Chromoendoscopy with targeted biopsies is superior to white-light endoscopy for the long-term follow-up detection of dysplasia in ulcerative colitis patients: a multicenter randomized–controlled trial. Wan, J., Zhang, Q., Liang, S., Zhong, J., Li, J., Ran, Z., Zhi, F., Wang, X., Zhang, X., Wen, Z., Sheng, J., Shi, H., Mei, Q., & Wu, K. Gastroenterology Report, 9(1):14–21, January, 2021. 00000 ZSCC: NoCitationData[s0]![Chromoendoscopy with targeted biopsies is superior to white-light endoscopy for the long-term follow-up detection of dysplasia in ulcerative colitis patients: a multicenter randomized–controlled trial [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Data from single-center experience or small sample-sized studies have shown that chromoendoscopy (CE) might be superior to white-light endoscopy (WLE) for dysplasia surveillance in ulcerative colitis (UC) patients. We performed a prospective randomized trial with a long-term follow-up to compare the detection rate of dysplasia among WLE with targeted biopsies (WLT), WLE with random biopsies (WLR), and dye-based CE with targeted biopsies (CET) in UC patients.Patients with long-standing UC were enrolled from 11 medical centers from March 2012 to December 2013 and randomized into three arms (WLT, WLR, and CET). Only high-definition endoscopy was used in all three groups. The patients were followed up by annual endoscopy with biopsies through December 2017.With a median follow-up time of 55 months, a total of 122 patients with 447 colonoscopies were finally analysed in the per-protocol set: WLT (n = 43), WLR (n = 40), and CET (n = 39). A total of 34 dysplastic lesions were found in 29 colonoscopies of 21 patients. WLR and CET could identify more colonoscopies that diagnosed dysplasia than WLT (8.1% and 9.7% vs 1.9%; P = 0.014 and 0.004, respectively). WLR obtained more biopsied samples than WLT and CET (16.4 ± 5.1 vs 4.3 ± 1.4 and 4.3 ± 1.4; both P < 0.001). During the second half of the follow-up (37 − 69 months), CET could identify more colonoscopies that diagnosed dysplasia than WLT (13.3% vs 1.6%, P = 0.015) and showed a trend for increasing the detection rate compared with WLR (13.3% vs 4.9%, P = 0.107).For a better outcome of cancer/dysplasia surveillance in patients with long-standing UC, CET appeared to be more effective than WLT and less tedious than WLR. CET was found to be particularly useful when a long-term (>3 years) follow-up was conducted for dysplasia surveillance. The trial was registered on www.chictr.org.cn (ChiCTR1900023689).
@article{wan_chromoendoscopy_2021,
title = {Chromoendoscopy with targeted biopsies is superior to white-light endoscopy for the long-term follow-up detection of dysplasia in ulcerative colitis patients: a multicenter randomized–controlled trial},
volume = {9},
issn = {2052-0034},
shorttitle = {Chromoendoscopy with targeted biopsies is superior to white-light endoscopy for the long-term follow-up detection of dysplasia in ulcerative colitis patients},
url = {https://doi.org/10.1093/gastro/goaa028},
doi = {10/gm972k},
abstract = {Data from single-center experience or small sample-sized studies have shown that chromoendoscopy (CE) might be superior to white-light endoscopy (WLE) for dysplasia surveillance in ulcerative colitis (UC) patients. We performed a prospective randomized trial with a long-term follow-up to compare the detection rate of dysplasia among WLE with targeted biopsies (WLT), WLE with random biopsies (WLR), and dye-based CE with targeted biopsies (CET) in UC patients.Patients with long-standing UC were enrolled from 11 medical centers from March 2012 to December 2013 and randomized into three arms (WLT, WLR, and CET). Only high-definition endoscopy was used in all three groups. The patients were followed up by annual endoscopy with biopsies through December 2017.With a median follow-up time of 55 months, a total of 122 patients with 447 colonoscopies were finally analysed in the per-protocol set: WLT (n = 43), WLR (n = 40), and CET (n = 39). A total of 34 dysplastic lesions were found in 29 colonoscopies of 21 patients. WLR and CET could identify more colonoscopies that diagnosed dysplasia than WLT (8.1\% and 9.7\% vs 1.9\%; P = 0.014 and 0.004, respectively). WLR obtained more biopsied samples than WLT and CET (16.4 ± 5.1 vs 4.3 ± 1.4 and 4.3 ± 1.4; both P \< 0.001). During the second half of the follow-up (37 − 69 months), CET could identify more colonoscopies that diagnosed dysplasia than WLT (13.3\% vs 1.6\%, P = 0.015) and showed a trend for increasing the detection rate compared with WLR (13.3\% vs 4.9\%, P = 0.107).For a better outcome of cancer/dysplasia surveillance in patients with long-standing UC, CET appeared to be more effective than WLT and less tedious than WLR. CET was found to be particularly useful when a long-term (\>3 years) follow-up was conducted for dysplasia surveillance. The trial was registered on www.chictr.org.cn (ChiCTR1900023689).},
number = {1},
urldate = {2021-11-02},
journal = {Gastroenterology Report},
author = {Wan, Jian and Zhang, Qin and Liang, Shu-Hui and Zhong, Jie and Li, Jing-Nan and Ran, Zhi-Hua and Zhi, Fa-Chao and Wang, Xiao-Di and Zhang, Xiao-Lan and Wen, Zhong-Hui and Sheng, Jian-Qiu and Shi, Hua-Xiu and Mei, Qiao and Wu, Kai-Chun},
month = jan,
year = {2021},
note = {00000
ZSCC: NoCitationData[s0]},
pages = {14--21},
}
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{"_id":"poTkvmKLA66Fid5kb","bibbaseid":"wan-zhang-liang-zhong-li-ran-zhi-wang-etal-chromoendoscopywithtargetedbiopsiesissuperiortowhitelightendoscopyforthelongtermfollowupdetectionofdysplasiainulcerativecolitispatientsamulticenterrandomizedcontrolledtrial-2021","author_short":["Wan, J.","Zhang, Q.","Liang, S.","Zhong, J.","Li, J.","Ran, Z.","Zhi, F.","Wang, X.","Zhang, X.","Wen, Z.","Sheng, J.","Shi, H.","Mei, Q.","Wu, K."],"bibdata":{"bibtype":"article","type":"article","title":"Chromoendoscopy with targeted biopsies is superior to white-light endoscopy for the long-term follow-up detection of dysplasia in ulcerative colitis patients: a multicenter randomized–controlled trial","volume":"9","issn":"2052-0034","shorttitle":"Chromoendoscopy with targeted biopsies is superior to white-light endoscopy for the long-term follow-up detection of dysplasia in ulcerative colitis patients","url":"https://doi.org/10.1093/gastro/goaa028","doi":"10/gm972k","abstract":"Data from single-center experience or small sample-sized studies have shown that chromoendoscopy (CE) might be superior to white-light endoscopy (WLE) for dysplasia surveillance in ulcerative colitis (UC) patients. We performed a prospective randomized trial with a long-term follow-up to compare the detection rate of dysplasia among WLE with targeted biopsies (WLT), WLE with random biopsies (WLR), and dye-based CE with targeted biopsies (CET) in UC patients.Patients with long-standing UC were enrolled from 11 medical centers from March 2012 to December 2013 and randomized into three arms (WLT, WLR, and CET). Only high-definition endoscopy was used in all three groups. The patients were followed up by annual endoscopy with biopsies through December 2017.With a median follow-up time of 55 months, a total of 122 patients with 447 colonoscopies were finally analysed in the per-protocol set: WLT (n = 43), WLR (n = 40), and CET (n = 39). A total of 34 dysplastic lesions were found in 29 colonoscopies of 21 patients. WLR and CET could identify more colonoscopies that diagnosed dysplasia than WLT (8.1% and 9.7% vs 1.9%; P = 0.014 and 0.004, respectively). WLR obtained more biopsied samples than WLT and CET (16.4 ± 5.1 vs 4.3 ± 1.4 and 4.3 ± 1.4; both P < 0.001). During the second half of the follow-up (37 − 69 months), CET could identify more colonoscopies that diagnosed dysplasia than WLT (13.3% vs 1.6%, P = 0.015) and showed a trend for increasing the detection rate compared with WLR (13.3% vs 4.9%, P = 0.107).For a better outcome of cancer/dysplasia surveillance in patients with long-standing UC, CET appeared to be more effective than WLT and less tedious than WLR. CET was found to be particularly useful when a long-term (>3 years) follow-up was conducted for dysplasia surveillance. The trial was registered on www.chictr.org.cn (ChiCTR1900023689).","number":"1","urldate":"2021-11-02","journal":"Gastroenterology Report","author":[{"propositions":[],"lastnames":["Wan"],"firstnames":["Jian"],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Qin"],"suffixes":[]},{"propositions":[],"lastnames":["Liang"],"firstnames":["Shu-Hui"],"suffixes":[]},{"propositions":[],"lastnames":["Zhong"],"firstnames":["Jie"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Jing-Nan"],"suffixes":[]},{"propositions":[],"lastnames":["Ran"],"firstnames":["Zhi-Hua"],"suffixes":[]},{"propositions":[],"lastnames":["Zhi"],"firstnames":["Fa-Chao"],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Xiao-Di"],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Xiao-Lan"],"suffixes":[]},{"propositions":[],"lastnames":["Wen"],"firstnames":["Zhong-Hui"],"suffixes":[]},{"propositions":[],"lastnames":["Sheng"],"firstnames":["Jian-Qiu"],"suffixes":[]},{"propositions":[],"lastnames":["Shi"],"firstnames":["Hua-Xiu"],"suffixes":[]},{"propositions":[],"lastnames":["Mei"],"firstnames":["Qiao"],"suffixes":[]},{"propositions":[],"lastnames":["Wu"],"firstnames":["Kai-Chun"],"suffixes":[]}],"month":"January","year":"2021","note":"00000 ZSCC: NoCitationData[s0]","pages":"14–21","bibtex":"@article{wan_chromoendoscopy_2021,\n\ttitle = {Chromoendoscopy with targeted biopsies is superior to white-light endoscopy for the long-term follow-up detection of dysplasia in ulcerative colitis patients: a multicenter randomized–controlled trial},\n\tvolume = {9},\n\tissn = {2052-0034},\n\tshorttitle = {Chromoendoscopy with targeted biopsies is superior to white-light endoscopy for the long-term follow-up detection of dysplasia in ulcerative colitis patients},\n\turl = {https://doi.org/10.1093/gastro/goaa028},\n\tdoi = {10/gm972k},\n\tabstract = {Data from single-center experience or small sample-sized studies have shown that chromoendoscopy (CE) might be superior to white-light endoscopy (WLE) for dysplasia surveillance in ulcerative colitis (UC) patients. We performed a prospective randomized trial with a long-term follow-up to compare the detection rate of dysplasia among WLE with targeted biopsies (WLT), WLE with random biopsies (WLR), and dye-based CE with targeted biopsies (CET) in UC patients.Patients with long-standing UC were enrolled from 11 medical centers from March 2012 to December 2013 and randomized into three arms (WLT, WLR, and CET). Only high-definition endoscopy was used in all three groups. The patients were followed up by annual endoscopy with biopsies through December 2017.With a median follow-up time of 55 months, a total of 122 patients with 447 colonoscopies were finally analysed in the per-protocol set: WLT (n = 43), WLR (n = 40), and CET (n = 39). A total of 34 dysplastic lesions were found in 29 colonoscopies of 21 patients. WLR and CET could identify more colonoscopies that diagnosed dysplasia than WLT (8.1\\% and 9.7\\% vs 1.9\\%; P = 0.014 and 0.004, respectively). WLR obtained more biopsied samples than WLT and CET (16.4 ± 5.1 vs 4.3 ± 1.4 and 4.3 ± 1.4; both P \\< 0.001). During the second half of the follow-up (37 − 69 months), CET could identify more colonoscopies that diagnosed dysplasia than WLT (13.3\\% vs 1.6\\%, P = 0.015) and showed a trend for increasing the detection rate compared with WLR (13.3\\% vs 4.9\\%, P = 0.107).For a better outcome of cancer/dysplasia surveillance in patients with long-standing UC, CET appeared to be more effective than WLT and less tedious than WLR. CET was found to be particularly useful when a long-term (\\>3 years) follow-up was conducted for dysplasia surveillance. 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