@article{wag123,
	author = {Wagner, Viktoria and Kern, Fabian and Hahn, Oliver and Schaum, Nick and Ludwig, Nicole and Fehlmann, Tobias and Engel, Annika and Henn, Dominic and Rishik, Shusruto and Isakova, Alina and Tan, Michelle and Sit, Rene and Neff, Norma and Hart, Martin and Meese, Eckart and Quake, Steve and Wyss-Coray, Tony and Keller, Andreas},
	year = {2023},
	month = {04},
	abstract = "{Molecular mechanisms of organismal and cell aging remain incompletely understood. We, therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 organs at ten timepoints from 1 to 27 months) and rejuvenated mice. We found molecular aging trajectories are largely tissue-specific except for eight broadly deregulated microRNAs (miRNAs). Their individual abundance mirrors their presence in circulating plasma and extracellular vesicles (EVs) whereas tissue-specific ncRNAs were less present. For miR-29c-3p, we observe the largest correlation with aging in solid organs, plasma and EVs. In mice rejuvenated by heterochronic parabiosis, miR-29c-3p was the most prominent miRNA restored to similar levels found in young liver. miR-29c-3p targets the extracellular matrix and secretion pathways, known to be implicated in aging. We provide a map of organism-wide expression of ncRNAs with aging and rejuvenation and identify a set of broadly deregulated miRNAs, which may function as systemic regulators of aging via plasma and EVs.}",
	pages = {1-10},
	title = {Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues},
	journal = {Nature Biotechnology},
    	url = {https://doi.org/10.1038/s41587-023-01751-6},
	doi = {10.1038/s41587-023-01751-6}
}

{"_id":"omd5uqgx9Ag6GXZn4","bibbaseid":"wagner-kern-hahn-schaum-ludwig-fehlmann-engel-henn-etal-characterizingexpressionchangesinnoncodingrnasduringagingandheterochronicparabiosisacrossmousetissues-2023","author_short":["Wagner, V.","Kern, F.","Hahn, O.","Schaum, N.","Ludwig, N.","Fehlmann, T.","Engel, A.","Henn, D.","Rishik, S.","Isakova, A.","Tan, M.","Sit, R.","Neff, N.","Hart, M.","Meese, E.","Quake, S.","Wyss-Coray, T.","Keller, A."],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Wagner"],"firstnames":["Viktoria"],"suffixes":[]},{"propositions":[],"lastnames":["Kern"],"firstnames":["Fabian"],"suffixes":[]},{"propositions":[],"lastnames":["Hahn"],"firstnames":["Oliver"],"suffixes":[]},{"propositions":[],"lastnames":["Schaum"],"firstnames":["Nick"],"suffixes":[]},{"propositions":[],"lastnames":["Ludwig"],"firstnames":["Nicole"],"suffixes":[]},{"propositions":[],"lastnames":["Fehlmann"],"firstnames":["Tobias"],"suffixes":[]},{"propositions":[],"lastnames":["Engel"],"firstnames":["Annika"],"suffixes":[]},{"propositions":[],"lastnames":["Henn"],"firstnames":["Dominic"],"suffixes":[]},{"propositions":[],"lastnames":["Rishik"],"firstnames":["Shusruto"],"suffixes":[]},{"propositions":[],"lastnames":["Isakova"],"firstnames":["Alina"],"suffixes":[]},{"propositions":[],"lastnames":["Tan"],"firstnames":["Michelle"],"suffixes":[]},{"propositions":[],"lastnames":["Sit"],"firstnames":["Rene"],"suffixes":[]},{"propositions":[],"lastnames":["Neff"],"firstnames":["Norma"],"suffixes":[]},{"propositions":[],"lastnames":["Hart"],"firstnames":["Martin"],"suffixes":[]},{"propositions":[],"lastnames":["Meese"],"firstnames":["Eckart"],"suffixes":[]},{"propositions":[],"lastnames":["Quake"],"firstnames":["Steve"],"suffixes":[]},{"propositions":[],"lastnames":["Wyss-Coray"],"firstnames":["Tony"],"suffixes":[]},{"propositions":[],"lastnames":["Keller"],"firstnames":["Andreas"],"suffixes":[]}],"year":"2023","month":"04","abstract":"Molecular mechanisms of organismal and cell aging remain incompletely understood. We, therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 organs at ten timepoints from 1 to 27 months) and rejuvenated mice. We found molecular aging trajectories are largely tissue-specific except for eight broadly deregulated microRNAs (miRNAs). Their individual abundance mirrors their presence in circulating plasma and extracellular vesicles (EVs) whereas tissue-specific ncRNAs were less present. For miR-29c-3p, we observe the largest correlation with aging in solid organs, plasma and EVs. In mice rejuvenated by heterochronic parabiosis, miR-29c-3p was the most prominent miRNA restored to similar levels found in young liver. miR-29c-3p targets the extracellular matrix and secretion pathways, known to be implicated in aging. We provide a map of organism-wide expression of ncRNAs with aging and rejuvenation and identify a set of broadly deregulated miRNAs, which may function as systemic regulators of aging via plasma and EVs.","pages":"1-10","title":"Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues","journal":"Nature Biotechnology","url":"https://doi.org/10.1038/s41587-023-01751-6","doi":"10.1038/s41587-023-01751-6","bibtex":"@article{wag123,\n\tauthor = {Wagner, Viktoria and Kern, Fabian and Hahn, Oliver and Schaum, Nick and Ludwig, Nicole and Fehlmann, Tobias and Engel, Annika and Henn, Dominic and Rishik, Shusruto and Isakova, Alina and Tan, Michelle and Sit, Rene and Neff, Norma and Hart, Martin and Meese, Eckart and Quake, Steve and Wyss-Coray, Tony and Keller, Andreas},\n\tyear = {2023},\n\tmonth = {04},\n\tabstract = \"{Molecular mechanisms of organismal and cell aging remain incompletely understood. We, therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 organs at ten timepoints from 1 to 27 months) and rejuvenated mice. We found molecular aging trajectories are largely tissue-specific except for eight broadly deregulated microRNAs (miRNAs). Their individual abundance mirrors their presence in circulating plasma and extracellular vesicles (EVs) whereas tissue-specific ncRNAs were less present. For miR-29c-3p, we observe the largest correlation with aging in solid organs, plasma and EVs. In mice rejuvenated by heterochronic parabiosis, miR-29c-3p was the most prominent miRNA restored to similar levels found in young liver. miR-29c-3p targets the extracellular matrix and secretion pathways, known to be implicated in aging. We provide a map of organism-wide expression of ncRNAs with aging and rejuvenation and identify a set of broadly deregulated miRNAs, which may function as systemic regulators of aging via plasma and EVs.}\",\n\tpages = {1-10},\n\ttitle = {Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues},\n\tjournal = {Nature Biotechnology},\n \turl = {https://doi.org/10.1038/s41587-023-01751-6},\n\tdoi = {10.1038/s41587-023-01751-6}\n}\n","author_short":["Wagner, V.","Kern, F.","Hahn, O.","Schaum, N.","Ludwig, N.","Fehlmann, T.","Engel, A.","Henn, D.","Rishik, S.","Isakova, A.","Tan, M.","Sit, R.","Neff, N.","Hart, M.","Meese, E.","Quake, S.","Wyss-Coray, T.","Keller, A."],"key":"wag123","id":"wag123","bibbaseid":"wagner-kern-hahn-schaum-ludwig-fehlmann-engel-henn-etal-characterizingexpressionchangesinnoncodingrnasduringagingandheterochronicparabiosisacrossmousetissues-2023","role":"author","urls":{"Paper":"https://doi.org/10.1038/s41587-023-01751-6"},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://www.ccb.uni-saarland.de/wp-content/uploads/2024/01/references.bib_.txt","dataSources":["Pny5E4E9kc7C8gG8g","SiGP46KPWizw6ihLJ"],"keywords":[],"search_terms":["characterizing","expression","changes","noncoding","rnas","during","aging","heterochronic","parabiosis","mouse","tissues","wagner","kern","hahn","schaum","ludwig","fehlmann","engel","henn","rishik","isakova","tan","sit","neff","hart","meese","quake","wyss-coray","keller"],"title":"Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues","year":2023}