To investigate the neuronal mechanisms underlying neuropsychological language impairment, activation maps and functional connectivity networks were studied by fMRI of language. METHOD: Fifty-two patients with cryptogenic localization-related epilepsy and 27 healthy controls underwent neuropsychological assessment of IQ, word fluency, and text reading. fMRI was performed with a standard covert word-generation and text-reading paradigm. Functional connectivity analysis comprised cross-correlation of signal time series of the characteristic and most strongly activated regions involved in the language tasks. RESULTS: After careful selection, 34 patients and 20 healthy controls were found eligible for analysis. Patients displayed lower IQ, lower fluency word count, and lower number of words correctly read compared to controls. fMRI activation maps did not differ significantly between patients and controls. For the word-generation paradigm, patients with epilepsy had significantly lower functional connectivity than controls in the prefrontal network. Patients performing worse on the word-fluency test demonstrated a significantly lower mean functional connectivity than controls. Text reading demonstrated lower functional connectivity in patients with epilepsy in the frontotemporal network. Similarly, lower mean functional connectivity was observed in patients with lowest reading performance compared to controls. A relation between reduced functional connectivity and performance on word-fluency and text-reading tests was demonstrated in epilepsy patients. CONCLUSION: Impaired performance on language assessment in epilepsy patients is associated with loss of functional connectivity in the cognitive language networks.","keywords":"Adolescent Adult Brain/*physiopathology Brain Mapping Case-Control Studies Epilepsies, Partial/*physiopathology Female Humans Intelligence Intelligence Tests Language Language Disorders/*physiopathology Language Tests Magnetic Resonance Imaging Male Middle Aged Neural Pathways/physiopathology Neuropsychological Tests Reading Signal Processing, Computer-Assisted Young Adult","issn":"1526-632X (Electronic) 0028-3878 (Linking)","doi":"10.1212/WNL.0b013e3181ebdd3e","url":"http://www.ncbi.nlm.nih.gov/pubmed/20679633 https://n.neurology.org/content/75/5/395.long","year":"2010","bibtex":"@article{RN144,\n author = {Vlooswijk, M. C. and Jansen, J. F. and Majoie, H. J. and Hofman, P. A. and de Krom, M. C. and Aldenkamp, A. P. and Backes, W. H.},\n title = {Functional connectivity and language impairment in cryptogenic localization-related epilepsy},\n journal = {Neurology},\n volume = {75},\n number = {5},\n pages = {395-402},\n note = {Vlooswijk, M C G\nJansen, J F A\nMajoie, H J M\nHofman, P A M\nde Krom, M C T F M\nAldenkamp, A P\nBackes, W H\neng\nResearch Support, Non-U.S. Gov't\n2010/08/04 06:00\nNeurology. 2010 Aug 3;75(5):395-402. doi: 10.1212/WNL.0b013e3181ebdd3e.},\n abstract = {BACKGROUND: An often underestimated cognitive morbidity in patients with epilepsy is language dysfunction. To investigate the neuronal mechanisms underlying neuropsychological language impairment, activation maps and functional connectivity networks were studied by fMRI of language. METHOD: Fifty-two patients with cryptogenic localization-related epilepsy and 27 healthy controls underwent neuropsychological assessment of IQ, word fluency, and text reading. fMRI was performed with a standard covert word-generation and text-reading paradigm. Functional connectivity analysis comprised cross-correlation of signal time series of the characteristic and most strongly activated regions involved in the language tasks. RESULTS: After careful selection, 34 patients and 20 healthy controls were found eligible for analysis. Patients displayed lower IQ, lower fluency word count, and lower number of words correctly read compared to controls. fMRI activation maps did not differ significantly between patients and controls. For the word-generation paradigm, patients with epilepsy had significantly lower functional connectivity than controls in the prefrontal network. Patients performing worse on the word-fluency test demonstrated a significantly lower mean functional connectivity than controls. Text reading demonstrated lower functional connectivity in patients with epilepsy in the frontotemporal network. Similarly, lower mean functional connectivity was observed in patients with lowest reading performance compared to controls. A relation between reduced functional connectivity and performance on word-fluency and text-reading tests was demonstrated in epilepsy patients. 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