@article{
 title = {Peripheral adiponectin levels in anxiety, mood, trauma- and stressor-related disorders: A systematic review and meta-analysis},
 type = {article},
 year = {2020},
 identifiers = {[object Object]},
 keywords = {Adiponectin,Anxiety,Depression,Mood disorders,Post-traumatic stress disorder,Trauma},
 pages = {372-409},
 volume = {260},
 websites = {https://doi.org/10.1016/j.jad.2019.09.050},
 publisher = {Elsevier B.V.},
 id = {85a4de12-dc59-3dcf-801b-c5d9807ace02},
 created = {2020-09-17T09:27:45.817Z},
 file_attached = {false},
 profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},
 group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},
 last_modified = {2020-09-17T09:27:45.817Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 private_publication = {false},
 abstract = {Background: Anxiety, mood, trauma- and stressor-related disorders confer increased risk for metabolic disease. Adiponectin, a cytokine released by adipose tissue is associated with these disorders and obesity via inflammatory processes. Available data describing associations with mental disorders remain limited and conflicted. Methods: A systematic search was conducted for English, peer-reviewed articles from inception until February 2019 that assessed for serum or plasma adiponectin levels in adults with an anxiety, mood or trauma-related disorder. Diagnoses were determined by psychiatric interview, based on DSM-IV, DSM-5 or ICD-10 criteria. Analyses were performed using STATA 15 and Standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size of meta-analysis studies. Results: In total 65 eligible studies were included in the systematic review and 30 studies in this meta-analysis. 19,178 participants (11,262 females and 7916 males), comprising healthy adults and adults with anxiety, mood and trauma-related disorders, were included. Overall results indicated an inverse association between adiponectin levels and examined mental disorders. Specifically, patients with an anxiety disorder (SMD = −1.18 µg/mL, 95% CI, −2.34; −0.01, p = 0.047); trauma or stressor-related disorder (SMD = −0.34 µg/mL, 95% CI, −0.52; −0.17, p = 0.0000) or bipolar disorder (SMD = −0.638 µg/mL, 95% CI, −1.16, −0.12, p = 0.017) had significant lower adiponectin levels compared to healthy adults. Limitations: Heterogeneity, potential publication bias, and lack of control for important potential confounders were significant limitations. Conclusion: Peripheral adiponectin levels appear to be inversely associated with anxiety, mood, trauma- and stressor related disorders and may be a promising biomarker for diagnosis and disease monitoring.},
 bibtype = {article},
 author = {Vuong, E. and Nothling, J. and Lombard, C. and Jewkes, R. and Peer, N. and Abrahams, N. and Seedat, S.},
 journal = {Journal of Affective Disorders},
 number = {July 2019}
}

{"_id":"WprgXdXmZJGGwSf7E","bibbaseid":"vuong-nothling-lombard-jewkes-peer-abrahams-seedat-peripheraladiponectinlevelsinanxietymoodtraumaandstressorrelateddisordersasystematicreviewandmetaanalysis-2020","authorIDs":[],"author_short":["Vuong, E.","Nothling, J.","Lombard, C.","Jewkes, R.","Peer, N.","Abrahams, N.","Seedat, S."],"bibdata":{"title":"Peripheral adiponectin levels in anxiety, mood, trauma- and stressor-related disorders: A systematic review and meta-analysis","type":"article","year":"2020","identifiers":"[object Object]","keywords":"Adiponectin,Anxiety,Depression,Mood disorders,Post-traumatic stress disorder,Trauma","pages":"372-409","volume":"260","websites":"https://doi.org/10.1016/j.jad.2019.09.050","publisher":"Elsevier B.V.","id":"85a4de12-dc59-3dcf-801b-c5d9807ace02","created":"2020-09-17T09:27:45.817Z","file_attached":false,"profile_id":"20f87055-ac78-3c65-9cf5-216a3558d16a","group_id":"14ca8526-77d5-34fd-89de-e48cae5e6ee2","last_modified":"2020-09-17T09:27:45.817Z","read":false,"starred":false,"authored":false,"confirmed":"true","hidden":false,"private_publication":false,"abstract":"Background: Anxiety, mood, trauma- and stressor-related disorders confer increased risk for metabolic disease. Adiponectin, a cytokine released by adipose tissue is associated with these disorders and obesity via inflammatory processes. Available data describing associations with mental disorders remain limited and conflicted. Methods: A systematic search was conducted for English, peer-reviewed articles from inception until February 2019 that assessed for serum or plasma adiponectin levels in adults with an anxiety, mood or trauma-related disorder. Diagnoses were determined by psychiatric interview, based on DSM-IV, DSM-5 or ICD-10 criteria. Analyses were performed using STATA 15 and Standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size of meta-analysis studies. Results: In total 65 eligible studies were included in the systematic review and 30 studies in this meta-analysis. 19,178 participants (11,262 females and 7916 males), comprising healthy adults and adults with anxiety, mood and trauma-related disorders, were included. Overall results indicated an inverse association between adiponectin levels and examined mental disorders. Specifically, patients with an anxiety disorder (SMD = −1.18 µg/mL, 95% CI, −2.34; −0.01, p = 0.047); trauma or stressor-related disorder (SMD = −0.34 µg/mL, 95% CI, −0.52; −0.17, p = 0.0000) or bipolar disorder (SMD = −0.638 µg/mL, 95% CI, −1.16, −0.12, p = 0.017) had significant lower adiponectin levels compared to healthy adults. Limitations: Heterogeneity, potential publication bias, and lack of control for important potential confounders were significant limitations. Conclusion: Peripheral adiponectin levels appear to be inversely associated with anxiety, mood, trauma- and stressor related disorders and may be a promising biomarker for diagnosis and disease monitoring.","bibtype":"article","author":"Vuong, E. and Nothling, J. and Lombard, C. and Jewkes, R. and Peer, N. and Abrahams, N. and Seedat, S.","journal":"Journal of Affective Disorders","number":"July 2019","bibtex":"@article{\n title = {Peripheral adiponectin levels in anxiety, mood, trauma- and stressor-related disorders: A systematic review and meta-analysis},\n type = {article},\n year = {2020},\n identifiers = {[object Object]},\n keywords = {Adiponectin,Anxiety,Depression,Mood disorders,Post-traumatic stress disorder,Trauma},\n pages = {372-409},\n volume = {260},\n websites = {https://doi.org/10.1016/j.jad.2019.09.050},\n publisher = {Elsevier B.V.},\n id = {85a4de12-dc59-3dcf-801b-c5d9807ace02},\n created = {2020-09-17T09:27:45.817Z},\n file_attached = {false},\n profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},\n group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},\n last_modified = {2020-09-17T09:27:45.817Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n private_publication = {false},\n abstract = {Background: Anxiety, mood, trauma- and stressor-related disorders confer increased risk for metabolic disease. Adiponectin, a cytokine released by adipose tissue is associated with these disorders and obesity via inflammatory processes. Available data describing associations with mental disorders remain limited and conflicted. Methods: A systematic search was conducted for English, peer-reviewed articles from inception until February 2019 that assessed for serum or plasma adiponectin levels in adults with an anxiety, mood or trauma-related disorder. Diagnoses were determined by psychiatric interview, based on DSM-IV, DSM-5 or ICD-10 criteria. Analyses were performed using STATA 15 and Standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size of meta-analysis studies. Results: In total 65 eligible studies were included in the systematic review and 30 studies in this meta-analysis. 19,178 participants (11,262 females and 7916 males), comprising healthy adults and adults with anxiety, mood and trauma-related disorders, were included. Overall results indicated an inverse association between adiponectin levels and examined mental disorders. Specifically, patients with an anxiety disorder (SMD = −1.18 µg/mL, 95% CI, −2.34; −0.01, p = 0.047); trauma or stressor-related disorder (SMD = −0.34 µg/mL, 95% CI, −0.52; −0.17, p = 0.0000) or bipolar disorder (SMD = −0.638 µg/mL, 95% CI, −1.16, −0.12, p = 0.017) had significant lower adiponectin levels compared to healthy adults. Limitations: Heterogeneity, potential publication bias, and lack of control for important potential confounders were significant limitations. 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