@article{Waalewijn2023,
abstract = {Background There are few pharmacokinetic data of tenofovir alafenamide fumarate (TAF) in children. We evaluated the pharmacokinetics of TAF and tenofovir in a subset of African children enrolled in the CHAPAS-4-trial (ISRCTN22964075). Methods Children with HIV infection aged 3-15 years failing first-line antiretroviral therapy (ART) were randomised to emtricitabine/TAF versus standard-of-care nucleoside reverse transcriptase inhibitor combination, plus dolutegravir, atazanavir/ritonavir, darunavir/ritonavir, or lopinavir/ritonavir. Daily emtricitabine/TAF was dosed according to WHO-recommended weight bands: 120/15mg in children weighing 14-{\textless}-25kg and 200/25mg in those ≥25kg, regardless of anchor drug in the combination.At steady state, 8-9 blood samples were taken to construct pharmacokinetic curves. Geometric mean (GM) area under the concentration-time curve (AUC) and the maximum concentration (Cmax) were calculated for TAF and tenofovir and compared to reference exposures in adults taking 25mg TAF with/without a boosted PI. Results Pharmacokinetic results from 104 children taking TAF were analysed. GM(CV{\%}) TAF AUClast when combined with dolutegravir (n=18), darunavir/ritonavir (n=34) or lopinavir/ritonavir (n=20) were 284.5(79), 232.0(61), and 210.2(98) ng*h/mL, respectively, and were comparable to adult reference values. When combined with atazanavir/ritonavir (n=32), TAF AUClast increased to 511.4(68) ng*h/mL. For each combination, tenofovir GM(CV{\%}) AUCtau and Cmax remained below reference values in adults taking 25mg TAF with a boosted PI. Conclusions In children, TAF combined with boosted PIs or dolutegravir and dosed according to WHO-recommended weight bands provides TAF and tenofovir concentrations previously demonstrated to be well tolerated and effective in adults. These data provide the first evidence for use of these combinations in African children.},
author = {Waalewijn, Hylke and Szubert, Alexander J and Wasmann, Roeland E and Wiesner, Lubbe and Chabala, Chishala and Bwakura-Dangarembizi, Mutsa and Makumbi, Shafic and Nangiya, Joan and Mumbiro, Vivian and Mulenga, Veronica and Musiime, Victor and Monkiewicz, Lara N and Griffiths, Anna L and Bamford, Alasdair and Doerholt, Katja and Denti, Paolo and Burger, David M and Gibb, Diana M and McIlleron, Helen M and Colbers, Angela and trial Team, the CHAPAS-4 and {Di Gibb}, Di Gibb and Walker, Sarah and Turkova, Anna and Shakeshaft, Clare and Spyer, Moira and Thomason, Margaret and Griffiths, Anna and Monkiewicz, Lara and Massingham, Sue and Szubert, Alex and Bamford, Alasdair and Doerholt, Katja and Bigault, Amanda and Dudakia, Nimisha and South, Annabelle and {Van Looy}, Nadine and Au, Carly and Sweeney, Hannah and Kityo, Cissy M and Musiime, Victor and Natukunda, Eva and Nambi, Esether and Antonia, Diana Rutebarika and Nazzinda, Rashida and Namyalo, Imelda and Nangiya, Joan and Nabeeta, Lilian and Nakalyango, Aidah and Kobusingye, Lilian and Otike, Caroline and Namala, Winnie and Ampaire, Phionah and Edgar, Ayesiga and Nasaazi, Claire and Ndigendawani, Milly and Ociti, Paul and Kyobutungi, Priscilla and Mbabazi, Ritah and Rubondo, Phyllis Mwesigwa and Ankunda, Juliet and Naabalamba, Mariam and Nannungi, Mary and Musiime, Alex and Mbasani, Faith and Louis, Babu Enoch and Namusanje, Josephine and Odoch, Denis and Bagirigomwa, Edward and Rubanga, Eddie and Mulima, Disan and Oronon, Paul and Williams, Eram David and Baliruno, David and Kobusingye, Josephine and Uyungrwoth, Agnes and Mukanza, Barbara and Okello, Jimmy and Ninsiima, Emily and Ezra, Lutaro and Nambi, Christine and Mangadalen, Nansaigi and Sharif, Musumba and Serunjogi, Nobert B and Thomas, Otim and Lugemwa, Abbas and Makumbi, Shafic and Musumba, Sharif and Mawejje, Edward and Yawe, Ibrahim and Kyomuhendo, Linda Jovia and Kasozi, Mariam and Ankunda, Rogers and Kariisa, Samson and Inyakuwa, Christine and Ninsiima, Emily and Atwine, Lorna and Tumusiime, Beatrice and Ahuura, John and Tukwasibwe, Deogracious and Nagasha, Violet and Kukundakwe, Judith and Nakisekka, Mariam Zahara and Nambejja, Ritah Winnie and Tukamushaba, Mercy and Baker, Rubinga and Keminyeto, Edridah and Ainebyoona, Barbara and Myalo, Sula and Acen, Juliet and Wangwe, Nicholas Jinta and Natuhurira, Ian and Natukunatsa, Gershom Kananura and Mulenga, Veronica and Chabala, Chishala and Lungu, Joyce Chipili and Kapasa, Monica and Zyambo, Khonzya and Zimba, Kevin and Zangata, Dorothy and Shingalili, Ellen and Mumba, Naomi and Kaonga, Nayunda and Kabesha, Mukumbi and Mwenechanya, Oliver and Chipoya, Terrence and Manakalanga, Friday and Malama, Stephen and Chola, Daniel and Nduna, Bwendo and Mwamabazi, Mwate and Banda, Kabwe and Kabamba, Beatrice and Inambao, Muleya and Mukandila, Pauline Mahy and Nachamba, Mwizukanji and Himabala, Stella and Ngosa, Shadrick and Sondashi, Davies and Banda, Collins and Munyangabe, Mark and Ngoma, Grace Mbewe and Chimfwembe, Sarah and Malasha, Mercy Lukonde and Kajimalwendo, Mumba and Musukwa, Henry and Mumba, Shadrick and Hakim, James and Bwakura-Dangarembizi, Mutsa and Nathoo, Kusum and Kamuzungu, Taneal and Chidziva, Ennie and Bhiri, Joyline and Choga, Joshua and Mujuru, Hilda Angela and Musoro, Godfrey and Mumbiro, Vivian and Chitsamatanga, Moses and Mutata, Constantine and Zimunhu, Rudo and Mudzingwa, Shepherd and Gondo, Secrecy and Moyo, Columbus and Nhema, Ruth and Boyd, Kathryn and Matimba, Farai and Kouamou, Vinie and Matarise, Richard and Tangwena, Zorodzai and Mudzviti, Taona and Matubu, Allen and Kateta, Alfred and Chinembiri, Victor and Mukura, Dorinda and Chimanzi, Joy and Murungu, Dorothy and Mapfumo, Wendy and Ngwaru, Pia and Chivere, Lynette and Dube, Prosper and Mukanganiki, Trust and Weza, Sibusisiwe and Gwenzi, Tsitsi and Mutsai, Shirley and Phiri, Misheck and Ndlovu, Makhosonke and Gwaze, Tapiwa and Chitongo, Stuart and Njaravani, Winisayi and Musarurwa, Sandra and Langa, Cleopatra and Tafeni, Sue and Ishemunyoro, Wilbert and Mudzimirema, Nathalie and Ndebele, Wedu and Nyathi, Mary and Siziba, Grace and Tawodzera, Getrude and Makuchete, Tracey and Chidarura, Takudzwa and Murangandi, Shingaidzo and Mafaro, Lawrence and Chivima, Owen and Dumani, Sifiso and Mampondo, Beaullar and Maphosa, Constance and Mwale, Debra and Dhlamini, Rangarirai and Sibanda, Thabani and Madubeko, Nobukhosi and Nyathi, Silibaziso and Matiwaza, Zibusiso and Nabukenya, Sylvia and Tibakabikoba, Harriet and Nakalanzi, Sarah and Williams, Cynthia and Chandiwana, Precious and Gozhora, Winnie and Dube, Benedictor and Mulambo, Sylvia and Mwanyungwi, Hope and Burger, David and Colbers, Angela and Waalewijn, Hylke and Bevers, Lisanne and Mohsenian-Naghani, Shaghayegh and McIlleron, Helen and Norman, Jennifer and Wiesner, Lubbe and Wasmann, Roeland and Denti, Paolo and Galileya, Lufina Tsirizani and Natukunda, Eva and Musiime, Victor and Musoke, Phillipa and Revill, Paul and Walker, Simon and Kekitiinwa, Adeodata and Mushavi, Angela and Kawamya, Febby Banda and Tindyebwa, Denis and Lyall, Hermione and Weller, Ian and Peto, Tim and Musoke, Philippa and Siwale, Margaret and Kambarami, Rose and Roth, Johanna and Beattie, Pauline},
doi = {10.1093/CID/CIAD267},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Waalewijn et al. - 2023 - First pharmacokinetic data of tenofovir alafenamide fumarate and tenofovir with dolutegravir or boosted protea.pdf:pdf},
journal = {Clinical Infectious Diseases},
keywords = {Children,Drug-interaction,HIV,OA,OA{\_}PMC,Pharmacokinetics,TAF,fund{\_}not{\_}ack,original},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}not{\_}ack,original},
number = {6},
pages = {875--882},
pmid = {37315296},
title = {{First pharmacokinetic data of tenofovir alafenamide fumarate and tenofovir with dolutegravir or boosted protease inhibitors in African children: a substudy of the CHAPAS-4 trial}},
url = {https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad267/7158422},
volume = {77},
year = {2023}
}

{"_id":"kHTk3zqQ4ywFarFKN","bibbaseid":"waalewijn-szubert-wasmann-wiesner-chabala-bwakuradangarembizi-makumbi-nangiya-etal-firstpharmacokineticdataoftenofoviralafenamidefumarateandtenofovirwithdolutegravirorboostedproteaseinhibitorsinafricanchildrenasubstudyofthechapas4trial-2023","author_short":["Waalewijn, H.","Szubert, A. J","Wasmann, R. E","Wiesner, L.","Chabala, C.","Bwakura-Dangarembizi, M.","Makumbi, S.","Nangiya, J.","Mumbiro, V.","Mulenga, V.","Musiime, V.","Monkiewicz, L. N","Griffiths, A. L","Bamford, A.","Doerholt, K.","Denti, P.","Burger, D. M","Gibb, D. M","McIlleron, H. M","Colbers, A.","trial Team, t. C.","Di Gibb, D. G.","Walker, S.","Turkova, A.","Shakeshaft, C.","Spyer, M.","Thomason, M.","Griffiths, A.","Monkiewicz, L.","Massingham, S.","Szubert, A.","Bamford, A.","Doerholt, K.","Bigault, A.","Dudakia, N.","South, A.","Van Looy, N.","Au, C.","Sweeney, H.","Kityo, C. M","Musiime, V.","Natukunda, E.","Nambi, E.","Antonia, D. R.","Nazzinda, R.","Namyalo, I.","Nangiya, J.","Nabeeta, L.","Nakalyango, A.","Kobusingye, L.","Otike, C.","Namala, W.","Ampaire, P.","Edgar, A.","Nasaazi, C.","Ndigendawani, M.","Ociti, P.","Kyobutungi, P.","Mbabazi, R.","Rubondo, P. M.","Ankunda, J.","Naabalamba, M.","Nannungi, M.","Musiime, A.","Mbasani, F.","Louis, B. E.","Namusanje, J.","Odoch, D.","Bagirigomwa, E.","Rubanga, E.","Mulima, D.","Oronon, P.","Williams, E. D.","Baliruno, D.","Kobusingye, J.","Uyungrwoth, A.","Mukanza, B.","Okello, J.","Ninsiima, E.","Ezra, L.","Nambi, C.","Mangadalen, N.","Sharif, M.","Serunjogi, N. B","Thomas, O.","Lugemwa, A.","Makumbi, S.","Musumba, S.","Mawejje, E.","Yawe, I.","Kyomuhendo, L. J.","Kasozi, M.","Ankunda, R.","Kariisa, S.","Inyakuwa, C.","Ninsiima, E.","Atwine, L.","Tumusiime, B.","Ahuura, J.","Tukwasibwe, D.","Nagasha, V.","Kukundakwe, J.","Nakisekka, M. Z.","Nambejja, R. W.","Tukamushaba, M.","Baker, R.","Keminyeto, E.","Ainebyoona, B.","Myalo, S.","Acen, J.","Wangwe, N. J.","Natuhurira, I.","Natukunatsa, G. K.","Mulenga, V.","Chabala, C.","Lungu, J. C.","Kapasa, M.","Zyambo, K.","Zimba, K.","Zangata, D.","Shingalili, E.","Mumba, N.","Kaonga, N.","Kabesha, M.","Mwenechanya, O.","Chipoya, T.","Manakalanga, F.","Malama, S.","Chola, D.","Nduna, B.","Mwamabazi, M.","Banda, K.","Kabamba, B.","Inambao, M.","Mukandila, P. M.","Nachamba, M.","Himabala, S.","Ngosa, S.","Sondashi, D.","Banda, C.","Munyangabe, M.","Ngoma, G. M.","Chimfwembe, S.","Malasha, M. L.","Kajimalwendo, M.","Musukwa, H.","Mumba, S.","Hakim, J.","Bwakura-Dangarembizi, M.","Nathoo, K.","Kamuzungu, T.","Chidziva, E.","Bhiri, J.","Choga, J.","Mujuru, H. A.","Musoro, G.","Mumbiro, V.","Chitsamatanga, M.","Mutata, C.","Zimunhu, R.","Mudzingwa, S.","Gondo, S.","Moyo, C.","Nhema, R.","Boyd, K.","Matimba, F.","Kouamou, V.","Matarise, R.","Tangwena, Z.","Mudzviti, T.","Matubu, A.","Kateta, A.","Chinembiri, V.","Mukura, D.","Chimanzi, J.","Murungu, D.","Mapfumo, W.","Ngwaru, P.","Chivere, L.","Dube, P.","Mukanganiki, T.","Weza, S.","Gwenzi, T.","Mutsai, S.","Phiri, M.","Ndlovu, M.","Gwaze, T.","Chitongo, S.","Njaravani, W.","Musarurwa, S.","Langa, C.","Tafeni, S.","Ishemunyoro, W.","Mudzimirema, N.","Ndebele, W.","Nyathi, M.","Siziba, G.","Tawodzera, G.","Makuchete, T.","Chidarura, T.","Murangandi, S.","Mafaro, L.","Chivima, O.","Dumani, S.","Mampondo, B.","Maphosa, C.","Mwale, D.","Dhlamini, R.","Sibanda, T.","Madubeko, N.","Nyathi, S.","Matiwaza, Z.","Nabukenya, S.","Tibakabikoba, H.","Nakalanzi, S.","Williams, C.","Chandiwana, P.","Gozhora, W.","Dube, B.","Mulambo, S.","Mwanyungwi, H.","Burger, D.","Colbers, A.","Waalewijn, H.","Bevers, L.","Mohsenian-Naghani, S.","McIlleron, H.","Norman, J.","Wiesner, L.","Wasmann, R.","Denti, P.","Galileya, L. T.","Natukunda, E.","Musiime, V.","Musoke, P.","Revill, P.","Walker, S.","Kekitiinwa, A.","Mushavi, A.","Kawamya, F. B.","Tindyebwa, D.","Lyall, H.","Weller, I.","Peto, T.","Musoke, P.","Siwale, M.","Kambarami, R.","Roth, J.","Beattie, P."],"bibdata":{"bibtype":"article","type":"article","abstract":"Background There are few pharmacokinetic data of tenofovir alafenamide fumarate (TAF) in children. We evaluated the pharmacokinetics of TAF and tenofovir in a subset of African children enrolled in the CHAPAS-4-trial (ISRCTN22964075). Methods Children with HIV infection aged 3-15 years failing first-line antiretroviral therapy (ART) were randomised to emtricitabine/TAF versus standard-of-care nucleoside reverse transcriptase inhibitor combination, plus dolutegravir, atazanavir/ritonavir, darunavir/ritonavir, or lopinavir/ritonavir. Daily emtricitabine/TAF was dosed according to WHO-recommended weight bands: 120/15mg in children weighing 14-\\textless-25kg and 200/25mg in those ≥25kg, regardless of anchor drug in the combination.At steady state, 8-9 blood samples were taken to construct pharmacokinetic curves. Geometric mean (GM) area under the concentration-time curve (AUC) and the maximum concentration (Cmax) were calculated for TAF and tenofovir and compared to reference exposures in adults taking 25mg TAF with/without a boosted PI. Results Pharmacokinetic results from 104 children taking TAF were analysed. GM(CV%) TAF AUClast when combined with dolutegravir (n=18), darunavir/ritonavir (n=34) or lopinavir/ritonavir (n=20) were 284.5(79), 232.0(61), and 210.2(98) ng*h/mL, respectively, and were comparable to adult reference values. When combined with atazanavir/ritonavir (n=32), TAF AUClast increased to 511.4(68) ng*h/mL. For each combination, tenofovir GM(CV%) AUCtau and Cmax remained below reference values in adults taking 25mg TAF with a boosted PI. Conclusions In children, TAF combined with boosted PIs or dolutegravir and dosed according to WHO-recommended weight bands provides TAF and tenofovir concentrations previously demonstrated to be well tolerated and effective in adults. These data provide the first evidence for use of these combinations in African children.","author":[{"propositions":[],"lastnames":["Waalewijn"],"firstnames":["Hylke"],"suffixes":[]},{"propositions":[],"lastnames":["Szubert"],"firstnames":["Alexander","J"],"suffixes":[]},{"propositions":[],"lastnames":["Wasmann"],"firstnames":["Roeland","E"],"suffixes":[]},{"propositions":[],"lastnames":["Wiesner"],"firstnames":["Lubbe"],"suffixes":[]},{"propositions":[],"lastnames":["Chabala"],"firstnames":["Chishala"],"suffixes":[]},{"propositions":[],"lastnames":["Bwakura-Dangarembizi"],"firstnames":["Mutsa"],"suffixes":[]},{"propositions":[],"lastnames":["Makumbi"],"firstnames":["Shafic"],"suffixes":[]},{"propositions":[],"lastnames":["Nangiya"],"firstnames":["Joan"],"suffixes":[]},{"propositions":[],"lastnames":["Mumbiro"],"firstnames":["Vivian"],"suffixes":[]},{"propositions":[],"lastnames":["Mulenga"],"firstnames":["Veronica"],"suffixes":[]},{"propositions":[],"lastnames":["Musiime"],"firstnames":["Victor"],"suffixes":[]},{"propositions":[],"lastnames":["Monkiewicz"],"firstnames":["Lara","N"],"suffixes":[]},{"propositions":[],"lastnames":["Griffiths"],"firstnames":["Anna","L"],"suffixes":[]},{"propositions":[],"lastnames":["Bamford"],"firstnames":["Alasdair"],"suffixes":[]},{"propositions":[],"lastnames":["Doerholt"],"firstnames":["Katja"],"suffixes":[]},{"propositions":[],"lastnames":["Denti"],"firstnames":["Paolo"],"suffixes":[]},{"propositions":[],"lastnames":["Burger"],"firstnames":["David","M"],"suffixes":[]},{"propositions":[],"lastnames":["Gibb"],"firstnames":["Diana","M"],"suffixes":[]},{"propositions":[],"lastnames":["McIlleron"],"firstnames":["Helen","M"],"suffixes":[]},{"propositions":[],"lastnames":["Colbers"],"firstnames":["Angela"],"suffixes":[]},{"propositions":["trial"],"lastnames":["Team"],"firstnames":["the","CHAPAS-4"],"suffixes":[]},{"propositions":[],"lastnames":["Di Gibb"],"firstnames":["Di","Gibb"],"suffixes":[]},{"propositions":[],"lastnames":["Walker"],"firstnames":["Sarah"],"suffixes":[]},{"propositions":[],"lastnames":["Turkova"],"firstnames":["Anna"],"suffixes":[]},{"propositions":[],"lastnames":["Shakeshaft"],"firstnames":["Clare"],"suffixes":[]},{"propositions":[],"lastnames":["Spyer"],"firstnames":["Moira"],"suffixes":[]},{"propositions":[],"lastnames":["Thomason"],"firstnames":["Margaret"],"suffixes":[]},{"propositions":[],"lastnames":["Griffiths"],"firstnames":["Anna"],"suffixes":[]},{"propositions":[],"lastnames":["Monkiewicz"],"firstnames":["Lara"],"suffixes":[]},{"propositions":[],"lastnames":["Massingham"],"firstnames":["Sue"],"suffixes":[]},{"propositions":[],"lastnames":["Szubert"],"firstnames":["Alex"],"suffixes":[]},{"propositions":[],"lastnames":["Bamford"],"firstnames":["Alasdair"],"suffixes":[]},{"propositions":[],"lastnames":["Doerholt"],"firstnames":["Katja"],"suffixes":[]},{"propositions":[],"lastnames":["Bigault"],"firstnames":["Amanda"],"suffixes":[]},{"propositions":[],"lastnames":["Dudakia"],"firstnames":["Nimisha"],"suffixes":[]},{"propositions":[],"lastnames":["South"],"firstnames":["Annabelle"],"suffixes":[]},{"propositions":[],"lastnames":["Van Looy"],"firstnames":["Nadine"],"suffixes":[]},{"propositions":[],"lastnames":["Au"],"firstnames":["Carly"],"suffixes":[]},{"propositions":[],"lastnames":["Sweeney"],"firstnames":["Hannah"],"suffixes":[]},{"propositions":[],"lastnames":["Kityo"],"firstnames":["Cissy","M"],"suffixes":[]},{"propositions":[],"lastnames":["Musiime"],"firstnames":["Victor"],"suffixes":[]},{"propositions":[],"lastnames":["Natukunda"],"firstnames":["Eva"],"suffixes":[]},{"propositions":[],"lastnames":["Nambi"],"firstnames":["Esether"],"suffixes":[]},{"propositions":[],"lastnames":["Antonia"],"firstnames":["Diana","Rutebarika"],"suffixes":[]},{"propositions":[],"lastnames":["Nazzinda"],"firstnames":["Rashida"],"suffixes":[]},{"propositions":[],"lastnames":["Namyalo"],"firstnames":["Imelda"],"suffixes":[]},{"propositions":[],"lastnames":["Nangiya"],"firstnames":["Joan"],"suffixes":[]},{"propositions":[],"lastnames":["Nabeeta"],"firstnames":["Lilian"],"suffixes":[]},{"propositions":[],"lastnames":["Nakalyango"],"firstnames":["Aidah"],"suffixes":[]},{"propositions":[],"lastnames":["Kobusingye"],"firstnames":["Lilian"],"suffixes":[]},{"propositions":[],"lastnames":["Otike"],"firstnames":["Caroline"],"suffixes":[]},{"propositions":[],"lastnames":["Namala"],"firstnames":["Winnie"],"suffixes":[]},{"propositions":[],"lastnames":["Ampaire"],"firstnames":["Phionah"],"suffixes":[]},{"propositions":[],"lastnames":["Edgar"],"firstnames":["Ayesiga"],"suffixes":[]},{"propositions":[],"lastnames":["Nasaazi"],"firstnames":["Claire"],"suffixes":[]},{"propositions":[],"lastnames":["Ndigendawani"],"firstnames":["Milly"],"suffixes":[]},{"propositions":[],"lastnames":["Ociti"],"firstnames":["Paul"],"suffixes":[]},{"propositions":[],"lastnames":["Kyobutungi"],"firstnames":["Priscilla"],"suffixes":[]},{"propositions":[],"lastnames":["Mbabazi"],"firstnames":["Ritah"],"suffixes":[]},{"propositions":[],"lastnames":["Rubondo"],"firstnames":["Phyllis","Mwesigwa"],"suffixes":[]},{"propositions":[],"lastnames":["Ankunda"],"firstnames":["Juliet"],"suffixes":[]},{"propositions":[],"lastnames":["Naabalamba"],"firstnames":["Mariam"],"suffixes":[]},{"propositions":[],"lastnames":["Nannungi"],"firstnames":["Mary"],"suffixes":[]},{"propositions":[],"lastnames":["Musiime"],"firstnames":["Alex"],"suffixes":[]},{"propositions":[],"lastnames":["Mbasani"],"firstnames":["Faith"],"suffixes":[]},{"propositions":[],"lastnames":["Louis"],"firstnames":["Babu","Enoch"],"suffixes":[]},{"propositions":[],"lastnames":["Namusanje"],"firstnames":["Josephine"],"suffixes":[]},{"propositions":[],"lastnames":["Odoch"],"firstnames":["Denis"],"suffixes":[]},{"propositions":[],"lastnames":["Bagirigomwa"],"firstnames":["Edward"],"suffixes":[]},{"propositions":[],"lastnames":["Rubanga"],"firstnames":["Eddie"],"suffixes":[]},{"propositions":[],"lastnames":["Mulima"],"firstnames":["Disan"],"suffixes":[]},{"propositions":[],"lastnames":["Oronon"],"firstnames":["Paul"],"suffixes":[]},{"propositions":[],"lastnames":["Williams"],"firstnames":["Eram","David"],"suffixes":[]},{"propositions":[],"lastnames":["Baliruno"],"firstnames":["David"],"suffixes":[]},{"propositions":[],"lastnames":["Kobusingye"],"firstnames":["Josephine"],"suffixes":[]},{"propositions":[],"lastnames":["Uyungrwoth"],"firstnames":["Agnes"],"suffixes":[]},{"propositions":[],"lastnames":["Mukanza"],"firstnames":["Barbara"],"suffixes":[]},{"propositions":[],"lastnames":["Okello"],"firstnames":["Jimmy"],"suffixes":[]},{"propositions":[],"lastnames":["Ninsiima"],"firstnames":["Emily"],"suffixes":[]},{"propositions":[],"lastnames":["Ezra"],"firstnames":["Lutaro"],"suffixes":[]},{"propositions":[],"lastnames":["Nambi"],"firstnames":["Christine"],"suffixes":[]},{"propositions":[],"lastnames":["Mangadalen"],"firstnames":["Nansaigi"],"suffixes":[]},{"propositions":[],"lastnames":["Sharif"],"firstnames":["Musumba"],"suffixes":[]},{"propositions":[],"lastnames":["Serunjogi"],"firstnames":["Nobert","B"],"suffixes":[]},{"propositions":[],"lastnames":["Thomas"],"firstnames":["Otim"],"suffixes":[]},{"propositions":[],"lastnames":["Lugemwa"],"firstnames":["Abbas"],"suffixes":[]},{"propositions":[],"lastnames":["Makumbi"],"firstnames":["Shafic"],"suffixes":[]},{"propositions":[],"lastnames":["Musumba"],"firstnames":["Sharif"],"suffixes":[]},{"propositions":[],"lastnames":["Mawejje"],"firstnames":["Edward"],"suffixes":[]},{"propositions":[],"lastnames":["Yawe"],"firstnames":["Ibrahim"],"suffixes":[]},{"propositions":[],"lastnames":["Kyomuhendo"],"firstnames":["Linda","Jovia"],"suffixes":[]},{"propositions":[],"lastnames":["Kasozi"],"firstnames":["Mariam"],"suffixes":[]},{"propositions":[],"lastnames":["Ankunda"],"firstnames":["Rogers"],"suffixes":[]},{"propositions":[],"lastnames":["Kariisa"],"firstnames":["Samson"],"suffixes":[]},{"propositions":[],"lastnames":["Inyakuwa"],"firstnames":["Christine"],"suffixes":[]},{"propositions":[],"lastnames":["Ninsiima"],"firstnames":["Emily"],"suffixes":[]},{"propositions":[],"lastnames":["Atwine"],"firstnames":["Lorna"],"suffixes":[]},{"propositions":[],"lastnames":["Tumusiime"],"firstnames":["Beatrice"],"suffixes":[]},{"propositions":[],"lastnames":["Ahuura"],"firstnames":["John"],"suffixes":[]},{"propositions":[],"lastnames":["Tukwasibwe"],"firstnames":["Deogracious"],"suffixes":[]},{"propositions":[],"lastnames":["Nagasha"],"firstnames":["Violet"],"suffixes":[]},{"propositions":[],"lastnames":["Kukundakwe"],"firstnames":["Judith"],"suffixes":[]},{"propositions":[],"lastnames":["Nakisekka"],"firstnames":["Mariam","Zahara"],"suffixes":[]},{"propositions":[],"lastnames":["Nambejja"],"firstnames":["Ritah","Winnie"],"suffixes":[]},{"propositions":[],"lastnames":["Tukamushaba"],"firstnames":["Mercy"],"suffixes":[]},{"propositions":[],"lastnames":["Baker"],"firstnames":["Rubinga"],"suffixes":[]},{"propositions":[],"lastnames":["Keminyeto"],"firstnames":["Edridah"],"suffixes":[]},{"propositions":[],"lastnames":["Ainebyoona"],"firstnames":["Barbara"],"suffixes":[]},{"propositions":[],"lastnames":["Myalo"],"firstnames":["Sula"],"suffixes":[]},{"propositions":[],"lastnames":["Acen"],"firstnames":["Juliet"],"suffixes":[]},{"propositions":[],"lastnames":["Wangwe"],"firstnames":["Nicholas","Jinta"],"suffixes":[]},{"propositions":[],"lastnames":["Natuhurira"],"firstnames":["Ian"],"suffixes":[]},{"propositions":[],"lastnames":["Natukunatsa"],"firstnames":["Gershom","Kananura"],"suffixes":[]},{"propositions":[],"lastnames":["Mulenga"],"firstnames":["Veronica"],"suffixes":[]},{"propositions":[],"lastnames":["Chabala"],"firstnames":["Chishala"],"suffixes":[]},{"propositions":[],"lastnames":["Lungu"],"firstnames":["Joyce","Chipili"],"suffixes":[]},{"propositions":[],"lastnames":["Kapasa"],"firstnames":["Monica"],"suffixes":[]},{"propositions":[],"lastnames":["Zyambo"],"firstnames":["Khonzya"],"suffixes":[]},{"propositions":[],"lastnames":["Zimba"],"firstnames":["Kevin"],"suffixes":[]},{"propositions":[],"lastnames":["Zangata"],"firstnames":["Dorothy"],"suffixes":[]},{"propositions":[],"lastnames":["Shingalili"],"firstnames":["Ellen"],"suffixes":[]},{"propositions":[],"lastnames":["Mumba"],"firstnames":["Naomi"],"suffixes":[]},{"propositions":[],"lastnames":["Kaonga"],"firstnames":["Nayunda"],"suffixes":[]},{"propositions":[],"lastnames":["Kabesha"],"firstnames":["Mukumbi"],"suffixes":[]},{"propositions":[],"lastnames":["Mwenechanya"],"firstnames":["Oliver"],"suffixes":[]},{"propositions":[],"lastnames":["Chipoya"],"firstnames":["Terrence"],"suffixes":[]},{"propositions":[],"lastnames":["Manakalanga"],"firstnames":["Friday"],"suffixes":[]},{"propositions":[],"lastnames":["Malama"],"firstnames":["Stephen"],"suffixes":[]},{"propositions":[],"lastnames":["Chola"],"firstnames":["Daniel"],"suffixes":[]},{"propositions":[],"lastnames":["Nduna"],"firstnames":["Bwendo"],"suffixes":[]},{"propositions":[],"lastnames":["Mwamabazi"],"firstnames":["Mwate"],"suffixes":[]},{"propositions":[],"lastnames":["Banda"],"firstnames":["Kabwe"],"suffixes":[]},{"propositions":[],"lastnames":["Kabamba"],"firstnames":["Beatrice"],"suffixes":[]},{"propositions":[],"lastnames":["Inambao"],"firstnames":["Muleya"],"suffixes":[]},{"propositions":[],"lastnames":["Mukandila"],"firstnames":["Pauline","Mahy"],"suffixes":[]},{"propositions":[],"lastnames":["Nachamba"],"firstnames":["Mwizukanji"],"suffixes":[]},{"propositions":[],"lastnames":["Himabala"],"firstnames":["Stella"],"suffixes":[]},{"propositions":[],"lastnames":["Ngosa"],"firstnames":["Shadrick"],"suffixes":[]},{"propositions":[],"lastnames":["Sondashi"],"firstnames":["Davies"],"suffixes":[]},{"propositions":[],"lastnames":["Banda"],"firstnames":["Collins"],"suffixes":[]},{"propositions":[],"lastnames":["Munyangabe"],"firstnames":["Mark"],"suffixes":[]},{"propositions":[],"lastnames":["Ngoma"],"firstnames":["Grace","Mbewe"],"suffixes":[]},{"propositions":[],"lastnames":["Chimfwembe"],"firstnames":["Sarah"],"suffixes":[]},{"propositions":[],"lastnames":["Malasha"],"firstnames":["Mercy","Lukonde"],"suffixes":[]},{"propositions":[],"lastnames":["Kajimalwendo"],"firstnames":["Mumba"],"suffixes":[]},{"propositions":[],"lastnames":["Musukwa"],"firstnames":["Henry"],"suffixes":[]},{"propositions":[],"lastnames":["Mumba"],"firstnames":["Shadrick"],"suffixes":[]},{"propositions":[],"lastnames":["Hakim"],"firstnames":["James"],"suffixes":[]},{"propositions":[],"lastnames":["Bwakura-Dangarembizi"],"firstnames":["Mutsa"],"suffixes":[]},{"propositions":[],"lastnames":["Nathoo"],"firstnames":["Kusum"],"suffixes":[]},{"propositions":[],"lastnames":["Kamuzungu"],"firstnames":["Taneal"],"suffixes":[]},{"propositions":[],"lastnames":["Chidziva"],"firstnames":["Ennie"],"suffixes":[]},{"propositions":[],"lastnames":["Bhiri"],"firstnames":["Joyline"],"suffixes":[]},{"propositions":[],"lastnames":["Choga"],"firstnames":["Joshua"],"suffixes":[]},{"propositions":[],"lastnames":["Mujuru"],"firstnames":["Hilda","Angela"],"suffixes":[]},{"propositions":[],"lastnames":["Musoro"],"firstnames":["Godfrey"],"suffixes":[]},{"propositions":[],"lastnames":["Mumbiro"],"firstnames":["Vivian"],"suffixes":[]},{"propositions":[],"lastnames":["Chitsamatanga"],"firstnames":["Moses"],"suffixes":[]},{"propositions":[],"lastnames":["Mutata"],"firstnames":["Constantine"],"suffixes":[]},{"propositions":[],"lastnames":["Zimunhu"],"firstnames":["Rudo"],"suffixes":[]},{"propositions":[],"lastnames":["Mudzingwa"],"firstnames":["Shepherd"],"suffixes":[]},{"propositions":[],"lastnames":["Gondo"],"firstnames":["Secrecy"],"suffixes":[]},{"propositions":[],"lastnames":["Moyo"],"firstnames":["Columbus"],"suffixes":[]},{"propositions":[],"lastnames":["Nhema"],"firstnames":["Ruth"],"suffixes":[]},{"propositions":[],"lastnames":["Boyd"],"firstnames":["Kathryn"],"suffixes":[]},{"propositions":[],"lastnames":["Matimba"],"firstnames":["Farai"],"suffixes":[]},{"propositions":[],"lastnames":["Kouamou"],"firstnames":["Vinie"],"suffixes":[]},{"propositions":[],"lastnames":["Matarise"],"firstnames":["Richard"],"suffixes":[]},{"propositions":[],"lastnames":["Tangwena"],"firstnames":["Zorodzai"],"suffixes":[]},{"propositions":[],"lastnames":["Mudzviti"],"firstnames":["Taona"],"suffixes":[]},{"propositions":[],"lastnames":["Matubu"],"firstnames":["Allen"],"suffixes":[]},{"propositions":[],"lastnames":["Kateta"],"firstnames":["Alfred"],"suffixes":[]},{"propositions":[],"lastnames":["Chinembiri"],"firstnames":["Victor"],"suffixes":[]},{"propositions":[],"lastnames":["Mukura"],"firstnames":["Dorinda"],"suffixes":[]},{"propositions":[],"lastnames":["Chimanzi"],"firstnames":["Joy"],"suffixes":[]},{"propositions":[],"lastnames":["Murungu"],"firstnames":["Dorothy"],"suffixes":[]},{"propositions":[],"lastnames":["Mapfumo"],"firstnames":["Wendy"],"suffixes":[]},{"propositions":[],"lastnames":["Ngwaru"],"firstnames":["Pia"],"suffixes":[]},{"propositions":[],"lastnames":["Chivere"],"firstnames":["Lynette"],"suffixes":[]},{"propositions":[],"lastnames":["Dube"],"firstnames":["Prosper"],"suffixes":[]},{"propositions":[],"lastnames":["Mukanganiki"],"firstnames":["Trust"],"suffixes":[]},{"propositions":[],"lastnames":["Weza"],"firstnames":["Sibusisiwe"],"suffixes":[]},{"propositions":[],"lastnames":["Gwenzi"],"firstnames":["Tsitsi"],"suffixes":[]},{"propositions":[],"lastnames":["Mutsai"],"firstnames":["Shirley"],"suffixes":[]},{"propositions":[],"lastnames":["Phiri"],"firstnames":["Misheck"],"suffixes":[]},{"propositions":[],"lastnames":["Ndlovu"],"firstnames":["Makhosonke"],"suffixes":[]},{"propositions":[],"lastnames":["Gwaze"],"firstnames":["Tapiwa"],"suffixes":[]},{"propositions":[],"lastnames":["Chitongo"],"firstnames":["Stuart"],"suffixes":[]},{"propositions":[],"lastnames":["Njaravani"],"firstnames":["Winisayi"],"suffixes":[]},{"propositions":[],"lastnames":["Musarurwa"],"firstnames":["Sandra"],"suffixes":[]},{"propositions":[],"lastnames":["Langa"],"firstnames":["Cleopatra"],"suffixes":[]},{"propositions":[],"lastnames":["Tafeni"],"firstnames":["Sue"],"suffixes":[]},{"propositions":[],"lastnames":["Ishemunyoro"],"firstnames":["Wilbert"],"suffixes":[]},{"propositions":[],"lastnames":["Mudzimirema"],"firstnames":["Nathalie"],"suffixes":[]},{"propositions":[],"lastnames":["Ndebele"],"firstnames":["Wedu"],"suffixes":[]},{"propositions":[],"lastnames":["Nyathi"],"firstnames":["Mary"],"suffixes":[]},{"propositions":[],"lastnames":["Siziba"],"firstnames":["Grace"],"suffixes":[]},{"propositions":[],"lastnames":["Tawodzera"],"firstnames":["Getrude"],"suffixes":[]},{"propositions":[],"lastnames":["Makuchete"],"firstnames":["Tracey"],"suffixes":[]},{"propositions":[],"lastnames":["Chidarura"],"firstnames":["Takudzwa"],"suffixes":[]},{"propositions":[],"lastnames":["Murangandi"],"firstnames":["Shingaidzo"],"suffixes":[]},{"propositions":[],"lastnames":["Mafaro"],"firstnames":["Lawrence"],"suffixes":[]},{"propositions":[],"lastnames":["Chivima"],"firstnames":["Owen"],"suffixes":[]},{"propositions":[],"lastnames":["Dumani"],"firstnames":["Sifiso"],"suffixes":[]},{"propositions":[],"lastnames":["Mampondo"],"firstnames":["Beaullar"],"suffixes":[]},{"propositions":[],"lastnames":["Maphosa"],"firstnames":["Constance"],"suffixes":[]},{"propositions":[],"lastnames":["Mwale"],"firstnames":["Debra"],"suffixes":[]},{"propositions":[],"lastnames":["Dhlamini"],"firstnames":["Rangarirai"],"suffixes":[]},{"propositions":[],"lastnames":["Sibanda"],"firstnames":["Thabani"],"suffixes":[]},{"propositions":[],"lastnames":["Madubeko"],"firstnames":["Nobukhosi"],"suffixes":[]},{"propositions":[],"lastnames":["Nyathi"],"firstnames":["Silibaziso"],"suffixes":[]},{"propositions":[],"lastnames":["Matiwaza"],"firstnames":["Zibusiso"],"suffixes":[]},{"propositions":[],"lastnames":["Nabukenya"],"firstnames":["Sylvia"],"suffixes":[]},{"propositions":[],"lastnames":["Tibakabikoba"],"firstnames":["Harriet"],"suffixes":[]},{"propositions":[],"lastnames":["Nakalanzi"],"firstnames":["Sarah"],"suffixes":[]},{"propositions":[],"lastnames":["Williams"],"firstnames":["Cynthia"],"suffixes":[]},{"propositions":[],"lastnames":["Chandiwana"],"firstnames":["Precious"],"suffixes":[]},{"propositions":[],"lastnames":["Gozhora"],"firstnames":["Winnie"],"suffixes":[]},{"propositions":[],"lastnames":["Dube"],"firstnames":["Benedictor"],"suffixes":[]},{"propositions":[],"lastnames":["Mulambo"],"firstnames":["Sylvia"],"suffixes":[]},{"propositions":[],"lastnames":["Mwanyungwi"],"firstnames":["Hope"],"suffixes":[]},{"propositions":[],"lastnames":["Burger"],"firstnames":["David"],"suffixes":[]},{"propositions":[],"lastnames":["Colbers"],"firstnames":["Angela"],"suffixes":[]},{"propositions":[],"lastnames":["Waalewijn"],"firstnames":["Hylke"],"suffixes":[]},{"propositions":[],"lastnames":["Bevers"],"firstnames":["Lisanne"],"suffixes":[]},{"propositions":[],"lastnames":["Mohsenian-Naghani"],"firstnames":["Shaghayegh"],"suffixes":[]},{"propositions":[],"lastnames":["McIlleron"],"firstnames":["Helen"],"suffixes":[]},{"propositions":[],"lastnames":["Norman"],"firstnames":["Jennifer"],"suffixes":[]},{"propositions":[],"lastnames":["Wiesner"],"firstnames":["Lubbe"],"suffixes":[]},{"propositions":[],"lastnames":["Wasmann"],"firstnames":["Roeland"],"suffixes":[]},{"propositions":[],"lastnames":["Denti"],"firstnames":["Paolo"],"suffixes":[]},{"propositions":[],"lastnames":["Galileya"],"firstnames":["Lufina","Tsirizani"],"suffixes":[]},{"propositions":[],"lastnames":["Natukunda"],"firstnames":["Eva"],"suffixes":[]},{"propositions":[],"lastnames":["Musiime"],"firstnames":["Victor"],"suffixes":[]},{"propositions":[],"lastnames":["Musoke"],"firstnames":["Phillipa"],"suffixes":[]},{"propositions":[],"lastnames":["Revill"],"firstnames":["Paul"],"suffixes":[]},{"propositions":[],"lastnames":["Walker"],"firstnames":["Simon"],"suffixes":[]},{"propositions":[],"lastnames":["Kekitiinwa"],"firstnames":["Adeodata"],"suffixes":[]},{"propositions":[],"lastnames":["Mushavi"],"firstnames":["Angela"],"suffixes":[]},{"propositions":[],"lastnames":["Kawamya"],"firstnames":["Febby","Banda"],"suffixes":[]},{"propositions":[],"lastnames":["Tindyebwa"],"firstnames":["Denis"],"suffixes":[]},{"propositions":[],"lastnames":["Lyall"],"firstnames":["Hermione"],"suffixes":[]},{"propositions":[],"lastnames":["Weller"],"firstnames":["Ian"],"suffixes":[]},{"propositions":[],"lastnames":["Peto"],"firstnames":["Tim"],"suffixes":[]},{"propositions":[],"lastnames":["Musoke"],"firstnames":["Philippa"],"suffixes":[]},{"propositions":[],"lastnames":["Siwale"],"firstnames":["Margaret"],"suffixes":[]},{"propositions":[],"lastnames":["Kambarami"],"firstnames":["Rose"],"suffixes":[]},{"propositions":[],"lastnames":["Roth"],"firstnames":["Johanna"],"suffixes":[]},{"propositions":[],"lastnames":["Beattie"],"firstnames":["Pauline"],"suffixes":[]}],"doi":"10.1093/CID/CIAD267","file":":C$\\$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Waalewijn et al. - 2023 - First pharmacokinetic data of tenofovir alafenamide fumarate and tenofovir with dolutegravir or boosted protea.pdf:pdf","journal":"Clinical Infectious Diseases","keywords":"Children,Drug-interaction,HIV,OA,OA_PMC,Pharmacokinetics,TAF,fund_not_ack,original","mendeley-tags":"OA,OA_PMC,fund_not_ack,original","number":"6","pages":"875–882","pmid":"37315296","title":"First pharmacokinetic data of tenofovir alafenamide fumarate and tenofovir with dolutegravir or boosted protease inhibitors in African children: a substudy of the CHAPAS-4 trial","url":"https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad267/7158422","volume":"77","year":"2023","bibtex":"@article{Waalewijn2023,\r\nabstract = {Background There are few pharmacokinetic data of tenofovir alafenamide fumarate (TAF) in children. We evaluated the pharmacokinetics of TAF and tenofovir in a subset of African children enrolled in the CHAPAS-4-trial (ISRCTN22964075). Methods Children with HIV infection aged 3-15 years failing first-line antiretroviral therapy (ART) were randomised to emtricitabine/TAF versus standard-of-care nucleoside reverse transcriptase inhibitor combination, plus dolutegravir, atazanavir/ritonavir, darunavir/ritonavir, or lopinavir/ritonavir. Daily emtricitabine/TAF was dosed according to WHO-recommended weight bands: 120/15mg in children weighing 14-{\\textless}-25kg and 200/25mg in those ≥25kg, regardless of anchor drug in the combination.At steady state, 8-9 blood samples were taken to construct pharmacokinetic curves. Geometric mean (GM) area under the concentration-time curve (AUC) and the maximum concentration (Cmax) were calculated for TAF and tenofovir and compared to reference exposures in adults taking 25mg TAF with/without a boosted PI. Results Pharmacokinetic results from 104 children taking TAF were analysed. GM(CV{\\%}) TAF AUClast when combined with dolutegravir (n=18), darunavir/ritonavir (n=34) or lopinavir/ritonavir (n=20) were 284.5(79), 232.0(61), and 210.2(98) ng*h/mL, respectively, and were comparable to adult reference values. When combined with atazanavir/ritonavir (n=32), TAF AUClast increased to 511.4(68) ng*h/mL. For each combination, tenofovir GM(CV{\\%}) AUCtau and Cmax remained below reference values in adults taking 25mg TAF with a boosted PI. Conclusions In children, TAF combined with boosted PIs or dolutegravir and dosed according to WHO-recommended weight bands provides TAF and tenofovir concentrations previously demonstrated to be well tolerated and effective in adults. These data provide the first evidence for use of these combinations in African children.},\r\nauthor = {Waalewijn, Hylke and Szubert, Alexander J and Wasmann, Roeland E and Wiesner, Lubbe and Chabala, Chishala and Bwakura-Dangarembizi, Mutsa and Makumbi, Shafic and Nangiya, Joan and Mumbiro, Vivian and Mulenga, Veronica and Musiime, Victor and Monkiewicz, Lara N and Griffiths, Anna L and Bamford, Alasdair and Doerholt, Katja and Denti, Paolo and Burger, David M and Gibb, Diana M and McIlleron, Helen M and Colbers, Angela and trial Team, the CHAPAS-4 and {Di Gibb}, Di Gibb and Walker, Sarah and Turkova, Anna and Shakeshaft, Clare and Spyer, Moira and Thomason, Margaret and Griffiths, Anna and Monkiewicz, Lara and Massingham, Sue and Szubert, Alex and Bamford, Alasdair and Doerholt, Katja and Bigault, Amanda and Dudakia, Nimisha and South, Annabelle and {Van Looy}, Nadine and Au, Carly and Sweeney, Hannah and Kityo, Cissy M and Musiime, Victor and Natukunda, Eva and Nambi, Esether and Antonia, Diana Rutebarika and Nazzinda, Rashida and Namyalo, Imelda and Nangiya, Joan and Nabeeta, Lilian and Nakalyango, Aidah and Kobusingye, Lilian and Otike, Caroline and Namala, Winnie and Ampaire, Phionah and Edgar, Ayesiga and Nasaazi, Claire and Ndigendawani, Milly and Ociti, Paul and Kyobutungi, Priscilla and Mbabazi, Ritah and Rubondo, Phyllis Mwesigwa and Ankunda, Juliet and Naabalamba, Mariam and Nannungi, Mary and Musiime, Alex and Mbasani, Faith and Louis, Babu Enoch and Namusanje, Josephine and Odoch, Denis and Bagirigomwa, Edward and Rubanga, Eddie and Mulima, Disan and Oronon, Paul and Williams, Eram David and Baliruno, David and Kobusingye, Josephine and Uyungrwoth, Agnes and Mukanza, Barbara and Okello, Jimmy and Ninsiima, Emily and Ezra, Lutaro and Nambi, Christine and Mangadalen, Nansaigi and Sharif, Musumba and Serunjogi, Nobert B and Thomas, Otim and Lugemwa, Abbas and Makumbi, Shafic and Musumba, Sharif and Mawejje, Edward and Yawe, Ibrahim and Kyomuhendo, Linda Jovia and Kasozi, Mariam and Ankunda, Rogers and Kariisa, Samson and Inyakuwa, Christine and Ninsiima, Emily and Atwine, Lorna and Tumusiime, Beatrice and Ahuura, John and Tukwasibwe, Deogracious and Nagasha, Violet and Kukundakwe, Judith and Nakisekka, Mariam Zahara and Nambejja, Ritah Winnie and Tukamushaba, Mercy and Baker, Rubinga and Keminyeto, Edridah and Ainebyoona, Barbara and Myalo, Sula and Acen, Juliet and Wangwe, Nicholas Jinta and Natuhurira, Ian and Natukunatsa, Gershom Kananura and Mulenga, Veronica and Chabala, Chishala and Lungu, Joyce Chipili and Kapasa, Monica and Zyambo, Khonzya and Zimba, Kevin and Zangata, Dorothy and Shingalili, Ellen and Mumba, Naomi and Kaonga, Nayunda and Kabesha, Mukumbi and Mwenechanya, Oliver and Chipoya, Terrence and Manakalanga, Friday and Malama, Stephen and Chola, Daniel and Nduna, Bwendo and Mwamabazi, Mwate and Banda, Kabwe and Kabamba, Beatrice and Inambao, Muleya and Mukandila, Pauline Mahy and Nachamba, Mwizukanji and Himabala, Stella and Ngosa, Shadrick and Sondashi, Davies and Banda, Collins and Munyangabe, Mark and Ngoma, Grace Mbewe and Chimfwembe, Sarah and Malasha, Mercy Lukonde and Kajimalwendo, Mumba and Musukwa, Henry and Mumba, Shadrick and Hakim, James and Bwakura-Dangarembizi, Mutsa and Nathoo, Kusum and Kamuzungu, Taneal and Chidziva, Ennie and Bhiri, Joyline and Choga, Joshua and Mujuru, Hilda Angela and Musoro, Godfrey and Mumbiro, Vivian and Chitsamatanga, Moses and Mutata, Constantine and Zimunhu, Rudo and Mudzingwa, Shepherd and Gondo, Secrecy and Moyo, Columbus and Nhema, Ruth and Boyd, Kathryn and Matimba, Farai and Kouamou, Vinie and Matarise, Richard and Tangwena, Zorodzai and Mudzviti, Taona and Matubu, Allen and Kateta, Alfred and Chinembiri, Victor and Mukura, Dorinda and Chimanzi, Joy and Murungu, Dorothy and Mapfumo, Wendy and Ngwaru, Pia and Chivere, Lynette and Dube, Prosper and Mukanganiki, Trust and Weza, Sibusisiwe and Gwenzi, Tsitsi and Mutsai, Shirley and Phiri, Misheck and Ndlovu, Makhosonke and Gwaze, Tapiwa and Chitongo, Stuart and Njaravani, Winisayi and Musarurwa, Sandra and Langa, Cleopatra and Tafeni, Sue and Ishemunyoro, Wilbert and Mudzimirema, Nathalie and Ndebele, Wedu and Nyathi, Mary and Siziba, Grace and Tawodzera, Getrude and Makuchete, Tracey and Chidarura, Takudzwa and Murangandi, Shingaidzo and Mafaro, Lawrence and Chivima, Owen and Dumani, Sifiso and Mampondo, Beaullar and Maphosa, Constance and Mwale, Debra and Dhlamini, Rangarirai and Sibanda, Thabani and Madubeko, Nobukhosi and Nyathi, Silibaziso and Matiwaza, Zibusiso and Nabukenya, Sylvia and Tibakabikoba, Harriet and Nakalanzi, Sarah and Williams, Cynthia and Chandiwana, Precious and Gozhora, Winnie and Dube, Benedictor and Mulambo, Sylvia and Mwanyungwi, Hope and Burger, David and Colbers, Angela and Waalewijn, Hylke and Bevers, Lisanne and Mohsenian-Naghani, Shaghayegh and McIlleron, Helen and Norman, Jennifer and Wiesner, Lubbe and Wasmann, Roeland and Denti, Paolo and Galileya, Lufina Tsirizani and Natukunda, Eva and Musiime, Victor and Musoke, Phillipa and Revill, Paul and Walker, Simon and Kekitiinwa, Adeodata and Mushavi, Angela and Kawamya, Febby Banda and Tindyebwa, Denis and Lyall, Hermione and Weller, Ian and Peto, Tim and Musoke, Philippa and Siwale, Margaret and Kambarami, Rose and Roth, Johanna and Beattie, Pauline},\r\ndoi = {10.1093/CID/CIAD267},\r\nfile = {:C$\\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Waalewijn et al. - 2023 - First pharmacokinetic data of tenofovir alafenamide fumarate and tenofovir with dolutegravir or boosted protea.pdf:pdf},\r\njournal = {Clinical Infectious Diseases},\r\nkeywords = {Children,Drug-interaction,HIV,OA,OA{\\_}PMC,Pharmacokinetics,TAF,fund{\\_}not{\\_}ack,original},\r\nmendeley-tags = {OA,OA{\\_}PMC,fund{\\_}not{\\_}ack,original},\r\nnumber = {6},\r\npages = {875--882},\r\npmid = {37315296},\r\ntitle = {{First pharmacokinetic data of tenofovir alafenamide fumarate and tenofovir with dolutegravir or boosted protease inhibitors in African children: a substudy of the CHAPAS-4 trial}},\r\nurl = {https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad267/7158422},\r\nvolume = {77},\r\nyear = {2023}\r\n}\r\n","author_short":["Waalewijn, H.","Szubert, A. J","Wasmann, R. E","Wiesner, L.","Chabala, C.","Bwakura-Dangarembizi, M.","Makumbi, S.","Nangiya, J.","Mumbiro, V.","Mulenga, V.","Musiime, V.","Monkiewicz, L. N","Griffiths, A. L","Bamford, A.","Doerholt, K.","Denti, P.","Burger, D. M","Gibb, D. M","McIlleron, H. M","Colbers, A.","trial Team, t. C.","Di Gibb, D. G.","Walker, S.","Turkova, A.","Shakeshaft, C.","Spyer, M.","Thomason, M.","Griffiths, A.","Monkiewicz, L.","Massingham, S.","Szubert, A.","Bamford, A.","Doerholt, K.","Bigault, A.","Dudakia, N.","South, A.","Van Looy, N.","Au, C.","Sweeney, H.","Kityo, C. M","Musiime, V.","Natukunda, E.","Nambi, E.","Antonia, D. R.","Nazzinda, R.","Namyalo, I.","Nangiya, J.","Nabeeta, L.","Nakalyango, A.","Kobusingye, L.","Otike, C.","Namala, W.","Ampaire, P.","Edgar, A.","Nasaazi, C.","Ndigendawani, M.","Ociti, P.","Kyobutungi, P.","Mbabazi, R.","Rubondo, P. M.","Ankunda, J.","Naabalamba, M.","Nannungi, M.","Musiime, A.","Mbasani, F.","Louis, B. E.","Namusanje, J.","Odoch, D.","Bagirigomwa, E.","Rubanga, E.","Mulima, D.","Oronon, P.","Williams, E. D.","Baliruno, D.","Kobusingye, J.","Uyungrwoth, A.","Mukanza, B.","Okello, J.","Ninsiima, E.","Ezra, L.","Nambi, C.","Mangadalen, N.","Sharif, M.","Serunjogi, N. B","Thomas, O.","Lugemwa, A.","Makumbi, S.","Musumba, S.","Mawejje, E.","Yawe, I.","Kyomuhendo, L. J.","Kasozi, M.","Ankunda, R.","Kariisa, S.","Inyakuwa, C.","Ninsiima, E.","Atwine, L.","Tumusiime, B.","Ahuura, J.","Tukwasibwe, D.","Nagasha, V.","Kukundakwe, J.","Nakisekka, M. Z.","Nambejja, R. W.","Tukamushaba, M.","Baker, R.","Keminyeto, E.","Ainebyoona, B.","Myalo, S.","Acen, J.","Wangwe, N. J.","Natuhurira, I.","Natukunatsa, G. K.","Mulenga, V.","Chabala, C.","Lungu, J. C.","Kapasa, M.","Zyambo, K.","Zimba, K.","Zangata, D.","Shingalili, E.","Mumba, N.","Kaonga, N.","Kabesha, M.","Mwenechanya, O.","Chipoya, T.","Manakalanga, F.","Malama, S.","Chola, D.","Nduna, B.","Mwamabazi, M.","Banda, K.","Kabamba, B.","Inambao, M.","Mukandila, P. M.","Nachamba, M.","Himabala, S.","Ngosa, S.","Sondashi, D.","Banda, C.","Munyangabe, M.","Ngoma, G. M.","Chimfwembe, S.","Malasha, M. L.","Kajimalwendo, M.","Musukwa, H.","Mumba, S.","Hakim, J.","Bwakura-Dangarembizi, M.","Nathoo, K.","Kamuzungu, T.","Chidziva, E.","Bhiri, J.","Choga, J.","Mujuru, H. A.","Musoro, G.","Mumbiro, V.","Chitsamatanga, M.","Mutata, C.","Zimunhu, R.","Mudzingwa, S.","Gondo, S.","Moyo, C.","Nhema, R.","Boyd, K.","Matimba, F.","Kouamou, V.","Matarise, R.","Tangwena, Z.","Mudzviti, T.","Matubu, A.","Kateta, A.","Chinembiri, V.","Mukura, D.","Chimanzi, J.","Murungu, D.","Mapfumo, W.","Ngwaru, P.","Chivere, L.","Dube, P.","Mukanganiki, T.","Weza, S.","Gwenzi, T.","Mutsai, S.","Phiri, M.","Ndlovu, M.","Gwaze, T.","Chitongo, S.","Njaravani, W.","Musarurwa, S.","Langa, C.","Tafeni, S.","Ishemunyoro, W.","Mudzimirema, N.","Ndebele, W.","Nyathi, M.","Siziba, G.","Tawodzera, G.","Makuchete, T.","Chidarura, T.","Murangandi, S.","Mafaro, L.","Chivima, O.","Dumani, S.","Mampondo, B.","Maphosa, C.","Mwale, D.","Dhlamini, R.","Sibanda, T.","Madubeko, N.","Nyathi, S.","Matiwaza, Z.","Nabukenya, S.","Tibakabikoba, H.","Nakalanzi, S.","Williams, C.","Chandiwana, P.","Gozhora, W.","Dube, B.","Mulambo, S.","Mwanyungwi, H.","Burger, D.","Colbers, A.","Waalewijn, H.","Bevers, L.","Mohsenian-Naghani, S.","McIlleron, H.","Norman, J.","Wiesner, L.","Wasmann, R.","Denti, P.","Galileya, L. T.","Natukunda, E.","Musiime, V.","Musoke, P.","Revill, P.","Walker, S.","Kekitiinwa, A.","Mushavi, A.","Kawamya, F. B.","Tindyebwa, D.","Lyall, H.","Weller, I.","Peto, T.","Musoke, P.","Siwale, M.","Kambarami, R.","Roth, J.","Beattie, P."],"key":"Waalewijn2023","id":"Waalewijn2023","bibbaseid":"waalewijn-szubert-wasmann-wiesner-chabala-bwakuradangarembizi-makumbi-nangiya-etal-firstpharmacokineticdataoftenofoviralafenamidefumarateandtenofovirwithdolutegravirorboostedproteaseinhibitorsinafricanchildrenasubstudyofthechapas4trial-2023","role":"author","urls":{"Paper":"https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad267/7158422"},"keyword":["Children","Drug-interaction","HIV","OA","OA_PMC","Pharmacokinetics","TAF","fund_not_ack","original"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://drive.google.com/uc?export=download&id=1-JLqZ7RwZ3VC2d6ErLGHAtOeMRS_7GCz","dataSources":["Krmt6gt9ktB2s6ARh"],"keywords":["children","drug-interaction","hiv","oa","oa_pmc","pharmacokinetics","taf","fund_not_ack","original"],"search_terms":["first","pharmacokinetic","data","tenofovir","alafenamide","fumarate","tenofovir","dolutegravir","boosted","protease","inhibitors","african","children","substudy","chapas","trial","waalewijn","szubert","wasmann","wiesner","chabala","bwakura-dangarembizi","makumbi","nangiya","mumbiro","mulenga","musiime","monkiewicz","griffiths","bamford","doerholt","denti","burger","gibb","mcilleron","colbers","trial team","di gibb","walker","turkova","shakeshaft","spyer","thomason","griffiths","monkiewicz","massingham","szubert","bamford","doerholt","bigault","dudakia","south","van looy","au","sweeney","kityo","musiime","natukunda","nambi","antonia","nazzinda","namyalo","nangiya","nabeeta","nakalyango","kobusingye","otike","namala","ampaire","edgar","nasaazi","ndigendawani","ociti","kyobutungi","mbabazi","rubondo","ankunda","naabalamba","nannungi","musiime","mbasani","louis","namusanje","odoch","bagirigomwa","rubanga","mulima","oronon","williams","baliruno","kobusingye","uyungrwoth","mukanza","okello","ninsiima","ezra","nambi","mangadalen","sharif","serunjogi","thomas","lugemwa","makumbi","musumba","mawejje","yawe","kyomuhendo","kasozi","ankunda","kariisa","inyakuwa","ninsiima","atwine","tumusiime","ahuura","tukwasibwe","nagasha","kukundakwe","nakisekka","nambejja","tukamushaba","baker","keminyeto","ainebyoona","myalo","acen","wangwe","natuhurira","natukunatsa","mulenga","chabala","lungu","kapasa","zyambo","zimba","zangata","shingalili","mumba","kaonga","kabesha","mwenechanya","chipoya","manakalanga","malama","chola","nduna","mwamabazi","banda","kabamba","inambao","mukandila","nachamba","himabala","ngosa","sondashi","banda","munyangabe","ngoma","chimfwembe","malasha","kajimalwendo","musukwa","mumba","hakim","bwakura-dangarembizi","nathoo","kamuzungu","chidziva","bhiri","choga","mujuru","musoro","mumbiro","chitsamatanga","mutata","zimunhu","mudzingwa","gondo","moyo","nhema","boyd","matimba","kouamou","matarise","tangwena","mudzviti","matubu","kateta","chinembiri","mukura","chimanzi","murungu","mapfumo","ngwaru","chivere","dube","mukanganiki","weza","gwenzi","mutsai","phiri","ndlovu","gwaze","chitongo","njaravani","musarurwa","langa","tafeni","ishemunyoro","mudzimirema","ndebele","nyathi","siziba","tawodzera","makuchete","chidarura","murangandi","mafaro","chivima","dumani","mampondo","maphosa","mwale","dhlamini","sibanda","madubeko","nyathi","matiwaza","nabukenya","tibakabikoba","nakalanzi","williams","chandiwana","gozhora","dube","mulambo","mwanyungwi","burger","colbers","waalewijn","bevers","mohsenian-naghani","mcilleron","norman","wiesner","wasmann","denti","galileya","natukunda","musiime","musoke","revill","walker","kekitiinwa","mushavi","kawamya","tindyebwa","lyall","weller","peto","musoke","siwale","kambarami","roth","beattie"],"title":"First pharmacokinetic data of tenofovir alafenamide fumarate and tenofovir with dolutegravir or boosted protease inhibitors in African children: a substudy of the CHAPAS-4 trial","year":2023}