Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. Vos, M., Verduyn, S., Gorgels, A., Lipcsei, G., & Wellens, H. j-C, 91(3):864--72, 1995. bibtex @Article{RSM:Vos95,
author = "M.A. Vos and S.C. Verduyn and A.P. Gorgels and G.C.
Lipcsei and H.J. Wellens",
title = "Reproducible induction of early afterdepolarizations
and torsade de pointes arrhythmias by d-sotalol and
pacing in dogs with chronic atrioventricular block",
journal = j-C,
year = "1995",
volume = "91",
number = "3",
pages = "864--72",
robnote = "It was the purpose of this study to create an animal
model with a high incidence of reproducible TdP that
occurs under clinically relevant circumstances.
Experiments were performed in anesthetized dogs that
had been in chronic atrioventricular block for 9 +/- 6
weeks. TdP inducibility was attempted using different
pacing modes before and after the administration of 2
mg/kg d-sotalol. d-Sotalol increased the cycle length
of the idioventricular rhythm (1475 +/- 460 to 1730 +/-
570 ms, P < .01) and the QT time (390 +/- 65 to 480 +/-
85 ms, P < .01). In 10\% of the experiments, spontaneous
TdP occurred after d- sotalol. Our animal model shows a
high incidence of reproducible acquired TdP
arrhythmias, allowing study of the mechanism and
treatment of TdP. TdP induction was related to the
combination of a slow ventricular rate, the
prolongation of QT time, a sudden induced rate change
that often required two or more cycle length changes,
and the presence of early afterdepolarizations. LQTS.",
}
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