Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review. Walsh, Z., Mollaahmetoglu, O. M., Rootman, J., Golsof, S., Keeler, J., Marsh, B., Nutt, D. J., & Morgan, C. J. A. BJPsych Open, January, 2022. Publisher: Cambridge University Press![Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background In the past two decades, subanaesthetic doses of ketamine have been demonstrated to have rapid and sustained antidepressant effects, and accumulating research has demonstrated ketamine's therapeutic effects for a range of psychiatric conditions. Aims In light of these findings surrounding ketamine's psychotherapeutic potential, we systematically review the extant evidence on ketamine's effects in treating mental health disorders. Method The systematic review protocol was registered in PROSPERO (identifier CRD42019130636). Human studies investigating the therapeutic effects of ketamine in the treatment of mental health disorders were included. Because of the extensive research in depression, bipolar disorder and suicidal ideation, only systematic reviews and meta-analyses were included. We searched Medline and PsycINFO on 21 October 2020. Risk-of-bias analysis was assessed with the Cochrane Risk of Bias tools and A Measurement Tool to Assess Systematic Reviews (AMSTAR) Checklist. Results We included 83 published reports in the final review: 33 systematic reviews, 29 randomised controlled trials, two randomised trials without placebo, three non-randomised trials with controls, six open-label trials and ten retrospective reviews. The results were presented via narrative synthesis. Conclusions Systematic reviews and meta-analyses provide support for robust, rapid and transient antidepressant and anti-suicidal effects of ketamine. Evidence for other indications is less robust, but suggests similarly positive and short-lived effects. The conclusions should be interpreted with caution because of the high risk of bias of included studies. Optimal dosing, modes of administration and the most effective forms of adjunctive psychotherapeutic support should be examined further.
@article{walsh_ketamine_2022,
title = {Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review},
volume = {8},
issn = {2056-4724},
shorttitle = {Ketamine for the treatment of mental health and substance use disorders},
url = {https://www.cambridge.org/core/journals/bjpsych-open/article/ketamine-for-the-treatment-of-mental-health-and-substance-use-disorders-comprehensive-systematic-review/36E261BFA62CDA6459B88F7777415FDA},
doi = {10.1192/bjo.2021.1061},
abstract = {Background
In the past two decades, subanaesthetic doses of ketamine have been demonstrated to have rapid and sustained antidepressant effects, and accumulating research has demonstrated ketamine's therapeutic effects for a range of psychiatric conditions.
Aims
In light of these findings surrounding ketamine's psychotherapeutic potential, we systematically review the extant evidence on ketamine's effects in treating mental health disorders.
Method
The systematic review protocol was registered in PROSPERO (identifier CRD42019130636). Human studies investigating the therapeutic effects of ketamine in the treatment of mental health disorders were included. Because of the extensive research in depression, bipolar disorder and suicidal ideation, only systematic reviews and meta-analyses were included. We searched Medline and PsycINFO on 21 October 2020. Risk-of-bias analysis was assessed with the Cochrane Risk of Bias tools and A Measurement Tool to Assess Systematic Reviews (AMSTAR) Checklist.
Results
We included 83 published reports in the final review: 33 systematic reviews, 29 randomised controlled trials, two randomised trials without placebo, three non-randomised trials with controls, six open-label trials and ten retrospective reviews. The results were presented via narrative synthesis.
Conclusions
Systematic reviews and meta-analyses provide support for robust, rapid and transient antidepressant and anti-suicidal effects of ketamine. Evidence for other indications is less robust, but suggests similarly positive and short-lived effects. The conclusions should be interpreted with caution because of the high risk of bias of included studies. Optimal dosing, modes of administration and the most effective forms of adjunctive psychotherapeutic support should be examined further.},
language = {en},
number = {1},
urldate = {2022-05-02},
journal = {BJPsych Open},
author = {Walsh, Zach and Mollaahmetoglu, Ozden Merve and Rootman, Joseph and Golsof, Shannon and Keeler, Johanna and Marsh, Beth and Nutt, David J. and Morgan, Celia J. A.},
month = jan,
year = {2022},
note = {Publisher: Cambridge University Press},
keywords = {Alcohol disorders, anxiety disorders, depressive disorders, ketamine, mental health disorders},
}
Downloads: 0
{"_id":"7ABh56FHCz7Rz956g","bibbaseid":"walsh-mollaahmetoglu-rootman-golsof-keeler-marsh-nutt-morgan-ketamineforthetreatmentofmentalhealthandsubstanceusedisorderscomprehensivesystematicreview-2022","author_short":["Walsh, Z.","Mollaahmetoglu, O. M.","Rootman, J.","Golsof, S.","Keeler, J.","Marsh, B.","Nutt, D. J.","Morgan, C. J. A."],"bibdata":{"bibtype":"article","type":"article","title":"Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review","volume":"8","issn":"2056-4724","shorttitle":"Ketamine for the treatment of mental health and substance use disorders","url":"https://www.cambridge.org/core/journals/bjpsych-open/article/ketamine-for-the-treatment-of-mental-health-and-substance-use-disorders-comprehensive-systematic-review/36E261BFA62CDA6459B88F7777415FDA","doi":"10.1192/bjo.2021.1061","abstract":"Background In the past two decades, subanaesthetic doses of ketamine have been demonstrated to have rapid and sustained antidepressant effects, and accumulating research has demonstrated ketamine's therapeutic effects for a range of psychiatric conditions. Aims In light of these findings surrounding ketamine's psychotherapeutic potential, we systematically review the extant evidence on ketamine's effects in treating mental health disorders. Method The systematic review protocol was registered in PROSPERO (identifier CRD42019130636). Human studies investigating the therapeutic effects of ketamine in the treatment of mental health disorders were included. Because of the extensive research in depression, bipolar disorder and suicidal ideation, only systematic reviews and meta-analyses were included. We searched Medline and PsycINFO on 21 October 2020. Risk-of-bias analysis was assessed with the Cochrane Risk of Bias tools and A Measurement Tool to Assess Systematic Reviews (AMSTAR) Checklist. Results We included 83 published reports in the final review: 33 systematic reviews, 29 randomised controlled trials, two randomised trials without placebo, three non-randomised trials with controls, six open-label trials and ten retrospective reviews. The results were presented via narrative synthesis. Conclusions Systematic reviews and meta-analyses provide support for robust, rapid and transient antidepressant and anti-suicidal effects of ketamine. Evidence for other indications is less robust, but suggests similarly positive and short-lived effects. The conclusions should be interpreted with caution because of the high risk of bias of included studies. Optimal dosing, modes of administration and the most effective forms of adjunctive psychotherapeutic support should be examined further.","language":"en","number":"1","urldate":"2022-05-02","journal":"BJPsych Open","author":[{"propositions":[],"lastnames":["Walsh"],"firstnames":["Zach"],"suffixes":[]},{"propositions":[],"lastnames":["Mollaahmetoglu"],"firstnames":["Ozden","Merve"],"suffixes":[]},{"propositions":[],"lastnames":["Rootman"],"firstnames":["Joseph"],"suffixes":[]},{"propositions":[],"lastnames":["Golsof"],"firstnames":["Shannon"],"suffixes":[]},{"propositions":[],"lastnames":["Keeler"],"firstnames":["Johanna"],"suffixes":[]},{"propositions":[],"lastnames":["Marsh"],"firstnames":["Beth"],"suffixes":[]},{"propositions":[],"lastnames":["Nutt"],"firstnames":["David","J."],"suffixes":[]},{"propositions":[],"lastnames":["Morgan"],"firstnames":["Celia","J.","A."],"suffixes":[]}],"month":"January","year":"2022","note":"Publisher: Cambridge University Press","keywords":"Alcohol disorders, anxiety disorders, depressive disorders, ketamine, mental health disorders","bibtex":"@article{walsh_ketamine_2022,\n\ttitle = {Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review},\n\tvolume = {8},\n\tissn = {2056-4724},\n\tshorttitle = {Ketamine for the treatment of mental health and substance use disorders},\n\turl = {https://www.cambridge.org/core/journals/bjpsych-open/article/ketamine-for-the-treatment-of-mental-health-and-substance-use-disorders-comprehensive-systematic-review/36E261BFA62CDA6459B88F7777415FDA},\n\tdoi = {10.1192/bjo.2021.1061},\n\tabstract = {Background\nIn the past two decades, subanaesthetic doses of ketamine have been demonstrated to have rapid and sustained antidepressant effects, and accumulating research has demonstrated ketamine's therapeutic effects for a range of psychiatric conditions.\n\nAims\nIn light of these findings surrounding ketamine's psychotherapeutic potential, we systematically review the extant evidence on ketamine's effects in treating mental health disorders.\n\nMethod\nThe systematic review protocol was registered in PROSPERO (identifier CRD42019130636). Human studies investigating the therapeutic effects of ketamine in the treatment of mental health disorders were included. Because of the extensive research in depression, bipolar disorder and suicidal ideation, only systematic reviews and meta-analyses were included. We searched Medline and PsycINFO on 21 October 2020. Risk-of-bias analysis was assessed with the Cochrane Risk of Bias tools and A Measurement Tool to Assess Systematic Reviews (AMSTAR) Checklist.\n\nResults\nWe included 83 published reports in the final review: 33 systematic reviews, 29 randomised controlled trials, two randomised trials without placebo, three non-randomised trials with controls, six open-label trials and ten retrospective reviews. The results were presented via narrative synthesis.\n\nConclusions\nSystematic reviews and meta-analyses provide support for robust, rapid and transient antidepressant and anti-suicidal effects of ketamine. Evidence for other indications is less robust, but suggests similarly positive and short-lived effects. The conclusions should be interpreted with caution because of the high risk of bias of included studies. Optimal dosing, modes of administration and the most effective forms of adjunctive psychotherapeutic support should be examined further.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2022-05-02},\n\tjournal = {BJPsych Open},\n\tauthor = {Walsh, Zach and Mollaahmetoglu, Ozden Merve and Rootman, Joseph and Golsof, Shannon and Keeler, Johanna and Marsh, Beth and Nutt, David J. and Morgan, Celia J. A.},\n\tmonth = jan,\n\tyear = {2022},\n\tnote = {Publisher: Cambridge University Press},\n\tkeywords = {Alcohol disorders, anxiety disorders, depressive disorders, ketamine, mental health disorders},\n}\n\n","author_short":["Walsh, Z.","Mollaahmetoglu, O. M.","Rootman, J.","Golsof, S.","Keeler, J.","Marsh, B.","Nutt, D. J.","Morgan, C. J. A."],"key":"walsh_ketamine_2022","id":"walsh_ketamine_2022","bibbaseid":"walsh-mollaahmetoglu-rootman-golsof-keeler-marsh-nutt-morgan-ketamineforthetreatmentofmentalhealthandsubstanceusedisorderscomprehensivesystematicreview-2022","role":"author","urls":{"Paper":"https://www.cambridge.org/core/journals/bjpsych-open/article/ketamine-for-the-treatment-of-mental-health-and-substance-use-disorders-comprehensive-systematic-review/36E261BFA62CDA6459B88F7777415FDA"},"keyword":["Alcohol disorders","anxiety disorders","depressive disorders","ketamine","mental health disorders"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/CECTC","dataSources":["WJssAw9LjPNgXmhEE"],"keywords":["alcohol disorders","anxiety disorders","depressive disorders","ketamine","mental health disorders"],"search_terms":["ketamine","treatment","mental","health","substance","use","disorders","comprehensive","systematic","review","walsh","mollaahmetoglu","rootman","golsof","keeler","marsh","nutt","morgan"],"title":"Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review","year":2022}