@article{voelkl_reproducibility_2020,
	title = {Reproducibility of animal research in light of biological variation},
	volume = {21},
	copyright = {2020 Springer Nature Limited},
	issn = {1471-0048},
	url = {https://www.nature.com/articles/s41583-020-0313-3},
	doi = {10/ggzqdk},
	abstract = {Context-dependent biological variation presents a unique challenge to the reproducibility of results in experimental animal research, because organisms’ responses to experimental treatments can vary with both genotype and environmental conditions. In March 2019, experts in animal biology, experimental design and statistics convened in Blonay, Switzerland, to discuss strategies addressing this challenge. In contrast to the current gold standard of rigorous standardization in experimental animal research, we recommend the use of systematic heterogenization of study samples and conditions by actively incorporating biological variation into study design through diversifying study samples and conditions. Here we provide the scientific rationale for this approach in the hope that researchers, regulators, funders and editors can embrace this paradigm shift. We also present a road map towards better practices in view of improving the reproducibility of animal research.},
	language = {en},
	number = {7},
	urldate = {2020-08-13},
	journal = {Nature Reviews Neuroscience},
	author = {Voelkl, Bernhard and Altman, Naomi S. and Forsman, Anders and Forstmeier, Wolfgang and Gurevitch, Jessica and Jaric, Ivana and Karp, Natasha A. and Kas, Martien J. and Schielzeth, Holger and Van de Casteele, Tom and Würbel, Hanno},
	month = jul,
	year = {2020},
	note = {Number: 7
Publisher: Nature Publishing Group},
	keywords = {Domie-biblio-FE, G-modeles, LASbiblio, LASmodeles, LASstat-design, NC3Rs-SyRF-EDA-ARRIVE-quality},
	pages = {384--393},
}

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In March 2019, experts in animal biology, experimental design and statistics convened in Blonay, Switzerland, to discuss strategies addressing this challenge. In contrast to the current gold standard of rigorous standardization in experimental animal research, we recommend the use of systematic heterogenization of study samples and conditions by actively incorporating biological variation into study design through diversifying study samples and conditions. Here we provide the scientific rationale for this approach in the hope that researchers, regulators, funders and editors can embrace this paradigm shift. 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In March 2019, experts in animal biology, experimental design and statistics convened in Blonay, Switzerland, to discuss strategies addressing this challenge. In contrast to the current gold standard of rigorous standardization in experimental animal research, we recommend the use of systematic heterogenization of study samples and conditions by actively incorporating biological variation into study design through diversifying study samples and conditions. Here we provide the scientific rationale for this approach in the hope that researchers, regulators, funders and editors can embrace this paradigm shift. 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