Early developmental outcome following surgery for oesophageal atresia. Walker, K., Halliday, R., Badawi, N., Stewart, J., & Holland, A. J. Journal of Paediatrics and Child Health, 49(6):467–470, June, 2013.
doi  abstract   bibtex   
AIM: To compare the developmental outcome of infants with oesophageal atresia with or without trachea-oesophageal fistula (OA/TOF) who underwent surgery in early infancy with healthy control infants in New South Wales, Australia. METHODS: Infants diagnosed with OA/TOF requiring surgical intervention were enrolled prospectively between 1 August 2006 and the 31 December 2008. Healthy control infants were enrolled in the same time period. The children underwent a developmental assessment at 1 year of age (corrected) using the Bayley Scales of Infant and Toddler Development (Version III). RESULTS: Of 34 infants with OA/TOF that were enrolled, 31 had developmental assessments. The majority (75%) were term infants (≥37 weeks gestation) with a mean birth weight of 2717 g. Fourteen infants (44%) had an associated birth defect and one infant with multiple associated anomalies subsequently died. Developmental assessments were also performed on 62 control infants matched for gestational age. Infants with OA/TOF had a mean score significantly lower on the expressive language subscale (P \textless 0.05) compared with the control infants. CONCLUSIONS: This study found a lower than expected developmental score for infants following surgery for OA/TOF in the expressive language subscale compared with the healthy control infants. These findings support concerns over the potential impact of OA/TOF and its effects on development. Further studies, including continuing developmental review to determine whether these differences persist and their functional importance, should be performed.
@article{walker_early_2013,
	title = {Early developmental outcome following surgery for oesophageal atresia},
	volume = {49},
	issn = {1440-1754},
	doi = {10.1111/jpc.12206},
	abstract = {AIM: To compare the developmental outcome of infants with oesophageal atresia with or without trachea-oesophageal fistula (OA/TOF) who underwent surgery in early infancy with healthy control infants in New South Wales, Australia.
METHODS: Infants diagnosed with OA/TOF requiring surgical intervention were enrolled prospectively between 1 August 2006 and the 31 December 2008. Healthy control infants were enrolled in the same time period. The children underwent a developmental assessment at 1 year of age (corrected) using the Bayley Scales of Infant and Toddler Development (Version III).
RESULTS: Of 34 infants with OA/TOF that were enrolled, 31 had developmental assessments. The majority (75\%) were term infants (≥37 weeks gestation) with a mean birth weight of 2717 g. Fourteen infants (44\%) had an associated birth defect and one infant with multiple associated anomalies subsequently died. Developmental assessments were also performed on 62 control infants matched for gestational age. Infants with OA/TOF had a mean score significantly lower on the expressive language subscale (P {\textless} 0.05) compared with the control infants.
CONCLUSIONS: This study found a lower than expected developmental score for infants following surgery for OA/TOF in the expressive language subscale compared with the healthy control infants. These findings support concerns over the potential impact of OA/TOF and its effects on development. Further studies, including continuing developmental review to determine whether these differences persist and their functional importance, should be performed.},
	language = {eng},
	number = {6},
	journal = {Journal of Paediatrics and Child Health},
	author = {Walker, Karen and Halliday, Robert and Badawi, Nadia and Stewart, Jan and Holland, Andrew Ja},
	month = jun,
	year = {2013},
	keywords = {Case-Control Studies, Child Development, Child Language, Developmental Disabilities, Esophageal Atresia, Humans, Infant, Prospective Studies, Tracheoesophageal Fistula, Treatment Outcome},
	pages = {467--470},
}

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