Comparing Bayesian estimates of genetic differentiation of molecular markers and quantitative traits: an application to Pinus sylvestris. Waldmann, P., García-Gil, M. R., & Sillanpää, M. J. Heredity, 94(6):623–629, June, 2005. Number: 6 Publisher: Nature Publishing Group
Comparing Bayesian estimates of genetic differentiation of molecular markers and quantitative traits: an application to Pinus sylvestris [link]Paper  doi  abstract   bibtex   
Comparison of the level of differentiation at neutral molecular markers (estimated as FST or GST) with the level of differentiation at quantitative traits (estimated as QST) has become a standard tool for inferring that there is differential selection between populations. We estimated QST of timing of bud set from a latitudinal cline of Pinus sylvestris with a Bayesian hierarchical variance component method utilizing the information on the pre-estimated population structure from neutral molecular markers. Unfortunately, the between-family variances differed substantially between populations that resulted in a bimodal posterior of QST that could not be compared in any sensible way with the unimodal posterior of the microsatellite FST. In order to avoid publishing studies with flawed QST estimates, we recommend that future studies should present heritability estimates for each trait and population. Moreover, to detect variance heterogeneity in frequentist methods (ANOVA and REML), it is of essential importance to check also that the residuals are normally distributed and do not follow any systematically deviating trends.
@article{waldmann_comparing_2005,
	title = {Comparing {Bayesian} estimates of genetic differentiation of molecular markers and quantitative traits: an application to {Pinus} sylvestris},
	volume = {94},
	copyright = {2005 The Genetics Society},
	issn = {1365-2540},
	shorttitle = {Comparing {Bayesian} estimates of genetic differentiation of molecular markers and quantitative traits},
	url = {https://www.nature.com/articles/6800672},
	doi = {10.1038/sj.hdy.6800672},
	abstract = {Comparison of the level of differentiation at neutral molecular markers (estimated as FST or GST) with the level of differentiation at quantitative traits (estimated as QST) has become a standard tool for inferring that there is differential selection between populations. We estimated QST of timing of bud set from a latitudinal cline of Pinus sylvestris with a Bayesian hierarchical variance component method utilizing the information on the pre-estimated population structure from neutral molecular markers. Unfortunately, the between-family variances differed substantially between populations that resulted in a bimodal posterior of QST that could not be compared in any sensible way with the unimodal posterior of the microsatellite FST. In order to avoid publishing studies with flawed QST estimates, we recommend that future studies should present heritability estimates for each trait and population. Moreover, to detect variance heterogeneity in frequentist methods (ANOVA and REML), it is of essential importance to check also that the residuals are normally distributed and do not follow any systematically deviating trends.},
	language = {en},
	number = {6},
	urldate = {2021-06-11},
	journal = {Heredity},
	author = {Waldmann, P. and García-Gil, M. R. and Sillanpää, M. J.},
	month = jun,
	year = {2005},
	note = {Number: 6
Publisher: Nature Publishing Group},
	pages = {623--629},
}

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