@article{RN134,
   author = {Vlooswijk, M. C. and Jansen, J. F. and Reijs, R. P. and de Krom, M. C. and Kooi, M. E. and Majoie, H. J. and Hofman, P. A. and Backes, W. H. and Aldenkamp, A. P.},
   title = {Cognitive fMRI and neuropsychological assessment in patients with secondarily generalized seizures},
   journal = {Clin Neurol Neurosurg},
   volume = {110},
   number = {5},
   pages = {441-50},
   note = {Vlooswijk, Marielle C G
Jansen, Jacobus F A
Reijs, Rianne P
de Krom, Marc C T F M
Kooi, M Eline
Majoie, H J Marian
Hofman, Paul A M
Backes, Walter H
Aldenkamp, Albert P
eng
Netherlands
2008/03/15 09:00
Clin Neurol Neurosurg. 2008 May;110(5):441-50. doi: 10.1016/j.clineuro.2008.01.007. Epub 2008 Mar 12.},
   abstract = {OBJECTIVES: Cognitive dysfunction is a frequent comorbid disorder in epilepsy which has been associated with high seizure frequency. We examined the effect of secondarily generalized tonic-clonic seizures (SGTCS) on cognitive dysfunction using neuropsychological assessment and fMRI. PATIENTS AND METHODS: Sixteen patients with localization-related epilepsy of varying etiologies and SGTCS underwent extensive neuropsychological assessment. Functional MRI was performed probing the frontal and temporal lobes with two paradigms aimed at investigating speed of mental processing and working memory. RESULTS: A high number of total lifetime SGTCS was associated with lower intelligence scores. Moreover, a trend towards cognitive decline related to the number of SGTCS was observed. A relatively increased prefrontal activation related to the number of SGTCS was demonstrated, plus a trend towards a decreased activation in the frontotemporal areas. CONCLUSION: High numbers of SGTCS are associated with a drop in intelligence scores and altered prefrontal brain activation. A shift from frontotemporal to prefrontal activation seems to have occurred, suggesting that a functional reorganization of working memory is induced by a high number of SGTCS. It remains uncertain if this reorganization reflects a compensation mechanism, or the underlying pathological processes of cognitive dysfunction.},
   keywords = {Adult
*Brain Mapping
Cognition Disorders/*complications/diagnosis
Epilepsy, Tonic-Clonic/*complications/physiopathology
Female
Frontal Lobe/physiopathology
Humans
Intelligence Tests
Linear Models
Magnetic Resonance Imaging
Male
Memory, Short-Term
Middle Aged
Neuropsychological Tests
Prefrontal Cortex/*physiopathology
Problem Solving
Seizures/*complications/physiopathology
Temporal Lobe/physiopathology},
   ISSN = {0303-8467 (Print)
0303-8467 (Linking)},
   DOI = {10.1016/j.clineuro.2008.01.007},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/18339478
https://www.sciencedirect.com/science/article/abs/pii/S030384670800019X?via%3Dihub},
   year = {2008},
   type = {Journal Article}
}

{"_id":"im7mp6KDNtZ7AdP4S","bibbaseid":"vlooswijk-jansen-reijs-dekrom-kooi-majoie-hofman-backes-etal-cognitivefmriandneuropsychologicalassessmentinpatientswithsecondarilygeneralizedseizures-2008","downloads":0,"creationDate":"2017-09-02T18:10:13.579Z","title":"Cognitive fMRI and neuropsychological assessment in patients with secondarily generalized seizures","author_short":["Vlooswijk, M. C.","Jansen, J. F.","Reijs, R. P.","de Krom, M. C.","Kooi, M. E.","Majoie, H. J.","Hofman, P. A.","Backes, W. H.","Aldenkamp, A. P."],"year":2008,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Vlooswijk"],"firstnames":["M.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Reijs"],"firstnames":["R.","P."],"suffixes":[]},{"propositions":["de"],"lastnames":["Krom"],"firstnames":["M.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Kooi"],"firstnames":["M.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Majoie"],"firstnames":["H.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]}],"title":"Cognitive fMRI and neuropsychological assessment in patients with secondarily generalized seizures","journal":"Clin Neurol Neurosurg","volume":"110","number":"5","pages":"441-50","note":"Vlooswijk, Marielle C G Jansen, Jacobus F A Reijs, Rianne P de Krom, Marc C T F M Kooi, M Eline Majoie, H J Marian Hofman, Paul A M Backes, Walter H Aldenkamp, Albert P eng Netherlands 2008/03/15 09:00 Clin Neurol Neurosurg. 2008 May;110(5):441-50. doi: 10.1016/j.clineuro.2008.01.007. Epub 2008 Mar 12.","abstract":"OBJECTIVES: Cognitive dysfunction is a frequent comorbid disorder in epilepsy which has been associated with high seizure frequency. We examined the effect of secondarily generalized tonic-clonic seizures (SGTCS) on cognitive dysfunction using neuropsychological assessment and fMRI. PATIENTS AND METHODS: Sixteen patients with localization-related epilepsy of varying etiologies and SGTCS underwent extensive neuropsychological assessment. Functional MRI was performed probing the frontal and temporal lobes with two paradigms aimed at investigating speed of mental processing and working memory. RESULTS: A high number of total lifetime SGTCS was associated with lower intelligence scores. Moreover, a trend towards cognitive decline related to the number of SGTCS was observed. A relatively increased prefrontal activation related to the number of SGTCS was demonstrated, plus a trend towards a decreased activation in the frontotemporal areas. CONCLUSION: High numbers of SGTCS are associated with a drop in intelligence scores and altered prefrontal brain activation. A shift from frontotemporal to prefrontal activation seems to have occurred, suggesting that a functional reorganization of working memory is induced by a high number of SGTCS. It remains uncertain if this reorganization reflects a compensation mechanism, or the underlying pathological processes of cognitive dysfunction.","keywords":"Adult *Brain Mapping Cognition Disorders/*complications/diagnosis Epilepsy, Tonic-Clonic/*complications/physiopathology Female Frontal Lobe/physiopathology Humans Intelligence Tests Linear Models Magnetic Resonance Imaging Male Memory, Short-Term Middle Aged Neuropsychological Tests Prefrontal Cortex/*physiopathology Problem Solving Seizures/*complications/physiopathology Temporal Lobe/physiopathology","issn":"0303-8467 (Print) 0303-8467 (Linking)","doi":"10.1016/j.clineuro.2008.01.007","url":"http://www.ncbi.nlm.nih.gov/pubmed/18339478 https://www.sciencedirect.com/science/article/abs/pii/S030384670800019X?via%3Dihub","year":"2008","bibtex":"@article{RN134,\n author = {Vlooswijk, M. C. and Jansen, J. F. and Reijs, R. P. and de Krom, M. C. and Kooi, M. E. and Majoie, H. J. and Hofman, P. A. and Backes, W. H. and Aldenkamp, A. P.},\n title = {Cognitive fMRI and neuropsychological assessment in patients with secondarily generalized seizures},\n journal = {Clin Neurol Neurosurg},\n volume = {110},\n number = {5},\n pages = {441-50},\n note = {Vlooswijk, Marielle C G\nJansen, Jacobus F A\nReijs, Rianne P\nde Krom, Marc C T F M\nKooi, M Eline\nMajoie, H J Marian\nHofman, Paul A M\nBackes, Walter H\nAldenkamp, Albert P\neng\nNetherlands\n2008/03/15 09:00\nClin Neurol Neurosurg. 2008 May;110(5):441-50. doi: 10.1016/j.clineuro.2008.01.007. Epub 2008 Mar 12.},\n abstract = {OBJECTIVES: Cognitive dysfunction is a frequent comorbid disorder in epilepsy which has been associated with high seizure frequency. We examined the effect of secondarily generalized tonic-clonic seizures (SGTCS) on cognitive dysfunction using neuropsychological assessment and fMRI. PATIENTS AND METHODS: Sixteen patients with localization-related epilepsy of varying etiologies and SGTCS underwent extensive neuropsychological assessment. Functional MRI was performed probing the frontal and temporal lobes with two paradigms aimed at investigating speed of mental processing and working memory. RESULTS: A high number of total lifetime SGTCS was associated with lower intelligence scores. Moreover, a trend towards cognitive decline related to the number of SGTCS was observed. A relatively increased prefrontal activation related to the number of SGTCS was demonstrated, plus a trend towards a decreased activation in the frontotemporal areas. CONCLUSION: High numbers of SGTCS are associated with a drop in intelligence scores and altered prefrontal brain activation. A shift from frontotemporal to prefrontal activation seems to have occurred, suggesting that a functional reorganization of working memory is induced by a high number of SGTCS. It remains uncertain if this reorganization reflects a compensation mechanism, or the underlying pathological processes of cognitive dysfunction.},\n keywords = {Adult\n*Brain Mapping\nCognition Disorders/*complications/diagnosis\nEpilepsy, Tonic-Clonic/*complications/physiopathology\nFemale\nFrontal Lobe/physiopathology\nHumans\nIntelligence Tests\nLinear Models\nMagnetic Resonance Imaging\nMale\nMemory, Short-Term\nMiddle Aged\nNeuropsychological Tests\nPrefrontal Cortex/*physiopathology\nProblem Solving\nSeizures/*complications/physiopathology\nTemporal Lobe/physiopathology},\n ISSN = {0303-8467 (Print)\n0303-8467 (Linking)},\n DOI = {10.1016/j.clineuro.2008.01.007},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/18339478\nhttps://www.sciencedirect.com/science/article/abs/pii/S030384670800019X?via%3Dihub},\n year = {2008},\n type = {Journal Article}\n}\n\n","author_short":["Vlooswijk, M. C.","Jansen, J. F.","Reijs, R. P.","de Krom, M. C.","Kooi, M. E.","Majoie, H. J.","Hofman, P. 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